Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice

Journal of Neuroscience

Volumn 25, Issue 4, 2005, Pages 977-984

  Ko, Shanelle ^a   Zhao, Ming Gao ^a   Toyoda, Hiroki ^a   Qiu, Chang Shen ^a   Zhuo, Min ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Capsaicin; Complete Freund's adjuvant; Fear memory; Inflammatory pain; Kainate receptor; Knock out mice

Indexed keywords

CAPSAICIN; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; KAINIC ACID RECEPTOR;

AMINO ACID DEFICIENCY; AMNESIA; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL SCIENCE; EXCITATION AND STIMULATION; FEAR; INHIBITION KINETICS; KNOCKOUT MOUSE; MALE; MECHANICAL STIMULATION; MEMORY; MOUSE; NERVE CELL PLASTICITY; NEUROTRANSMITTER RELEASE; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION; THERMAL STIMULATION; TRAINING;

AMYGDALA; ANIMALS; AUDITORY CORTEX; BEHAVIOR, ANIMAL; CAPSAICIN; CONDITIONING, CLASSICAL; EXCITATORY POSTSYNAPTIC POTENTIALS; FEAR; FORMALDEHYDE; HEAT; INFLAMMATION; MALE; MEMORY; MICE; MICE, KNOCKOUT; NEURONAL PLASTICITY; PAIN; REACTION TIME; RECEPTORS, KAINIC ACID;

EID: 12844287661     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4059-04.2005     Document Type: Article

References (45)

1. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
2. Braga MF, Aroniadou-Anderjaska V, Xie J, Li H (2003) Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. J Neurosci 23:442-452.
3. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313.
4. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55-63.
5. Cossart R, Epsztein J, Tyzio R, Becq H, Hirsch J, Ben-Ari Y, Crepel V (2002) Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons. Neuron 35:147-159.
6. Davies J, Evans RH, Francis AA, Watkins JC (1979) Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system. J Physiol (Paris) 75:641-654.
7. Davis M, Walker DL, Lee Y (1997) Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex. Philos Trans R Soc Lond B Biol Sci 352:1675-1687.
8. Frankland PW, O'Brien C, Ohno M, Kirkwood A, Silva AJ (2001) α-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature 411:309-313.
9. Frerking M, Nicoll RA (2000) Synaptic kainate receptors. Curr Opin Neurobiol 10:342-351.
10. Guo W, Zou S, Tal M, Ren K (2002) Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression. Eur J Pharmacol 452:309-318.
11. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
12. Huettner JE (1990) Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 5:255-266.
13. Huettner JE (2003) Kainate receptors and synaptic transmission. Prog Neurobiol 70:387-407.
14. Huettner JE, Kerchner GA, Zhuo M (2002) Glutamate and the presynaptic control of spinal sensory transmission. The Neuroscientist 8:89-92.
15. Hwang SJ, Pagliardini S, Rustioni A, Valtschanoff JG (2001) Presynaptic kainate receptors in primary afferents to the superficial laminae of the rat spinal cord. J Comp Neurol 436:275-289.
16. Kerchner GA, Zhuo M (2002) Presynaptic suppression of dorsal horn inhibitory transmission by μ-opioid receptors. J Neurophysiol 88:520-522.
17. Kerchner GA, Wilding TJ, Li P, Zhuo M, Huettner JE (2001a) Presynaptic kainate receptors regulate spinal sensory transmission. J Neurosci 21:59-66.
18. Kerchner GA, Wang GD, Qiu CS, Huettner JE, Zhuo M (2001b) Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism. Neuron 32:477-488.
19. Kerchner GA, Wilding TJ, Huettner JE, Zhuo M (2002) Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. J Neurosci 22:8010-8017.
20. Kullmann DM (2001) Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity. Neuron 32:561-564.
21. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
22. Lerma J (2003) Roles and rules of kainate receptors in synaptic transmission. Nat Rev Neurosci 4:481-495.
23. Li H, Rogawski MA (1998) GluR5 kainate receptor mediated synaptic transmission in rat basolateral amygdala in vitro. Neuropharmacology 37:1279-1286.
24. Li H, Chen A, Xing G, Wei ML, Rogawski MA (2001) Kainate receptor-mediated heterosynaptic facilitation in the amygdala. Nat Neurosci 4:612-620.
25. Li P, Wilding TJ, Kim SJ, Calejesan AA, Huettner JE, Zhuo M (1999) Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature 397:161-164.
26. Maren S (1999) Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. Trends Neurosci 22:561-567.
27. Maren S (2001) Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24:897-931.
28. McKernan MG, Shinnick-Gallagher P (1997) Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 390:607-611.
29. Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Bettler B, Heinemann SF (1998) Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 392:601-605.
30. Mulle C, Sailer A, Swanson GT, Brana C, O'Gorman S, Bettler B, Heinemann SF (2000) Subunit composition of kainate receptors in hippocampal interneurons. Neuron 28:475-484.
31. Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082.
32. Paternain AV, Morales M, Lerma J (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
33. Procter MJ, Houghton AK, Faber ES, Chizh BA, Ornstein PL, Lodge D, Headley PM (1998) Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord. Neuropharmacology 37:1287-1297.
34. Rogan MT, Staubli UV, LeDoux JE (1997) Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390:604-607.
35. Rogawski MA, Gryder D, Castaneda D, Yonekawa W, Banks MK, Lia H (2003) GluR5 kainate receptors, seizures, and the amygdala. Ann NY Acad Sci 985:150-162.
36. Sailer A, Swanson GT, Perez-Otano I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF (1999) Generation and analysis of GluR5(Q636R) kainate receptor mutant mice. J Neurosci 19:8757-8764.
37. Simmons RM, Li DL, Hoo KH, Deverill M, Ornstein PL, Iyengar S (1998) Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat. Neuropharmacology 37:25-36.
38. Sutherland RJ, McDonald RJ (1990) Hippocampus, amygdala, and memory deficits in rats. Behav Brain Res 37:57-79.
39. Tolle TR, Berthele A, Zieglgansberger W, Seeburg PH, Wisden W (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J Neurosci 13:5009-5028.
40. Tsvetkov E, Carlezon WA, Benes FM, Kandel ER, Bolshakov VY (2002) Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron 34:289-300.
41. Tsvetkov E, Shin RM, Bolshakov VY (2004) Glutamate uptake determines pathway specificity of long-term potentiation in the neural circuitry of fear conditioning. Neuron 41:139-151.
42. Wei F, Wang GD, Kerchner GA, Kim SJ, Xu HM, Chen ZF, Zhuo M (2001) Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci 4:164-169.
43. Wei F, Qiu CS, Liauw J, Robinson DA, Ho N, Chatila T, Zhuo M (2002) Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci 5:573-579.
44. Wilding TJ, Huettner JE (1995) Differential antagonism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Mol Pharmacol 47:582-587.
45. Youn DH, Randic M (2004) Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in kainate receptor GluR5 or 6 subunit. J Physiol (Lond) 555:683-698.