Presenilins are essential for regulating neurotransmitter release

Nature

Volumn 460, Issue 7255, 2009, Pages 632-636

  Zhang, Chen ^a,b   Wu, Bei ^a   Beglopoulos, Vassilios ^a   Wines Samuelson, Mary ^a   Zhang, Dawei ^a   Dragatsis, Ioannis ^c   Südhof, Thomas C ^b   Shen, Jie ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DIZOCILPINE; GLUTAMIC ACID; NEUROTRANSMITTER; PRESENILIN; RYANODINE RECEPTOR; THAPSIGARGIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM;

GENE EXPRESSION; MUTATION; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; PATHOGEN;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; ENDOPLASMIC RETICULUM; LONG TERM POTENTIATION; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPSE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; METABOLISM; MOUSE MUTANT; SYNAPTOSOME; TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; NEUROTRANSMITTER AGENTS; PRESENILINS; PRESYNAPTIC TERMINALS;

EID: 67949086707     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08177     Document Type: Article

References (34)

1. Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
2. Hsia, A. Y. et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl Acad. Sci. USA 96, 3228-3233 (1999).
3. Saura, C. A. et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42, 23-36 (2004).
4. Selkoe, D. J. Alzheimer's disease is a synaptic failure. Science 298, 789-791 (2002).
5. Shen, J. & Kelleher, R. J. III. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc. Natl Acad. Sci. USA 104, 403-409 (2007).
6. Feng, R. et al. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc. Natl Acad. Sci. USA 101, 8162-8167 (2004).
7. Zakharenko, S. S. et al. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. Neuron 39, 975-990 (2003).
8. Nakazawa, K. et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297, 211-218 (2002).
9. Yu, H. et al. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31, 713-726 (2001).
10. Hessler, N. A., Shirke, A. M. & Malinow, R. The probability of transmitter release at a mammalian central synapse. Nature 366, 569-572 (1993).
11. Rosenmund, C., Clements, J. D. & Westbrook, G. L. Nonuniform probability of glutamate release at a hippocampal synapse. Science 262, 754-757 (1993).
12. 2+ entry, and spontaneous transmitter release. Neuron 29, 197-208 (2001).
13. Chan, S. L., Mayne, M., Holden, C. P., Geiger, J. D. & Mattson, M. P. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J. Biol. Chem. 275, 18195-18200 (2000).
14. Green, K. N. et al. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J. Cell Biol. 181, 1107-1116 (2008).
15. 2+ signals and altered membrane excitability. J. Neurosci. 24, 508-513 (2004).
16. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126, 981-993 (2006).
17. 2+-ATPases. Trends Pharmacol. Sci. 19, 131-135 (1998).
18. Gafni, J. et al. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron 19, 723-733 (1997).
19. 2+ release channel of sarcoplasmic reticulum. J. Biol. Chem. 261, 6300-6306 (1986).
20. 2+ disruptions in young, adult, and aged Alzheimer's disease mice. J. Neurosci. 26, 5180-5189 (2006).
21. Handler, M., Yang, X. & Shen, J. Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127, 2593-2606 (2000).
22. Shen, J. et al. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89, 629-639 (1997).
23. Kamenetz, F. et al. APP processing and synaptic function. Neuron 37, 925-937 (2003).
24. Snyder, E. M. et al. Regulation of NMDA receptor trafficking by amyloid-β. Nature Neurosci. 8, 1051-1058 (2005).
25. Buxbaum, J. D. et al. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J. Neurosci. 18, 9629-9637 (1998).
26. Lazarov, O., Lee, M., Peterson, D. A. & Sisodia, S. S. Evidence that synaptically released β-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J. Neurosci. 22, 9785-9793 (2002).
27. Yao, P. J. & Coleman, P. D. Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease. Neurosci. Lett. 252, 33-36 (1998).
28. Saura, C. A. et al. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J. Neurosci. 25, 6755-6764 (2005).
29. Goldberg, M. S. et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45, 489-496 (2005).
30. Kitada, T. et al. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc. Natl Acad. Sci. USA 104, 11441-11446 (2007).
31. Steiner, H. et al. A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and notch signaling. J. Biol. Chem. 274, 28669-28673 (1999).
32. Wines-Samuelson, M., Handler, M. & Shen, J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev. Biol. 277, 332-346 (2005).
33. Watanabe, H. et al. Indirect regulation of presenilins in CREB-mediated transcription. J. Biol. Chem. 284, 13705-13713 (2009).
34. 2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nature Neurosci. 5, 425-430 (2002).