Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis

Respiration

Volumn 77, Issue 3, 2009, Pages 311-319

  Aoki, Yasuhiro ^a   Maeno, Toshitaka ^a   Aoyagi, Kana ^a   Ueno, Manabu ^a   Aoki, Fumiaki ^a   Aoki, Nozomi ^a   Nakagawa, Junichi ^a   Sando, Yoshichika ^b   Shimizu, Yuji ^a   Suga, Tatsuo ^a   Arai, Masashi ^a   Kurabayashi, Masahiko ^a,c  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Koyagi Clinic   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Connective tissue growth factor; Idiopathic pulmonary fibrosis; Interstitial pneumonia, usual; Peroxisome proliferator activated receptor ; Pioglitazone hydrochloride; Tumor necrosis factor

Indexed keywords

BLEOMYCIN; CONNECTIVE TISSUE GROWTH FACTOR; HYDROXYPROLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE LUNG INJURY; ANIMALS; BLEOMYCIN; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLASTS; FIBROSIS; HUMANS; HYPOGLYCEMIC AGENTS; LUNG; MACROPHAGES, ALVEOLAR; MALE; PPAR GAMMA; RATS; RATS, WISTAR; THIAZOLIDINEDIONES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 64449087454     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000168676     Document Type: Article

References (42)

1. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000; 161: 646-664.
2. Gross T, Hunninghake G: Idiopathic pulmonary fibrosis. N Engl J Med 2001; 345: 517-525.
3. Adamson I, Bowden D: The pathogenesis of bloemycin-induced pulmonary fibrosis in mice. Am J Pathol 1974; 77: 185-197.
4. Fukuda Y, Basset F, Ferrans VJ, Yamanaka N: Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis. Hum Pathol 1995; 26: 53-61.
5. Kamp D: Idiopathic pulmonary fibrosis: the inflammation hypothesis revisited. Chest 2003; 124: 1187-1190.
6. Parra E, Kairalla R, Ribeiro de Carvalho C, Eher E, Capelozzi V: Inflammatory cell phenotyping of the pulmonary interstitium in idiopathic interstitial pneumonia. Respiration 2007; 74: 159-169.
7. Broekelmann T, Limper A, Colby T, McDonald J: Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991; 88: 6642-6646.
8. Keane M, Strieter R: The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir Res 2002; 3: 5.
9. Elias J, Freundlich B, Kern J, Rosenbloom J: Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest 1990; 97: 1439-1445.
10. Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T: Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur Respir J 2001; 17: 1220-1227.
11. Golec M, Lambers C, Hofbauer E, Geleff S, Bankier A, Czerny M, Ziesche R: Assessment of gene transcription demonstrates connection with the clinical course of idiopathic interstitial pneumonia. Respiration 2008;76: 261-269.
12. Bradham DM, Igarashi A, Potter RL, Grotendorst GR: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991; 114: 1285-1294.
13. Grotendorst GR: Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997; 8: 171-179.
14. Bonniaud P, Martin G, Margetts P, Ask K, Robertson J, Gauldie J, Kolb M: Connective tissue growth factor is crucial to inducing a profibrotic environment in 'fibrosis-resistant' BALB/c mouse lungs. Am J Respir Cell Mol Biol 2004; 31: 510-516.
15. Evans R: The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-895.
16. Tontonoz P, Hu E, Spiegelman BM: Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994; 79: 1147-1156.
17. Liu D, Zeng B, Shang Y: Decreased expression of peroxisome proliferator-activated receptor gamma in endotoxin-induced acute lung injury. Physiol Res 2006; 55: 291-299.
18. Ricote M, Li A, Willson T, Kelly C, Glass C: The peroxisome proliferator-activated receptor- gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
19. Daynes R, Jones D: Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002; 2: 748-759.
20. Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastruzzo C, Catalano P, Sortino M, Crimi N, Caputi AP, Thiemermann C, Vancheri C: Effect of rosiglitazone and 15-deoxy- delta12,14-prostaglandin J2 on bleomycin- induced lung injury. Eur Respir J 2005; 25: 225-234.
21. Lehmann J, Moore L, Smith-Oliver T, Wilkison W, Willson T, Kliewer S: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995; 270: 12953-12956.
22. Woessner JJ: The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961; 93: 440-447.
23. Giri SN, Hyde DM, Hollinger MA: Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-966.
24. Sime P, Xing Z, Graham F, Csaky K, Gauldie J: Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997; 100: 768-776.
25. Grotendorst G, Okochi H, Hayashi N: A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996; 7: 469-480.
26. Hay J, Shahzeidi S, Laurent G: Mechanisms of bleomycin-induced lung damage. Arch Toxicol 1991; 65: 81-94.
27. Sugiura Y, Suzuki T, Kuwahara J, Tanaka H: On the mechanism of hydrogen peroxide-, superoxide-, and ultraviolet light-induced DNA cleavages of inactive bleomycin-iron (III) complex. Biochem Biophys Res Commun 1982; 105: 1511-1518.
28. Torres M, Forman H: Redox signaling and the map kinase pathways. Biofactors 2003; 17: 287-296.
29. Simonin M, Bordji K, Boyault S, Bianchi A, Gouze E, Bécuwe P, Dauça M, Netter P, Terlain B: PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. Am J Physiol Cell Physiol 2002; 282: C125-C133.
30. Reddy R, Keshamouni V, Jaigirdar S, Zeng X, Leff T, Thannickal V, Standiford T: Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptorgamma ligands. Am J Physiol Lung Cell Mol Physiol 2004; 286:L613-L619.
31. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P: Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 1989; 170: 655-663.
32. Piguet PF, Collart MA, Grau GE, Sappino AP, Vassalli P: Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990; 344: 245-247.
33. Piguet PF, Vesin C: Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 1994; 7: 515-518.
34. Miyazaki Y, Araki K, Vesin C, Garcia I, Kapanci Y, Whitsett JA, Piguet PF, Vassalli P: Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 1995; 96: 250-259.
35. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J: Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol 1998; 153: 825-832.
36. Kothapalli D, Frazier KS, Welply A, Segarini PR, Grotendorst GR: Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway. Cell Growth Differ 1997; 8: 61-68.
37. Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, Lungarella G, Brody A, Friedman M: Connective tissue growth factor mRNA expression is upregulated in bleomycin- induced lung fibrosis. Am J Physiol 1998; 275:L365-L371.
38. Breen E, Shull S, Burne S, Absher M, Kelley J, Phan S, Cutroneo K: Bleomycin regulation of transforming growth factor-beta mRNA in rat lung fibroblasts. Am J Respir Cell Mol Biol 1992; 6: 146-152.
39. Fu M, Zhang J, Zhu X, Myles D, Willson T, Liu X, Chen Y: Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem 2001; 276: 45888-45894.
40. Guo B, Koya D, Isono M, Sugimoto T, Kashiwagi A, Haneda M: Peroxisome proliferatoractivated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cells. Diabetes 2004; 53: 200-208.
41. Dormandy J, Charbonnel B, Eckland D, Erdmann E, Massi-Benedetti M, Moules I, Skene A, Tan M, Lefèbvre P, Murray G, Standl E, Wilcox R, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine R, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive investigators: Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial In macro-Vascular Events): a randomised controlled trial. Lancet 2005; 366: 1279-1289.
42. Nissen S, Nicholls S, Wolski K, Nesto R, Kupfer S, Perez A, Jure H, De Larochellière R, Staniloae C, Mavromatis K, Saw J, Hu B, Lincoff A, Tuzcu E; PERISCOPE Investigators: Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. JAMA 2008; 299: 1561-1573.