Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures

Nature Neuroscience

Volumn 5, Issue 8, 2002, Pages 796-804

  Smolders, Ilse ^a   Bortolotto, Zuner A ^b   Clarke, Vernon R J ^b   Warre, Ruth ^b   Khan, Ghous M ^a   O’Neill, Michael J ^c   Ornstein, Paul L ^c   Bleakman, David ^c   Ogden, AnnMarie ^c   Weiss, Brianne ^c   Stables, James P ^d   Ho, Ken H ^e   Ebinger, Guy ^f   Collingridge, Graham L ^b   Lodge, David ^c   Michotte, Yvette ^a  

^a PHARMACEUTICAL INSTITUTE   (Belgium)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c ELI LILLY AND COMPANY   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e Allelix Pharmaceuticals   (Belgium)

^f UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 6 (4 CARBOXYBENZYL) 1,2,3,4,4A,5,6,7,8,8A DECAHYDRO 3 ISOQUINOLINECARBOXYLIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; KAINIC ACID RECEPTOR ANTAGONIST; LY 377770; PILOCARPINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROSTIMULATION; EPILEPSY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SYNAPTIC TRANSMISSION;

ACTION POTENTIALS; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTRIC STIMULATION; ELECTROSHOCK; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; ISOQUINOLINES; KAINIC ACID; LIMBIC SYSTEM; MALE; MICE; PILOCARPINE; RATS; RATS, WISTAR; RECEPTORS, KAINIC ACID; SUBSTRATE SPECIFICITY; TREATMENT OUTCOME;

EID: 0036321170     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn880     Document Type: Article

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