메뉴 건너뛰기




Volumn 88, Issue 9, 2008, Pages 973-985

Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway

Author keywords

Collagen; Fibrosis; Human intrahepatic fibroblasts; IL 4; Liver transplantation and STAT 6

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; SMALL INTERFERING RNA; STAT6 PROTEIN;

EID: 50249121141     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.61     Document Type: Article
Times cited : (75)

References (69)
  • 1
    • 33747584867 scopus 로고    scopus 로고
    • Hepatic stellate cells and the reversal of fibrosis
    • Kisseleva T, Brenner DA. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 2006;21:84-87.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 84-87
    • Kisseleva, T.1    Brenner, D.A.2
  • 2
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117:539-548.
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 3
    • 0034809414 scopus 로고    scopus 로고
    • Hepatic stellate cell behavior during resolution of liver injury
    • Iredale JP. Hepatic stellate cell behavior during resolution of liver injury. Semin Liver Dis 2001;21:427-436.
    • (2001) Semin Liver Dis , vol.21 , pp. 427-436
    • Iredale, J.P.1
  • 4
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • Bataller R. Liver fibrosis. J Clin Invest 2005;115:209-218.
    • (2005) J Clin Invest , vol.115 , pp. 209-218
    • Bataller, R.1
  • 5
    • 0026076062 scopus 로고
    • Proliferation and transformation of cultured liver fat-storing cells perisinusoidal lipocytes under conditions of β-D-xyloside-induced abrogation of proteoglycan synthesis
    • Gressner AM. Proliferation and transformation of cultured liver fat-storing cells perisinusoidal lipocytes under conditions of β-D-xyloside-induced abrogation of proteoglycan synthesis. Exp Mol Pathol 1991;55:143-169.
    • (1991) Exp Mol Pathol , vol.55 , pp. 143-169
    • Gressner, A.M.1
  • 6
    • 0041844981 scopus 로고    scopus 로고
    • The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection
    • Sato J, Schorey J, Ploplis VA, et al. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol 2003;163:517-531.
    • (2003) Am J Pathol , vol.163 , pp. 517-531
    • Sato, J.1    Schorey, J.2    Ploplis, V.A.3
  • 8
    • 0032737478 scopus 로고    scopus 로고
    • Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: Distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair
    • Knittel T, Kobold D, Piscaglia F, et al. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 1999;112:387-401.
    • (1999) Histochem Cell Biol , vol.112 , pp. 387-401
    • Knittel, T.1    Kobold, D.2    Piscaglia, F.3
  • 9
    • 0037329896 scopus 로고    scopus 로고
    • The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis
    • Kinnman N, Francoz C, Barbu V, et al. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab Invest 2003;83:163-173.
    • (2003) Lab Invest , vol.83 , pp. 163-173
    • Kinnman, N.1    Francoz, C.2    Barbu, V.3
  • 10
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-2250.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 11
    • 0025827178 scopus 로고
    • Immunohistochemical detection of transforming growth factor-beta 1 in fibrotic liver diseases
    • Nagy P, Schaff Z, Lapis K. Immunohistochemical detection of transforming growth factor-beta 1 in fibrotic liver diseases. Hepatol 1991;14:269-273.
    • (1991) Hepatol , vol.14 , pp. 269-273
    • Nagy, P.1    Schaff, Z.2    Lapis, K.3
  • 12
    • 0025855367 scopus 로고
    • Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy
    • Castilla A, Prieto J, Fausto N. Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med 1991;324:933-940.
    • (1991) N Engl J Med , vol.324 , pp. 933-940
    • Castilla, A.1    Prieto, J.2    Fausto, N.3
  • 13
    • 19944389858 scopus 로고    scopus 로고
    • Predictors of survival after liver transplantation for hepatocellular carcinoma associated with Hepatitis C
    • Shimoda M, Ghobrial RM, Carmody IC, et al. Predictors of survival after liver transplantation for hepatocellular carcinoma associated with Hepatitis C. Liver Transpl 2004;10:1478-1486.
    • (2004) Liver Transpl , vol.10 , pp. 1478-1486
    • Shimoda, M.1    Ghobrial, R.M.2    Carmody, I.C.3
  • 14
    • 10344243982 scopus 로고    scopus 로고
    • Impact of mycophenolate mofetil vs azathioprine on early recurrence of hepatitis C after liver transplantation
    • Kornberg A, Kqpper B, Tannapfel A, et al. Impact of mycophenolate mofetil vs azathioprine on early recurrence of hepatitis C after liver transplantation. Int Immunopharmacol 2005;5:107-115.
    • (2005) Int Immunopharmacol , vol.5 , pp. 107-115
    • Kornberg, A.1    Kqpper, B.2    Tannapfel, A.3
  • 15
    • 7244251955 scopus 로고    scopus 로고
    • Fibrosis progression after liver transplantation in patients with recurrent hepatitis
    • Feray C. Fibrosis progression after liver transplantation in patients with recurrent hepatitis. J of Hepatol 2004;41:862-863.
    • (2004) J of Hepatol , vol.41 , pp. 862-863
    • Feray, C.1
  • 16
    • 6344263380 scopus 로고    scopus 로고
    • Hepatitis B and Hepatitis C viruses in liver transplantation
    • Curry MP. Hepatitis B and Hepatitis C viruses in liver transplantation. Transplantation 2004;78:955-963.
    • (2004) Transplantation , vol.78 , pp. 955-963
    • Curry, M.P.1
  • 18
    • 0033849629 scopus 로고    scopus 로고
    • Liver-derived hepatitis C virus (HCV)-specific CD41 T cells recognize multiple HCV epitopes and produce interferon gamma
    • Schirren CA, Jung MC, Gerlach JT, et al. Liver-derived hepatitis C virus (HCV)-specific CD41 T cells recognize multiple HCV epitopes and produce interferon gamma. Hepatol 2000;32:597-603.
    • (2000) Hepatol , vol.32 , pp. 597-603
    • Schirren, C.A.1    Jung, M.C.2    Gerlach, J.T.3
  • 19
    • 0036199339 scopus 로고    scopus 로고
    • Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury
    • Zekry A, Bishop GA, Bowen DG, et al. Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury. Liver Transpl 2002;8:292-301.
    • (2002) Liver Transpl , vol.8 , pp. 292-301
    • Zekry, A.1    Bishop, G.A.2    Bowen, D.G.3
  • 20
    • 3042651960 scopus 로고    scopus 로고
    • Defective inhibition of peripheral CD8+ T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection
    • Boleslawski E, Conti F, Sanquer S, et al. Defective inhibition of peripheral CD8+ T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection. Transplantation 2004;77:1815-1820.
    • (2004) Transplantation , vol.77 , pp. 1815-1820
    • Boleslawski, E.1    Conti, F.2    Sanquer, S.3
  • 21
    • 0033000166 scopus 로고    scopus 로고
    • Increased expression and role of interleukin-4 during liver allograft rejection
    • Conti F, Calmus Y, Rouer E, et al. Increased expression and role of interleukin-4 during liver allograft rejection. J Hepatol 1999;30:935-943.
    • (1999) J Hepatol , vol.30 , pp. 935-943
    • Conti, F.1    Calmus, Y.2    Rouer, E.3
  • 22
    • 34247578038 scopus 로고    scopus 로고
    • Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation
    • Dharancy S, Podevin P, Aoudjehane L, et al. Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation. Transplantation 2007;83:906-911.
    • (2007) Transplantation , vol.83 , pp. 906-911
    • Dharancy, S.1    Podevin, P.2    Aoudjehane, L.3
  • 23
    • 3042742916 scopus 로고    scopus 로고
    • IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21Waf1, cyclin D1, and cyclin E expression
    • Kim J, Cheon IS, Won YJ, et al. IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21Waf1, cyclin D1, and cyclin E expression. Mol Cells 2003;16:92-96.
    • (2003) Mol Cells , vol.16 , pp. 92-96
    • Kim, J.1    Cheon, I.S.2    Won, Y.J.3
  • 24
    • 2942644653 scopus 로고    scopus 로고
    • Interleukin-4 stimulates papillary thyroid cancer cell survival: Implications in patients with thyroid cancer and concomitant Graves' disease
    • Vella V, Mineo R, Frasca F, et al. Interleukin-4 stimulates papillary thyroid cancer cell survival: implications in patients with thyroid cancer and concomitant Graves' disease. J Clin Endocrinol Metab 2004;89:2880-2889.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2880-2889
    • Vella, V.1    Mineo, R.2    Frasca, F.3
  • 25
    • 0033010373 scopus 로고    scopus 로고
    • The IL-4 receptor: Signaling mechanisms and biologic functions
    • Nelms K, Keegan AD, Zamorano J, et al. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunology 1999;17:701-738.
    • (1999) Annu Rev Immunology , vol.17 , pp. 701-738
    • Nelms, K.1    Keegan, A.D.2    Zamorano, J.3
  • 26
    • 0028224194 scopus 로고
    • Subsets of murine lung fibroblasts express receptors membrane-bound and soluble IL-4: Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis
    • Sempowski GD, Beckmann MP, Derdak S, et al. Subsets of murine lung fibroblasts express receptors membrane-bound and soluble IL-4: role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J Immunol 1994;152:3606-3614.
    • (1994) J Immunol , vol.152 , pp. 3606-3614
    • Sempowski, G.D.1    Beckmann, M.P.2    Derdak, S.3
  • 27
    • 0031661468 scopus 로고    scopus 로고
    • IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts
    • Doucet C, Brouty-Boye D, Pottin-Clemenceau C, et al. IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. Int Immunol 1998;10:1421-1433.
    • (1998) Int Immunol , vol.10 , pp. 1421-1433
    • Doucet, C.1    Brouty-Boye, D.2    Pottin-Clemenceau, C.3
  • 28
    • 0037337768 scopus 로고    scopus 로고
    • Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: Implication in tissue remodelling
    • Liu X, Conner H, Kobayashi T, et al. Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: implication in tissue remodelling. Chest 2003;123:427-428.
    • (2003) Chest , vol.123 , pp. 427-428
    • Liu, X.1    Conner, H.2    Kobayashi, T.3
  • 29
    • 0037288086 scopus 로고    scopus 로고
    • IL-4-induced cell proliferation and production of extracellular matrix proteins in human conjunctival fibroblasts
    • Fujitsua Y, Fukudaa K, Kumagaia BN, et al. IL-4-induced cell proliferation and production of extracellular matrix proteins in human conjunctival fibroblasts. Exp Eye Res 2003;76:107-114.
    • (2003) Exp Eye Res , vol.76 , pp. 107-114
    • Fujitsua, Y.1    Fukudaa, K.2    Kumagaia, B.N.3
  • 30
    • 0033385544 scopus 로고    scopus 로고
    • Interleukin-4-producing cells in idiopathic pulmonary fibrosis: An immunohistochemical study
    • Ando M, Miyazaki E, Fukami T, et al. Interleukin-4-producing cells in idiopathic pulmonary fibrosis: an immunohistochemical study. Respirology 1999;4:383-391.
    • (1999) Respirology , vol.4 , pp. 383-391
    • Ando, M.1    Miyazaki, E.2    Fukami, T.3
  • 31
    • 0029941568 scopus 로고    scopus 로고
    • Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis
    • Salmon-Ehr V, Serpier H, Nawrocki B, et al. Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis. Arch Dermatol 1996;132:802-806.
    • (1996) Arch Dermatol , vol.132 , pp. 802-806
    • Salmon-Ehr, V.1    Serpier, H.2    Nawrocki, B.3
  • 32
    • 0029093152 scopus 로고
    • Collagen synthesis by human liver (myo)fibroblasts in culture: Evidence for a regulatory role of IL-1 beta, IL-4, TGFβ and IFN gamma
    • Tiggelman AM, Boers W, Linthorst C, et al. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1 beta, IL-4, TGFβ and IFN gamma. J Hepatol 1995;23:307-317.
    • (1995) J Hepatol , vol.23 , pp. 307-317
    • Tiggelman, A.M.1    Boers, W.2    Linthorst, C.3
  • 33
    • 20144387991 scopus 로고    scopus 로고
    • Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cells
    • Sugimoto R, Enjoji M, Nakamuta M, et al. Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cells. Liver Int 2005;25:420-428.
    • (2005) Liver Int , vol.25 , pp. 420-428
    • Sugimoto, R.1    Enjoji, M.2    Nakamuta, M.3
  • 34
    • 0034657182 scopus 로고    scopus 로고
    • Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: Role of TGF-beta and IL-4
    • Farah IO, Mola PW, Kariuki TM, et al. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J Immunol 2000;164:5337-5343.
    • (2000) J Immunol , vol.164 , pp. 5337-5343
    • Farah, I.O.1    Mola, P.W.2    Kariuki, T.M.3
  • 35
    • 0028363023 scopus 로고
    • Anti-lL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis
    • Cheever AW, Williams ME, Wynn TA, et al. Anti-lL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol 1994;153:753-759.
    • (1994) J Immunol , vol.153 , pp. 753-759
    • Cheever, A.W.1    Williams, M.E.2    Wynn, T.A.3
  • 36
    • 0027932658 scopus 로고
    • Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
    • Hillaire S, Boucher E, Calmus Y, et al. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 1994;107:781-788.
    • (1994) Gastroenterology , vol.107 , pp. 781-788
    • Hillaire, S.1    Boucher, E.2    Calmus, Y.3
  • 37
    • 0027166733 scopus 로고
    • Mitogenic effect of transforming growth factor-beta 1 on human Ito cells in culture: Evidence for mediation by endogenous platelet-derived growth factor
    • Win KM, Charlotte F, Mallat A, et al. Mitogenic effect of transforming growth factor-beta 1 on human Ito cells in culture: evidence for mediation by endogenous platelet-derived growth factor. Hepatology 1993;18:137-145.
    • (1993) Hepatology , vol.18 , pp. 137-145
    • Win, K.M.1    Charlotte, F.2    Mallat, A.3
  • 38
    • 0037623947 scopus 로고    scopus 로고
    • Interleukin-15 production during liver allograft rejection in humans
    • Conti F, Frappier J, Dharancy S, et al. Interleukin-15 production during liver allograft rejection in humans. Transplantation 2003;76:210-216.
    • (2003) Transplantation , vol.76 , pp. 210-216
    • Conti, F.1    Frappier, J.2    Dharancy, S.3
  • 39
    • 0036022840 scopus 로고    scopus 로고
    • Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate
    • Sohara N, Znoyko I, Levy MT, et al. Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. J Hepatol 2002;37:214-221.
    • (2002) J Hepatol , vol.37 , pp. 214-221
    • Sohara, N.1    Znoyko, I.2    Levy, M.T.3
  • 40
    • 0037020075 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts
    • Davaille J, Li L, Mallat A, et al. Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts. J Biol Chem 2002;277:37323-37330.
    • (2002) J Biol Chem , vol.277 , pp. 37323-37330
    • Davaille, J.1    Li, L.2    Mallat, A.3
  • 41
    • 0032190884 scopus 로고    scopus 로고
    • Interleukin-4 receptors on human bronchial epithelial cells. An in vivo and vitro analysis of expression and function
    • Van der Velden VHJ, Naber BAE, Wierenga-Wolf AF, et al. Interleukin-4 receptors on human bronchial epithelial cells. An in vivo and vitro analysis of expression and function. Cytokine 1998;10:803-813.
    • (1998) Cytokine , vol.10 , pp. 803-813
    • Van der Velden, V.H.J.1    Naber, B.A.E.2    Wierenga-Wolf, A.F.3
  • 42
    • 0024830707 scopus 로고
    • Quantitative comparison of mRNA levels in mammalian tissues: 28 s ribosomal RNA level as an accurate internal control
    • De Leeuw WJ, Slagboom PE, Vijg J. Quantitative comparison of mRNA levels in mammalian tissues: 28 s ribosomal RNA level as an accurate internal control. Nucleic Acids Res 1989;23:10137-10138.
    • (1989) Nucleic Acids Res , vol.23 , pp. 10137-10138
    • De Leeuw, W.J.1    Slagboom, P.E.2    Vijg, J.3
  • 43
    • 0042844786 scopus 로고    scopus 로고
    • Effects of IL-4 on conjunctival fibroblasts: Possible role in ocular cicatricial pemphigoid
    • Razzaque MS, Ahmed BS, Foster S, et al. Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci 2003;44:3417-3423.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3417-3423
    • Razzaque, M.S.1    Ahmed, B.S.2    Foster, S.3
  • 44
    • 0042703174 scopus 로고    scopus 로고
    • Antisense suppression of collagen VI synthesis results in reduced expression of collagen I in normal human osteoblast-like cells
    • Harumiya S, Gibson MA, Koshira Y. Antisense suppression of collagen VI synthesis results in reduced expression of collagen I in normal human osteoblast-like cells. Biosci Biotechnol Biochem 2002;66:2743-2747.
    • (2002) Biosci Biotechnol Biochem , vol.66 , pp. 2743-2747
    • Harumiya, S.1    Gibson, M.A.2    Koshira, Y.3
  • 45
    • 3242661630 scopus 로고    scopus 로고
    • Secretion of collagen type IV by human renal fibroblasts is increased by high glucose via a TGF-beta-independent pathway
    • Lam S, Van der Geest RN, Verhagen NA, et al. Secretion of collagen type IV by human renal fibroblasts is increased by high glucose via a TGF-beta-independent pathway. Nephrol Dial Transplant 2004;19:1694-1701.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 1694-1701
    • Lam, S.1    Van der Geest, R.N.2    Verhagen, N.A.3
  • 46
    • 33745503676 scopus 로고    scopus 로고
    • Characterization of smooth muscle-like cells in circulating human peripheral blood
    • Sugiyama S, Kugiyama K, Nakamura S, et al. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis 2006;187:351-362.
    • (2006) Atherosclerosis , vol.187 , pp. 351-362
    • Sugiyama, S.1    Kugiyama, K.2    Nakamura, S.3
  • 47
    • 0037438664 scopus 로고    scopus 로고
    • Down-modulation of responses to type I IFN upon T cell activation
    • Dondi E, Rogge L, Lutfalla G, et al. Down-modulation of responses to type I IFN upon T cell activation. J Immunol 2003;170:749-756.
    • (2003) J Immunol , vol.170 , pp. 749-756
    • Dondi, E.1    Rogge, L.2    Lutfalla, G.3
  • 48
    • 33744474042 scopus 로고    scopus 로고
    • Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells
    • Zhang MS, Zhou YF, Zhang WJ, et al. Apoptosis induced by short hairpin RNA-mediated STAT6 gene silencing in human colon cancer cells. Chin Med J 2006;119:801-808.
    • (2006) Chin Med J , vol.119 , pp. 801-808
    • Zhang, M.S.1    Zhou, Y.F.2    Zhang, W.J.3
  • 49
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta (CT)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta (CT)) method. Methods 2001;25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 50
    • 0032737478 scopus 로고    scopus 로고
    • Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: Distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair
    • Knittel T, Kobold D, Piscaglia F, et al. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Bio 1999;112:387-401.
    • (1999) Histochem Cell Bio , vol.112 , pp. 387-401
    • Knittel, T.1    Kobold, D.2    Piscaglia, F.3
  • 51
    • 33646122663 scopus 로고    scopus 로고
    • The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro
    • Koenig S, Krause P, Drabent B, et al. The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro. J Hepatol 2006;44:1115-1124.
    • (2006) J Hepatol , vol.44 , pp. 1115-1124
    • Koenig, S.1    Krause, P.2    Drabent, B.3
  • 52
    • 0031681318 scopus 로고    scopus 로고
    • The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1
    • Saalbach A, Kraft R, Herrmann K, et al. The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1. Arch Dermatol Res 1998;290:360-366.
    • (1998) Arch Dermatol Res , vol.290 , pp. 360-366
    • Saalbach, A.1    Kraft, R.2    Herrmann, K.3
  • 53
    • 50249166793 scopus 로고    scopus 로고
    • The study of CD90 expressing in orbital fibroblasts of thyroid associated ophthalmopathy
    • Tang L, Luo QL, Xia QJ, et al. The study of CD90 expressing in orbital fibroblasts of thyroid associated ophthalmopathy. Sichuan Da Xue Xue Bao Yi Xue Ban 2006;37:37879-37881.
    • (2006) Sichuan Da Xue Xue Bao Yi Xue Ban , vol.37 , pp. 37879-37881
    • Tang, L.1    Luo, Q.L.2    Xia, Q.J.3
  • 54
    • 33846829642 scopus 로고    scopus 로고
    • Characterization and induction of human pre-adipocytes
    • Raposio E, Guida C, Baldelli I, et al. Characterization and induction of human pre-adipocytes. Toxicol In Vitro 2007;21:330-334.
    • (2007) Toxicol In Vitro , vol.21 , pp. 330-334
    • Raposio, E.1    Guida, C.2    Baldelli, I.3
  • 55
    • 0036793302 scopus 로고    scopus 로고
    • Natural history of recurrent hepatitis C
    • Berenguer M. Natural history of recurrent hepatitis C. Liver Transpl 2002;8:14-18.
    • (2002) Liver Transpl , vol.8 , pp. 14-18
    • Berenguer, M.1
  • 56
    • 7244247475 scopus 로고    scopus 로고
    • Fibrosis progression after liver transplantation in patients with recurrent hepatitis C
    • Neumann UP, Berg T, Bahra M, et al. Fibrosis progression after liver transplantation in patients with recurrent hepatitis C. J Hepatol 2004;41:830-836.
    • (2004) J Hepatol , vol.41 , pp. 830-836
    • Neumann, U.P.1    Berg, T.2    Bahra, M.3
  • 57
    • 34247637682 scopus 로고    scopus 로고
    • Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathway
    • Aoudjehane L, Podevin P, Scatton O, et al. Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathway. FASEB J 2007;21:1433-1444.
    • (2007) FASEB J , vol.21 , pp. 1433-1444
    • Aoudjehane, L.1    Podevin, P.2    Scatton, O.3
  • 58
    • 0032483171 scopus 로고    scopus 로고
    • Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2
    • Gallois C, Habib A, Tao J, et al. Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2. J Biol Chem 1998;273:23183-23190.
    • (1998) J Biol Chem , vol.273 , pp. 23183-23190
    • Gallois, C.1    Habib, A.2    Tao, J.3
  • 59
    • 33644882743 scopus 로고    scopus 로고
    • Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells
    • Gressner AM, Lahme B, Meurer SK, et al. Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells. World J Gastroenterol 2006;12:731-738.
    • (2006) World J Gastroenterol , vol.12 , pp. 731-738
    • Gressner, A.M.1    Lahme, B.2    Meurer, S.K.3
  • 60
    • 27744580669 scopus 로고    scopus 로고
    • Hepatic fibrosis and cirrhosis. The (myo)fibroblastic cell subpopulations involved
    • Guyot C, Lepreux S, Combe C, et al. Hepatic fibrosis and cirrhosis. The (myo)fibroblastic cell subpopulations involved. Int J Biochem Cell Biol 2006;38:135-151.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 135-151
    • Guyot, C.1    Lepreux, S.2    Combe, C.3
  • 61
    • 0042834253 scopus 로고    scopus 로고
    • Crucial role of IL4/STAT6 in T cell-mediated hepatitis: Up-regulation eotaxin and IL5 and recruiting leukocytes
    • Jaruga B, Hong F, Sun R. Crucial role of IL4/STAT6 in T cell-mediated hepatitis: up-regulation eotaxin and IL5 and recruiting leukocytes. J Immunol 2003;171:3233-3244.
    • (2003) J Immunol , vol.171 , pp. 3233-3244
    • Jaruga, B.1    Hong, F.2    Sun, R.3
  • 62
    • 30744441442 scopus 로고    scopus 로고
    • IL-4 inhibits calcium transients in bovine rachealis cells by a ryanodine receptor dependent mechanism
    • Ethier MF, Madison JM. IL-4 inhibits calcium transients in bovine rachealis cells by a ryanodine receptor dependent mechanism. FASEB J 2005;20:154-156.
    • (2005) FASEB J , vol.20 , pp. 154-156
    • Ethier, M.F.1    Madison, J.M.2
  • 63
    • 33745537971 scopus 로고    scopus 로고
    • Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism
    • Li B, Sun R, Wei H, et al. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 2006;43:1211-1219.
    • (2006) Hepatology , vol.43 , pp. 1211-1219
    • Li, B.1    Sun, R.2    Wei, H.3
  • 64
    • 31644449220 scopus 로고    scopus 로고
    • Cytokine serum levels in patients infected by human immunodeficiency virus with and without Trypanosoma cruzi coinfection
    • Rodrigues DB, Correia D, Marra MD, et al. Cytokine serum levels in patients infected by human immunodeficiency virus with and without Trypanosoma cruzi coinfection. Rev Soc Bras Med Trop 2005;38:483-487.
    • (2005) Rev Soc Bras Med Trop , vol.38 , pp. 483-487
    • Rodrigues, D.B.1    Correia, D.2    Marra, M.D.3
  • 65
    • 10744232289 scopus 로고    scopus 로고
    • Identification of the interleukin 4 receptor alpha gene as a direct target for p73
    • Sasaki Y, Mita H, Toyota M, et al. Identification of the interleukin 4 receptor alpha gene as a direct target for p73. Cancer Res 2003;63:8145-8152.
    • (2003) Cancer Res , vol.63 , pp. 8145-8152
    • Sasaki, Y.1    Mita, H.2    Toyota, M.3
  • 68
    • 0043074620 scopus 로고    scopus 로고
    • Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts
    • McGaha TL, Le M, Kodera T, et al. Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. Arthritis Rheum 2003;48:2275-2284.
    • (2003) Arthritis Rheum , vol.48 , pp. 2275-2284
    • McGaha1    TL, L.M.2    Kodera, T.3
  • 69
    • 1642458087 scopus 로고    scopus 로고
    • Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: Analysis of the functional collagen promoter sequences
    • Buttner C, Skupin A, Riebe EP. Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: analysis of the functional collagen promoter sequences. J Cell Physiol 2004;198:248-258.
    • (2004) J Cell Physiol , vol.198 , pp. 248-258
    • Buttner, C.1    Skupin, A.2    Riebe, E.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.