Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 3, 2011, Pages 358-369

  Nan, Yue Min ^a   Han, Fang ^a   Kong, Ling Bo ^a   Zhao, Su Xian ^a   Wang, Rong Qi ^a   Wu, Wen Juan ^a   Yu, Jun ^b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

adiponectin; hepatic fibrosis; non alcoholic steatohepatitis; peroxisome proliferator activated receptor gamma

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; CHOLINE; GELATINASE A; GELATINASE B; HEME OXYGENASE 1; INTERLEUKIN 6; METHIONINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; DRUG MECHANISM; HEPATITIS; HISTOPATHOLOGY; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION;

ADENOVIRIDAE; ANILIDES; ANIMALS; BETA-GALACTOSIDASE; CHOLINE; DIET; FATTY LIVER; GENETIC VECTORS; INFLAMMATION; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; METHIONINE; MICE; MICE, INBRED C57BL; PPAR GAMMA; RANDOM ALLOCATION; THIAZOLIDINEDIONES; TRANSFECTION;

EID: 79751491258     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2010.525717     Document Type: Article

References (42)

1. Koca SS, Bahcecioglu IH, Poyrazoglu OK, Ozercan IH, Sahin K, Ustundag B. The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine-and choline-deficient diet. Inflammation 2008;31:91-8.
2. Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol 2008;103:1372-9. (Pubitemid 351813900)
3. Uemura M, Swenson ES, Gaça MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell 2005;16:4214-24. (Pubitemid 41262890)
4. Galli A, Svegliati-Baroni G, Ceni E, Milani S, Ridolfi F, Salzano R, et al. Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology 2005;41:1074-84. (Pubitemid 40593915)
5. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 2003; 100:15712-17. (Pubitemid 38021055)
6. Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proin-flammatory actions in hepatic stellate cells. Gastroenterology 2000;119:466-78. (Pubitemid 30621997)
7. Nan YM, Fu N, Wu WJ, Liang BL, Wang RQ, Zhao SX, et al. Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand J Gastroenterol 2009;44: 358-65.
8. Yu J, Zhang S, Chu ES, Go MY, Lau RH, Zhao J, et al. Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. Int J Biochem Cell Biol 2010; 42:948-57.
9. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94:2467-2474. (Pubitemid 29420675)
10. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Nonalcoholic Steatohe-patitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver dis-ease. Hepatology 2005;41:1313-21. (Pubitemid 40770284)
11. Yu J, Ip E, Dela Peña A, Hou JY, Sesha J, Pera N, et al. COX-2 induction in mice with experimental nutritional steatohepatitis: role as pro-inflammatory mediator. Hepatol-ogy 2006;43:826-36.
12. Day CP, Saksena S. Non-alcoholic steatohepatitis: defini-tions and pathogenesis. J Gastroenterol Hepatol 2002; 17(Suppl 3):S377-84.
13. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998;114:842-5.
14. Nan YM, Wu WJ, Fu N, Liang BL, Wang RQ, Li LX, et al. Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental nonalcoholic steatohepatitis in mice. Scand J Gastroenterol 2009;44:1121-31.
15. Kumagai T, Kawamoto Y, Nakamura Y, Hatayama I, Satoh K, Osawa T, et al. 4-hydroxy-2-nonenal, the end product of lipid peroxidation, is a specific inducer of cyclooxygenase-2 gene expression. Biochem Biophys Res Commun 2000;273:437-41. (Pubitemid 30599004)
16. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995;96:2461-8.
17. Leclercq IA, Farrell GC, Sempoux C, dela Peña A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol 2004;41:926-34. (Pubitemid 39575659)
18. Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut 2008;57:655-63. (Pubitemid 351579980)
19. Uchimura K, Nakamuta M, Enjoji M, Irie T, Sugimoto R, Muta T, et al. Activation of retinoic X receptor and perox-isome proliferator-activated receptor-g inhibits nitric oxide and tumor necrosis factor-a production in rat Kupffer cells. Hepatology 2001;33:91-9. (Pubitemid 32016891)
20. Wagstaff AJ, Goa KL. Rosiglitazone: a review of its use in the management of type 2 diabetes mellitus. Drugs 2002;62: 1805-37. (Pubitemid 34948176)
21. Tahan V, Eren F, Avsar E, Yavuz D, Yuksel M, Emekli E, et al. Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis. Dig Dis Sci 2007;52:3465-72. (Pubitemid 350077190)
22. Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-6. (Pubitemid 28079219)
23. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a neg-ative regulator of macrophage activation. Nature 1998;391: 79-82. (Pubitemid 28079218)
24. Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, et al. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004;89: 2728-35.
25. Asada K, Sasaki S, Suda T, Chida K, Nakamura H. Anti-inflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages. Am J Respir Crit Care Med 2004;169:195-200. (Pubitemid 38114534)
26. Galli A, Crabb DW, Ceni E, Salzano R, Mello T, Svegliati-Baroni G, et al. Antidiabetic thiazolidinedions inhibit colla-gen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 2002;122:1924-40. (Pubitemid 34651436)
27. Svegliati-Baroni G, De Minicis S, Marzioni M. Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition. Liver Int 2008;28:1052-64.
28. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-50. (Pubitemid 30081976)
29. Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R. Differential effects of TGF-beta on connec-tive tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007;47: 699-710. (Pubitemid 47503426)
30. Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 2002;82:767-74.
31. Corcoran ML, Hewitt R, Kleiner DE Jr, Stetler-Stevenson WG. MMP-2: expression, activation and inhibi-tion. Enzyme Protein 1996;49:7-19.
32. Hemmann S, Graf J, Roderfeld M, Roeb E. Expression of MMPs and TIMPs in liver fibrosis-a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 2007; 46:955-75. (Pubitemid 46529049)
33. Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 2004;40:177-84. (Pubitemid 38868936)
34. Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, et al. Hepatic adipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Hepatology 2008;48:458-73.
35. Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 2005;166:1655-69. (Pubitemid 40734389)
36. Wu CW, Chu ES, Lam CN, Cheng AS, Lee CW, WongVW,etal.PPARgammaisessential for protectionagainst nonalcoholic steatohepatitis. Gene Ther 2010;17:790-8.
37. Mandal P, Pritchard MT, Nagy LE. Anti-inflammatory path-ways and alcoholic liver disease: role of an adiponectin/interleukin-10/heme oxygenase-1 pathway. World J Gastro-enterol 2010;16:1330-6.
38. Zingarelli B, Sheehan M, Hake PW, O'Connor M, Denenberg A, Cook JA. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta-(12,14) -prosta-glandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. J Immunol 2003;171:6827-37. (Pubitemid 37532118)
39. Li M, Li Z, Sun X, Yang L, Fang P, Liu Y, et al. Heme oxygenase-1/p21WAF1 mediates peroxisome proliferator-activated receptor-gamma signaling inhibition of prolifera-tion of rat pulmonary artery smooth muscle cells. FEBS J 2010;277:1543-50.
40. Kitamura Y, Kakimura J, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhi-bit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neurosci Lett 1999;262:129-32. (Pubitemid 29130305)
41. Yu J, Chu ES, Wang R, Wang S, Wu CW, Wong VW, et al. Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice. Gastroenterology 2010;138: 694-704.
42. Li L, Grenard P, Nhieu JT, Julien B, Mallat A, Habib A, et al. Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. Gastroenterology 2003;125:460-9.