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Volumn 161, Issue 2, 2009, Pages 237-248

Interleukin (IL)-6 modulates transforming growth factor-b expression in skin and dermal fibroblasts from IL-6-deficient mice

Author keywords

Collagen; Fibroblast; IL 6; Inflammation; Skin; TGF b

Indexed keywords

INTERLEUKIN 6; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

EID: 73349121322     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09215.x     Document Type: Article
Times cited : (64)

References (85)
  • 1
    • 33845975971 scopus 로고    scopus 로고
    • Novel therapies in diabetes mellitus
    • Bandyopadhyay P. Novel therapies in diabetes mellitus. Drug News Perspect 2006; 19:499-507.
    • (2006) Drug News Perspect , vol.19 , pp. 499-507
    • Bandyopadhyay, P.1
  • 2
    • 34247382060 scopus 로고    scopus 로고
    • Measures of adiposity and cardiovascular disease risk factors
    • Menke A, Muntner P, Wildman RP et al. Measures of adiposity and cardiovascular disease risk factors. Obesity (Silver Spring) 2007; 15:785-95.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 785-795
    • Menke, A.1    Muntner, P.2    Wildman, R.P.3
  • 3
    • 0033971707 scopus 로고    scopus 로고
    • Recent advances in wound healing
    • Bello YM, Phillips TJ. Recent advances in wound healing. J Am Med Assoc 2000; 283:716-18.
    • (2000) J Am Med Assoc , vol.283 , pp. 716-718
    • Bello, Y.M.1    Phillips, T.J.2
  • 4
    • 0036587571 scopus 로고    scopus 로고
    • Transforming growth factor beta signal transduction
    • Dennler S, Goumans MJ, ten Dijke P. Transforming growth factor beta signal transduction. J Leukoc Biol 2002; 71:731-40.
    • (2002) J Leukoc Biol , vol.71 , pp. 731-740
    • Dennler, S.1    Goumans, M.J.2    Ten Dijke, P.3
  • 5
    • 0036549082 scopus 로고    scopus 로고
    • Control of connective tissue gene expression by TGF beta: Role of Smad proteins in fibrosis
    • Verrecchia F, Mauviel A. Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep 2002; 4:143-9.
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 143-149
    • Verrecchia, F.1    Mauviel, A.2
  • 6
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003; 425:577-84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 7
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signaling
    • ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004; 29:265-73.
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 8
    • 0036910425 scopus 로고    scopus 로고
    • Two major Smad pathways in TGF-beta superfamily signalling
    • Miyazawa K, Shinozaki M, Hara T et al. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 2002; 7:1191-204.
    • (2002) Genes Cells , vol.7 , pp. 1191-1204
    • Miyazawa, K.1    Shinozaki, M.2    Hara, T.3
  • 9
    • 0033926275 scopus 로고    scopus 로고
    • Delayed wound healing in immunodeficient TGF-beta 1 knockout mice
    • Crowe MJ, Doetschman T, Greenhalgh DG. Delayed wound healing in immunodeficient TGF-beta 1 knockout mice. J Invest Dermatol 2000; 115:3-11.
    • (2000) J Invest Dermatol , vol.115 , pp. 3-11
    • Crowe, M.J.1    Doetschman, T.2    Greenhalgh, D.G.3
  • 10
    • 0034713224 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast
    • Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res 2000; 257:180-9.
    • (2000) Exp Cell Res , vol.257 , pp. 180-189
    • Vaughan, M.B.1    Howard, E.W.2    Tomasek, J.J.3
  • 11
    • 13844292451 scopus 로고    scopus 로고
    • Transforming growth factor-beta and its effect on reepithelialization of partial-thickness ear wounds in transgenic mice
    • Tredget EB, Demare J, Chandran G et al. Transforming growth factor-beta and its effect on reepithelialization of partial-thickness ear wounds in transgenic mice. Wound Repair Regen 2005; 13:61-7.
    • (2005) Wound Repair Regen , vol.13 , pp. 61-67
    • Tredget, E.B.1    Demare, J.2    Chandran, G.3
  • 12
    • 0035163082 scopus 로고    scopus 로고
    • Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions
    • Laplante AF, Germain L, Auger FA et al. Mechanisms of wound reepithelialization: hints from a tissue-engineered reconstructed skin to long-standing questions. FASEB J 2001; 15:2377-89.
    • (2001) FASEB J , vol.15 , pp. 2377-2389
    • Laplante, A.F.1    Germain, L.2    Auger, F.A.3
  • 13
    • 0027743449 scopus 로고
    • Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair
    • Levine JH, Moses HL, Gold LI et al. Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair. Am J Pathol 1993; 143:368-80.
    • (1993) Am J Pathol , vol.143 , pp. 368-380
    • Levine, J.H.1    Moses, H.L.2    Gold, L.I.3
  • 14
    • 0036177427 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation
    • Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002; 118:211-15.
    • (2002) J Invest Dermatol , vol.118 , pp. 211-215
    • Verrecchia, F.1    Mauviel, A.2
  • 15
    • 0026600495 scopus 로고
    • Increased transforming growth factor-beta 1 gene expression in human liver disease
    • Annoni G, Weiner FR, Zern MA. Increased transforming growth factor-beta 1 gene expression in human liver disease. J Hepatol 1992; 14:259-64.
    • (1992) J Hepatol , vol.14 , pp. 259-264
    • Annoni, G.1    Weiner, F.R.2    Zern, M.A.3
  • 17
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342:1350-8.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 18
    • 39049174093 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in the pathogenesis of diabetic retinopathy
    • [In Polish]
    • Gacka M, Adamiec J. [The role of transforming growth factor-beta in the pathogenesis of diabetic retinopathy]. Przegl Lek 2006; 63:296-8 [In Polish].
    • (2006) Przegl Lek , vol.63 , pp. 296-298
    • Gacka, M.1    Adamiec, J.2
  • 19
    • 0025363091 scopus 로고
    • Interleukin-6: Molecular pathophysiology
    • Sehgal PB. Interleukin-6: molecular pathophysiology. J Invest Dermatol 1990; 94:S2-6.
    • (1990) J Invest Dermatol , vol.94
    • Sehgal, P.B.1
  • 21
    • 0343019918 scopus 로고
    • Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes
    • Grossman RM, Krueger J, Yourish D et al. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 1989; 86:6367-71.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6367-6371
    • Grossman, R.M.1    Krueger, J.2    Yourish, D.3
  • 22
    • 0027717313 scopus 로고
    • In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease
    • Koch AE, Kronfeld-Harrington LB, Szekanecz Z et al. In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease. Pathobiology 1993; 61:239-46.
    • (1993) Pathobiology , vol.61 , pp. 239-246
    • Koch, A.E.1    Kronfeld-Harrington, L.B.2    Szekanecz, Z.3
  • 23
    • 0024951017 scopus 로고
    • IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes
    • Fugger L, Morling N, Bendtzen K et al. IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes. J Immunogenet 1989; 16:461-5.
    • (1989) J Immunogenet , vol.16 , pp. 461-465
    • Fugger, L.1    Morling, N.2    Bendtzen, K.3
  • 24
    • 0032533824 scopus 로고    scopus 로고
    • Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes
    • Sawamura D, Meng X, Ina S et al. Induction of keratinocyte proliferation and lymphocytic infiltration by in vivo introduction of the IL-6 gene into keratinocytes and possibility of keratinocyte gene therapy for inflammatory skin diseases using IL-6 mutant genes. J Immunol 1998; 161:5633-9.
    • (1998) J Immunol , vol.161 , pp. 5633-5639
    • Sawamura, D.1    Meng, X.2    Ina, S.3
  • 25
    • 0026724459 scopus 로고
    • Interleukin 6: Insights to its function in skin by overexpression in transgenic mice
    • Turksen K, Kupper T, Degenstein L et al. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci USA 1992; 89:5068-72.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5068-5072
    • Turksen, K.1    Kupper, T.2    Degenstein, L.3
  • 26
    • 0034803639 scopus 로고    scopus 로고
    • Interleukin-6 treatment augments cutaneous wound healing in immunosuppressed mice
    • Gallucci RM, Sugawara T, Yucesoy B et al. Interleukin-6 treatment augments cutaneous wound healing in immunosuppressed mice. J Interferon Cytokine Res 2001; 21:603-9.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 603-609
    • Gallucci, R.M.1    Sugawara, T.2    Yucesoy, B.3
  • 27
    • 0038341934 scopus 로고    scopus 로고
    • Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice
    • Lin ZQ, Kondo T, Ishida Y et al. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 2003; 73:713-21.
    • (2003) J Leukoc Biol , vol.73 , pp. 713-721
    • Lin, Z.Q.1    Kondo, T.2    Ishida, Y.3
  • 28
    • 0033617143 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts
    • Eickelberg O, Pansky A, Mussmann R et al. Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts. J Biol Chem 1999; 274:12933-8.
    • (1999) J Biol Chem , vol.274 , pp. 12933-12938
    • Eickelberg, O.1    Pansky, A.2    Mussmann, R.3
  • 29
    • 33748039410 scopus 로고    scopus 로고
    • Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells
    • Aoki H, Ohnishi H, Hama K et al. Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. J Cell Biochem 2006; 99:221-8.
    • (2006) J Cell Biochem , vol.99 , pp. 221-228
    • Aoki, H.1    Ohnishi, H.2    Hama, K.3
  • 30
    • 0003633755 scopus 로고
    • National Institutes for Health. NIH publication no. 86-23. Bethesda MD: NIH
    • National Institutes for Health. Guide for the Care and Use of Laboratory Animals. NIH publication no. 86-23. Bethesda, MD: NIH, 1985.
    • (1985) Guide for the Care and Use of Laboratory Animals
  • 31
    • 1842740165 scopus 로고    scopus 로고
    • Interleukin 6 indirectly induces keratinocyte migration
    • Gallucci RM, Sloan DK, Heck JM et al. Interleukin 6 indirectly induces keratinocyte migration. J Invest Dermatol 2004; 122:764-72.
    • (2004) J Invest Dermatol , vol.122 , pp. 764-772
    • Gallucci, R.M.1    Sloan, D.K.2    Heck, J.M.3
  • 32
    • 0030954952 scopus 로고    scopus 로고
    • Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton
    • Tomasek JJ, Halliday NL, Updike DL et al. Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton. J Biol Chem 1997; 272:7482-7.
    • (1997) J Biol Chem , vol.272 , pp. 7482-7487
    • Tomasek, J.J.1    Halliday, N.L.2    Updike, D.L.3
  • 33
    • 16344380754 scopus 로고    scopus 로고
    • A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    • Song H, Wang R, Wang S et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci USA 2005; 102:4700-5.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4700-4705
    • Song, H.1    Wang, R.2    Wang, S.3
  • 34
    • 17844386070 scopus 로고    scopus 로고
    • Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    • Tomasek JJ, McRae J, Owens GK et al. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am J Pathol 2005; 166:1343-51.
    • (2005) Am J Pathol , vol.166 , pp. 1343-1351
    • Tomasek, J.J.1    McRae, J.2    Owens, G.K.3
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechanoregulation of connective tissue remodelling
    • Tomasek JJ, Gabbiani G, Hinz B et al. Myofibroblasts and mechanoregulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3:349-63.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 349-363
    • Tomasek, J.J.1    Gabbiani, G.2    Hinz, B.3
  • 37
    • 34447104560 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL-6KO mice
    • Luckett LR, Gallucci RM. Interleukin-6 (IL-6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL-6KO mice. Br J Dermatol 2007; 156:1163-71.
    • (2007) Br J Dermatol , vol.156 , pp. 1163-1171
    • Luckett, L.R.1    Gallucci, R.M.2
  • 38
    • 0033664369 scopus 로고    scopus 로고
    • Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice
    • Gallucci RM, Simeonova PP, Matheson JM et al. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J 2000; 14:2525-31.
    • (2000) FASEB J , vol.14 , pp. 2525-2531
    • Gallucci, R.M.1    Simeonova, P.P.2    Matheson, J.M.3
  • 39
    • 0038676258 scopus 로고    scopus 로고
    • Regulation of wound healing by growth factors and cytokines
    • Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83:835-70.
    • (2003) Physiol Rev , vol.83 , pp. 835-870
    • Werner, S.1    Grose, R.2
  • 40
    • 2542478053 scopus 로고    scopus 로고
    • Wound healing: An overview of acute, fibrotic and delayed healing
    • Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 2004; 9:283-9.
    • (2004) Front Biosci , vol.9 , pp. 283-289
    • Diegelmann, R.F.1    Evans, M.C.2
  • 41
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • Heinrich PC, Behrmann I, Haan S et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374:1-20.
    • (2003) Biochem J , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3
  • 42
    • 0031013030 scopus 로고    scopus 로고
    • Type i (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair
    • Gold LI, Sung JJ, Siebert JW et al. Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair. Am J Pathol 1997; 150:209-22.
    • (1997) Am J Pathol , vol.150 , pp. 209-222
    • Gold, L.I.1    Sung, J.J.2    Siebert, J.W.3
  • 43
    • 0028221614 scopus 로고
    • Transforming growth factor beta: A matter of life and death
    • McCartney-Francis NL, Wahl SM. Transforming growth factor beta: a matter of life and death. J Leukoc Biol 1994; 55:401-9.
    • (1994) J Leukoc Biol , vol.55 , pp. 401-409
    • McCartney-Francis, N.L.1    Wahl, S.M.2
  • 44
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-aiming for perfect skin regeneration
    • Martin P. Wound healing-aiming for perfect skin regeneration. Science 1997; 276:75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 45
    • 33846548599 scopus 로고    scopus 로고
    • Trichostatin A blocks TGFbeta-induced collagen gene expression in skin fibroblasts: Involvement of Sp1
    • Ghosh AK, Mori Y, Dowling E et al. Trichostatin A blocks TGFbeta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. Biochem Biophys Res Commun 2007; 354:420-6.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 420-426
    • Ghosh, A.K.1    Mori, Y.2    Dowling, E.3
  • 46
    • 0036335974 scopus 로고    scopus 로고
    • Modulation of fibrinolytic and gelatinolytic activity during adipose tissue development in a mouse model of nutritionally induced obesity
    • Lijnen HR, Maquoi E, Demeulemeester D et al. Modulation of fibrinolytic and gelatinolytic activity during adipose tissue development in a mouse model of nutritionally induced obesity. Thromb Haemost 2002; 88:345-53.
    • (2002) Thromb Haemost , vol.88 , pp. 345-353
    • Lijnen, H.R.1    Maquoi, E.2    Demeulemeester, D.3
  • 47
    • 33748800983 scopus 로고    scopus 로고
    • Role of TGF beta-mediated inflammation in cutaneous wound healing
    • Wang XJ, Han G, Owens P et al. Role of TGF beta-mediated inflammation in cutaneous wound healing. J Investig Dermatol Symp Proc 2006; 11:112-17.
    • (2006) J Investig Dermatol Symp Proc , vol.11 , pp. 112-117
    • Wang, X.J.1    Han, G.2    Owens, P.3
  • 48
    • 0024043131 scopus 로고
    • Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: Implications for wound healing
    • Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci USA 1988; 85:4894-7.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4894-4897
    • Montesano, R.1    Orci, L.2
  • 49
    • 32844464795 scopus 로고    scopus 로고
    • IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
    • Gallucci RM, Lee EG, Tomasek JJ. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol 2006; 126:561-8.
    • (2006) J Invest Dermatol , vol.126 , pp. 561-568
    • Gallucci, R.M.1    Lee, E.G.2    Tomasek, J.J.3
  • 50
    • 16844377774 scopus 로고    scopus 로고
    • Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling
    • Zhang XL, Topley N, Ito T et al. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. J Biol Chem 2005; 280:12239-45.
    • (2005) J Biol Chem , vol.280 , pp. 12239-12245
    • Zhang, X.L.1    Topley, N.2    Ito, T.3
  • 51
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 2004; 21:491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3
  • 52
    • 0029959416 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 inhibits synthesis of cytokines in endotoxin-stimulated human whole blood
    • discussion 6-7
    • Karres I, Kremer JP, Steckholzer U et al. Transforming growth factor-beta 1 inhibits synthesis of cytokines in endotoxin-stimulated human whole blood. Arch Surg 1996; 131:1310-16; discussion 6-7.
    • (1996) Arch Surg , vol.131 , pp. 1310-1316
    • Karres, I.1    Kremer, J.P.2    Steckholzer, U.3
  • 53
    • 0032195413 scopus 로고    scopus 로고
    • Study on gene expression of TGF beta 1 and its receptor in leukemia cells and the serum TGF beta 1 level in the patients with acute leukemia
    • [In Chinese]
    • Chen Y, Lu L, Wang L. [Study on gene expression of TGF beta 1 and its receptor in leukemia cells and the serum TGF beta 1 level in the patients with acute leukemia]. Zhonghua Xue Ye Xue Za Zhi 1998; 19:576-80 [In Chinese].
    • (1998) Zhonghua Xue Ye Xue Za Zhi , vol.19 , pp. 576-580
    • Chen, Y.1    Lu, L.2    Wang, L.3
  • 54
    • 0029944242 scopus 로고    scopus 로고
    • Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins
    • Clark RA, Ashcroft GS, Spencer MJ et al. Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins. Br J Dermatol 1996; 135:46-51.
    • (1996) Br J Dermatol , vol.135 , pp. 46-51
    • Clark, R.A.1    Ashcroft, G.S.2    Spencer, M.J.3
  • 55
    • 0029875396 scopus 로고    scopus 로고
    • Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing
    • Frank S, Madlener M, Werner S. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem 1996; 271:10188-93.
    • (1996) J Biol Chem , vol.271 , pp. 10188-10193
    • Frank, S.1    Madlener, M.2    Werner, S.3
  • 56
    • 0022465625 scopus 로고
    • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl JH, Wakefield LM, Roberts AB et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986; 163:1037-50.
    • (1986) J Exp Med , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3
  • 57
    • 0023216905 scopus 로고
    • Human transforming growth factor type beta 2: Production by a prostatic adenocarcinoma cell line, purification, and initial characterization
    • Ikeda T, Lioubin MN, Marquardt H. Human transforming growth factor type beta 2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry 1987; 26:2406-10.
    • (1987) Biochemistry , vol.26 , pp. 2406-2410
    • Ikeda, T.1    Lioubin, M.N.2    Marquardt, H.3
  • 58
    • 0024755673 scopus 로고
    • Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis
    • Glick AB, Flanders KC, Danielpour D et al. Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. Cell Regul 1989; 1:87-97.
    • (1989) Cell Regul , vol.1 , pp. 87-97
    • Glick, A.B.1    Flanders, K.C.2    Danielpour, D.3
  • 59
    • 0026708669 scopus 로고
    • Post-transcriptional regulation of the human transforming growth factor-beta 1 gene
    • Kim SJ, Park K, Koeller D et al. Post-transcriptional regulation of the human transforming growth factor-beta 1 gene. J Biol Chem 1992; 267:13702-7.
    • (1992) J Biol Chem , vol.267 , pp. 13702-13707
    • Kim, S.J.1    Park, K.2    Koeller, D.3
  • 60
    • 0029166667 scopus 로고
    • A synthetic inhibitor of the mitogen-activated protein kinase cascade
    • Dudley DT, Pang L, Decker SJ et al. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 1995; 92:7686-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7686-7689
    • Dudley, D.T.1    Pang, L.2    Decker, S.J.3
  • 61
    • 34147195051 scopus 로고    scopus 로고
    • Induction of transforming growth factorbeta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK?ERK signaling and AP-1 activation
    • Dhandapani KM, Khan MM, Wade FM et al. Induction of transforming growth factorbeta1 by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK?ERK signaling and AP-1 activation. J Neurosci Res 2007; 85:1033-45.
    • (2007) J Neurosci Res , vol.85 , pp. 1033-1045
    • Dhandapani, K.M.1    Khan, M.M.2    Wade, F.M.3
  • 62
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: The signal orchestration model
    • Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 2003; 149:1-38.
    • (2003) Rev Physiol Biochem Pharmacol , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 63
    • 0029133702 scopus 로고
    • Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon betastimulated gene expression through STAT proteins
    • David M, Petricoin E III, Benjamin C et al. Requirement for MAP kinase (ERK2) activity in interferon alpha-and interferon betastimulated gene expression through STAT proteins. Science 1995; 269:1721-3.
    • (1995) Science , vol.269 , pp. 1721-1723
    • David, M.1    Petricoin III, E.2    Benjamin, C.3
  • 64
    • 0030772458 scopus 로고    scopus 로고
    • STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    • Chung J, Uchida E, Grammer TC et al. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 1997; 17: 6508-16.
    • (1997) Mol Cell Biol , vol.17 , pp. 6508-6516
    • Chung, J.1    Uchida, E.2    Grammer, T.C.3
  • 65
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995; 82:241-50.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 66
    • 0028942656 scopus 로고
    • Requirement of serine phosphorylation for formation of STAT-promoter complexes
    • Zhang X, Blenis J, Li HC et al. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 1995; 267:1990-4.
    • (1995) Science , vol.267 , pp. 1990-1994
    • Zhang, X.1    Blenis, J.2    Li, H.C.3
  • 67
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene 2000; 19:2628-37.
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 68
    • 0032530159 scopus 로고    scopus 로고
    • Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogenactivated protein kinases
    • Sengupta TK, Talbot ES, Scherle PA et al. Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogenactivated protein kinases. Proc Natl Acad Sci USA 1998; 95:11107-12.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11107-11112
    • Sengupta, T.K.1    Talbot, E.S.2    Scherle, P.A.3
  • 69
    • 33744937083 scopus 로고    scopus 로고
    • Involvement of H-and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis
    • Martinez-Salgado C, Fuentes-Calvo I, Garcia-Cenador B et al. Involvement of H-and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis. Exp Cell Res 2006; 312:2093-106.
    • (2006) Exp Cell Res , vol.312 , pp. 2093-2106
    • Martinez-Salgado, C.1    Fuentes-Calvo, I.2    Garcia-Cenador, B.3
  • 70
    • 0036301992 scopus 로고    scopus 로고
    • Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
    • Grimm OH, Gurdon JB. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat Cell Biol 2002; 4:519-22.
    • (2002) Nat Cell Biol , vol.4 , pp. 519-522
    • Grimm, O.H.1    Gurdon, J.B.2
  • 71
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFbeta?Smad signaling by oncogenic Ras
    • Kretzschmar M, Doody J, Timokhina I et al. A mechanism of repression of TGFbeta?Smad signaling by oncogenic Ras. Genes Dev 1999; 13:804-16.
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3
  • 72
    • 0033373484 scopus 로고    scopus 로고
    • Estradiol suppresses mesangial cell type i collagen synthesis via activation of the MAP kinase cascade
    • Neugarten J, Medve I, Lei J et al. Estradiol suppresses mesangial cell type I collagen synthesis via activation of the MAP kinase cascade. Am J Physiol 1999; 277:F875-81.
    • (1999) Am J Physiol , vol.277
    • Neugarten, J.1    Medve, I.2    Lei, J.3
  • 73
    • 0034602286 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase 1?2 inhibits type i collagen expression by human skin fibroblasts
    • Reunanen N, Foschi M, Han J et al. Activation of extracellular signal-regulated kinase 1?2 inhibits type I collagen expression by human skin fibroblasts. J Biol Chem 2000; 275:34634-9.
    • (2000) J Biol Chem , vol.275 , pp. 34634-34639
    • Reunanen, N.1    Foschi, M.2    Han, J.3
  • 74
    • 26844436963 scopus 로고    scopus 로고
    • Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK?p38 MAP kinase pathway through antioxidant mechanisms
    • Lee SY, Lee JW, Lee H et al. Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK?p38 MAP kinase pathway through antioxidant mechanisms. Brain Res Mol Brain Res 2005; 140:45-54.
    • (2005) Brain Res Mol Brain Res , vol.140 , pp. 45-54
    • Lee, S.Y.1    Lee, J.W.2    Lee, H.3
  • 75
    • 22044452586 scopus 로고    scopus 로고
    • Antioxidant N-acetylcysteine blocks nerve growth factor-induced H2O2?ERK signaling in PC12 cells
    • Yang LY, Ko WC, Lin CM et al. Antioxidant N-acetylcysteine blocks nerve growth factor-induced H2O2?ERK signaling in PC12 cells. Ann N Y Acad Sci 2005; 1042:325-37.
    • (2005) Ann N y Acad Sci , vol.1042 , pp. 325-337
    • Yang, L.Y.1    Ko, W.C.2    Lin, C.M.3
  • 76
    • 33747039211 scopus 로고    scopus 로고
    • STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells
    • Arany I, Megyesi JK, Nelkin BD et al. STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney Int 2006; 70:669-74.
    • (2006) Kidney Int , vol.70 , pp. 669-674
    • Arany, I.1    Megyesi, J.K.2    Nelkin, B.D.3
  • 77
    • 0020576560 scopus 로고
    • Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization
    • Assoian RK, Komoriya A, Meyers CA et al. Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem 1983; 258:7155-60.
    • (1983) J Biol Chem , vol.258 , pp. 7155-7160
    • Assoian, R.K.1    Komoriya, A.2    Meyers, C.A.3
  • 78
    • 3042635767 scopus 로고    scopus 로고
    • The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
    • Wang XP, Schunck M, Kallen KJ et al. The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J Invest Dermatol 2004; 123:124-31.
    • (2004) J Invest Dermatol , vol.123 , pp. 124-131
    • Wang, X.P.1    Schunck, M.2    Kallen, K.J.3
  • 79
    • 3142600668 scopus 로고    scopus 로고
    • JP-8 jet fuel exposure induces inflammatory cytokines in rat skin
    • Gallucci RM, O'Dell SK, Rabe D et al. JP-8 jet fuel exposure induces inflammatory cytokines in rat skin. Int Immunopharmacol 2004; 4:1159-69.
    • (2004) Int Immunopharmacol , vol.4 , pp. 1159-1169
    • Gallucci, R.M.1    O'dell, S.K.2    Rabe, D.3
  • 80
    • 33947519009 scopus 로고    scopus 로고
    • Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: Could it be related to a different cytokine microenvironment?
    • Moretti S, Spallanzani A, Pinzi C et al. Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance: could it be related to a different cytokine microenvironment? J Cutan Pathol 2007; 34:301-8.
    • (2007) J Cutan Pathol , vol.34 , pp. 301-308
    • Moretti, S.1    Spallanzani, A.2    Pinzi, C.3
  • 81
    • 33947219001 scopus 로고    scopus 로고
    • Radiation-induced alterations in cytokine production by skin cells
    • Muller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 2007; 35:96-104.
    • (2007) Exp Hematol , vol.35 , pp. 96-104
    • Muller, K.1    Meineke, V.2
  • 82
    • 0026455156 scopus 로고
    • Connective tissue metabolism including cytokines in scleroderma
    • Smith EA. Connective tissue metabolism including cytokines in scleroderma. Curr Opin Rheumatol 1992; 4:869-77.
    • (1992) Curr Opin Rheumatol , vol.4 , pp. 869-877
    • Smith, E.A.1
  • 83
    • 7044247951 scopus 로고    scopus 로고
    • Animal models of systemic sclerosis: Insights into systemic sclerosis pathogenesis and potential therapeutic approaches
    • Christner PJ, Jimenez SA. Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches. Curr Opin Rheumatol 2004; 16:746-52.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 746-752
    • Christner, P.J.1    Jimenez, S.A.2
  • 84
    • 20644457110 scopus 로고    scopus 로고
    • Pathogenesis of systemic sclerosis: Altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
    • Hasegawa M, Fujimoto M, Takehara K et al. Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis. J Dermatol Sci 2005; 39:1-7.
    • (2005) J Dermatol Sci , vol.39 , pp. 1-7
    • Hasegawa, M.1    Fujimoto, M.2    Takehara, K.3
  • 85
    • 32144454167 scopus 로고    scopus 로고
    • Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: Association of interleukin 12 elevation with spontaneous regression of skin sclerosis
    • Matsushita T, Hasegawa M, Hamaguchi Y et al. Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis. J Rheumatol 2006; 33:275-84.
    • (2006) J Rheumatol , vol.33 , pp. 275-284
    • Matsushita, T.1    Hasegawa, M.2    Hamaguchi, Y.3


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