Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)

Science

Volumn 281, Issue 5378, 1998, Pages 818-821

  Marx, Steven O ^a   Ondrias, Karol ^b   Marks, Andrew R ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CHANNEL ACCESSORY PROTEIN FKBP12; RECEPTOR PROTEIN; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CELL ULTRASTRUCTURE; CHANNEL GATING; EXCITATION CONTRACTION COUPLING; INSECT; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CARRIER PROTEINS; CELL LINE; DNA-BINDING PROTEINS; HEAT-SHOCK PROTEINS; ION CHANNEL GATING; LIPID BILAYERS; MUSCLE, SKELETAL; POLYENES; PROBABILITY; RABBITS; RECOMBINANT PROTEINS; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SIROLIMUS; SPODOPTERA; TACROLIMUS BINDING PROTEINS;

INSECTA;

EID: 0032493913     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.281.5378.818     Document Type: Article

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24. calc is the calculated open probability of the 4-pA currents and P2 is the observed open probability of the 8-pA currents (10). The formula is useful when the open probabilities of two channels are approximately equal and pertains to all experimentally observed values for P2. Student's t test was used for statistical analysis of the dwell-time distributions and open probabilities.
25. calc is the calculated open probability of the 4-pA currents and P2 is the observed open probability of the 8-pA currents (10). The formula is useful when the open probabilities of two channels are approximately equal and pertains to all experimentally observed values for P2. Student's t test was used for statistical analysis of the dwell-time distributions and open probabilities.
26. We thank R. Kass, Q. Al-Awqati, S. Siegelbaum, B. Ehrlich, and S. Hamilton for critical reading of the manuscript and for helpful discussions. Supported by NIH grants R01HL56180, R01A139794 and R03TW00949 (A.R.M.), the Muscular Dystrophy Association (A.R.M.), the American Heart Association (A.R.M. and S.O.M.), and the Richard and Lynne Kaiser Family Foundation.