Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation

Journal of Clinical Investigation

Volumn 101, Issue 12, 1998, Pages 2650-2657

  Jobson, Timothy M ^a   Billington, Charlotte K ^a   Hall, Ian P ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Cytokines; Fibrosis; Growth factors; Inflammatory bowel disease; Vasoactive intestinal peptide

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; EPIDERMAL GROWTH FACTOR; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN B; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; CELL DENSITY; CELL PROLIFERATION; CELL SURVIVAL; COLON; CONTROLLED STUDY; ENTERITIS; HUMAN; HUMAN CELL; MYOFIBROBLAST; PRIORITY JOURNAL; SCAR FORMATION; WOUND HEALING;

EID: 0032526069     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1876     Document Type: Article

References (44)

1. Desmouliere, A., M. Redard, I. Darby, and G. Gabbiani. 1995. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am. J. Pathol. 146:55-66.
2. Schmitt-Graff, A., A. Desmouliere, and G. Gabbiani. 1994. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Archiv. 425:3-24.
3. Misiewicz, J.J., C.I. Bartram, P.B. Cotton, A.S. Mee, A.B. Price, and R.P.H. Thompson. 1988. Ulcerative colitis. In Diseases of the Colon and Rectum: A Guide to Diagnosis. Gower Medical Publishing, London, U.K. 62-94.
4. Chowdhury, A., R. Fukuda, and S. Fukumoto. 1996. Growth factor mRNA expression in normal colorectal mucosa and in uninvolved mucosa from ulcerative colitis patients. J. Gastroenterol. 13:353-360.
5. Cordon-Cardo, C., I. Vlodavsky, A. Haimovitz-Friedman, D. Hicklin, and Z. Fuks. 1990. Expression of basic fibroblast growth factor in normal human tissues. Lab. Invest. 63:832-840.
6. Zimmermann, E.M., K. McNaughton, R.B. Sartor, and P.K. Lund. 1993. IGF-I is over expressed in cells with a smooth muscle phenotype in peptidoglycan-polysaccharide induced chronic enterocolitis in the rat. Gastroenterology. 104:A808. (Abstr.)
7. Stewart, C.E.H., and P. Rotwein. 1996. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. J. Biol. Chem. 271: 11330-11338.
8. Mahida, Y.R., K. Wu, and D.P. Jewell. 1989. Enhanced production of interleukin 1β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut. 30:835-838.
9. Reinecker, H.C., M. Steffen, T. Witthoef, I. Pflueger, S. Schreiber, R.P. MacDermott, and A. Raedler. 1993. Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin. Exp. Immunol. 94:174-181.
10. Wardle, T.D., and L.A. Turnberg. 1994. Potential role for interleukin-1 in the pathophysiology of ulcerative colitis. Clin. Sci. 86:619-626.
11. Niessner, M., and B.A. Volk. 1995. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin. Exp. Immunol. 101:428-435.
12. Schreiber, S., T. Heinig, H.G. Thiele, and A. Raedler. 1995. Immuno-regulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology. 108:1434-1444.
13. Shanahan, F., and P. Anton. 1988. Neuroendocrine modulation of the immune system. Possible implications for inflammatory bowel disease. Dig. Dis. Sci. 33:415-495.
14. Polak, J.M., and S.R. Bloom. 1982. Localisation of regulatory peptides in the gut. Br. Med. Bull. 38:303-308.
15. Metwali, A., A.M. Blum, L. Ferraris, J.S. Klein, C. Fiocchi, and J.V. Weinstock. 1994. Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J. Neuroimmunol. 52: 69-78.
16. Tomlinson, P.R., J.W. Wilson, and A.G. Stewart. 1995. Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels. Biochem. Pharmacol. 49:1809-1819.
17. Valentich, J.D., and D.W. Powell. 1994 Intestinal sub-epithelial myofibroblasts and mucosal immunophysiology. Curr. Opin. Gastroenterology. 10: 645-651.
18. Owens, M.W., and M.B. Grisham. 1993. Cytokines increase proliferation of human intestinal smooth muscle cells: possible role in inflammation-induced stricture formation. Inflammation. 17:481-487.
19. Graham, M.F., G.R. Bryson, and R.F. Diegelmann. 1989. Interleukin-1 is a mitogen for and selectively augments collagen production by human intestinal smooth muscle cells. Gastroenterology. 106:A181. (Abstr.)
20. Mahida, Y.R., J. Beltinger, S. Makh, M. Goke, T. Gray, D.K. Podolsky, and C.J. Hawkey. 1997. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am. J. Physiol. 273:G1341-G1348.
21. Mahida, Y.R., A.M. Galvin, T. Gray, S. Makh, M.E. McAllindon, H.F. Sewell, and D.K. Podolosky. 1997. Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following loss of surface epithelial cells. Clin. Exp. Immunol. 109. 377-386.
22. Danielpour, D., L.L. Dart, K.C. Flanders, A.B. Roberts, and M.B. Sporn. 1989. Immunodetection and quantitation of the two forms of transforming growth factor beta (TGF-beta1 and TGF-beta2) secreted by cells in culture. J. Cell. Physiol. 138:79-86.
23. Hall, I.P., S. Widdop, P. Townsend, and K. Daykin. 1992. Control of cyclic AMP levels in primary cultures of human tracheal smooth muscle cells. Br. J. Pharmacol. 107:422-428.
24. Donaldson, J., S.J. Hill, and A.M. Brown 1988. Kinetic studies on the mechanism by which histamine H1 receptors potentiate cyclic AMP accumulation in guinea-pig cerebral cortical slices. Mol. Pharmacol. 33:626-633.
25. Daniel, W.W. 1995. Biostatistics: A Foundation for Analysis in the Health Sciences. Sixth edition. John Wiley & Sons, Inc., New York. 780 pp.
26. Skalli, O., W. Schurch, T. Seemayer, R. Lagace, D. Montandon, B. Pittet, and G. Gabbiani. 1989. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest. 60:275-285.
27. Kaye, G.I., N. Lane, and R.R. Pascal. 1968. Colonie pericryptal fibroblast sheath: replication, migration and cytodifferentiation of a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon. Gastroenterology. 54:852-865.
28. Abboud, H.E. 1993. Growth factors in glomerulonephritis. Kidney Int. 43:252-57.
29. Sandor, Z., D. Szeli, M. Charette, and S. Szabo. 1995. Platelet derived growth factor accelerates the healing of experimental ulcerative colitis in rats. Gastroenterology. 108:A887. (Abstr.)
30. Satoh, H., K. Takami, K. Kato, J. Folkman, and S. Szabo. 1990. Effect of bFGF and its motein on healing of colonie ulcers induced by N-ethylmaleimide in rats. Gastroenterology. 98:A203. (Abstr.)
31. Luck, M.S., and P. Bass. 1993. Effect of epidermal growth factor on experimental colitis in the rat. J. Pharmacol. Exp. Ther. 264:984-990.
32. Procaccino, F., M. Reinshagen, P. Hoffmann, J.M. Zech, J. Lakshmanan, J.A. McRoberts, A. Patel, S. French, and V.E. Eysselein. 1994. Protective effect of epidermal growth factor in an experimental model of colitis in rats. Gastroenterology. 107:12-17.
33. Clemmons, D.R., and D.S. Shaw. 1986. Purification and biological properties of fibroblast somatomedin. J. Biol. Chem. 261:10293-10298.
34. Stallmach, A., D. Schuppan, H.H. Riese, H. Matthes, and E.O. Riecken. 1992. Increased collagen synthesis by fibroblasts isolated from strictures of patients with Crohn's disease. Gastroenterology. 102:1920-1929.
35. Kirstein, M., C. Aston, R. Hintz, and H. Vlassara. 1992. Receptor specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation and product-modified proteins. J. Clin. Invest. 90:439-446.
36. Hirst, S.J., P.J. Barnes, and C.H.C. Twort. 1996. PDGF isofrom-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am. J. Physiol. 270:L415-L428.
37. Bagby, S.P., M.M. O'Reilly, E.A. Kirk, L.H. Mitchell, P.E. Stenberg, M.T. Makler, and A.C. Bakke. 1992. EGF is incomplete mitogen in porcine aortic smooth muscle cells: DNA synthesis without cell division. Am. J. Physiol. 262:C578-C588.
38. Reape, T.J., J.M. Kanzcler, J.P.T. Ward, and C.R. Thomas. 1996. IGF-I increases bFGF induced mitogenesis and upregulates FGFR-1 in rabbit vascular smooth muscle cells. Am. J. Physiol. 270:H1141-H1148.
39. Mooney, A., T. Jobson, R. Bacon, M. Kitamura, and J. Savill. 1997. Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis. J. Immunol. 159(8):3949-3960.
40. Tsukamoto, T., T. Matsui, H. Nakata, M. Ito, T. Natazuka, M. Fukase, and T. Fujita. 1991. Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation. J. Biol. Chem. 266:10143-10147.
41. Maruno, K., A. Absood, and S.I. Said. 1995. VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells. Am. J. Physiol. 268:L1047-L1051.
42. Bishop, A.E., J.M. Polak, M.G. Bryant, S.R. Bloom, and S. Hamilton. 1980. Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's Disease. Gastroenterology. 79:853-860.
43. O'Morain, C., A.E. Bishop, G.P. McGregor, A.J. Levi, S.R. Bloom, J.M. Polak, and T.J. Peters. 1984. Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease. Gut. 25:57-61.
44. Metwali, A., A.M., Blum, L. Ferraris, J.S. Klein, C. Fiocchi, and J.V. Weinstock. 1994. Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J. Neuroimmunol. 52(1): 69-78.