Interleukin-21 (IL-21) controls inflammatory pathways in the gut

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 7, Issue 4, 2007, Pages 288-291

  Fina, Daniele ^a   Caruso, Roberta ^a   Pallone, Francesco ^a   Monteleone, Giovanni ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Common chain; Cytokines; IBD; IL 21; IL 21R; Matrix metalloproteinases; MIP 3

Indexed keywords

CD45RB ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYTOKINE; GELATINASE A; GELATINASE B; INTEGRIN; INTEGRIN ALPHA4BETA7; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; INTERSTITIAL COLLAGENASE; JANUS KINASE 1; JANUS KINASE 3; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; UNCLASSIFIED DRUG;

CD4+ T LYMPHOCYTE; CELL INTERACTION; CELLULAR IMMUNITY; CROHN DISEASE; CYTOKINE PRODUCTION; DRUG TARGETING; EFFECTOR CELL; ENTERITIS; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; IMMUNE RESPONSE; INTESTINAL FIBROSIS; INTESTINE FLORA; INTESTINE INJURY; NATURAL KILLER CELL; NONHUMAN; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; TH1 CELL; ULCERATIVE COLITIS;

ANIMALS; COLITIS, ULCERATIVE; CROHN DISEASE; HUMANS; INTERLEUKINS; INTESTINES;

EID: 37549022580     PISSN: 18715303     EISSN: None     Source Type: Journal    
DOI: 10.2174/187153007782794308     Document Type: Review

References (35)

1. Strober, W.; Fuss, I. and Mannon, P. (2007) J. Clin. Invest., 117(3), 514-521.
2. Hanauer, S.B. (2006) Inflamm. Bowel. Dis., 12 Suppl 1(S3-9).
3. Strober, W. and Fuss, I.J. (2006) Adv. Exp. Med. Biol., 579, 55-97.
4. Monteleone, G.; Biancone, L.; Marasco, R.; Morrone, G.; Marasco, O.; Luzza, F. and Pallone, F. (1997) Gastroenterology, 112(4), 1169-1178.
5. Parrello, T.; Monteleone, G.; Cucchiara, S.; Monteleone, I.; Sebkova, L.; Doldo, P.; Luzza, F. and Pallone, F. (2000) J. Immunol., 165(12), 7234-7239.
6. Neurath, M.F.; Weigmann, B.; Finotto, S.; Glickman, J.; Nieuwenhuis, E.; Iijima, H.; Mizoguchi, A.; Mizogucbi, E.; Mudter, J.; Galle, P.R.; Bhan, A.; Autschbach, F.; Sullivan, B.M.; Szabo, S.J.; Glimcher, L.H. and Blumberg, R.S. (2002) J. Exp. Med., 195(9), 1129-1143.
7. Neurath, M.F.; Fuss, I.; Kelsall, B.L.; Stuber, E. and Strober, W. (1995) J. Exp. Med., 182(5), 1281-1290.
8. Mannon, P.J.; Fuss, I.J.; Mayer, L.; Elson, C.O.; Sandborn, W.J.; Present, D.; Dolin, B.; Goodman, N.; Groden, C.; Hornung, R.L.; Quezado, M.; Yang, Z.; Neurath, M.F.; Salfeld, J.; Veldman, G.M.; Schwertschlag, U. and Strober, W. (2004) N. Engl. J. Med., 351(20), 2069-79.
9. Oppmann, B.; Lesley, R.; Blom, B.; Timans, J.C.; Xu, Y.; Hunte, B.; Vega, F.; Yu, N.; Wang, J.; Singh, K.; Zonin, F.; Vaisberg, E.; Churakova, T.; Liu, M.; Gorman, D.; Wagner, J.; Zurawski, S.; Liu, Y.; Abrams, J.S.; Moore, K.W.; Rennick, D.; de Waal-Malefyt, R.; Hannum, C.; Bazan, J.F. and Kastelein, R.A. (2000) Immunity, 13(5), 715-725.
10. Monteleone, G.; Parrello, T.; Luzza, F. and Pallone, F. (1998) Gut, 43(5), 620-628.
11. Parrish-Novak, J.; Dillon, S.R.; Nelson, A.; Hammond, A.; Sprecher, C.; Gross, J.A.; Johnston, J.; Madden, K.; Xu, W.; West, J.; Schrader, S.; Burkhead, S.; Heipel, M.; Brandt, C.; Kuijper, J.L.; Kramer, J.; Conklin, D.; Presnell, S.R.; Berry, J.; Shiota, F.; Bort, S.; Hambly, K.; Mudri, S.; Clegg, C.; Moore, M.; Grant, F.J.; Lofton-Day, C.; Gilbert, T.; Rayond, F.; Ching, A.; Yao, L.; Smith, D.; Webster, P.; Whitmore, T.; Maurer, M.; Kaushansky, K.; Holly, R.D. and Foster, D. (2000) Nature, 408(6808), 57-63.
12. Coquet, J.M.; Kyparissoudis, K.; Pellicci, D.G.; Besra, G.; Berzins, S.P.; Smyth, M.J. and Godfrey, D.I. (2007) J. Immunol., 178(5), 2827-2834.
13. Ozaki, K.; Kikly, K.; Michalovich, D.; Young, P.R. and Leonard, W.J. (2000) Proc. Natl. Acad. Sci. USA, 97(21), 11439-11444.
14. Jungel, A.; Distler, J.H.; Kurowska-Stolarska, M.; Seemayer, C.A.; Seibl, R.; Forster, A.; Michel, B.A.; Gay, R.E.; Emmrich, F.; Gay, S. and Distler, O. (2004) Arthritis Rheum., 50(5), 1468-1476.
15. Distler, J.H.; Jungel, A.; Kowal-Bielecka, O.; Michel, B.A.; Gay, R.E.; Sprott, H.; Matucci-Cerinic, M.; Chilla, M.; Reich, K.; Kalden, J.R.; Muller-Ladner, U.; Lorenz, H.M.; Gay, S. and Distler, O. (2005) Arthritis Rheum., 52(3), 856-864.
16. Leonard, W.J. and Spolski, R. (2005) Nat. Rev. Immunol., 5(9), 688-698.
17. Habib, T.; Senadheera, S.; Weinberg, K. and Kaushansky, K. (2002) Biochemistry, 41(27), 8725-8731.
18. Asao, H.; Okuyama, C.; Kumaki, S.; Ishii, N.; Tsuchiya, S.; Foster, D. and Sugamura, K. (2001) J. Immunol., 167(1), 1-5.
19. Monteleone, G,; Monteleone, I.; Fina, D.; Vavassori, P.; Del Vecchio Blanco, G.; Caruso, R.; Tersigni, R.; Alessandroni, L.; Biancone, L.; Naccari, G.C.; MacDonald, T.T. and Pallone, F. (2005) Gastroenterology, 128(3), 687-694.
20. Kunkel, E.J.; Campbell, D.J. and Butcher, E.C. (2003) Microcirculation, 10(34), 313-323.
21. Caruso, R.; Fina, D.; Peluso, I.; Stolfi, C.; Fantini, M.C.; Gioia, V.; Caprioli, F.; Del Vecchio Blanco, G.; Paoluzi, O.A.; Macdonald, T.T.; Pallone, F. and Monteleone, G. (2007) Gastroenterology, 132(1), 166-175.
22. Izadpanah, A.; Dwinell, M.B.; Eckmann, L.; Varki, N.M. and Kagnoff, M.F. (2001) Am. J. Physiol. Gastrointest. Liver Physiol., 280(4), G710-719.
23. Kwon, J.H.; Keates, S.; Bassani, L.; Mayer, L.F. and Keates, A.C. (2002) Gut, 51(6), 818-826.
24. Teramoto, K.; Miura, S.; Tsuzuki, Y.; Hokari, R.; Watanabe, C.; Inamura, T.; Ogawa, T.; Hosoe, N.; Nagata, H.; Ishii, H. and Hibi, T. (2005) Clin. Exp. Immunol., 139(3), 421-428.
25. Scheerens, H.; Hessel, E.; de Waal-Malefyt, R.; Leach, M.W. and Rennick, D. (2001) Eur. J. Immunol., 31(5), 1465-1474.
26. Katchar, K.; Kelly, C.; Keates, S.; O'Brien, M. and Keates, A. (2007) Am. J. Physiol. Gastrointest. Liver Physiol., 292(5), G1263-1271.
27. Pender, S.L.; Tickle, S.P.; Docherty, A.J.; Howie, D.; Wathen, N.C. and MacDonald, T.T. (1997) J. Immunol., 158(4), 1582-1590.
28. Kirkegaard, T.; Hansen, A.; Bruun, E. and Brynskov, J. (2004) Gut, 53(5), 701-709.
29. von Lampe, B.; Barthet, B.; Coupland, S.E.; Riecken, E.O. and Rosewicz, S. (2000) Gut, 47(1), 63-73.
30. Louis, E.; Ribbens, C.; Godon, A.; Franchimont, D.; De Groote, D.; Hardy, N.; Boniver, J.; Belaiche, J. and Malaise, M. (2000) Clin. Exp. Immunol., 120(2), 241-246.
31. Pender, S.L. and MacDonald, T.T. (2004) Curr. Opin. Pharmacol., 4(6), 546-550.
32. Heuschkel, R.B.; MacDonald, T.T.; Monteleone, G.; Bajaj-Elliott, M.; Smith, J.A. and Pender, S.L. (2000) Gut, 47(1), 57-62.
33. Monteleone, G.; MacDonald, T.T.; Wathen, N.C.; Pallone, F. and Pender, S.L. (1999) Gastroenterology, 117(5), 1069-1077.
34. Monteleone, G.; Caruso, R.; Fina, D.; Peluso, I.; Gioia, V.; Stolfi, C.; Fantini, M.C.; Caprioli, F.; Tersigni, R.; Alessandroni, L.; MacDonald, T.T. and Pallone, F. (2006) Gut, 55(12), 1774-1780.
35. Pesce, J.; Kaviratne, M.; Ramalingam, T.R.; Thompson, R.W.; Urban, J.F. Jr.; Cheever, A.W.; Young, D.A.; Collins, M.; Grusby, M.J. and Wynn, T.A. (2006) J. Clin. Invest., 116(7), 2044-2055.