Blockade of transforming growth factor β upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa

Gut

Volumn 57, Issue 5, 2008, Pages 605-612

  Di Sabatino, A ^a   Pickard, K M ^b   Rampton, D ^a   Kruidenier, L ^c   Rovedatti, L ^d   Leakey, N A B ^a   Corazza, G R ^d   Monteleone, G ^e   MacDonald, T T ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF PAVIA   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; NEUTRALIZING ANTIBODY; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; APOPTOSIS; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; INTERFERON PRODUCTION; INTESTINE BIOPSY; LAMINA PROPRIA; MEASUREMENT; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; TH1 CELL; UPREGULATION;

ADULT; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERFERON TYPE II; INTERLEUKINS; MALE; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-BOX DOMAIN PROTEINS; TH1 CELLS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 42549143615     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.130922     Document Type: Article

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