Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease

Tohoku Journal of Experimental Medicine

Volumn 195, Issue 1, 2001, Pages 21-33

  Kumagai, Shinji ^a   Ohtani, Haruo ^a   Nagai, Tadashi ^a   Funa, Keiko ^b   Hiwatashi, Nobuo ^a   Shimosegawa, Tooru ^a   Nagura, Hiroshi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Inflammatory bowel disease; PDGF receptor; PGDF

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; GLUCOCORTICOID; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN; SALAZOSULFAPYRIDINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; FEMALE; FIBROBLAST; FIBROSIS; FROZEN SECTION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IN SITU HYBRIDIZATION; INFLAMMATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MALE; MONOCYTE; MYOFIBROBLAST; NEUTROPHIL; PROTEIN EXPRESSION; SCAR; TISSUE INJURY; TISSUE REPAIR; ULCER; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; CICATRIX; FEMALE; FIBROSIS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY BOWEL DISEASES; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR;

EID: 0035677983     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.195.21     Document Type: Article

References (29)

1. In situ expression of fibrogenic growth factors and their receptors in biliary atresia: Comparison between early and late stages
2. Expression of growth factor receptor-encoded mRNA by colonic epithelial cells is altered in inflammatory bowel disease
3. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF-β receptors
4. Platelet-derived growth factor is a potent biologic response modifier of T cells
5. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor
6. Growth factors and wound healing: Platelet-derived growth factor as a model cytokine
7. Expression of platelet-derived growth factor receptors in normal and diseased human kidney
8. Transforming growth factor-β1 selectively augments collagen synthesis by human intestinal smooth muscle cells
9. Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets
10. Procollagen-positive fibroblasts predominantly express fibrogenic growth factors and their receptors in human encapsulation process against foreign body
11. Growth factor and procollagen type I gene expression in human liver disease
12. Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis
13. Similarities of in situ mRNA expression between gelatinase A (MMP-2) and type-I procollagen in human gastrointestinal carcinoma: Comparison with granulation-tissue reaction
14. Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy
15. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
16. Involvement of platelet-derived growth factor in disease: Development of specific antagonists
17. Cyclic nucleotides regulate collagen production by human intestinal smooth muscle
18. Role of platelet-derived growth factor in wound healing
19. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB
20. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds
21. Tissue localization of β receptor for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans
22. Platelet-derived growth factor is angiogenic in vivo
23. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro
24. Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue
25. Platelet-derived growth factor is chemotactic for fibroblasts
26. Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin
27. Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease
28. Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma
29. Basic fibroblast growth factor and PDGF in GI diseases