Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

Journal of Neurochemistry

Volumn 115, Issue 5, 2010, Pages 1215-1221

  Zhang, Dawei ^a   Zhang, Chen ^a,b   Ho, Angela ^a,c   Kirkwood, Alfredo ^d   SüDhof, Thomas C ^b   Shen, Jie ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Boston University   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Conditional knockout; LTP; Neurodegeneration; Neurotransmitter release; NMDA receptor; Synaptic dysfunction; Synaptic facilitation

Indexed keywords

CALCIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PRESENILIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; KNOCKOUT MOUSE; LONG TERM POTENTIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPATHY; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC DEFECT; PRESYNAPTIC DEFECT; PRIORITY JOURNAL; PROTEIN DEPLETION; SYNAPSE; THETA RHYTHM;

AGING; ANIMALS; BIOPHYSICS; CALCIUM; CEREBRAL CORTEX; ELECTRIC STIMULATION; LONG-TERM POTENTIATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PRESENILINS; PROBABILITY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

MUS;

EID: 78149259168     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07011.x     Document Type: Article

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