-
1
-
-
38549159026
-
Cellular and molecular mechanisms of fibrosis
-
Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210
-
(2008)
J Pathol
, vol.214
, pp. 199-210
-
-
Wynn, T.A.1
-
3
-
-
33846488954
-
Fibrogenesis in Crohn's disease
-
Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, O'Connell PR. Fibrogenesis in Crohn's disease. Am J Gastroenterol 2007; 102: 439-448
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 439-448
-
-
Burke, J.P.1
Mulsow, J.J.2
O'Keane, C.3
Docherty, N.G.4
Watson, R.W.5
O'Connell, P.R.6
-
4
-
-
65549115862
-
Plasticity of CD4+ T cell lineage differentiation
-
Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009; 30: 646-655
-
(2009)
Immunity
, vol.30
, pp. 646-655
-
-
Zhou, L.1
Chong, M.M.2
Littman, D.R.3
-
5
-
-
58149268107
-
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein
-
Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009; 30: 80-91
-
(2009)
Immunity
, vol.30
, pp. 80-91
-
-
Lu, L.F.1
Thai, T.H.2
Calado, D.P.3
Chaudhry, A.4
Kubo, M.5
Tanaka, K.6
Loeb, G.B.7
Lee, H.8
Yoshimura, A.9
Rajewsky, K.10
Rudensky, A.Y.11
-
6
-
-
0033933804
-
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
-
von Lampe B, Barthel B, Coupland SE, Riecken EO, Rosewicz S. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 2000; 47: 63-73
-
(2000)
Gut
, vol.47
, pp. 63-73
-
-
von Lampe, B.1
Barthel, B.2
Coupland, S.E.3
Riecken, E.O.4
Rosewicz, S.5
-
7
-
-
0034903792
-
The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study
-
Faubion WA, Loftus EV, Harmsen WS, Zinsmeister AR, Sandborn WJ. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology 2001; 121: 255-260
-
(2001)
Gastroenterology
, vol.121
, pp. 255-260
-
-
Faubion, W.A.1
Loftus, E.V.2
Harmsen, W.S.3
Zinsmeister, A.R.4
Sandborn, W.J.5
-
8
-
-
12344291265
-
Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
-
Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005; 54: 237-241
-
(2005)
Gut
, vol.54
, pp. 237-241
-
-
Cosnes, J.1
Nion-Larmurier, I.2
Beaugerie, L.3
Afchain, P.4
Tiret, E.5
Gendre, J.P.6
-
9
-
-
0000487030
-
Complete bowel obstruction following initial response to infliximab therapy for Crohn's disease: A series of a newly described complication
-
Toy LS, Scherl EJ, Kornbluth A, Marion JF, Greenstein AJ, Agus S, Gerson C, Fox N, Present DH. Complete bowel obstruction following initial response to infliximab therapy for Crohn's disease: A series of a newly described complication. Gastroenterology 2000; 118 (Suppl 2) A569
-
(2000)
Gastroenterology
, vol.118
, Issue.SUPPL. 2
-
-
Toy, L.S.1
Scherl, E.J.2
Kornbluth, A.3
Marion, J.F.4
Greenstein, A.J.5
Agus, S.6
Gerson, C.7
Fox, N.8
Present, D.H.9
-
10
-
-
34249881088
-
Operative management of small bowel Crohn's disease
-
Gardiner KR, Dasari BV. Operative management of small bowel Crohn's disease. Surg Clin North Am 2007; 87: 587-610
-
(2007)
Surg Clin North Am
, vol.87
, pp. 587-610
-
-
Gardiner, K.R.1
Dasari, B.V.2
-
11
-
-
49649123332
-
Surgery for inflammatory bowel disease
-
Hwang JM, Varma MG. Surgery for inflammatory bowel disease. World J Gastroenterol 2008; 14: 2678-2690
-
(2008)
World J Gastroenterol
, vol.14
, pp. 2678-2690
-
-
Hwang, J.M.1
Varma, M.G.2
-
12
-
-
33947245615
-
Endoscopic balloon dilatation of intestinal strictures in Crohn's disease: Safe alternative to surgery
-
Ajlouni Y, Iser JH, Gibson PR. Endoscopic balloon dilatation of intestinal strictures in Crohn's disease: safe alternative to surgery. J Gastroenterol Hepatol 2007; 22: 486-490
-
(2007)
J Gastroenterol Hepatol
, vol.22
, pp. 486-490
-
-
Ajlouni, Y.1
Iser, J.H.2
Gibson, P.R.3
-
13
-
-
4644308778
-
Prevention of fibrosis in experimental colitis by captopril: The role of tgfbeta1
-
Wengrower D, Zanninelli G, Pappo O, Latella G, Sestieri M, Villanova A, Faitelson Y, Pines M, Goldin E. Prevention of fibrosis in experimental colitis by captopril: the role of tgfbeta1. Inflamm Bowel Dis 2004; 10: 536-545
-
(2004)
Inflamm Bowel Dis
, vol.10
, pp. 536-545
-
-
Wengrower, D.1
Zanninelli, G.2
Pappo, O.3
Latella, G.4
Sestieri, M.5
Villanova, A.6
Faitelson, Y.7
Pines, M.8
Goldin, E.9
-
14
-
-
44049097231
-
Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid
-
Latella G, Sferra R, Vetuschi A, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Gaudio E. Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid. Eur J Clin Invest 2008; 38: 410-420
-
(2008)
Eur J Clin Invest
, vol.38
, pp. 410-420
-
-
Latella, G.1
Sferra, R.2
Vetuschi, A.3
Zanninelli, G.4
D'Angelo, A.5
Catitti, V.6
Caprilli, R.7
Gaudio, E.8
-
15
-
-
33846001022
-
Wound healing and fibrosis in intestinal disease
-
Rieder F, Brenmoehl J, Leeb S, Schölmerich J, Rogler G. Wound healing and fibrosis in intestinal disease. Gut 2007; 56: 130-139
-
(2007)
Gut
, vol.56
, pp. 130-139
-
-
Rieder, F.1
Brenmoehl, J.2
Leeb, S.3
Schölmerich, J.4
Rogler, G.5
-
16
-
-
0033618337
-
Matrix metalloproteinases
-
Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem 1999; 274: 21491-21494
-
(1999)
J Biol Chem
, vol.274
, pp. 21491-21494
-
-
Nagase, H.1
Woessner, J.F.2
-
17
-
-
33847350691
-
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
-
Wynn TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524-529
-
(2007)
J Clin Invest
, vol.117
, pp. 524-529
-
-
Wynn, T.A.1
-
18
-
-
0042768013
-
Inflammatory joint disease: Clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destruction
-
McCartney-Francis NL, Chan J, Wahl SM. Inflammatory joint disease: clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destruction. Methods Mol Biol 2003; 225: 147-159
-
(2003)
Methods Mol Biol
, vol.225
, pp. 147-159
-
-
McCartney-Francis, N.L.1
Chan, J.2
Wahl, S.M.3
-
19
-
-
62449175839
-
Interactions between extracellular matrix and growth factors in wound healing
-
Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen 2009; 17: 153-162
-
(2009)
Wound Repair Regen
, vol.17
, pp. 153-162
-
-
Schultz, G.S.1
Wysocki, A.2
-
20
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5: 446-458
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
21
-
-
36849077704
-
Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease
-
Szebeni B, Veres G, Dezsõfi A, Rusai K, Vannay A, Mraz M, Majorova E, Arató A. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin Exp Immunol 2008; 151: 34-41
-
(2008)
Clin Exp Immunol
, vol.151
, pp. 34-41
-
-
Szebeni, B.1
Veres, G.2
Dezsõfi, A.3
Rusai, K.4
Vannay, A.5
Mraz, M.6
Majorova, E.7
Arató, A.8
-
22
-
-
0034445697
-
Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
-
Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000; 68: 7010-7017
-
(2000)
Infect Immun
, vol.68
, pp. 7010-7017
-
-
Cario, E.1
Podolsky, D.K.2
-
23
-
-
3042521641
-
Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn' s disease and ulcerative colitis
-
Franchimont D, Vermeire S, El Housni H, Pierik M, Van Steen K, Gustot T, Quertinmont E, Abramowicz M, Van Gossum A, Devière J, Rutgeerts P. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn' s disease and ulcerative colitis. Gut 2004; 53: 987-992
-
(2004)
Gut
, vol.53
, pp. 987-992
-
-
Franchimont, D.1
Vermeire, S.2
El Housni, H.3
Pierik, M.4
van Steen, K.5
Gustot, T.6
Quertinmont, E.7
Abramowicz, M.8
van Gossum, A.9
Devière, J.10
Rutgeerts, P.11
-
24
-
-
2942689466
-
Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: Association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis
-
Török HP, Glas J, Tonenchi L, Mussack T, Folwaczny C. Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis. Clin Immunol 2004; 112: 85-91
-
(2004)
Clin Immunol
, vol.112
, pp. 85-91
-
-
Török, H.P.1
Glas, J.2
Tonenchi, L.3
Mussack, T.4
Folwaczny, C.5
-
25
-
-
52949145981
-
Increased immune reactivity predicts aggressive complicating Crohn' s disease in children
-
Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J. Increased immune reactivity predicts aggressive complicating Crohn' s disease in children. Clin Gastroenterol Hepatol 2008; 6: 1105-1111
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 1105-1111
-
-
Dubinsky, M.C.1
Kugathasan, S.2
Mei, L.3
Picornell, Y.4
Nebel, J.5
Wrobel, I.6
Quiros, A.7
Silber, G.8
Wahbeh, G.9
Katzir, L.10
Vasiliauskas, E.11
Bahar, R.12
Otley, A.13
Mck, D.14
Evans, J.15
Rosh, J.16
Hemker, M.O.17
Leleiko, N.18
Crandall, W.19
Langton, C.20
Landers, C.21
Taylor, K.D.22
Targan, S.R.23
Rotter, J.I.24
Markowitz, J.25
Hyams, J.26
more..
-
27
-
-
67649888821
-
Intestinal fibrosis in IBD--a dynamic, multifactorial process
-
Rieder F, Fiocchi C. Intestinal fibrosis in IBD--a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol 2009; 6: 228-235
-
(2009)
Nat Rev Gastroenterol Hepatol
, vol.6
, pp. 228-235
-
-
Rieder, F.1
Fiocchi, C.2
-
28
-
-
33847361903
-
Infectious disease, the innate immune response, and fibrosis
-
Meneghin A, Hogaboam CM. Infectious disease, the innate immune response, and fibrosis. J Clin Invest 2007; 117: 530-538
-
(2007)
J Clin Invest
, vol.117
, pp. 530-538
-
-
Meneghin, A.1
Hogaboam, C.M.2
-
29
-
-
58549089483
-
Toll-like receptors, wound healing, and carcinogenesis
-
Kluwe J, Mencin A, Schwabe RF. Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl) 2009; 87: 125-138
-
(2009)
J Mol Med (Berl)
, vol.87
, pp. 125-138
-
-
Kluwe, J.1
Mencin, A.2
Schwabe, R.F.3
-
30
-
-
35948958955
-
TLR4 enhances TGF-beta signaling and hepatic fibrosis
-
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007; 13: 1324-1332
-
(2007)
Nat Med
, vol.13
, pp. 1324-1332
-
-
Seki, E.1
de Minicis, S.2
Osterreicher, C.H.3
Kluwe, J.4
Osawa, Y.5
Brenner, D.A.6
Schwabe, R.F.7
-
31
-
-
0033619255
-
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI
-
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massagué J, Niehrs C. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401: 480-485
-
(1999)
Nature
, vol.401
, pp. 480-485
-
-
Onichtchouk, D.1
Chen, Y.G.2
Dosch, R.3
Gawantka, V.4
Delius, H.5
Massagué, J.6
Niehrs, C.7
-
32
-
-
0038281478
-
Intestinal myofibroblasts in innate immune responses of the intestine
-
Otte JM, Rosenberg IM, Podolsky DK. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003; 124: 1866-1878
-
(2003)
Gastroenterology
, vol.124
, pp. 1866-1878
-
-
Otte, J.M.1
Rosenberg, I.M.2
Podolsky, D.K.3
-
33
-
-
84864428677
-
Pro-Fibrogenic Activity of Toll-Like Receptor (TLR) and NOD-Like Receptor (NLR) Ligands on Human Intestinal Myofibroblasts (HIF)-Linking Bacterial Innate Immunity to Intestinal Fibrosis
-
S-35
-
Rieder F, Schirbel A, Ouygan Z, West G, Rho H, de la Motte C, Fiocchi C. Pro-Fibrogenic Activity of Toll-Like Receptor (TLR) and NOD-Like Receptor (NLR) Ligands on Human Intestinal Myofibroblasts (HIF)-Linking Bacterial Innate Immunity to Intestinal Fibrosis. Gastroenterology 2010; 138: S-35
-
(2010)
Gastroenterology
, vol.138
-
-
Rieder, F.1
Schirbel, A.2
Ouygan, Z.3
West, G.4
Rho, H.5
de la Motte, C.6
Fiocchi, C.7
-
34
-
-
0031201212
-
The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis
-
Keane MP, Arenberg DA, Lynch JP, Whyte RI, Iannettoni MD, Burdick MD, Wilke CA, Morris SB, Glass MC, Di-Giovine B, Kunkel SL, Strieter RM. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol 1997; 159: 1437-1443
-
(1997)
J Immunol
, vol.159
, pp. 1437-1443
-
-
Keane, M.P.1
Arenberg, D.A.2
Lynch, J.P.3
Whyte, R.I.4
Iannettoni, M.D.5
Burdick, M.D.6
Wilke, C.A.7
Morris, S.B.8
Glass, M.C.9
Di-Giovine, B.10
Kunkel, S.L.11
Strieter, R.M.12
-
35
-
-
77950995288
-
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease
-
Gazouli M, Pachoula I, Panayotou I, Mantzaris G, Chrousos G, Anagnou NP, Roma-Giannikou E. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J Gastroenterol 2010; 16: 1753-1758
-
(2010)
World J Gastroenterol
, vol.16
, pp. 1753-1758
-
-
Gazouli, M.1
Pachoula, I.2
Panayotou, I.3
Mantzaris, G.4
Chrousos, G.5
Anagnou, N.P.6
Roma-Giannikou, E.7
-
36
-
-
0842321801
-
The frameshift mutation of the NOD2/CARD15 gene is significantly increased in ulcerative colitis: An *IG-IBD study
-
Andriulli A, Annese V, Latiano A, Palmieri O, Fortina P, Ardizzone S, Cottone M, D'Inca R, Riegler G. The frameshift mutation of the NOD2/CARD15 gene is significantly increased in ulcerative colitis: an *IG-IBD study. Gastroenterology 2004; 126: 625-627
-
(2004)
Gastroenterology
, vol.126
, pp. 625-627
-
-
Andriulli, A.1
Annese, V.2
Latiano, A.3
Palmieri, O.4
Fortina, P.5
Ardizzone, S.6
Cottone, M.7
D'Inca, R.8
Riegler, G.9
-
37
-
-
4444253690
-
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
-
Watanabe T, Kitani A, Murray PJ, Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004; 5: 800-808
-
(2004)
Nat Immunol
, vol.5
, pp. 800-808
-
-
Watanabe, T.1
Kitani, A.2
Murray, P.J.3
Strober, W.4
-
38
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
-
Wehkamp J, Harder J, Weichenthal M, Schwab M, Schäffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schröder JM, Bevins CL, Fellermann K, Stange EF. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004; 53: 1658-1664
-
(2004)
Gut
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
Schwab, M.4
Schäffeler, E.5
Schlee, M.6
Herrlinger, K.R.7
Stallmach, A.8
Noack, F.9
Fritz, P.10
Schröder, J.M.11
Bevins, C.L.12
Fellermann, K.13
Stange, E.F.14
-
39
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell RA. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005; 307: 731-734
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
Henegariu, O.4
Inohara, N.5
Nuñez, G.6
Flavell, R.A.7
-
40
-
-
0036725827
-
Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
-
Abreu MT, Taylor KD, Lin YC, Hang T, Gaiennie J, Landers CJ, Vasiliauskas EA, Kam LY, Rojany M, Papadakis KA, Rotter JI, Targan SR, Yang H. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology 2002; 123: 679-688
-
(2002)
Gastroenterology
, vol.123
, pp. 679-688
-
-
Abreu, M.T.1
Taylor, K.D.2
Lin, Y.C.3
Hang, T.4
Gaiennie, J.5
Landers, C.J.6
Vasiliauskas, E.A.7
Kam, L.Y.8
Rojany, M.9
Papadakis, K.A.10
Rotter, J.I.11
Targan, S.R.12
Yang, H.13
-
41
-
-
51749106170
-
Genetics of inflammatory bowel disease: Clues to pathogenesis
-
Zhang H, Massey D, Tremelling M, Parkes M. Genetics of inflammatory bowel disease: clues to pathogenesis. Br Med Bull 2008; 87: 17-30
-
(2008)
Br Med Bull
, vol.87
, pp. 17-30
-
-
Zhang, H.1
Massey, D.2
Tremelling, M.3
Parkes, M.4
-
42
-
-
48349136889
-
Genome-wide association defines more than distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ. Genome-wide association defines more than distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40: 955-962
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
Bitton, A.11
Dassopoulos, T.12
Datta, L.W.13
Green, T.14
Griffiths, A.M.15
Kistner, E.O.16
Murtha, M.T.17
Regueiro, M.D.18
Rotter, J.I.19
Schumm, L.P.20
Steinhart, A.H.21
Targan, S.R.22
Xavier, R.J.23
Libioulle, C.24
Sandor, C.25
Lathrop, M.26
Belaiche, J.27
Dewit, O.28
Gut, I.29
Heath, S.30
Laukens, D.31
Mni, M.32
Rutgeerts, P.33
van Gossum, A.34
Zelenika, D.35
Franchimont, D.36
Hugot, J.P.37
de Vos, M.38
Vermeire, S.39
Louis, E.40
Cardon, L.R.41
Anderson, C.A.42
Drummond, H.43
Nimmo, E.44
Ahmad, T.45
Prescott, N.J.46
Onnie, C.M.47
Fisher, S.A.48
Marchini, J.49
Ghori, J.50
Bumpstead, S.51
Gwilliam, R.52
Tremelling, M.53
Deloukas, P.54
Mansfield, J.55
Jewell, D.56
Satsangi, J.57
Mathew, C.G.58
Parkes, M.59
Georges, M.60
Daly, M.J.61
more..
-
43
-
-
77950298959
-
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
-
McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010; 42: 332-337
-
(2010)
Nat Genet
, vol.42
, pp. 332-337
-
-
McGovern, D.P.1
Gardet, A.2
Törkvist, L.3
Goyette, P.4
Essers, J.5
Taylor, K.D.6
Neale, B.M.7
Ong, R.T.8
Lagacé, C.9
Li, C.10
Green, T.11
Stevens, C.R.12
Beauchamp, C.13
Fleshner, P.R.14
Carlson, M.15
D'Amato, M.16
Halfvarson, J.17
Hibberd, M.L.18
Lördal, M.19
Padyukov, L.20
Andriulli, A.21
Colombo, E.22
Latiano, A.23
Palmieri, O.24
Bernard, E.J.25
Deslandres, C.26
Hommes, D.W.27
de Jong, D.J.28
Stokkers, P.C.29
Weersma, R.K.30
Sharma, Y.31
Silverberg, M.S.32
Cho, J.H.33
Wu, J.34
Roeder, K.35
Brant, S.R.36
Schumm, L.P.37
Duerr, R.H.38
Dubinsky, M.C.39
Glazer, N.L.40
Haritunians, T.41
Ippoliti, A.42
Melmed, G.Y.43
Siscovick, D.S.44
Vasiliauskas, E.A.45
Targan, S.R.46
Annese, V.47
Wijmenga, C.48
Pettersson, S.49
Rotter, J.I.50
Xavier, R.J.51
Daly, M.J.52
Rioux, J.D.53
Seielstad, M.54
more..
-
44
-
-
34447101822
-
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease
-
Meijer MJ, Mieremet-Ooms MA, van Hogezand RA, Lamers CB, Hommes DW, Verspaget HW. Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. World J Gastroenterol 2007; 13: 2960-2966
-
(2007)
World J Gastroenterol
, vol.13
, pp. 2960-2966
-
-
Meijer, M.J.1
Mieremet-Ooms, M.A.2
van Hogezand, R.A.3
Lamers, C.B.4
Hommes, D.W.5
Verspaget, H.W.6
-
45
-
-
62049085384
-
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
-
Weersma RK, Stokkers PC, Cleynen I, Wolfkamp SC, Henckaerts L, Schreiber S, Dijkstra G, Franke A, Nolte IM, Rutgeerts P, Wijmenga C, Vermeire S. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol 2009; 104: 630-638
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 630-638
-
-
Weersma, R.K.1
Stokkers, P.C.2
Cleynen, I.3
Wolfkamp, S.C.4
Henckaerts, L.5
Schreiber, S.6
Dijkstra, G.7
Franke, A.8
Nolte, I.M.9
Rutgeerts, P.10
Wijmenga, C.11
Vermeire, S.12
-
46
-
-
69249152654
-
Genetic risk profiling and prediction of disease course in Crohn's disease patients
-
Henckaerts L, Van Steen K, Verstreken I, Cleynen I, Franke A, Schreiber S, Rutgeerts P, Vermeire S. Genetic risk profiling and prediction of disease course in Crohn's disease patients. Clin Gastroenterol Hepatol 2009; 7: 972-980. e2
-
(2009)
Clin Gastroenterol Hepatol
, vol.7
, pp. 972-980
-
-
Henckaerts, L.1
van Steen, K.2
Verstreken, I.3
Cleynen, I.4
Franke, A.5
Schreiber, S.6
Rutgeerts, P.7
Vermeire, S.8
-
47
-
-
53849097306
-
Nonimmune cells in inflammatory bowel disease: From victim to villain
-
Danese S. Nonimmune cells in inflammatory bowel disease: from victim to villain. Trends Immunol 2008; 29: 555-564
-
(2008)
Trends Immunol
, vol.29
, pp. 555-564
-
-
Danese, S.1
-
49
-
-
34249944864
-
Inflammation and the mucosal microcirculation in inflammatory bowel disease: The ebb and flow
-
Danese S. Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow. Curr Opin Gastroenterol 2007; 23: 384-389
-
(2007)
Curr Opin Gastroenterol
, vol.23
, pp. 384-389
-
-
Danese, S.1
-
50
-
-
56449084208
-
Intestinal fibrosis in inflammatory bowel disease-Current knowledge and future perspectives
-
Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease-Current knowledge and future perspectives. J Crohns Colitis 2008; 2: 279-290
-
(2008)
J Crohns Colitis
, vol.2
, pp. 279-290
-
-
Rieder, F.1
Fiocchi, C.2
-
51
-
-
67649784378
-
Intestinal fibrosis in inflammatory bowel disease: Progress in basic and clinical science
-
Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol 2008; 24: 462-468
-
(2008)
Curr Opin Gastroenterol
, vol.24
, pp. 462-468
-
-
Rieder, F.1
Fiocchi, C.2
-
53
-
-
0034882269
-
Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease
-
Lawrance IC, Maxwell L, Doe W. Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflamm Bowel Dis 2001; 7: 226-236
-
(2001)
Inflamm Bowel Dis
, vol.7
, pp. 226-236
-
-
Lawrance, I.C.1
Maxwell, L.2
Doe, W.3
-
55
-
-
0036020947
-
Regulation of migration of human colonic myofibroblasts
-
Leeb SN, Vogl D, Falk W, Schölmerich J, Rogler G, Gelbmann CM. Regulation of migration of human colonic myofibroblasts. Growth Factors 2002; 20: 81-91
-
(2002)
Growth Factors
, vol.20
, pp. 81-91
-
-
Leeb, S.N.1
Vogl, D.2
Falk, W.3
Schölmerich, J.4
Rogler, G.5
Gelbmann, C.M.6
-
56
-
-
1442276971
-
Autocrine fibronectin-induced migration of human colonic fibroblasts
-
Leeb SN, Vogl D, Grossmann J, Falk W, Schölmerich J, Rogler G, Gelbmann CM. Autocrine fibronectin-induced migration of human colonic fibroblasts. Am J Gastroenterol 2004; 99: 335-340
-
(2004)
Am J Gastroenterol
, vol.99
, pp. 335-340
-
-
Leeb, S.N.1
Vogl, D.2
Grossmann, J.3
Falk, W.4
Schölmerich, J.5
Rogler, G.6
Gelbmann, C.M.7
-
57
-
-
0242490282
-
Reduced migration of fibroblasts in inflammatory bowel disease: Role of inflammatory mediators and focal adhesion kinase
-
Leeb SN, Vogl D, Gunckel M, Kiessling S, Falk W, Göke M, Schölmerich J, Gelbmann CM, Rogler G. Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase. Gastroenterology 2003; 125: 1341-1354
-
(2003)
Gastroenterology
, vol.125
, pp. 1341-1354
-
-
Leeb, S.N.1
Vogl, D.2
Gunckel, M.3
Kiessling, S.4
Falk, W.5
Göke, M.6
Schölmerich, J.7
Gelbmann, C.M.8
Rogler, G.9
-
58
-
-
77956286245
-
Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts
-
Rieder F, Georgieva M, Schirbel A, Artinger M, Zügner A, Blank M, Brenmoehl J, Schölmerich J, Rogler G. Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts. Inflamm Bowel Dis 2010; 16: 1505-1513
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1505-1513
-
-
Rieder, F.1
Georgieva, M.2
Schirbel, A.3
Artinger, M.4
Zügner, A.5
Blank, M.6
Brenmoehl, J.7
Schölmerich, J.8
Rogler, G.9
-
59
-
-
0037899249
-
The myofibroblast in wound healing and fibrocontractive diseases
-
Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003; 200: 500-503
-
(2003)
J Pathol
, vol.200
, pp. 500-503
-
-
Gabbiani, G.1
-
60
-
-
13844270572
-
Tissue repair, contraction, and the myofibroblast
-
Desmoulière A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 2005; 13: 7-12
-
(2005)
Wound Repair Regen
, vol.13
, pp. 7-12
-
-
Desmoulière, A.1
Chaponnier, C.2
Gabbiani, G.3
-
61
-
-
0032782848
-
Myofibroblasts. I. Paracrine cells important in health and disease
-
Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999; 277: C1-C9
-
(1999)
Am J Physiol
, vol.277
-
-
Powell, D.W.1
Mifflin, R.C.2
Valentich, J.D.3
Crowe, S.E.4
Saada, J.I.5
West, A.B.6
-
62
-
-
0032833987
-
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
-
Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 1999; 277: C183-C201
-
(1999)
Am J Physiol
, vol.277
-
-
Powell, D.W.1
Mifflin, R.C.2
Valentich, J.D.3
Crowe, S.E.4
Saada, J.I.5
West, A.B.6
-
63
-
-
0036083712
-
Physiology and pathophysiology of the interstitial cells of Cajal: From bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal
-
Sanders KM, Ordög T, Ward SM. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 2002; 282: G747-G756
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.282
-
-
Sanders, K.M.1
Ordög, T.2
Ward, S.M.3
-
64
-
-
47749130835
-
Regulation of inflammation by airway smooth muscle
-
Tliba O, Panettieri RA. Regulation of inflammation by airway smooth muscle. Curr Allergy Asthma Rep 2008; 8: 262-268
-
(2008)
Curr Allergy Asthma Rep
, vol.8
, pp. 262-268
-
-
Tliba, O.1
Panettieri, R.A.2
-
65
-
-
0037657907
-
Human intestinal epithelial and smooth muscle cells are potent producers of IL-6
-
Ng EK, Panesar N, Longo WE, Shapiro MJ, Kaminski DL, Tolman KC, Mazuski JE. Human intestinal epithelial and smooth muscle cells are potent producers of IL-6. Mediators Inflamm 2003; 12: 3-8
-
(2003)
Mediators Inflamm
, vol.12
, pp. 3-8
-
-
Ng, E.K.1
Panesar, N.2
Longo, W.E.3
Shapiro, M.J.4
Kaminski, D.L.5
Tolman, K.C.6
Mazuski, J.E.7
-
66
-
-
0032742051
-
Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential
-
Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F, Ramadori G. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999; 117: 1205-1221
-
(1999)
Gastroenterology
, vol.117
, pp. 1205-1221
-
-
Knittel, T.1
Kobold, D.2
Saile, B.3
Grundmann, A.4
Neubauer, K.5
Piscaglia, F.6
Ramadori, G.7
-
67
-
-
0032954505
-
Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
-
Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999; 44: 534-541
-
(1999)
Gut
, vol.44
, pp. 534-541
-
-
Apte, M.V.1
Haber, P.S.2
Darby, S.J.3
Rodgers, S.C.4
McCaughan, G.W.5
Korsten, M.A.6
Pirola, R.C.7
Wilson, J.S.8
-
68
-
-
0242405617
-
Endothelial-pericyte interactions in angiogenesis
-
Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003; 314: 15-23
-
(2003)
Cell Tissue Res
, vol.314
, pp. 15-23
-
-
Gerhardt, H.1
Betsholtz, C.2
-
69
-
-
33645302628
-
The epithelialmesenchymal transition: New insights in signaling, development, and disease
-
Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelialmesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 973-981
-
(2006)
J Cell Biol
, vol.172
, pp. 973-981
-
-
Lee, J.M.1
Dedhar, S.2
Kalluri, R.3
Thompson, E.W.4
-
70
-
-
77953769774
-
Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
-
Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010; 285: 20202-20212
-
(2010)
J Biol Chem
, vol.285
, pp. 20202-20212
-
-
Flier, S.N.1
Tanjore, H.2
Kokkotou, E.G.3
Sugimoto, H.4
Zeisberg, M.5
Kalluri, R.6
-
71
-
-
80054976356
-
Inflammationinduced endothelial-to-mesenchymal transition: A novel mechanism of intestinal fibrosis
-
Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C. Inflammationinduced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol 2011; 179: 2660-2673
-
(2011)
Am J Pathol
, vol.179
, pp. 2660-2673
-
-
Rieder, F.1
Kessler, S.P.2
West, G.A.3
Bhilocha, S.4
de la Motte, C.5
Sadler, T.M.6
Gopalan, B.7
Stylianou, E.8
Fiocchi, C.9
-
72
-
-
77958187285
-
Intestinal stem cells
-
Umar S. Intestinal stem cells. Curr Gastroenterol Rep 2010; 12: 340-348
-
(2010)
Curr Gastroenterol Rep
, vol.12
, pp. 340-348
-
-
Umar, S.1
-
73
-
-
18444374439
-
In vivo characterization of bone marrowderived fibroblasts recruited into fibrotic lesions
-
Ishii G, Sangai T, Sugiyama K, Ito T, Hasebe T, Endoh Y, Magae J, Ochiai A. In vivo characterization of bone marrowderived fibroblasts recruited into fibrotic lesions. Stem Cells 2005; 23: 699-706
-
(2005)
Stem Cells
, vol.23
, pp. 699-706
-
-
Ishii, G.1
Sangai, T.2
Sugiyama, K.3
Ito, T.4
Hasebe, T.5
Endoh, Y.6
Magae, J.7
Ochiai, A.8
-
78
-
-
80051507729
-
From intestinal stem cells to inflammatory bowel diseases
-
Gersemann M, Stange EF, Wehkamp J. From intestinal stem cells to inflammatory bowel diseases. World J Gastroenterol 2011; 17: 3198-3203
-
(2011)
World J Gastroenterol
, vol.17
, pp. 3198-3203
-
-
Gersemann, M.1
Stange, E.F.2
Wehkamp, J.3
-
79
-
-
0025705880
-
Transforming growth factor-beta: Multifunctional regulator of differentiation and development
-
Roberts AB, Flanders KC, Heine UI, Jakowlew S, Kondaiah P, Kim SJ, Sporn MB. Transforming growth factor-beta: multifunctional regulator of differentiation and development. Philos Trans R Soc Lond B Biol Sci 1990; 327: 145-154
-
(1990)
Philos Trans R Soc Lond B Biol Sci
, vol.327
, pp. 145-154
-
-
Roberts, A.B.1
Flanders, K.C.2
Heine, U.I.3
Jakowlew, S.4
Kondaiah, P.5
Kim, S.J.6
Sporn, M.B.7
-
80
-
-
0036177427
-
Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation
-
Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002; 118: 211-215
-
(2002)
J Invest Dermatol
, vol.118
, pp. 211-215
-
-
Verrecchia, F.1
Mauviel, A.2
-
81
-
-
0035907240
-
Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
-
Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001; 276: 17058-17062
-
(2001)
J Biol Chem
, vol.276
, pp. 17058-17062
-
-
Verrecchia, F.1
Chu, M.L.2
Mauviel, A.3
-
82
-
-
3242797424
-
Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
-
Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 2004; 66: 597-604
-
(2004)
Kidney Int
, vol.66
, pp. 597-604
-
-
Inazaki, K.1
Kanamaru, Y.2
Kojima, Y.3
Sueyoshi, N.4
Okumura, K.5
Kaneko, K.6
Yamashiro, Y.7
Ogawa, H.8
Nakao, A.9
-
83
-
-
33846951514
-
Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis
-
Inagaki Y, Okazaki I. Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis. Gut 2007; 56: 284-292
-
(2007)
Gut
, vol.56
, pp. 284-292
-
-
Inagaki, Y.1
Okazaki, I.2
-
84
-
-
58649088728
-
Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis
-
Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V, Caprilli R, Flanders KC, Gaudio E. Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis. Eur J Clin Invest 2009; 39: 145-156
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 145-156
-
-
Latella, G.1
Vetuschi, A.2
Sferra, R.3
Zanninelli, G.4
D'Angelo, A.5
Catitti, V.6
Caprilli, R.7
Flanders, K.C.8
Gaudio, E.9
-
85
-
-
33645523595
-
Smad3 knock-out mice as a useful model to study intestinal fibrogenesis
-
Zanninelli G, Vetuschi A, Sferra R, D'Angelo A, Fratticci A, Continenza MA, Chiaramonte M, Gaudio E, Caprilli R, Latella G. Smad3 knock-out mice as a useful model to study intestinal fibrogenesis. World J Gastroenterol 2006; 12: 1211-1218
-
(2006)
World J Gastroenterol
, vol.12
, pp. 1211-1218
-
-
Zanninelli, G.1
Vetuschi, A.2
Sferra, R.3
D'Angelo, A.4
Fratticci, A.5
Continenza, M.A.6
Chiaramonte, M.7
Gaudio, E.8
Caprilli, R.9
Latella, G.10
-
86
-
-
34548173504
-
TGF-beta, Smad3 and the process of progressive fibrosis
-
Gauldie J, Bonniaud P, Sime P, Ask K, Kolb M. TGF-beta, Smad3 and the process of progressive fibrosis. Biochem Soc Trans 2007; 35: 661-664
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 661-664
-
-
Gauldie, J.1
Bonniaud, P.2
Sime, P.3
Ask, K.4
Kolb, M.5
-
87
-
-
26844479068
-
TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis
-
Bonniaud P, Margetts PJ, Ask K, Flanders K, Gauldie J, Kolb M. TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol 2005; 175: 5390-5395
-
(2005)
J Immunol
, vol.175
, pp. 5390-5395
-
-
Bonniaud, P.1
Margetts, P.J.2
Ask, K.3
Flanders, K.4
Gauldie, J.5
Kolb, M.6
-
88
-
-
15444375634
-
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells
-
Tsukada S, Westwick JK, Ikejima K, Sato N, Rippe RA. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem 2005; 280: 10055-10064
-
(2005)
J Biol Chem
, vol.280
, pp. 10055-10064
-
-
Tsukada, S.1
Westwick, J.K.2
Ikejima, K.3
Sato, N.4
Rippe, R.A.5
-
89
-
-
3543150126
-
High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal--regulated kinase and protein kinase Cdelta activities in human mesangial cells
-
Hayashida T, Schnaper HW. High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal--regulated kinase and protein kinase Cdelta activities in human mesangial cells. J Am Soc Nephrol 2004; 15: 2032-2041
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 2032-2041
-
-
Hayashida, T.1
Schnaper, H.W.2
-
91
-
-
0036595049
-
Suppressors of cytokine signalling (SOCS) in the immune system
-
Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002; 2: 410-416
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 410-416
-
-
Alexander, W.S.1
-
92
-
-
34447318899
-
Increased mucosal matrix metalloproteinase-1,-2,-3 and-9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype
-
Meijer MJ, Mieremet-Ooms MA, van der Zon AM, van Duijn W, van Hogezand RA, Sier CF, Hommes DW, Lamers CB, Verspaget HW. Increased mucosal matrix metalloproteinase-1,-2,-3 and-9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype. Dig Liver Dis 2007; 39: 733-739
-
(2007)
Dig Liver Dis
, vol.39
, pp. 733-739
-
-
Meijer, M.J.1
Mieremet-Ooms, M.A.2
van der Zon, A.M.3
van Duijn, W.4
van Hogezand, R.A.5
Sier, C.F.6
Hommes, D.W.7
Lamers, C.B.8
Verspaget, H.W.9
-
93
-
-
42549143615
-
Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
-
Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA, Corazza GR, Monteleone G, Mac-Donald TT. Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 2008; 57: 605-612
-
(2008)
Gut
, vol.57
, pp. 605-612
-
-
Di Sabatino, A.1
Pickard, K.M.2
Rampton, D.3
Kruidenier, L.4
Rovedatti, L.5
Leakey, N.A.6
Corazza, G.R.7
Monteleone, G.8
McDonald, T.T.9
-
94
-
-
0025117393
-
Activin-binding protein from rat ovary is follistatin
-
Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H. Activin-binding protein from rat ovary is follistatin. Science 1990; 247: 836-838
-
(1990)
Science
, vol.247
, pp. 836-838
-
-
Nakamura, T.1
Takio, K.2
Eto, Y.3
Shibai, H.4
Titani, K.5
Sugino, H.6
-
95
-
-
33744515391
-
Roles of activin in tissue repair, fibrosis, and inflammatory disease
-
Werner S, Alzheimer C. Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev 2006; 17: 157-171
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 157-171
-
-
Werner, S.1
Alzheimer, C.2
-
96
-
-
0032982486
-
A novel role of activin in inflammation and repair
-
Munz B, Hübner G, Tretter Y, Alzheimer C, Werner S. A novel role of activin in inflammation and repair. J Endocrinol 1999; 161: 187-193
-
(1999)
J Endocrinol
, vol.161
, pp. 187-193
-
-
Munz, B.1
Hübner, G.2
Tretter, Y.3
Alzheimer, C.4
Werner, S.5
-
97
-
-
0031225015
-
Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
-
Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997; 8: 171-179
-
(1997)
Cytokine Growth Factor Rev
, vol.8
, pp. 171-179
-
-
Grotendorst, G.R.1
-
98
-
-
0036775477
-
Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
-
Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002; 21: 473-482
-
(2002)
Matrix Biol
, vol.21
, pp. 473-482
-
-
Blom, I.E.1
Goldschmeding, R.2
Leask, A.3
-
99
-
-
44149090296
-
Role of platelet-derived growth factors in physiology and medicine
-
Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22: 1276-1312
-
(2008)
Genes Dev
, vol.22
, pp. 1276-1312
-
-
Andrae, J.1
Gallini, R.2
Betsholtz, C.3
-
100
-
-
0035677983
-
Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease
-
Kumagai S, Ohtani H, Nagai T, Funa K, Hiwatashi NO, Shimosegawa H. Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease. Tohoku J Exp Med 2001; 195: 21-33
-
(2001)
Tohoku J Exp Med
, vol.195
, pp. 21-33
-
-
Kumagai, S.1
Ohtani, H.2
Nagai, T.3
Funa, K.4
Hiwatashi, N.O.5
Shimosegawa, H.6
-
101
-
-
0034803527
-
Insulin-like growth factor 1 (IGF-1): A growth hormone
-
Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol Path 2001; 54: 311-316
-
(2001)
Mol Path
, vol.54
, pp. 311-316
-
-
Laron, Z.1
-
102
-
-
36148998002
-
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth
-
Simmons JG, Ling Y, Wilkins H, Fuller CR, D'Ercole AJ, Fagin J, Lund PK. Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth. Am J Physiol Gastrointest Liver Physiol 2007; 293: G995-1003
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.293
-
-
Simmons, J.G.1
Ling, Y.2
Wilkins, H.3
Fuller, C.R.4
D'Ercole, A.J.5
Fagin, J.6
Lund, P.K.7
-
103
-
-
0034948082
-
Expression of insulin-like growth factor binding proteins and collagen in experimental colitis in rats
-
Zeeh JM, Riley NE, Hoffmann P, Reinshagen M, Goebell H, Gerken G. Expression of insulin-like growth factor binding proteins and collagen in experimental colitis in rats. Eur J Gastroenterol Hepatol 2001; 13: 851-858
-
(2001)
Eur J Gastroenterol Hepatol
, vol.13
, pp. 851-858
-
-
Zeeh, J.M.1
Riley, N.E.2
Hoffmann, P.3
Reinshagen, M.4
Goebell, H.5
Gerken, G.6
-
104
-
-
0035038445
-
Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease
-
Zimmermann EM, Li L, Hou YT, Mohapatra NK, Pucilowska JB. Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1022-G1029
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.280
-
-
Zimmermann, E.M.1
Li, L.2
Hou, Y.T.3
Mohapatra, N.K.4
Pucilowska, J.B.5
-
105
-
-
0035735965
-
Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease
-
Katsanos KH, Tsatsoulis A, Christodoulou D, Challa A, Katsaraki A, Tsianos EV. Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease. Growth Horm IGF Res 2001; 11: 364-367
-
(2001)
Growth Horm IGF Res
, vol.11
, pp. 364-367
-
-
Katsanos, K.H.1
Tsatsoulis, A.2
Christodoulou, D.3
Challa, A.4
Katsaraki, A.5
Tsianos, E.V.6
-
106
-
-
0042308353
-
The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4
-
discussion 333-334
-
Earp HS, Calvo BF, Sartor CI. The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. Trans Am Clin Climatol Assoc 2003; 114: 315-333; discussion 333-334
-
(2003)
Trans Am Clin Climatol Assoc
, vol.114
, pp. 315-333
-
-
Earp, H.S.1
Calvo, B.F.2
Sartor, C.I.3
-
107
-
-
0016834989
-
The isolation of the urogastrones-inhibitors of gastric acid secretion-from human urine
-
Gregory H, Willshire IR. The isolation of the urogastrones-inhibitors of gastric acid secretion-from human urine. Hoppe Seylers Z Physiol Chem 1975; 356: 1765-1774
-
(1975)
Hoppe Seylers Z Physiol Chem
, vol.356
, pp. 1765-1774
-
-
Gregory, H.1
Willshire, I.R.2
-
108
-
-
0024386092
-
Distribution and release of epidermal growth factor in man
-
Konturek JW, Bielanski W, Konturek SJ, Bogdal J, Oleksy J. Distribution and release of epidermal growth factor in man. Gut 1989; 30: 1194-1200
-
(1989)
Gut
, vol.30
, pp. 1194-1200
-
-
Konturek, J.W.1
Bielanski, W.2
Konturek, S.J.3
Bogdal, J.4
Oleksy, J.5
-
109
-
-
26444515531
-
Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts
-
Hetzel M, Bachem M, Anders D, Trischler G, Faehling M. Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung 2005; 183: 225-237
-
(2005)
Lung
, vol.183
, pp. 225-237
-
-
Hetzel, M.1
Bachem, M.2
Anders, D.3
Trischler, G.4
Faehling, M.5
-
110
-
-
0033636796
-
Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats
-
Hoffmann P, Reinshagen M, Zeeh JM, Lakshmanan J, Wu VS, Goebell H, Gerken G, Eysselein VE. Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats. Scand J Gastroenterol 2000; 35: 1174-1180
-
(2000)
Scand J Gastroenterol
, vol.35
, pp. 1174-1180
-
-
Hoffmann, P.1
Reinshagen, M.2
Zeeh, J.M.3
Lakshmanan, J.4
Wu, V.S.5
Goebell, H.6
Gerken, G.7
Eysselein, V.E.8
-
111
-
-
65549121606
-
Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration
-
Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Schölmerich J, Rogler G. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroenterol 2009; 15: 1431-1442
-
(2009)
World J Gastroenterol
, vol.15
, pp. 1431-1442
-
-
Brenmoehl, J.1
Miller, S.N.2
Hofmann, C.3
Vogl, D.4
Falk, W.5
Schölmerich, J.6
Rogler, G.7
-
112
-
-
79956313171
-
Migration of connective tissue-derived cells is mediated by ultra-low concentration gradient fields of EGF
-
Kong Q, Majeska RJ, Vazquez M. Migration of connective tissue-derived cells is mediated by ultra-low concentration gradient fields of EGF. Exp Cell Res 2011; 317: 1491-1502
-
(2011)
Exp Cell Res
, vol.317
, pp. 1491-1502
-
-
Kong, Q.1
Majeska, R.J.2
Vazquez, M.3
-
113
-
-
0030992509
-
Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines
-
Cunningham ME, Huribal M, Bala RJ, McMillen MA. Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines. Crit Care Med 1997; 25: 958-964
-
(1997)
Crit Care Med
, vol.25
, pp. 958-964
-
-
Cunningham, M.E.1
Huribal, M.2
Bala, R.J.3
McMillen, M.A.4
-
114
-
-
0031962181
-
Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small intestine
-
Boros M, Massberg S, Baranyi L, Okada H, Messmer K. Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small intestine. Gastroenterology 1998; 114: 103-114
-
(1998)
Gastroenterology
, vol.114
, pp. 103-114
-
-
Boros, M.1
Massberg, S.2
Baranyi, L.3
Okada, H.4
Messmer, K.5
-
115
-
-
0032984149
-
Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: Role of ET(A) receptors and platelet-activating factor
-
Zouki C, Baron C, Fournier A, Filep JG. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. Br J Pharmacol 1999; 127: 969-979
-
(1999)
Br J Pharmacol
, vol.127
, pp. 969-979
-
-
Zouki, C.1
Baron, C.2
Fournier, A.3
Filep, J.G.4
-
116
-
-
0028902067
-
Endothelin mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines
-
Klemm P, Warner TD, Hohlfeld T, Corder R, Vane JR. Endothelin mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc Natl Acad Sci USA 1995; 92: 2691-2695
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2691-2695
-
-
Klemm, P.1
Warner, T.D.2
Hohlfeld, T.3
Corder, R.4
Vane, J.R.5
-
117
-
-
0030041401
-
What turns on the endothelins?
-
Warner TD, Klemm P. What turns on the endothelins? Inflamm Res 1996; 45: 51-53
-
(1996)
Inflamm Res
, vol.45
, pp. 51-53
-
-
Warner, T.D.1
Klemm, P.2
-
118
-
-
34447505541
-
Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease
-
Anthoni C, Mennigen RB, Rijcken EJ, Laukötter MG, Spiegel HU, Senninger N, Schürmann G, Krieglstein CF. Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease. Int J Colorectal Dis 2006; 21: 409-418
-
(2006)
Int J Colorectal Dis
, vol.21
, pp. 409-418
-
-
Anthoni, C.1
Mennigen, R.B.2
Rijcken, E.J.3
Laukötter, M.G.4
Spiegel, H.U.5
Senninger, N.6
Schürmann, G.7
Krieglstein, C.F.8
-
119
-
-
35349030411
-
Fibrosis in connective tissue disease: The role of the myofibroblast and fibroblastepithelial cell interactions
-
Krieg T, Abraham D, Lafyatis R. Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblastepithelial cell interactions. Arthritis Res Ther 2007; 9 Suppl 2: S4
-
(2007)
Arthritis Res Ther
, vol.9
, Issue.SUPPL. 2
-
-
Krieg, T.1
Abraham, D.2
Lafyatis, R.3
-
120
-
-
0036136090
-
Endothelin-1 stimulates human colonic myofibroblast contraction and migration
-
Kernochan LE, Tran BN, Tangkijvanich P, Melton AC, Tam SP, Yee HF. Endothelin-1 stimulates human colonic myofibroblast contraction and migration. Gut 2002; 50: 65-70
-
(2002)
Gut
, vol.50
, pp. 65-70
-
-
Kernochan, L.E.1
Tran, B.N.2
Tangkijvanich, P.3
Melton, A.C.4
Tam, S.P.5
Yee, H.F.6
-
121
-
-
33846362954
-
Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system
-
Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007; 292: C82-C97
-
(2007)
Am J Physiol Cell Physiol
, vol.292
-
-
Mehta, P.K.1
Griendling, K.K.2
-
122
-
-
39149119226
-
The intracellular renin-angiotensin system: Implications in cardiovascular remodeling
-
Kumar R, Singh VP, Baker KM. The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens 2008; 17: 168-173
-
(2008)
Curr Opin Nephrol Hypertens
, vol.17
, pp. 168-173
-
-
Kumar, R.1
Singh, V.P.2
Baker, K.M.3
-
123
-
-
33745845825
-
Physiology of local reninangiotensin systems
-
Paul M, Poyan Mehr A, Kreutz R. Physiology of local reninangiotensin systems. Physiol Rev 2006; 86: 747-803
-
(2006)
Physiol Rev
, vol.86
, pp. 747-803
-
-
Paul, M.1
Poyan Mehr, A.2
Kreutz, R.3
-
124
-
-
33947526470
-
The physiology of a local renin-angiotensin system in the pancreas
-
Leung PS. The physiology of a local renin-angiotensin system in the pancreas. J Physiol 2007; 580: 31-37
-
(2007)
J Physiol
, vol.580
, pp. 31-37
-
-
Leung, P.S.1
-
125
-
-
0037901037
-
Minireview: Overview of the reninangiotensin system--an endocrine and paracrine system
-
Lavoie JL, Sigmund CD. Minireview: overview of the reninangiotensin system--an endocrine and paracrine system. Endocrinology 2003; 144: 2179-2183
-
(2003)
Endocrinology
, vol.144
, pp. 2179-2183
-
-
Lavoie, J.L.1
Sigmund, C.D.2
-
126
-
-
0036146790
-
Im-munohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa
-
Hirasawa K, Sato Y, Hosoda Y, Yamamoto T, Hanai H. Im-munohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa. J Histochem Cytochem 2002; 50: 275-282
-
(2002)
J Histochem Cytochem
, vol.50
, pp. 275-282
-
-
Hirasawa, K.1
Sato, Y.2
Hosoda, Y.3
Yamamoto, T.4
Hanai, H.5
-
127
-
-
29144517417
-
Antiinflammatory properties of drugs acting on the renin-angiotensin system
-
Sironi L, Nobili E, Gianella A, Gelosa P, Tremoli E. Antiinflammatory properties of drugs acting on the renin-angiotensin system. Drugs Today (Barc) 2005; 41: 609-622
-
(2005)
Drugs Today (Barc)
, vol.41
, pp. 609-622
-
-
Sironi, L.1
Nobili, E.2
Gianella, A.3
Gelosa, P.4
Tremoli, E.5
-
128
-
-
30344442801
-
Angiotensin II: A key factor in the inflammatory and fibrotic response in kidney diseases
-
Ruiz-Ortega M, Rupérez M, Esteban V, Rodríguez-Vita J, Sánchez-López E, Carvajal G, Egido J. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transplant 2006; 21: 16-20
-
(2006)
Nephrol Dial Transplant
, vol.21
, pp. 16-20
-
-
Ruiz-Ortega, M.1
Rupérez, M.2
Esteban, V.3
Rodríguez-Vita, J.4
Sánchez-López, E.5
Carvajal, G.6
Egido, J.7
-
129
-
-
0034802566
-
Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats
-
Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Nakatani T, Tsujinoue H, Fukui H. Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats. Hepatology 2001; 34: 745-750
-
(2001)
Hepatology
, vol.34
, pp. 745-750
-
-
Yoshiji, H.1
Kuriyama, S.2
Yoshii, J.3
Ikenaka, Y.4
Noguchi, R.5
Nakatani, T.6
Tsujinoue, H.7
Fukui, H.8
-
130
-
-
65549170489
-
Effects of angiotensin on the expression of fibrosis-associated cytokines, growth factors, and matrix proteins in human lung fibroblasts
-
Okada M, Suzuki K, Matsumoto M, Takada K, Nakanishi T, Horikoshi H, Higuchi T, Hosono Y, Nakayama M, Ohsuzu F. Effects of angiotensin on the expression of fibrosis-associated cytokines, growth factors, and matrix proteins in human lung fibroblasts. J Clin Pharm Ther 2009; 34: 288-299
-
(2009)
J Clin Pharm Ther
, vol.34
, pp. 288-299
-
-
Okada, M.1
Suzuki, K.2
Matsumoto, M.3
Takada, K.4
Nakanishi, T.5
Horikoshi, H.6
Higuchi, T.7
Hosono, Y.8
Nakayama, M.9
Ohsuzu, F.10
-
131
-
-
0042168915
-
An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells
-
Kurikawa N, Suga M, Kuroda S, Yamada K, Ishikawa H. An angiotensin II type 1 receptor antagonist, olmesartan medoxomil, improves experimental liver fibrosis by suppression of proliferation and collagen synthesis in activated hepatic stellate cells. Br J Pharmacol 2003; 139: 1085-1094
-
(2003)
Br J Pharmacol
, vol.139
, pp. 1085-1094
-
-
Kurikawa, N.1
Suga, M.2
Kuroda, S.3
Yamada, K.4
Ishikawa, H.5
-
132
-
-
59049099281
-
The importance of the intrarenal renin-angiotensin system
-
Velez JC. The importance of the intrarenal renin-angiotensin system. Nat Clin Pract Nephrol 2009; 5: 89-100
-
(2009)
Nat Clin Pract Nephrol
, vol.5
, pp. 89-100
-
-
Velez, J.C.1
-
133
-
-
14544296574
-
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice
-
Inokuchi Y, Morohashi T, Kawana I, Nagashima Y, Kihara M, Umemura S. Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. Gut 2005; 54: 349-356
-
(2005)
Gut
, vol.54
, pp. 349-356
-
-
Inokuchi, Y.1
Morohashi, T.2
Kawana, I.3
Nagashima, Y.4
Kihara, M.5
Umemura, S.6
-
134
-
-
0029913624
-
Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
-
Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996; 110: 975-984
-
(1996)
Gastroenterology
, vol.110
, pp. 975-984
-
-
Babyatsky, M.W.1
Rossiter, G.2
Podolsky, D.K.3
-
135
-
-
0025231985
-
Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis
-
Jaszewski R, Tolia V, Ehrinpreis MN, Bodzin JH, Peleman RR, Korlipara R, Weinstock JV. Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis. Gastroenterology 1990; 98: 1543-1548
-
(1990)
Gastroenterology
, vol.98
, pp. 1543-1548
-
-
Jaszewski, R.1
Tolia, V.2
Ehrinpreis, M.N.3
Bodzin, J.H.4
Peleman, R.R.5
Korlipara, R.6
Weinstock, J.V.7
-
136
-
-
39749136117
-
Dextran sulfate sodium-induced acute colonic inflammation in angiotensin II type 1a receptor deficient mice
-
Katada K, Yoshida N, Suzuki T, Okuda T, Mizushima K, Takagi T, Ichikawa H, Naito Y, Cepinskas G, Yoshikawa T. Dextran sulfate sodium-induced acute colonic inflammation in angiotensin II type 1a receptor deficient mice. Inflamm Res 2008; 57: 84-91
-
(2008)
Inflamm Res
, vol.57
, pp. 84-91
-
-
Katada, K.1
Yoshida, N.2
Suzuki, T.3
Okuda, T.4
Mizushima, K.5
Takagi, T.6
Ichikawa, H.7
Naito, Y.8
Cepinskas, G.9
Yoshikawa, T.10
-
137
-
-
84856403018
-
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats
-
Wengrower D, Zanninelli G, Latella G, Necozione S, Metanes I, Israeli E, Lysy J, Pines M, Papo O, Goldin E. Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. Can J Gastroenterol 2012; 26: 33-39
-
(2012)
Can J Gastroenterol
, vol.26
, pp. 33-39
-
-
Wengrower, D.1
Zanninelli, G.2
Latella, G.3
Necozione, S.4
Metanes, I.5
Israeli, E.6
Lysy, J.7
Pines, M.8
Papo, O.9
Goldin, E.10
-
138
-
-
78649506169
-
News from the "5th International Meeting on Inflammatory Bowel Diseases" CAPRI 2010
-
Latella G, Fiocchi C, Caprili R. News from the "5th International Meeting on Inflammatory Bowel Diseases" CAPRI 2010. J Crohns Colitis 2010; 4: 690-702
-
(2010)
J Crohns Colitis
, vol.4
, pp. 690-702
-
-
Latella, G.1
Fiocchi, C.2
Caprili, R.3
-
139
-
-
3543107212
-
Fibrotic disease and the T(H)1/T(H)2 paradigm
-
Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004; 4: 583-594
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 583-594
-
-
Wynn, T.A.1
-
140
-
-
0142053206
-
The immunological and genetic basis of inflammatory bowel disease
-
Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3: 521-533
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 521-533
-
-
Bouma, G.1
Strober, W.2
-
141
-
-
0035514724
-
Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions
-
Hoffmann KF, McCarty TC, Segal DH, Chiaramonte M, Hesse M, Davis EM, Cheever AW, Meltzer PS, Morse HC, Wynn TA. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. FASEB J 2001; 15: 2545-2547
-
(2001)
FASEB J
, vol.15
, pp. 2545-2547
-
-
Hoffmann, K.F.1
McCarty, T.C.2
Segal, D.H.3
Chiaramonte, M.4
Hesse, M.5
Davis, E.M.6
Cheever, A.W.7
Meltzer, P.S.8
Morse, H.C.9
Wynn, T.A.10
-
142
-
-
33646164439
-
Expanding the effector CD4 T-cell repertoire: The Th17 lineage
-
Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 2006; 18: 349-356
-
(2006)
Curr Opin Immunol
, vol.18
, pp. 349-356
-
-
Harrington, L.E.1
Mangan, P.R.2
Weaver, C.T.3
-
143
-
-
43549099743
-
The Interleukin-23 / Interleukin-17 axis in intestinal inflammation
-
Maloy KJ. The Interleukin-23 / Interleukin-17 axis in intestinal inflammation. J Intern Med 2008; 263: 584-590
-
(2008)
J Intern Med
, vol.263
, pp. 584-590
-
-
Maloy, K.J.1
-
145
-
-
57349194661
-
Inflammatory cytokines augments TGF-beta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I
-
Liu X. Inflammatory cytokines augments TGF-beta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I. Cell Motil Cytoskeleton 2008; 65: 935-944
-
(2008)
Cell Motil Cytoskeleton
, vol.65
, pp. 935-944
-
-
Liu, X.1
-
146
-
-
78650199530
-
Inflammatory bowel diseaseassociated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
-
Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarström C, Loos T, Kasprzycka M, Sørensen DR, Nilsen HR, Küchler AM, Vatn MH, Haraldsen G. Inflammatory bowel diseaseassociated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol 2010; 177: 2804-2815
-
(2010)
Am J Pathol
, vol.177
, pp. 2804-2815
-
-
Sponheim, J.1
Pollheimer, J.2
Olsen, T.3
Balogh, J.4
Hammarström, C.5
Loos, T.6
Kasprzycka, M.7
Sørensen, D.R.8
Nilsen, H.R.9
Küchler, A.M.10
Vatn, M.H.11
Haraldsen, G.12
-
147
-
-
43349091452
-
The IL-4Ralpha pathway in macrophages and its potential role in silicainduced pulmonary fibrosis
-
Migliaccio CT, Buford MC, Jessop F, Holian A. The IL-4Ralpha pathway in macrophages and its potential role in silicainduced pulmonary fibrosis. J Leukoc Biol 2008; 83: 630-639
-
(2008)
J Leukoc Biol
, vol.83
, pp. 630-639
-
-
Migliaccio, C.T.1
Buford, M.C.2
Jessop, F.3
Holian, A.4
-
148
-
-
50249121141
-
Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway
-
Aoudjehane L, Pissaia A, Scatton O, Podevin P, Massault PP, Chouzenoux S, Soubrane O, Calmus Y, Conti F. Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway. Lab Invest 2008; 88: 973-985
-
(2008)
Lab Invest
, vol.88
, pp. 973-985
-
-
Aoudjehane, L.1
Pissaia, A.2
Scatton, O.3
Podevin, P.4
Massault, P.P.5
Chouzenoux, S.6
Soubrane, O.7
Calmus, Y.8
Conti, F.9
-
149
-
-
34548027473
-
[Interleukin-4 and cardiac fibrosis in patients with heart failure]
-
Roselló-Lletí E, Rivera M, Bertomeu V, Cortés R, Jordán A, González-Molina A. [Interleukin-4 and cardiac fibrosis in patients with heart failure]. Rev Esp Cardiol 2007; 60: 777-780
-
(2007)
Rev Esp Cardiol
, vol.60
, pp. 777-780
-
-
Roselló-Lletí, E.1
Rivera, M.2
Bertomeu, V.3
Cortés, R.4
Jordán, A.5
González-Molina, A.6
-
150
-
-
0032697042
-
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
-
Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999; 104: 777-785
-
(1999)
J Clin Invest
, vol.104
, pp. 777-785
-
-
Chiaramonte, M.G.1
Donaldson, D.D.2
Cheever, A.W.3
Wynn, T.A.4
-
151
-
-
0034923170
-
Studies of murine schistosomiasis reveal interleukin-blockade as a treatment for established and progressive liver fibrosis
-
Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA. Studies of murine schistosomiasis reveal interleukin-blockade as a treatment for established and progressive liver fibrosis. Hepatology 2001; 34: 273-282
-
(2001)
Hepatology
, vol.34
, pp. 273-282
-
-
Chiaramonte, M.G.1
Cheever, A.W.2
Malley, J.D.3
Donaldson, D.D.4
Wynn, T.A.5
-
152
-
-
30044449492
-
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
-
Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 2006; 12: 99-106
-
(2006)
Nat Med
, vol.12
, pp. 99-106
-
-
Fichtner-Feigl, S.1
Strober, W.2
Kawakami, K.3
Puri, R.K.4
Kitani, A.5
-
153
-
-
54349096867
-
Cytokines mediating the induction of chronic colitis and colitisassociated fibrosis
-
Fichtner-Feigl S, Strober W, Geissler EK, Schlitt HJ. Cytokines mediating the induction of chronic colitis and colitisassociated fibrosis. Mucosal Immunol 2008; 1 Suppl 1: S24-S27
-
(2008)
Mucosal Immunol
, vol.1
, Issue.SUPPL. 1
-
-
Fichtner-Feigl, S.1
Strober, W.2
Geissler, E.K.3
Schlitt, H.J.4
-
154
-
-
57649100177
-
Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13
-
Bhogal RK, Bona CA. Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13. Int Rev Immunol 2008; 27: 472-496
-
(2008)
Int Rev Immunol
, vol.27
, pp. 472-496
-
-
Bhogal, R.K.1
Bona, C.A.2
-
155
-
-
67650935391
-
Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection
-
Diaz JA, Booth AJ, Lu G, Wood SC, Pinsky DJ, Bishop DK. Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 2009; 9: 1773-1783
-
(2009)
Am J Transplant
, vol.9
, pp. 1773-1783
-
-
Diaz, J.A.1
Booth, A.J.2
Lu, G.3
Wood, S.C.4
Pinsky, D.J.5
Bishop, D.K.6
-
156
-
-
73349121322
-
Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice
-
Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009; 161: 237-248
-
(2009)
Br J Dermatol
, vol.161
, pp. 237-248
-
-
Luckett-Chastain, L.R.1
Gallucci, R.M.2
-
157
-
-
64749092804
-
Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts
-
Liao W, Yu C, Wen J, Jia W, Li G, Ke Y, Zhao S, Campell W. Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts. Biol Cell 2009; 101: 263-272
-
(2009)
Biol Cell
, vol.101
, pp. 263-272
-
-
Liao, W.1
Yu, C.2
Wen, J.3
Jia, W.4
Li, G.5
Ke, Y.6
Zhao, S.7
Campell, W.8
-
159
-
-
33745840137
-
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
-
Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest 2006; 116: 2044-2055
-
(2006)
J Clin Invest
, vol.116
, pp. 2044-2055
-
-
Pesce, J.1
Kaviratne, M.2
Ramalingam, T.R.3
Thompson, R.W.4
Urban, J.F.5
Cheever, A.W.6
Young, D.A.7
Collins, M.8
Grusby, M.J.9
Wynn, T.A.10
-
161
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29: 947-957
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
Yancopoulos, G.D.2
Valenzuela, D.M.3
Murphy, A.J.4
Stevens, S.5
Flavell, R.A.6
-
162
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118: 534-544
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
Shimomura, Y.4
Andoh, A.5
Bhan, A.K.6
Blumberg, R.S.7
Xavier, R.J.8
Mizoguchi, A.9
-
163
-
-
77957736967
-
γδ T cells protect against lung fibrosis via IL-22
-
Simonian PL, Wehrmann F, Roark CL, Born WK, O'Brien RL, Fontenot AP. γδ T cells protect against lung fibrosis via IL-22. J Exp Med 2010; 207: 2239-2253
-
(2010)
J Exp Med
, vol.207
, pp. 2239-2253
-
-
Simonian, P.L.1
Wehrmann, F.2
Roark, C.L.3
Born, W.K.4
O'Brien, R.L.5
Fontenot, A.P.6
-
164
-
-
79960736362
-
Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis
-
Guan Q, Ma Y, Hillman CL, Qing G, Ma AG, Weiss CR, Zhou G, Bai A, Warrington RJ, Bernstein CN, Peng Z. Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis. Mol Med 2011; 17: 646-656
-
(2011)
Mol Med
, vol.17
, pp. 646-656
-
-
Guan, Q.1
Ma, Y.2
Hillman, C.L.3
Qing, G.4
Ma, A.G.5
Weiss, C.R.6
Zhou, G.7
Bai, A.8
Warrington, R.J.9
Bernstein, C.N.10
Peng, Z.11
-
165
-
-
0036088374
-
IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts
-
Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, Okuno T, Fujiyama Y, Bamba T. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 2002; 282: G1035-G1044
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.282
-
-
Hata, K.1
Andoh, A.2
Shimada, M.3
Fujino, S.4
Bamba, S.5
Araki, Y.6
Okuno, T.7
Fujiyama, Y.8
Bamba, T.9
-
166
-
-
80053070208
-
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and-independent mechanisms
-
Mi S, Li Z, Yang HZ, Liu H, Wang JP, Ma YG, Wang XX, Liu HZ, Sun W, Hu ZW. Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and-independent mechanisms. J Immunol 2011; 187: 3003-3014
-
(2011)
J Immunol
, vol.187
, pp. 3003-3014
-
-
Mi, S.1
Li, Z.2
Yang, H.Z.3
Liu, H.4
Wang, J.P.5
Ma, Y.G.6
Wang, X.X.7
Liu, H.Z.8
Sun, W.9
Hu, Z.W.10
-
167
-
-
77949516122
-
Bleomycin and IL-1betamediated pulmonary fibrosis is IL-17A dependent
-
Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA. Bleomycin and IL-1betamediated pulmonary fibrosis is IL-17A dependent. J Exp Med 2010; 207: 535-552
-
(2010)
J Exp Med
, vol.207
, pp. 535-552
-
-
Wilson, M.S.1
Madala, S.K.2
Ramalingam, T.R.3
Gochuico, B.R.4
Rosas, I.O.5
Cheever, A.W.6
Wynn, T.A.7
-
168
-
-
77953021137
-
Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy
-
Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 2010; 106: 1646-1655
-
(2010)
Circ Res
, vol.106
, pp. 1646-1655
-
-
Baldeviano, G.C.1
Barin, J.G.2
Talor, M.V.3
Srinivasan, S.4
Bedja, D.5
Zheng, D.6
Gabrielson, K.7
Iwakura, Y.8
Rose, N.R.9
Cihakova, D.10
-
169
-
-
67249159327
-
Interleukin-12 is the optimum cytokine to expand human Th17 cells in vitro
-
Nady S, Ignatz-Hoover J, Shata MT. Interleukin-12 is the optimum cytokine to expand human Th17 cells in vitro. Clin Vaccine Immunol 2009; 16: 798-805
-
(2009)
Clin Vaccine Immunol
, vol.16
, pp. 798-805
-
-
Nady, S.1
Ignatz-Hoover, J.2
Shata, M.T.3
-
170
-
-
34447650384
-
The role of TNFalpha in ulcerative colitis
-
Sands BE, Kaplan GG. The role of TNFalpha in ulcerative colitis. J Clin Pharmacol 2007; 47: 930-941
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 930-941
-
-
Sands, B.E.1
Kaplan, G.G.2
-
172
-
-
27744461703
-
Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2
-
Theiss AL, Simmons JG, Jobin C, Lund PK. Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 2005; 280: 36099-36109
-
(2005)
J Biol Chem
, vol.280
, pp. 36099-36109
-
-
Theiss, A.L.1
Simmons, J.G.2
Jobin, C.3
Lund, P.K.4
-
173
-
-
0032526069
-
Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation
-
Jobson TM, Billington CK, Hall IP. Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation. J Clin Invest 1998; 101: 2650-2657
-
(1998)
J Clin Invest
, vol.101
, pp. 2650-2657
-
-
Jobson, T.M.1
Billington, C.K.2
Hall, I.P.3
-
174
-
-
75149161836
-
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
-
Dignass A, Van Assche G, Lindsay JO, Lémann M, Söderholm J, Colombel JF, Danese S, D'Hoore A, Gassull M, Gomollón F, Hommes DW, Michetti P, O'Morain C, Oresland T, Windsor A, Stange EF, Travis SP. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management. J Crohns Colitis 2010; 4: 28-62
-
(2010)
J Crohns Colitis
, vol.4
, pp. 28-62
-
-
Dignass, A.1
van Assche, G.2
Lindsay, J.O.3
Lémann, M.4
Söderholm, J.5
Colombel, J.F.6
Danese, S.7
D'Hoore, A.8
Gassull, M.9
Gomollón, F.10
Hommes, D.W.11
Michetti, P.12
O'Morain, C.13
Oresland, T.14
Windsor, A.15
Stange, E.F.16
Travis, S.P.17
-
175
-
-
78649988873
-
Tumor necrosis factor blockade for treatment of inflammatory bowel disease: Efficacy and safety
-
Ngo B, Farrell CP, Barr M, Wolov K, Bailey R, Mullin JM, Thornton JJ. Tumor necrosis factor blockade for treatment of inflammatory bowel disease: efficacy and safety. Curr Mol Pharmacol 2010; 3: 145-152
-
(2010)
Curr Mol Pharmacol
, vol.3
, pp. 145-152
-
-
Ngo, B.1
Farrell, C.P.2
Barr, M.3
Wolov, K.4
Bailey, R.5
Mullin, J.M.6
Thornton, J.J.7
-
176
-
-
79751472562
-
The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: When to start, when to stop, which drug to choose, and how to predict response?
-
quiz 213
-
D'Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, Löfberg R, Quary A, Sands B, Sood A, Watermeyer G, Lashner B, Lémann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol 2011; 106: 199-212; quiz 213
-
(2011)
Am J Gastroenterol
, vol.106
, pp. 199-212
-
-
D'Haens, G.R.1
Panaccione, R.2
Higgins, P.D.3
Vermeire, S.4
Gassull, M.5
Chowers, Y.6
Hanauer, S.B.7
Herfarth, H.8
Hommes, D.W.9
Kamm, M.10
Löfberg, R.11
Quary, A.12
Sands, B.13
Sood, A.14
Watermeyer, G.15
Lashner, B.16
Lémann, M.17
Plevy, S.18
Reinisch, W.19
Schreiber, S.20
Siegel, C.21
Targan, S.22
Watanabe, M.23
Feagan, B.24
Sandborn, W.J.25
Colombel, J.F.26
Travis, S.27
more..
-
177
-
-
65649085279
-
Reactive oxygen species: A double-edged sword in oncogenesis
-
Pan JS, Hong MZ, Ren JL. Reactive oxygen species: a double-edged sword in oncogenesis. World J Gastroenterol 2009; 15: 1702-1707
-
(2009)
World J Gastroenterol
, vol.15
, pp. 1702-1707
-
-
Pan, J.S.1
Hong, M.Z.2
Ren, J.L.3
-
178
-
-
0028364576
-
Biological origin of free radicals, and mechanisms of antioxidant protection
-
Gutteridge JM. Biological origin of free radicals, and mechanisms of antioxidant protection. Chem Biol Interact 1994; 91: 133-140
-
(1994)
Chem Biol Interact
, vol.91
, pp. 133-140
-
-
Gutteridge, J.M.1
-
179
-
-
34347257042
-
Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy
-
Lambeth JD. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med 2007; 43: 332-347
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 332-347
-
-
Lambeth, J.D.1
-
181
-
-
0032812161
-
Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis
-
Rahman I, Skwarska E, Henry M, Davis M, O'Connor CM, FitzGerald MX, Greening A, MacNee W. Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis. Free Radic Biol Med 1999; 27: 60-68
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 60-68
-
-
Rahman, I.1
Skwarska, E.2
Henry, M.3
Davis, M.4
O'Connor, C.M.5
FitzGerald, M.X.6
Greening, A.7
McNee, W.8
-
182
-
-
22044435952
-
Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis
-
Rottoli P, Magi B, Cianti R, Bargagli E, Vagaggini C, Nikiforakis N, Pallini V, Bini L. Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 2005; 5: 2612-2618
-
(2005)
Proteomics
, vol.5
, pp. 2612-2618
-
-
Rottoli, P.1
Magi, B.2
Cianti, R.3
Bargagli, E.4
Vagaggini, C.5
Nikiforakis, N.6
Pallini, V.7
Bini, L.8
-
183
-
-
0037361993
-
In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats
-
Serrano-Mollar A, Closa D, Prats N, Blesa S, Martinez-Losa M, Cortijo J, Estrela JM, Morcillo EJ, Bulbena O. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br J Pharmacol 2003; 138: 1037-1048
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1037-1048
-
-
Serrano-Mollar, A.1
Closa, D.2
Prats, N.3
Blesa, S.4
Martinez-Losa, M.5
Cortijo, J.6
Estrela, J.M.7
Morcillo, E.J.8
Bulbena, O.9
-
184
-
-
0036468708
-
Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats
-
Wang HD, Yamaya M, Okinaga S, Jia YX, Kamanaka M, Takahashi H, Guo LY, Ohrui T, Sasaki H. Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. Am J Respir Crit Care Med 2002; 165: 406-411
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 406-411
-
-
Wang, H.D.1
Yamaya, M.2
Okinaga, S.3
Jia, Y.X.4
Kamanaka, M.5
Takahashi, H.6
Guo, L.Y.7
Ohrui, T.8
Sasaki, H.9
-
185
-
-
23844434686
-
The absence of reactive oxygen species production protects mice against bleomycininduced pulmonary fibrosis
-
Manoury B, Nenan S, Leclerc O, Guenon I, Boichot E, Planquois JM, Bertrand CP, Lagente V. The absence of reactive oxygen species production protects mice against bleomycininduced pulmonary fibrosis. Respir Res 2005; 6: 11
-
(2005)
Respir Res
, vol.6
, pp. 11
-
-
Manoury, B.1
Nenan, S.2
Leclerc, O.3
Guenon, I.4
Boichot, E.5
Planquois, J.M.6
Bertrand, C.P.7
Lagente, V.8
-
186
-
-
0035145392
-
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells
-
Svegliati-Baroni G, Saccomanno S, van Goor H, Jansen P, Benedetti A, Moshage H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 2001; 21: 1-12
-
(2001)
Liver
, vol.21
, pp. 1-12
-
-
Svegliati-Baroni, G.1
Saccomanno, S.2
van Goor, H.3
Jansen, P.4
Benedetti, A.5
Moshage, H.6
-
188
-
-
0029115715
-
Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
-
Rachmilewitz D, Karmeli F, Okon E, Bursztyn M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995; 37: 247-255
-
(1995)
Gut
, vol.37
, pp. 247-255
-
-
Rachmilewitz, D.1
Karmeli, F.2
Okon, E.3
Bursztyn, M.4
-
189
-
-
33751362282
-
The peroxisome-proliferatoractivated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)
-
Rousseaux C, Desreumaux P. [The peroxisome-proliferatoractivated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)]. J Soc Biol 2006; 200: 121-131
-
(2006)
J Soc Biol
, vol.200
, pp. 121-131
-
-
Rousseaux, C.1
Desreumaux, P.2
-
190
-
-
0036010783
-
Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: A review
-
Houseknecht KL, Cole BM, Steele PJ. Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review. Domest Anim Endocrinol 2002; 22: 1-23
-
(2002)
Domest Anim Endocrinol
, vol.22
, pp. 1-23
-
-
Houseknecht, K.L.1
Cole, B.M.2
Steele, P.J.3
-
191
-
-
0032553542
-
Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma
-
Uppenberg J, Svensson C, Jaki M, Bertilsson G, Jendeberg L, Berkenstam A. Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma. J Biol Chem 1998; 273: 31108-31112
-
(1998)
J Biol Chem
, vol.273
, pp. 31108-31112
-
-
Uppenberg, J.1
Svensson, C.2
Jaki, M.3
Bertilsson, G.4
Jendeberg, L.5
Berkenstam, A.6
-
192
-
-
0035923672
-
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
-
Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT, McKee DD, Moore JT, Willson TM. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 2001; 98: 13919-13924
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13919-13924
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
Plunket, K.D.4
Moore, L.B.5
Collins, J.L.6
Oplinger, J.A.7
Kliewer, S.A.8
Gampe, R.T.9
McKee, D.D.10
Moore, J.T.11
Willson, T.M.12
-
193
-
-
68649123084
-
Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro
-
Zhang GY, Cheng T, Zheng MH, Yi CG, Pan H, Li ZJ, Chen XL, Yu Q, Jiang LF, Zhou FY, Li XY, Yang JQ, Chu TG, Gao WY. Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. Arch Dermatol Res 2009; 301: 515-522
-
(2009)
Arch Dermatol Res
, vol.301
, pp. 515-522
-
-
Zhang, G.Y.1
Cheng, T.2
Zheng, M.H.3
Yi, C.G.4
Pan, H.5
Li, Z.J.6
Chen, X.L.7
Yu, Q.8
Jiang, L.F.9
Zhou, F.Y.10
Li, X.Y.11
Yang, J.Q.12
Chu, T.G.13
Gao, W.Y.14
-
194
-
-
77749249238
-
Rosiglitazone inhibits migration, proliferation, and phenotypic differentiation in cultured human lung fibroblasts
-
Lin Q, Fang LP, Zhou WW, Liu XM. Rosiglitazone inhibits migration, proliferation, and phenotypic differentiation in cultured human lung fibroblasts. Exp Lung Res 2010; 36: 120-128
-
(2010)
Exp Lung Res
, vol.36
, pp. 120-128
-
-
Lin, Q.1
Fang, L.P.2
Zhou, W.W.3
Liu, X.M.4
-
195
-
-
77952469124
-
Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells
-
Tan X, Dagher H, Hutton CA, Bourke JE. Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells. Respir Res 2010; 11: 21
-
(2010)
Respir Res
, vol.11
, pp. 21
-
-
Tan, X.1
Dagher, H.2
Hutton, C.A.3
Bourke, J.E.4
-
196
-
-
79251563128
-
PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: Implications for therapy of fibrosis
-
Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS One 2011; 6: e15909
-
(2011)
PLoS One
, vol.6
-
-
Kulkarni, A.A.1
Thatcher, T.H.2
Olsen, K.C.3
Maggirwar, S.B.4
Phipps, R.P.5
Sime, P.J.6
-
197
-
-
33749341729
-
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells
-
Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun 2006; 350: 385-391
-
(2006)
Biochem Biophys Res Commun
, vol.350
, pp. 385-391
-
-
Zhao, C.1
Chen, W.2
Yang, L.3
Chen, L.4
Stimpson, S.A.5
Diehl, A.M.6
-
198
-
-
79751491258
-
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice
-
Nan YM, Han F, Kong LB, Zhao SX, Wang RQ, Wu WJ, Yu J. Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. Scand J Gastroenterol 2011; 46: 358-369
-
(2011)
Scand J Gastroenterol
, vol.46
, pp. 358-369
-
-
Nan, Y.M.1
Han, F.2
Kong, L.B.3
Zhao, S.X.4
Wang, R.Q.5
Wu, W.J.6
Yu, J.7
-
199
-
-
69449094871
-
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
-
Kapoor M, McCann M, Liu S, Huh K, Denton CP, Abraham DJ, Leask A. Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum 2009; 60: 2822-2829
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2822-2829
-
-
Kapoor, M.1
McCann, M.2
Liu, S.3
Huh, K.4
Denton, C.P.5
Abraham, D.J.6
Leask, A.7
-
200
-
-
78349281192
-
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis
-
Wei J, Ghosh AK, Sargent JL, Komura K, Wu M, Huang QQ, Jain M, Whitfield ML, Feghali-Bostwick C, Varga J. PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. PLoS One 2010; 5: e13778
-
(2010)
PLoS One
, vol.5
-
-
Wei, J.1
Ghosh, A.K.2
Sargent, J.L.3
Komura, K.4
Wu, M.5
Huang, Q.Q.6
Jain, M.7
Whitfield, M.L.8
Feghali-Bostwick, C.9
Varga, J.10
-
201
-
-
78651308524
-
Effectiveness of the PPARγ agonist, GW570, in liver fibrosis
-
Yang L, Stimpson SA, Chen L, Wallace Harrington W, Rockey DC. Effectiveness of the PPARγ agonist, GW570, in liver fibrosis. Inflamm Res 2010; 59: 1061-1071
-
(2010)
Inflamm Res
, vol.59
, pp. 1061-1071
-
-
Yang, L.1
Stimpson, S.A.2
Chen, L.3
Wallace Harrington, W.4
Rockey, D.C.5
-
202
-
-
59649085854
-
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma
-
Wu M, Melichian DS, Chang E, Warner-Blankenship M, Ghosh AK, Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am J Pathol 2009; 174: 519-533
-
(2009)
Am J Pathol
, vol.174
, pp. 519-533
-
-
Wu, M.1
Melichian, D.S.2
Chang, E.3
Warner-Blankenship, M.4
Ghosh, A.K.5
Varga, J.6
-
203
-
-
58149127646
-
PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta
-
Kawai T, Masaki T, Doi S, Arakawa T, Yokoyama Y, Doi T, Kohno N, Yorioka N. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab Invest 2009; 89: 47-58
-
(2009)
Lab Invest
, vol.89
, pp. 47-58
-
-
Kawai, T.1
Masaki, T.2
Doi, S.3
Arakawa, T.4
Yokoyama, Y.5
Doi, T.6
Kohno, N.7
Yorioka, N.8
-
204
-
-
64449087454
-
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis
-
Aoki Y, Maeno T, Aoyagi K, Ueno M, Aoki F, Aoki N, Nakagawa J, Sando Y, Shimizu Y, Suga T, Arai M, Kurabayashi M. Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis. Respiration 2009; 77: 311-319
-
(2009)
Respiration
, vol.77
, pp. 311-319
-
-
Aoki, Y.1
Maeno, T.2
Aoyagi, K.3
Ueno, M.4
Aoki, F.5
Aoki, N.6
Nakagawa, J.7
Sando, Y.8
Shimizu, Y.9
Suga, T.10
Arai, M.11
Kurabayashi, M.12
-
205
-
-
37249092998
-
Pancreatic stellate cells: New target in the treatment of chronic pancreatitis
-
Talukdar R, Tandon RK. Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. J Gastroenterol Hepatol 2008; 23: 34-41
-
(2008)
J Gastroenterol Hepatol
, vol.23
, pp. 34-41
-
-
Talukdar, R.1
Tandon, R.K.2
-
206
-
-
48049115548
-
Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum
-
Chen H, He YW, Liu WQ, Zhang JH. Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum. World J Gastroenterol 2008; 14: 2905-2911
-
(2008)
World J Gastroenterol
, vol.14
, pp. 2905-2911
-
-
Chen, H.1
He, Y.W.2
Liu, W.Q.3
Zhang, J.H.4
-
207
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
Tsang CK, Qi H, Liu LF, Zheng XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007; 12: 112-124
-
(2007)
Drug Discov Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.4
-
208
-
-
33749431713
-
The mTOR pathway in the control of protein synthesis
-
Wang X, Proud CG. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006; 21: 362-369
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 362-369
-
-
Wang, X.1
Proud, C.G.2
-
209
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
-
Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992; 69: 1227-1236
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
210
-
-
34547134517
-
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
-
Land SC, Tee AR. Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007; 282: 20534-20543
-
(2007)
J Biol Chem
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
Tee, A.R.2
-
211
-
-
33846080045
-
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2
-
Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R. Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circ Res 2007; 100: 79-87
-
(2007)
Circ Res
, vol.100
, pp. 79-87
-
-
Li, W.1
Petrimpol, M.2
Molle, K.D.3
Hall, M.N.4
Battegay, E.J.5
Humar, R.6
-
212
-
-
0036275356
-
Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
-
Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002; 16: 771-780
-
(2002)
FASEB J
, vol.16
, pp. 771-780
-
-
Humar, R.1
Kiefer, F.N.2
Berns, H.3
Resink, T.J.4
Battegay, E.J.5
-
213
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2
-
Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem 2008; 283: 34495-34499
-
(2008)
J Biol Chem
, vol.283
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
Ohh, M.4
Foster, D.A.5
-
214
-
-
33745242315
-
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G, Milella M. Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006; 66: 5549-5554
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
Milella, M.7
-
215
-
-
72049105867
-
The role of the mammalian target of rapamycin (mTOR) in renal disease
-
Lieberthal W, Levine JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009; 20: 2493-2502
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2493-2502
-
-
Lieberthal, W.1
Levine, J.S.2
-
216
-
-
67649950978
-
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
-
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2009; 41: 562-572
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 562-572
-
-
Korfhagen, T.R.1
Le Cras, T.D.2
Davidson, C.R.3
Schmidt, S.M.4
Ikegami, M.5
Whitsett, J.A.6
Hardie, W.D.7
-
217
-
-
79959652692
-
Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin
-
Whaley-Connell A, Habibi J, Panfili Z, Hayden MR, Bagree S, Nistala R, Hyder S, Krueger B, Demarco V, Pulakat L, Ferrario CM, Parrish A, Sowers JR. Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin. Am J Nephrol 2011; 34: 115-125
-
(2011)
Am J Nephrol
, vol.34
, pp. 115-125
-
-
Whaley-Connell, A.1
Habibi, J.2
Panfili, Z.3
Hayden, M.R.4
Bagree, S.5
Nistala, R.6
Hyder, S.7
Krueger, B.8
Demarco, V.9
Pulakat, L.10
Ferrario, C.M.11
Parrish, A.12
Sowers, J.R.13
-
218
-
-
78751616780
-
Mammalian target of rapamycin (mTOR) inhibitors: Potential uses and a review of haematological adverse effects
-
Sofroniadou S, Goldsmith D. Mammalian target of rapamycin (mTOR) inhibitors: potential uses and a review of haematological adverse effects. Drug Saf 2011; 34: 97-115
-
(2011)
Drug Saf
, vol.34
, pp. 97-115
-
-
Sofroniadou, S.1
Goldsmith, D.2
-
219
-
-
0032738763
-
Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
-
Zhu J, Wu J, Frizell E, Liu SL, Bashey R, Rubin R, Norton P, Zern MA. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 1999; 117: 1198-1204
-
(1999)
Gastroenterology
, vol.117
, pp. 1198-1204
-
-
Zhu, J.1
Wu, J.2
Frizell, E.3
Liu, S.L.4
Bashey, R.5
Rubin, R.6
Norton, P.7
Zern, M.A.8
-
220
-
-
33750433893
-
Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
-
Neef M, Ledermann M, Saegesser H, Schneider V, Reichen J. Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis. J Hepatol 2006; 45: 786-796
-
(2006)
J Hepatol
, vol.45
, pp. 786-796
-
-
Neef, M.1
Ledermann, M.2
Saegesser, H.3
Schneider, V.4
Reichen, J.5
-
221
-
-
79960440859
-
Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis
-
Patsenker E, Schneider V, Ledermann M, Saegesser H, Dorn C, Hellerbrand C, Stickel F. Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis. J Hepatol 2011; 55: 388-398
-
(2011)
J Hepatol
, vol.55
, pp. 388-398
-
-
Patsenker, E.1
Schneider, V.2
Ledermann, M.3
Saegesser, H.4
Dorn, C.5
Hellerbrand, C.6
Stickel, F.7
-
222
-
-
78349313076
-
The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation
-
Geissler EK, Schlitt HJ. The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation. Kidney Int 2010; 78: 1075-1079
-
(2010)
Kidney Int
, vol.78
, pp. 1075-1079
-
-
Geissler, E.K.1
Schlitt, H.J.2
-
223
-
-
77955349716
-
Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis
-
Yoshizaki A, Yanaba K, Yoshizaki A, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis. Arthritis Rheum 2010; 62: 2476-2487
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2476-2487
-
-
Yoshizaki, A.1
Yanaba, K.2
Yoshizaki, A.3
Iwata, Y.4
Komura, K.5
Ogawa, F.6
Takenaka, M.7
Shimizu, K.8
Asano, Y.9
Hasegawa, M.10
Fujimoto, M.11
Sato, S.12
-
224
-
-
74049137551
-
Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis
-
Wang S, Wilkes MC, Leof EB, Hirschberg R. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Am J Physiol Renal Physiol 2010; 298: F142-F149
-
(2010)
Am J Physiol Renal Physiol
, vol.298
-
-
Wang, S.1
Wilkes, M.C.2
Leof, E.B.3
Hirschberg, R.4
-
225
-
-
33845938244
-
Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin
-
Poulalhon N, Farge D, Roos N, Tacheau C, Neuzillet C, Michel L, Mauviel A, Verrecchia F. Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent? J Biol Chem 2006; 281: 33045-33052
-
(2006)
A direct role as an antifibrotic agent? J Biol Chem
, vol.281
, pp. 33045-33052
-
-
Poulalhon, N.1
Farge, D.2
Roos, N.3
Tacheau, C.4
Neuzillet, C.5
Michel, L.6
Mauviel, A.7
Verrecchia, F.8
-
226
-
-
78549260675
-
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin
-
Osman B, el Akool S, Doller A, Müller R, Pfeilschifter J, Eberhardt W. Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. Biochem Pharmacol 2011; 81: 134-143
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 134-143
-
-
Osman, B.1
el Akool, S.2
Doller, A.3
Müller, R.4
Pfeilschifter, J.5
Eberhardt, W.6
-
227
-
-
34247121519
-
mTOR as a potential therapeutic target for treatment of keloids and excessive scars
-
Ong CT, Khoo YT, Mukhopadhyay A, Do DV, Lim IJ, Aalami O, Phan TT. mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Exp Dermatol 2007; 16: 394-404
-
(2007)
Exp Dermatol
, vol.16
, pp. 394-404
-
-
Ong, C.T.1
Khoo, Y.T.2
Mukhopadhyay, A.3
Do, D.V.4
Lim, I.J.5
Aalami, O.6
Phan, T.T.7
-
228
-
-
50249111131
-
Use of sirolimus (rapamycin) to treat refractory Crohn's disease
-
Massey DC, Bredin F, Parkes M. Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 2008; 57: 1294-1296
-
(2008)
Gut
, vol.57
, pp. 1294-1296
-
-
Massey, D.C.1
Bredin, F.2
Parkes, M.3
-
229
-
-
46049115921
-
Everolimus for refractory Crohn' s disease: A case report
-
Dumortier J, Lapalus MG, Guillaud O, Poncet G, Gagnieu MC, Partensky C, Scoazec JY. Everolimus for refractory Crohn' s disease: a case report. Inflamm Bowel Dis 2008; 14: 874-877
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 874-877
-
-
Dumortier, J.1
Lapalus, M.G.2
Guillaud, O.3
Poncet, G.4
Gagnieu, M.C.5
Partensky, C.6
Scoazec, J.Y.7
-
230
-
-
50649125243
-
A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease
-
Reinisch W, Panés J, Lémann M, Schreiber S, Feagan B, Schmidt S, Sturniolo GC, Mikhailova T, Alexeeva O, Sanna L, Haas T, Korom S, Mayer H. A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease. Am J Gastroenterol 2008; 103: 2284-2292
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 2284-2292
-
-
Reinisch, W.1
Panés, J.2
Lémann, M.3
Schreiber, S.4
Feagan, B.5
Schmidt, S.6
Sturniolo, G.C.7
Mikhailova, T.8
Alexeeva, O.9
Sanna, L.10
Haas, T.11
Korom, S.12
Mayer, H.13
-
231
-
-
33748455465
-
Matrix metalloproteinases as profibrotic factors in terminal ileum in Crohn's disease
-
Warnaar N, Hofker HS, Maathuis MH, Niesing J, Bruggink AH, Dijkstra G, Ploeg RJ, Schuurs TA. Matrix metalloproteinases as profibrotic factors in terminal ileum in Crohn's disease. Inflamm Bowel Dis 2006; 12: 863-869
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 863-869
-
-
Warnaar, N.1
Hofker, H.S.2
Maathuis, M.H.3
Niesing, J.4
Bruggink, A.H.5
Dijkstra, G.6
Ploeg, R.J.7
Schuurs, T.A.8
-
232
-
-
33846180682
-
Matrix metalloproteinases in inflammatory bowel disease: Boon or a bane?
-
Ravi A, Garg P, Sitaraman SV. Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 2007; 13: 97-107
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 97-107
-
-
Ravi, A.1
Garg, P.2
Sitaraman, S.V.3
-
233
-
-
79958255253
-
Do metalloproteinases contribute to tissue destruction or remodeling in the inflamed gut?
-
Pender SL. Do metalloproteinases contribute to tissue destruction or remodeling in the inflamed gut? Inflamm Bowel Dis 2008; 14 Suppl 2: S136-S137
-
(2008)
Inflamm Bowel Dis
, vol.14
, Issue.SUPPL. 2
-
-
Pender, S.L.1
-
234
-
-
33846785537
-
Matrix metalloproteinases in lung: Multiple, multifarious, and multifaceted
-
Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev 2007; 87: 69-98
-
(2007)
Physiol Rev
, vol.87
, pp. 69-98
-
-
Greenlee, K.J.1
Werb, Z.2
Kheradmand, F.3
-
235
-
-
0034075936
-
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease
-
Louis E, Ribbens C, Godon A, Franchimont D, De Groote D, Hardy N, Boniver J, Belaiche J, Malaise M. Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease. Clin Exp Immunol 2000; 120: 241-246
-
(2000)
Clin Exp Immunol
, vol.120
, pp. 241-246
-
-
Louis, E.1
Ribbens, C.2
Godon, A.3
Franchimont, D.4
de Groote, D.5
Hardy, N.6
Boniver, J.7
Belaiche, J.8
Malaise, M.9
-
236
-
-
28844444682
-
Expression of matrix metalloproteinases-2 and-9 in intestinal tissue of patients with inflammatory bowel diseases
-
Gao Q, Meijer MJ, Kubben FJ, Sier CF, Kruidenier L, van Duijn W, van den Berg M, van Hogezand RA, Lamers CB, Verspaget HW. Expression of matrix metalloproteinases-2 and-9 in intestinal tissue of patients with inflammatory bowel diseases. Dig Liver Dis 2005; 37: 584-592
-
(2005)
Dig Liver Dis
, vol.37
, pp. 584-592
-
-
Gao, Q.1
Meijer, M.J.2
Kubben, F.J.3
Sier, C.F.4
Kruidenier, L.5
van Duijn, W.6
van den Berg, M.7
van Hogezand, R.A.8
Lamers, C.B.9
Verspaget, H.W.10
-
237
-
-
0033916643
-
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease
-
Heuschkel RB, MacDonald TT, Monteleone G, Bajaj-Elliott M, Smith JA, Pender SL. Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut 2000; 47: 57-62
-
(2000)
Gut
, vol.47
, pp. 57-62
-
-
Heuschkel, R.B.1
McDonald, T.T.2
Monteleone, G.3
Bajaj-Elliott, M.4
Smith, J.A.5
Pender, S.L.6
-
238
-
-
2942571336
-
Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase
-
Stawowy P, Margeta C, Kallisch H, Seidah NG, Chrétien M, Fleck E, Graf K. Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovasc Res 2004; 63: 87-97
-
(2004)
Cardiovasc Res
, vol.63
, pp. 87-97
-
-
Stawowy, P.1
Margeta, C.2
Kallisch, H.3
Seidah, N.G.4
Chrétien, M.5
Fleck, E.6
Graf, K.7
-
239
-
-
0031568392
-
A major role for matrix metalloproteinases in T cell injury in the gut
-
Pender SL, Tickle SP, Docherty AJ, Howie D, Wathen NC, MacDonald TT. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997; 158: 1582-1590
-
(1997)
J Immunol
, vol.158
, pp. 1582-1590
-
-
Pender, S.L.1
Tickle, S.P.2
Docherty, A.J.3
Howie, D.4
Wathen, N.C.5
McDonald, T.T.6
-
240
-
-
0031898338
-
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations
-
Vaalamo M, Karjalainen-Lindsberg ML, Puolakkainen P, Kere J, Saarialho-Kere U. Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations. Am J Pathol 1998; 152: 1005-1014
-
(1998)
Am J Pathol
, vol.152
, pp. 1005-1014
-
-
Vaalamo, M.1
Karjalainen-Lindsberg, M.L.2
Puolakkainen, P.3
Kere, J.4
Saarialho-Kere, U.5
-
241
-
-
0032887929
-
Regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-beta1
-
Ma C, Chegini N. Regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-beta1. Mol Hum Reprod 1999; 5: 950-954
-
(1999)
Mol Hum Reprod
, vol.5
, pp. 950-954
-
-
Ma, C.1
Chegini, N.2
-
242
-
-
0345237913
-
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
-
McKaig BC, McWilliams D, Watson SA, Mahida YR. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am J Pathol 2003; 162: 1355-1360
-
(2003)
Am J Pathol
, vol.162
, pp. 1355-1360
-
-
McKaig, B.C.1
McWilliams, D.2
Watson, S.A.3
Mahida, Y.R.4
-
243
-
-
66649106333
-
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
-
Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NA, Picariello L, Cazzola P, Monteleone G, Tonelli F, Corazza GR, MacDonald TT, Pender SL. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009; 58: 777-789
-
(2009)
Gut
, vol.58
, pp. 777-789
-
-
Di Sabatino, A.1
Jackson, C.L.2
Pickard, K.M.3
Buckley, M.4
Rovedatti, L.5
Leakey, N.A.6
Picariello, L.7
Cazzola, P.8
Monteleone, G.9
Tonelli, F.10
Corazza, G.R.11
McDonald, T.T.12
Pender, S.L.13
-
244
-
-
0344792632
-
A murine model of chronic inflammationinduced intestinal fibrosis down-regulated by antisense NFkappa B
-
Lawrance IC, Wu F, Leite AZ, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammationinduced intestinal fibrosis down-regulated by antisense NFkappa B. Gastroenterology 2003; 125: 1750-1761
-
(2003)
Gastroenterology
, vol.125
, pp. 1750-1761
-
-
Lawrance, I.C.1
Wu, F.2
Leite, A.Z.3
Willis, J.4
West, G.A.5
Fiocchi, C.6
Chakravarti, S.7
-
245
-
-
34249341647
-
Effect of the anti-tumor necrosis factor-alpha antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease
-
Meijer MJ, Mieremet-Ooms MA, van Duijn W, van der Zon AM, Hanemaaijer R, Verheijen JH, van Hogezand RA, Lamers CB, Verspaget HW. Effect of the anti-tumor necrosis factor-alpha antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 200-210
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 200-210
-
-
Meijer, M.J.1
Mieremet-Ooms, M.A.2
van Duijn, W.3
van der Zon, A.M.4
Hanemaaijer, R.5
Verheijen, J.H.6
van Hogezand, R.A.7
Lamers, C.B.8
Verspaget, H.W.9
-
246
-
-
4644313552
-
Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis
-
Strup-Perrot C, Mathé D, Linard C, Violot D, Milliat F, François A, Bourhis J, Vozenin-Brotons MC. Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis. Am J Physiol Gastrointest Liver Physiol 2004; 287: G875-G885
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
-
-
Strup-Perrot, C.1
Mathé, D.2
Linard, C.3
Violot, D.4
Milliat, F.5
François, A.6
Bourhis, J.7
Vozenin-Brotons, M.C.8
-
247
-
-
34250687886
-
Differential expression of collagen, MMP, TIMP and fibrogenic-cytokine genes in the granulomatous colon of Schistosoma mansoniinfected mice
-
Singh KP, Gerard HC, Hudson AP, Boros DL. Differential expression of collagen, MMP, TIMP and fibrogenic-cytokine genes in the granulomatous colon of Schistosoma mansoniinfected mice. Ann Trop Med Parasitol 2006; 100: 611-620
-
(2006)
Ann Trop Med Parasitol
, vol.100
, pp. 611-620
-
-
Singh, K.P.1
Gerard, H.C.2
Hudson, A.P.3
Boros, D.L.4
-
248
-
-
72849130196
-
Targeting matrix metalloproteinases in inflammatory conditions
-
Clutterbuck AL, Asplin KE, Harris P, Allaway D, Mobasheri A. Targeting matrix metalloproteinases in inflammatory conditions. Curr Drug Targets 2009; 10: 1245-1254
-
(2009)
Curr Drug Targets
, vol.10
, pp. 1245-1254
-
-
Clutterbuck, A.L.1
Asplin, K.E.2
Harris, P.3
Allaway, D.4
Mobasheri, A.5
|