Endothelin-1 stimulates human colonic myofibroblast contraction and migration

Gut

Volumn 50, Issue 1, 2002, Pages 65-70

  Kernochan, L E ^a   Tran, B N ^a   Tangkijvanich, P ^a   Melton, A C ^a   Tam, S P ^a   Yee Jr , H F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM ION; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR AGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MYOSIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PLATELET DERIVED GROWTH FACTOR BB; RHO KINASE; SARAFOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CALCIUM CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; COLON INJURY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUSCLE FIBER CONTRACTION; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 0036136090     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.1.65     Document Type: Article

References (40)

1. Myofibroblasts. I. Paracrine cells important in health and disease
2. Myofibroblasts. II. Intestinal subepithelial myofibroblasts
3. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
4. Villus contraction aids repair of intestinal epithelium after injury
5. Induction of cell proliferation and collagen synthesis in human small intestinal lamina propria fibroblasts by lipopolysaccharide: Possible involvement of nitric oxide
6. Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation
7. Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors
8. An orally active non-selective endothelin receptor antagonist, bosentan, markedly reduces injury in a rat model of colitis
9. High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis
10. Endothelins in health and disease: An overview
11. Quantitation of rat hepatic stellate cell contraction: Stellate cells' contribution to sinusoidal resistance
12. Permissive role of nitric oxide in endothelin-induced migration of endothelial cells
13. Effect of the endothelin family of peptides on human coronary artery smooth-muscle cell migration
14. Role of endothelins on lymphocyte accumulation in allergic pleurisy
15. Growth regulatory properties of endothelins
16. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts
17. Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway
18. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
19. Intracellular calcium responses and shape conversions induced by endothelin in cultured subepithelial fibroblasts of rat duodenal villi
20. Phenotypic characterization of an intestinal subepithelial myofibroblast cell line
21. 2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts
22. Fluorescent indicators for cytosolic calcium based on rhodamine and
23. Effects of cGMP on [Ca2+]i, myosin light chain phosphorylation, and contraction in human myometrium
24. Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton
25. RhoA/rho-associated kinase mediates fibroblast contractile force generation
26. Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton
27. Quantification of adherent and nonadherent cells cultured in 96-well plates using the supravital stain neutral red
28. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
29. The small GTPase Rho: Cellular functions and signal transduction
30. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3
31. Fibroblasts, myofibroblasts, and wound contraction
32. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase, 1 and -2
33. Epithelial migration in the colon: Filling in the gaps
34. Pro-inflammatory cytokines in inflammatory bowel disease
35. Cytokines in inflammatory bowel disease
36. Endothelin receptor subtypes and their role in transmembrane signaling mechanisms
37. Signal transduction and regulation in smooth muscle
38. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
39. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
40. Cell migration: A physically integrated molecular process