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Volumn 23, Issue 4, 2007, Pages 384-389

Inflammation and the mucosal microcirculation in inflammatory bowel disease: The ebb and flow

Author keywords

Crohn's disease; Endothelium; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

AMINOSALICYLIC ACID DERIVATIVE; ANTIBIOTIC AGENT; AZATHIOPRINE; BIOLOGICAL MARKER; CORTICOSTEROID; CYTOKINE; EPIDERMAL GROWTH FACTOR; INTERFERON ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 23; MERCAPTOPURINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY CD3; PROBIOTIC AGENT; TACROLIMUS; THALIDOMIDE; TREFOIL PEPTIDE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ANTIBODY;

EID: 34249944864     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32810c8de3     Document Type: Review
Times cited : (53)

References (61)
  • 1
    • 0029153736 scopus 로고
    • High endothelial venules (HEVs): Specialized endothelium for lymphocyte migration
    • Girard JP, Springer TA. High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today 1995; 16:449-457.
    • (1995) Immunol Today , vol.16 , pp. 449-457
    • Girard, J.P.1    Springer, T.A.2
  • 2
    • 0028214238 scopus 로고
    • The microcirculation and inflammation: Modulation of leukocyte-endothelial cell adhesion
    • Granger DN, Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 1994; 55:662-675.
    • (1994) J Leukoc Biol , vol.55 , pp. 662-675
    • Granger, D.N.1    Kubes, P.2
  • 3
    • 0032525207 scopus 로고    scopus 로고
    • Endothelial cells in physiology and in the pathophysiology of vascular disorders
    • Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91:3527-3561.
    • (1998) Blood , vol.91 , pp. 3527-3561
    • Cines, D.B.1    Pollak, E.S.2    Buck, C.A.3
  • 4
    • 0026677532 scopus 로고
    • HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
    • Ades EW, Candal FJ, Swerlick RA, et al. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992; 99:683-690.
    • (1992) J Invest Dermatol , vol.99 , pp. 683-690
    • Ades, E.W.1    Candal, F.J.2    Swerlick, R.A.3
  • 5
    • 0031004878 scopus 로고    scopus 로고
    • Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease
    • Binion DG, West GA, Ina K, et al. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997; 112:1895-1907.
    • (1997) Gastroenterology , vol.112 , pp. 1895-1907
    • Binion, D.G.1    West, G.A.2    Ina, K.3
  • 6
    • 0022350252 scopus 로고
    • The vascular endothelium: A survey of some newly evolving biochemical and physiological features
    • Gerlach E, Nees S, Becker BF. The vascular endothelium: a survey of some newly evolving biochemical and physiological features. Basic Res Cardiol 1985; 80:459-474.
    • (1985) Basic Res Cardiol , vol.80 , pp. 459-474
    • Gerlach, E.1    Nees, S.2    Becker, B.F.3
  • 7
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115:182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 8
    • 0036241138 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Dogmas and heresies
    • Fiocchi C. Inflammatory bowel disease: dogmas and heresies. Dig Liver Dis 2002; 34:306-311.
    • (2002) Dig Liver Dis , vol.34 , pp. 306-311
    • Fiocchi, C.1
  • 9
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9:653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 10
    • 33745277632 scopus 로고    scopus 로고
    • Role of angiogenesis in inflammatory bowel disease
    • A comprehensive review on the importance of angiogenesis in IBD
    • Koutroubakis IE, Tsiolakidou G, Karmiris K, Kouroumalis EA. Role of angiogenesis in inflammatory bowel disease. Inflamm Bowel Dis 2006; 12:515-523. A comprehensive review on the importance of angiogenesis in IBD.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 515-523
    • Koutroubakis, I.E.1    Tsiolakidou, G.2    Karmiris, K.3    Kouroumalis, E.A.4
  • 11
    • 1242317779 scopus 로고    scopus 로고
    • Vascular endothelium and immune responses: Implications for inflammation and angiogenesis
    • Szekanecz Z, Koch AE. Vascular endothelium and immune responses: implications for inflammation and angiogenesis. Rheum Dis Clin North Am 2004; 30:97-114.
    • (2004) Rheum Dis Clin North Am , vol.30 , pp. 97-114
    • Szekanecz, Z.1    Koch, A.E.2
  • 12
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997; 386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 13
    • 0029117071 scopus 로고
    • Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma
    • Qu Z, Liebler JM, Powers MR, et al. Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am J Pathol 1995; 147:564-573.
    • (1995) Am J Pathol , vol.147 , pp. 564-573
    • Qu, Z.1    Liebler, J.M.2    Powers, M.R.3
  • 14
    • 0036604429 scopus 로고    scopus 로고
    • Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils
    • Scapini P, Nesi L, Morini M, et al. Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils. J Immunol 2002; 168:5798-5804.
    • (2002) J Immunol , vol.168 , pp. 5798-5804
    • Scapini, P.1    Nesi, L.2    Morini, M.3
  • 15
    • 18144391498 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis in rheumatoid arthritis
    • Taylor PC, Sivakumar B. Hypoxia and angiogenesis in rheumatoid arthritis. Curr Opin Rheumatol 2005; 17:293-298.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 293-298
    • Taylor, P.C.1    Sivakumar, B.2
  • 16
    • 0036786256 scopus 로고    scopus 로고
    • Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro
    • Collin-Osdoby P, Rothe L, Bekker S, et al. Basic fibroblast growth factor stimulates osteoclast recruitment, development, and bone pit resorption in association with angiogenesis in vivo on the chick chorioallantoic membrane and activates isolated avian osteoclast resorption in vitro. J Bone Miner Res 2002; 17:1859-1871.
    • (2002) J Bone Miner Res , vol.17 , pp. 1859-1871
    • Collin-Osdoby, P.1    Rothe, L.2    Bekker, S.3
  • 17
    • 17844404308 scopus 로고    scopus 로고
    • Involvement of mast cells in angiogenesis and chronic inflammation
    • Crivellato E, Ribatti D. Involvement of mast cells in angiogenesis and chronic inflammation. Curr Drug Targets Inflamm Allergy 2005; 4:9-11.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 9-11
    • Crivellato, E.1    Ribatti, D.2
  • 18
    • 0036928539 scopus 로고    scopus 로고
    • Inflammation and free radicals in tumor development and progression
    • Okada F. Inflammation and free radicals in tumor development and progression. Redox Rep 2002; 7:357-368.
    • (2002) Redox Rep , vol.7 , pp. 357-368
    • Okada, F.1
  • 19
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. NatMed 2000; 6:389-395.
    • (2000) NatMed , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 20
    • 0031688934 scopus 로고    scopus 로고
    • Chronic inflammation: Links with angiogenesis and wound healing
    • Majno G. Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol 1998; 153:1035-1039.
    • (1998) Am J Pathol , vol.153 , pp. 1035-1039
    • Majno, G.1
  • 22
    • 33744510694 scopus 로고    scopus 로고
    • Danese S, Sans M, de la Motte C, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006; 130: 2060-2073. The first report demonstrating immune-driven angiogenesis in human IBD.
    • Danese S, Sans M, de la Motte C, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006; 130: 2060-2073. The first report demonstrating immune-driven angiogenesis in human IBD.
  • 23
    • 29744445888 scopus 로고    scopus 로고
    • Increased expression of CD146, a new marker of the endothelial junction in active inflammatory bowel disease
    • An important study that further highlights the activation state of the microvasculature in IBD
    • Bardin N, Reumaux D, Geboes K, et al. Increased expression of CD146, a new marker of the endothelial junction in active inflammatory bowel disease. Inflamm Bowel Dis 2006; 12:16-21. An important study that further highlights the activation state of the microvasculature in IBD.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 16-21
    • Bardin, N.1    Reumaux, D.2    Geboes, K.3
  • 24
    • 0038071763 scopus 로고    scopus 로고
    • Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease
    • Saito S, Tsuno NH, Sunami E, et al. Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease. J Gastroenterol 2003; 38: 229-237.
    • (2003) J Gastroenterol , vol.38 , pp. 229-237
    • Saito, S.1    Tsuno, N.H.2    Sunami, E.3
  • 25
    • 0035072493 scopus 로고    scopus 로고
    • VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: A novel mechanism of chronic intestinal inflammation
    • Kanazawa S, Tsunoda T, Onuma E, et al. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 2001; 96:822-828.
    • (2001) Am J Gastroenterol , vol.96 , pp. 822-828
    • Kanazawa, S.1    Tsunoda, T.2    Onuma, E.3
  • 26
    • 0037716543 scopus 로고    scopus 로고
    • Altered expression of epimorphin in ulcerative colitis
    • Shirasaka T, Iizuka M, Yukawa M, et al. Altered expression of epimorphin in ulcerative colitis. J Gastroenterol Hepatol 2003; 18:570-577.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 570-577
    • Shirasaka, T.1    Iizuka, M.2    Yukawa, M.3
  • 27
    • 0031047591 scopus 로고    scopus 로고
    • Serum basic fibroblast growth factor in pediatric Crohn's disease: Implications for wound healing
    • Bousvaros A, Zurakowski D, Fishman SJ, et al. Serum basic fibroblast growth factor in pediatric Crohn's disease: implications for wound healing. Dig Dis Sci 1997; 42:378-386.
    • (1997) Dig Dis Sci , vol.42 , pp. 378-386
    • Bousvaros, A.1    Zurakowski, D.2    Fishman, S.J.3
  • 28
    • 0030791538 scopus 로고    scopus 로고
    • Clinical evaluation of hepatocyte growth factor in patients with gastrointestinal and pancreatic diseases with special reference to inflammatory bowel disease
    • Matsuno M, Shiota G, Umeki K, et al. Clinical evaluation of hepatocyte growth factor in patients with gastrointestinal and pancreatic diseases with special reference to inflammatory bowel disease. Res Commun Mol Pathol Pharmacol 1997; 97:25-37.
    • (1997) Res Commun Mol Pathol Pharmacol , vol.97 , pp. 25-37
    • Matsuno, M.1    Shiota, G.2    Umeki, K.3
  • 29
    • 33645065572 scopus 로고    scopus 로고
    • Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease
    • A report describing novel accessory molecules of inflammatory angiogenesis in IBD
    • Koutroubakis IE, Xidakis C, Karmiris K, et al. Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease. Eur J Clin Invest 2006; 36:127-132. A report describing novel accessory molecules of inflammatory angiogenesis in IBD.
    • (2006) Eur J Clin Invest , vol.36 , pp. 127-132
    • Koutroubakis, I.E.1    Xidakis, C.2    Karmiris, K.3
  • 30
    • 34548118400 scopus 로고    scopus 로고
    • Critical role of the CD40-CD40 ligand pathway in governing mucosal inflammation-driven angiogenesis in inflammatory bowel disease
    • in press
    • Danese S, Scaldaferri F, Graziani C, et al. Critical role of the CD40-CD40 ligand pathway in governing mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut (in press).
    • Gut
    • Danese, S.1    Scaldaferri, F.2    Graziani, C.3
  • 31
    • 34249947072 scopus 로고    scopus 로고
    • Danese S, Sans M, Spencer D, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2006; 14 December [Epub ahead of print]. This paper describes the importance of angiogenesis blockade as a novel therapeutic approach for experimental IBD.
    • Danese S, Sans M, Spencer D, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2006; 14 December [Epub ahead of print]. This paper describes the importance of angiogenesis blockade as a novel therapeutic approach for experimental IBD.
  • 32
    • 34249822849 scopus 로고    scopus 로고
    • Differential angiogenic regulation of experimental colitis
    • This paper describes the importance of angiogenesis blockade as a novel therapeutic approach for experimental IBD
    • Chidlow JH Jr, Langston W, Greer JJ, et al. Differential angiogenic regulation of experimental colitis. Am J Pathol 2006; 169:2014-2030. This paper describes the importance of angiogenesis blockade as a novel therapeutic approach for experimental IBD.
    • (2006) Am J Pathol , vol.169 , pp. 2014-2030
    • Chidlow Jr, J.H.1    Langston, W.2    Greer, J.J.3
  • 33
    • 33645815916 scopus 로고    scopus 로고
    • VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: Implications for inflammatory bowel disease
    • Gastrointest Liver Physiol, A well performed study suggesting that VEGF, in addition to being an angiogenic mediator, may contribute to IBD pathogenesis by acting as a proinflammatory cytokine
    • Goebel S, Huang M, Davis WC, et al. VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2006; 290:G648-G654. A well performed study suggesting that VEGF, in addition to being an angiogenic mediator, may contribute to IBD pathogenesis by acting as a proinflammatory cytokine.
    • (2006) Am J Physiol , vol.290
    • Goebel, S.1    Huang, M.2    Davis, W.C.3
  • 34
    • 0038297520 scopus 로고    scopus 로고
    • Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
    • Danese S, de la Motte C, Sturm A, et al. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 2003; 124:1249-1264.
    • (2003) Gastroenterology , vol.124 , pp. 1249-1264
    • Danese, S.1    de la Motte, C.2    Sturm, A.3
  • 35
    • 0029127023 scopus 로고
    • Chemokine and chemokine receptor mRNA expression in human platelets
    • Power CA, Clemetson JM, Clemetson KJ, Wells TN. Chemokine and chemokine receptor mRNA expression in human platelets. Cytokine 1995; 7:479-482.
    • (1995) Cytokine , vol.7 , pp. 479-482
    • Power, C.A.1    Clemetson, J.M.2    Clemetson, K.J.3    Wells, T.N.4
  • 36
    • 0028298049 scopus 로고
    • Production of the RANTES chemokine in delayed-type hypersensitivity reactions: Involvement of macrophages and endothelial cells
    • Devergne O, Marfaing-Koka A, Schall TJ, et al. Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells. J Exp Med 1994; 179:1689-1694.
    • (1994) J Exp Med , vol.179 , pp. 1689-1694
    • Devergne, O.1    Marfaing-Koka, A.2    Schall, T.J.3
  • 37
    • 0037227449 scopus 로고    scopus 로고
    • Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets
    • Russell J, Cooper D, Tailor A, et al. Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets. Am J Physiol Gastrointest Liver Physiol 2003; 284:G123-G129.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Russell, J.1    Cooper, D.2    Tailor, A.3
  • 38
    • 85050704161 scopus 로고    scopus 로고
    • CD40-CD40 Ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon
    • in press
    • Vowinkel T, Anthoni C, Wood KC, et al. CD40-CD40 Ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon. Gastroenterology (in press).
    • Gastroenterology
    • Vowinkel, T.1    Anthoni, C.2    Wood, K.C.3
  • 40
    • 32044474228 scopus 로고    scopus 로고
    • TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: A novel antiinflammatory mechanism of infliximab in Crohn's disease
    • This paper provides evidence on the role of TNF-α blockade in deactivation of microvascular inflammation in Crohn's disease
    • Danese S, Sans M, Scaldaferri F, et al. TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel antiinflammatory mechanism of infliximab in Crohn's disease. J Immunol 2006; 176:2617-2624. This paper provides evidence on the role of TNF-α blockade in deactivation of microvascular inflammation in Crohn's disease.
    • (2006) J Immunol , vol.176 , pp. 2617-2624
    • Danese, S.1    Sans, M.2    Scaldaferri, F.3
  • 41
    • 0017342254 scopus 로고
    • Regional intestinal blood flow in ulcerative colitis and Crohn's disease
    • Hulten L, Lindhagen J, Lundgren O, et al. Regional intestinal blood flow in ulcerative colitis and Crohn's disease. Gastroenterology 1977; 72:388-396.
    • (1977) Gastroenterology , vol.72 , pp. 388-396
    • Hulten, L.1    Lindhagen, J.2    Lundgren, O.3
  • 42
    • 0027380474 scopus 로고
    • Neoterminal ileal blood flow after ileocolonic resection for Crohn's disease
    • Angerson WJ, Allison MC, Baxter JN, Russell RI. Neoterminal ileal blood flow after ileocolonic resection for Crohn's disease. Gut 1993; 34:1531-1534.
    • (1993) Gut , vol.34 , pp. 1531-1534
    • Angerson, W.J.1    Allison, M.C.2    Baxter, J.N.3    Russell, R.I.4
  • 44
    • 0013973159 scopus 로고
    • Quantitative measurement of regional colon blood flow in the normal and pathological human bowel
    • Bacaner MB. Quantitative measurement of regional colon blood flow in the normal and pathological human bowel. Gastroenterology 1966; 51:764-777.
    • (1966) Gastroenterology , vol.51 , pp. 764-777
    • Bacaner, M.B.1
  • 45
    • 0015276147 scopus 로고
    • Microangiographic studies in Crohn's disease and ulcerative colitis
    • Johansson H, Krause U, Olding L. Microangiographic studies in Crohn's disease and ulcerative colitis. Acta Chir Scand 1972; 138:409-414.
    • (1972) Acta Chir Scand , vol.138 , pp. 409-414
    • Johansson, H.1    Krause, U.2    Olding, L.3
  • 46
    • 0036714058 scopus 로고    scopus 로고
    • Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis
    • Appleyard CB, Alvarez A, Percy WH. Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. Dig Dis Sci 2002; 47:2007-2014.
    • (2002) Dig Dis Sci , vol.47 , pp. 2007-2014
    • Appleyard, C.B.1    Alvarez, A.2    Percy, W.H.3
  • 47
    • 0034755535 scopus 로고    scopus 로고
    • Changes of colonic mucosal microcirculation and histology in two colitis models: An experimental study using intravital microscopy and a new histological scoring system
    • Kruschewski M, Foitzik T, Perez-Canto A, et al. Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system. Dig Dis Sci 2001; 46:2336-2343.
    • (2001) Dig Dis Sci , vol.46 , pp. 2336-2343
    • Kruschewski, M.1    Foitzik, T.2    Perez-Canto, A.3
  • 48
    • 0036842821 scopus 로고    scopus 로고
    • In vivo detection of morphological and microvascular changes of the colon in association with colitis using fiberoptic confocal imaging (FOCI)
    • McLaren WJ, Anikijenko P, Thomas SG, et al. In vivo detection of morphological and microvascular changes of the colon in association with colitis using fiberoptic confocal imaging (FOCI). Dig Dis Sci 2002; 47:2424-2433.
    • (2002) Dig Dis Sci , vol.47 , pp. 2424-2433
    • McLaren, W.J.1    Anikijenko, P.2    Thomas, S.G.3
  • 49
    • 0033021410 scopus 로고    scopus 로고
    • Does microcirculation play a role in the pathogenesis of inflammatory bowel diseases? Answers from intravital microscopic studies in animal models
    • Foitzik T, Kruschewski M, Kroesen A, Buhr HJ. Does microcirculation play a role in the pathogenesis of inflammatory bowel diseases? Answers from intravital microscopic studies in animal models. Int J Colorectal Dis 1999; 14:29-34.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 29-34
    • Foitzik, T.1    Kruschewski, M.2    Kroesen, A.3    Buhr, H.J.4
  • 50
    • 0032935731 scopus 로고    scopus 로고
    • Temporal patterns of colonic blood flow and tissue damage in an animal model of colitis
    • Appleyard CB, Williams JL, Hathaway CA, Percy WH. Temporal patterns of colonic blood flow and tissue damage in an animal model of colitis. Dig Dis Sci 1999; 44:431-438.
    • (1999) Dig Dis Sci , vol.44 , pp. 431-438
    • Appleyard, C.B.1    Williams, J.L.2    Hathaway, C.A.3    Percy, W.H.4
  • 51
    • 0030460013 scopus 로고    scopus 로고
    • Microvascular disease in the human large bowel
    • Carr N. Microvascular disease in the human large bowel. Gut 1996; 39:889-890.
    • (1996) Gut , vol.39 , pp. 889-890
    • Carr, N.1
  • 52
    • 34249930574 scopus 로고    scopus 로고
    • Ravnic DJ, Konerding MA, Tsuda A, et al. Structural adaptations in the murine colon microcirculation associated with hapten-induced inflammation. Gut 2006; 17 November [Epub ahead of print]. An elegant investigation of the microvascular changes that occur in TNBS-induced experimental colitis.
    • Ravnic DJ, Konerding MA, Tsuda A, et al. Structural adaptations in the murine colon microcirculation associated with hapten-induced inflammation. Gut 2006; 17 November [Epub ahead of print]. An elegant investigation of the microvascular changes that occur in TNBS-induced experimental colitis.
  • 53
    • 0038449206 scopus 로고    scopus 로고
    • Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation
    • Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 2003; 125:58-69.
    • (2003) Gastroenterology , vol.125 , pp. 58-69
    • Hatoum, O.A.1    Binion, D.G.2    Otterson, M.F.3    Gutterman, D.D.4
  • 54
    • 0027248939 scopus 로고
    • Attenuation of colitis in the cotton-top tamarin by antialpha 4 integrin monoclonal antibody
    • Podolsky DK, Lobb R, King N, et al. Attenuation of colitis in the cotton-top tamarin by antialpha 4 integrin monoclonal antibody. J Clin Invest 1993; 92:372-380.
    • (1993) J Clin Invest , vol.92 , pp. 372-380
    • Podolsky, D.K.1    Lobb, R.2    King, N.3
  • 55
    • 0034654535 scopus 로고    scopus 로고
    • Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa
    • Muehlhoefer A, Saubermann LJ, Gu X, et al. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 2000; 164:3368-3376.
    • (2000) J Immunol , vol.164 , pp. 3368-3376
    • Muehlhoefer, A.1    Saubermann, L.J.2    Gu, X.3
  • 56
    • 27144469582 scopus 로고    scopus 로고
    • New insights into the protein C pathway: Potential implications for the biological activities of drotrecogin alfa (activated)
    • Macias WL, Yan SB, Williams MD, et al. New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care 2005; 9 (Suppl 4):S38-S45.
    • (2005) Crit Care , vol.9 , Issue.SUPPL. 4
    • Macias, W.L.1    Yan, S.B.2    Williams, M.D.3
  • 57
    • 2942689242 scopus 로고    scopus 로고
    • Natural anticoagulant inhibitors: Activated protein C
    • Aird WC. Natural anticoagulant inhibitors: activated protein C. Best Pract Res Clin Haematol 2004; 17:161-182.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 161-182
    • Aird, W.C.1
  • 58
    • 2942705828 scopus 로고    scopus 로고
    • Human models of endotoxemia and recombinant human activated protein C
    • O'Brien JM Jr, Abraham E. Human models of endotoxemia and recombinant human activated protein C. Crit Care Med 2004; 32 (5 Suppl):S202-S208.
    • (2004) Crit Care Med , vol.32 , Issue.5 SUPPL.
    • O'Brien Jr, J.M.1    Abraham, E.2
  • 59
    • 1642566547 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by activated protein C: The molecular mechanism(s) and therapeutic implications
    • Okajima K. Regulation of inflammatory responses by activated protein C: the molecular mechanism(s) and therapeutic implications. Clin Chem Lab Med 2004; 42:132-141.
    • (2004) Clin Chem Lab Med , vol.42 , pp. 132-141
    • Okajima, K.1
  • 60
    • 2942720564 scopus 로고    scopus 로고
    • Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease
    • Faioni EM, Ferrero S, Fontana G, et al. Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease. Crit Care Med 2004; 32 (5 Suppl):S266-S270.
    • (2004) Crit Care Med , vol.32 , Issue.5 SUPPL.
    • Faioni, E.M.1    Ferrero, S.2    Fontana, G.3
  • 61
    • 85081449878 scopus 로고    scopus 로고
    • Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease
    • in press
    • Scaldaferri F, Sans M, Graziani C, et al. Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J Clin Invest (in press).
    • J Clin Invest
    • Scaldaferri, F.1    Sans, M.2    Graziani, C.3


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