Kainate receptors coming of age: Milestones of two decades of research

Trends in Neurosciences

Volumn 34, Issue 3, 2011, Pages 154-163

  Contractor, Anis ^a   Mulle, Christophe ^b   Swanson, Geoffrey T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KAINIC ACID RECEPTOR;

CENTRAL NERVOUS SYSTEM; HUMAN; MENTAL DISEASE; MENTAL RETARDATION MALFORMATION SYNDROME; MOLECULAR CLONING; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SYNAPTIC TRANSMISSION;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HUMANS; NEUROSCIENCES; RECEPTORS, KAINIC ACID;

EID: 79952245139     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2010.12.002     Document Type: Review

References (150)

1. Jane D.E., et al. Kainate receptors: pharmacology, function and therapeutic potential. Neuropharmacology 2009, 56:90-113.
2. Hollmann M., Heinemann S. Cloned glutamate receptors. Annu. Rev. Neurosci. 1994, 17:31-108.
3. Bettler B., et al. Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Neuron 1990, 5:583-595.
4. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985, 14:375-403.
5. Nadler J.V., et al. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature 1978, 271:676-677.
6. Herndon R.M., Coyle J.T. Selective destruction of neurons by a transmitter agonist. Science 1977, 198:71-72.
7. Lodge D. The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature. Neuropharmacology 2009, 56:6-21.
8. Monaghan D.T., et al. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 1989, 29:365-402.
9. Agrawal S.G., Evans R.H. The primary afferent depolarizing action of kainate in the rat. Br. J. Pharmacol. 1986, 87:345-355.
10. Huettner J.E. Glutamate receptor channels in rat DRG neurons: activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 1990, 5:255-266.
11. Boulter J., et al. Molecular cloning and functional expression of glutamate receptor subunit genes. Science 1990, 249:1033-1037.
12. Keinänen K., et al. A family of AMPA-selective glutamate receptors. Science 1990, 249:556-560.
13. Hollmann M., et al. Cloning by functional expression of a member of the glutamate receptor family. Nature 1989, 342:643-648.
14. Sommer B., et al. A glutamate receptor channel with high affinity for domoate and kainate. EMBO J. 1992, 11:1651-1656.
15. Egebjerg J., et al. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 1991, 351:745-748.
16. Bettler B., et al. Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit. Neuron 1992, 8:257-265.
17. 3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. 1982, 252:91-100.
18. Werner P., et al. Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells. Nature 1991, 351:742-744.
19. Herb A., et al. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron 1992, 8:775-785.
20. Sakimura K., et al. Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron 1992, 8:267-274.
21. 3H]kainic acid to receptor sites in rat brain. Mol. Pharmacol. 1979, 15:492-505.
22. 3H]kainic acid binding sites in the rat forebrain. Eur. J. Pharmacol. 1983, 86:361-371.
23. Schiffer H.H., et al. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron 1997, 19:1141-1146.
24. Wenthold R.J., et al. Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. J. Biol. Chem. 1994, 269:1332-1339.
25. Bettler B., Mulle C. Review: neurotransmitter receptors. II. AMPA and kainate receptors. Neuropharmacology 1995, 34:123-139.
26. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron 1993, 10:491-500.
27. Sommer B., et al. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 1991, 67:11-19.
28. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:755-759.
29. Swanson G.T., et al. Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors. J. Physiol. 1996, 492:129-142.
30. Hollmann M., et al. N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 1994, 13:1331-1343.
31. Wo Z.G., Oswald R.E. Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:7154-7158.
32. Stern-Bach Y., et al. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 1994, 13:1345-1357.
33. Kuryatov A., et al. Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron 1994, 12:1291-1300.
34. Kuusinen A., et al. Molecular dissection of the agonist binding site of an AMPA receptor. EMBO J. 1995, 14:6327-6332.
35. Armstrong N., et al. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 1998, 395:913-917.
36. Naur P., et al. Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. FEBS Lett. 2005, 579:1154-1160.
37. Nanao M.H., et al. Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:1708-1713.
38. Mayer M.L. Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity. Neuron 2005, 45:539-552.
39. Kumar J., et al. The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Nat. Struct. Mol. Biol. 2009, 16:631-638.
40. Jin R., et al. Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J. 2009, 28:1812-1823.
41. Ayalon G., Stern-Bach Y. Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron 2001, 31:103-113.
42. Hansen K.B., et al. Structural aspects of AMPA receptor activation, desensitization and deactivation. Curr. Opin. Neurobiol. 2007, 17:281-288.
43. Lerma J., et al. Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:11688-11692.
44. Heckmann M., et al. Kinetics of homomeric GluR6 glutamate receptor channels. Biophys. J. 1996, 71:1743-1750.
45. Weston M.C., et al. Conformational restriction blocks glutamate receptor desensitization. Nat. Struct. Mol. Biol. 2006, 13:1120-1127.
46. Plested A.J., Mayer M.L. Structure and mechanism of kainate receptor modulation by anions. Neuron 2007, 53:829-841.
47. Plested A.J., et al. Molecular basis of kainate receptor modulation by sodium. Neuron 2008, 58:720-735.
48. + in the channel gating of native and recombinant kainate receptors. J. Neurosci. 2003, 23:8641-8648.
49. Wong A.Y., et al. External ions are coactivators of kainate receptors. J. Neurosci. 2006, 26:5750-5755.
50. Bowie D. Ion-dependent gating of kainate receptors. J. Physiol. 2010, 588:67-81.
51. Garcia E.P., et al. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 1998, 21:727-739.
52. Hirbec H., et al. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Neuron 2003, 37:625-638.
53. Selak S., et al. A role for SNAP25 in internalization of kainate receptors and synaptic plasticity. Neuron 2009, 63:357-371.
54. Coussen F., et al. Co-assembly of two GluR6 kainate receptor splice variants within a functional protein complex. Neuron 2005, 47:555-566.
55. Salinas G.D., et al. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. J. Biol. Chem. 2006, 281:40164-40173.
56. Mondin M., et al. Profilin II regulates the exocytosis of kainate glutamate receptors. J. Biol. Chem. 2010, 17:40060-40071.
57. Laezza F., et al. KRIP6: a novel BTB/kelch protein regulating function of kainate receptors. Mol. Cell. Neurosci. 2007, 34:539-550.
58. Zhang W., et al. A transmembrane accessory subunit that modulates kainate-type glutamate receptors. Neuron 2009, 61:385-396.
59. Jaskolski F., et al. Subunit composition and alternative splicing regulate membrane delivery of kainate receptors. J. Neurosci. 2004, 24:2506-2515.
60. Yan S., et al. A C-terminal determinant of GluR6 kainate receptor trafficking. J. Neurosci. 2004, 24:679-691.
61. Nasu-Nishimura Y., et al. Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. J. Neurosci. 2006, 26:7014-7021.
62. Ren Z., et al. Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression. J. Neurosci. 2003, 23:6608-6616.
63. Ren Z., et al. Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal. J. Biol. Chem. 2003, 278:52700-52709.
64. Traynelis S.F., Wahl P. Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. J. Physiol. 1997, 503:513-531.
65. Pickering D.S., et al. Palmitoylation of the GluR6 kainate receptor. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:12090-12094.
66. Martin S., et al. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 2007, 447:321-325.
67. Jaskolski F., et al. Subcellular localization and trafficking of kainate receptors. Trends Pharmacol. Sci. 2005, 26:20-26.
68. Huxter J.R., et al. Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations. J. Neurosci. 2007, 27:2212-2223.
69. Alt A., et al. Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro. Neuropharmacology 2004, 46:793-806.
70. Donevan S.D., Rogawski M.A. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron 1993, 10:51-59.
71. Bleakman D., et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology 1996, 35:1689-1702.
72. Paternain A.V., et al. Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 1995, 14:185-189.
73. Castillo P.E., et al. Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature 1997, 388:182-186.
74. Vignes M., Collingridge G.L. The synaptic activation of kainate receptors. Nature 1997, 388:179-182.
75. Cossart R., et al. GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells. Nat. Neurosci. 1998, 1:470-478.
76. Frerking M., et al. Synaptic activation of kainate receptors on hippocampal interneurons. Nat. Neurosci. 1998, 1:479-486.
77. Bureau I., et al. Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:6838-6843.
78. Miyata M., Imoto K. Different composition of glutamate receptors in corticothalamic and lemniscal synaptic responses and their roles in the firing responses of ventrobasal thalamic neurons in juvenile mice. J. Physiol. 2006, 575:161-174.
79. -/- mice. J. Neurosci. 2003, 23:422-429.
80. Fernandes H.B., et al. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 2009, 63:818-829.
81. Barberis A., et al. GluR6/KA2 kainate receptors mediate slow-deactivating currents. J. Neurosci. 2008, 28:6402-6406.
82. Frerking M., Ohliger-Frerking P. AMPA receptors and kainate receptors encode different features of afferent activity. J. Neurosci. 2002, 22:7434-7443.
83. Sachidhanandam S., et al. Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. J. Neurosci. 2009, 29:5000-5008.
84. Goldin M., et al. Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency. J. Neurosci. 2007, 27:9560-9572.
85. Pinheiro P.S., Mulle C. Presynaptic glutamate receptors: physiological functions and mechanisms of action. Nat. Rev. Neurosci. 2008, 9:423-436.
86. Contractor A., Swanson G.T. Kainate receptors. The Glutamate Receptors 2008, 99-158. Humana Press. R.W. Gereau, G.T. Swanson (Eds.).
87. Chittajallu R., et al. Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature 1996, 379:78-81.
88. Lerma J. Kainate receptor physiology. Curr. Opin. Pharmacol. 2006, 6:89-97.
89. Huettner J.E. Kainate receptors and synaptic transmission. Prog. Neurobiol. 2003, 70:387-407.
90. Contractor A., et al. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 2001, 29:209-216.
91. Lauri S.E., et al. A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP. Neuron 2001, 32:697-709.
92. Pinheiro P.S., et al. GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12181-12186.
93. Schmitz D., et al. Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses. Science 2001, 291:1972-1976.
94. Bortolotto Z.A., et al. Kainate receptors are involved in synaptic plasticity. Nature 1999, 402:297-301.
95. Schmitz D., et al. Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat. Neurosci. 2003, 6:1058-1063.
96. 2+-store-dependent short-term plasticity at hippocampal mossy fiber synapses. J. Neurosci. 2008, 28:13139-13149.
97. Breustedt J., Schmitz D. Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses. J. Neurosci. 2004, 24:10093-10098.
98. More J.C., et al. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 2004, 47:46-64.
99. Perrais D., et al. Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology 2009, 56:131-140.
100. 2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron 2003, 39:327-341.
101. Darstein M., et al. Distribution of kainate receptor subunits at hippocampal mossy fiber synapses. J. Neurosci. 2003, 23:8013-8019.
102. Kwon H.B., Castillo P.E. Role of glutamate autoreceptors at hippocampal mossy fiber synapses. Neuron 2008, 60:1082-1094.
103. Pinheiro P., Mulle C. Kainate receptors. Cell Tissue Res. 2006, 326:457-482.
104. Clarke V.R., et al. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997, 389:599-603.
105. Rodriguez-Moreno A., et al. Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. Neuron 1997, 19:893-901.
106. Frerking M., et al. Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:12917-12922.
107. Rodriguez-Moreno A., et al. Two populations of kainate receptors with separate signaling mechanisms in hippocampal interneurons. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1293-1298.
108. Jiang L., et al. A kainate receptor increases the efficacy of GABAergic synapses. Neuron 2001, 30:503-513.
109. Cossart R., et al. Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons. Neuron 2001, 29:497-508.
110. Mulle C., et al. Subunit composition of kainate receptors in hippocampal interneurons. Neuron 2000, 28:475-484.
111. Sun H.Y., Dobrunz L.E. Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at Schaffer collateral synapses. J. Neurosci. 2006, 26:10796-10807.
112. Min M.Y., et al. Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:9932-9937.
113. Semyanov A., Kullmann D.M. Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons. Nat. Neurosci. 2001, 4:718-723.
114. Lourenco J., et al. Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. Nat. Neurosci. 2010, 13:197-204.
115. Rodriguez-Moreno A., Lerma J. Kainate receptor modulation of GABA release involves a metabotropic function. Neuron 1998, 20:1211-1218.
116. Melyan Z., et al. Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells. Neuron 2002, 34:107-114.
117. Ruiz A., et al. Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. J. Neurosci. 2005, 25:11710-11718.
118. Rozas J.L., et al. Noncanonical signaling by ionotropic kainate receptors. Neuron 2003, 39:543-553.
119. Segerstrale M., et al. High firing rate of neonatal hippocampal interneurons is caused by attenuation of afterhyperpolarizing potassium currents by tonically active kainate receptors. J. Neurosci. 2010, 30:6507-6514.
120. Chergui K., et al. Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. J. Neurosci. 2000, 20:2175-2182.
121. Li H., et al. Kainate receptor-mediated heterosynaptic facilitation in the amygdala. Nat. Neurosci. 2001, 4:612-620.
122. Wu L.J., et al. Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex. Curr. Pharm. Des. 2007, 13:1597-1605.
123. Mulle C., et al. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 1998, 392:601-605.
124. Vissel B., et al. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 2001, 29:217-227.
125. Smolders I., et al. Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat. Neurosci. 2002, 5:796-804.
126. Epsztein J., et al. Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats. J. Neurosci. 2005, 25:8229-8239.
127. Epsztein J., et al. A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats. Cereb. Cortex 2009, 20:898-911.
128. Alberdi E., et al. Activation of kainate receptors sensitizes oligodendrocytes to complement attack. J. Neurosci. 2006, 26:3220-3228.
129. Pickard B.S., et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry 2006, 11:847-857.
130. Shibata H., et al. Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia. Psychiatry Res. 2002, 113:59-67.
131. Sampaio A.S., et al. Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study. CNS Neurosci Ther 2010, 10.1111/j.1755-5949.2009.00130.x.
132. Delorme R., et al. Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. Neuroreport 2004, 15:699-702.
133. Schiffer H.H., Heinemann S.F. Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:20-26.
134. Jamain S., et al. Linkage and association of the glutamate receptor 6 gene with autism. Mol. Psychiatry 2002, 7:302-310.
135. Shuang M., et al. Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004, 131B:48-50.
136. Kim S.A., et al. Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios. Neurosci. Res. 2007, 58:332-335.
137. Dutta S., et al. Glutamate receptor 6 gene (GLUR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder. Cell. Mol. Neurobiol. 2007, 27:1035-1047.
138. Motazacker M.M., et al. A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation. Am. J. Hum. Genet. 2007, 81:792-798.
139. Lauri S.E., et al. Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus. J. Neurosci. 2005, 25:4473-4484.
140. Lauri S.E., et al. Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release. Neuron 2006, 50:415-429.
141. Marchal C., Mulle C. Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors. J. Physiol. 2004, 561:27-37.
142. Kidd F.L., et al. A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during development. Neuron 2002, 34:635-646.
143. Schmitz D., et al. Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses. Neuron 2000, 27:327-338.
144. Lomeli H., et al. High-affinity kainate and domoate receptors in rat brain. FEBS Lett. 1992, 307:139-143.
145. Morita T., et al. Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel. Brain Res. Mol. Brain Res. 1992, 14:143-146.
146. Kamboj R.K., et al. Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. Mol. Pharmacol. 1992, 42:10-15.
147. Kamboj R.K., et al. Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit. J. Neurochem. 1994, 62:1-9.
148. Nutt S.L., et al. Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. Receptors Channels 1994, 2:315-326.
149. Lodge D., Dingledine R. Ionotropic glutamate receptors. The IUPHAR Compendium of Receptor Characterization and Classification 2000, IUPHAR Media, 189-194. 2nd edn.
150. Collingridge G.L., et al. A nomenclature for ligand-gated ion channels. Neuropharmacology 2009, 56:2-5.