The myofibroblast in wound healing and fibrocontractive diseases

Journal of Pathology

Volumn 200, Issue 4, 2003, Pages 500-503

  Gabbiani, Giulio ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

smooth muscle actin; Inflammation; Stress fibres; Tension; TGF 1 fibronectin

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; CELL FUNCTION; CELL TRANSFORMATION; EPITHELIUM TUMOR; EPITHELIZATION; FIBROBLAST; FIBROCONTRACTIVE DISEASE; HUMAN; KIDNEY FIBROSIS; LIVER CIRRHOSIS; MECHANICAL STRESS; MUSCLE FIBER CONTRACTION; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; STROMA; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ACTINS; CELL ADHESION; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; INTEGRINS; MYOBLASTS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0037899249     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1427     Document Type: Review

References (20)

1. Serini G, Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res 1999; 250: 273-283.
2. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3: 349-363.
3. Desmoulir̀ee A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 1995; 146: 56-66.
4. Gabbiani G, Ryan GB, Majno G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971; 27: 549-550.
5. Darby I, Skalli O, Gabbiani G. α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 1990; 63; 21-29.
6. Dugina V, Fontao L, Chaponnier C, Vasiliev J, Gabbiani G. Focal adhesion features during myofibroblastic differentiation are controlled by intracellular and extracellular factors. J Cell Sci 2001; 114: 3285-3296.
7. Gabbiani G, Le Lous M, Bailey AJ, Bazin S, Delaunay A. Collagen and myofibroblasts of granulation tissue: a chemical, ultrastructural and immunologic study. Virchows Archiv B Cell Pathol 1976; 21: 133-145.
8. Borsi L, Castellani P, Risso AM, Leprini A, Zardi L. Transforming growth factor-beta regulates the splicing pattern of fibronectin messenger RNA precursor. FEBS Lett 1990; 261: 175-178.
9. Serini G, Bochaton-Piallat ML, Ropraz P, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1. J Cell Biol 1998; 142: 873-881.
10. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-β1 induces a-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122: 103 -111.
11. Ronnov-Jessen L, Petersen OW. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts: implications for myofibroblast generation in breast neoplasia. Lab Invest 1993; 68: 696-707.
12. Roberts AB, Sporn MB, Assoian RK, et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83: 4167-4171.
13. Xia P, Culp LA. Adhesion activity in fibronectin's alternatively spliced domain ED-A (EIIIA) and its neighboring type III repeats: oncogene-dependent regulation. Exp Cell Res 1994; 213: 253-265.
14. Chi-Rosso G, Gotwals PJ, Yang J, et al. Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins. J Biol Chem 1997; 272: 31447-31452.
15. Moyano JV, Carnemolla B, Dominguez-Jimenez C, et al. Fibronectin type III5 repeat contains a novel cell adhesion sequence, KLDAPT, which binds activated alpha4beta1 and alpha4beta7 integrins. J Biol Chem 1997; 272: 24 832-24 836.
16. Moyano JV, Carnemolla B, Albar JP, et al. Cooperative role for activated alpha4beta1 integrin and chondroitin sulfate proteoglycans in cell adhesion to be heparin III domain of fibronectin. Identification of a novel heparin and cell binding sequence in repeat III5. J Biol Chem 1999; 274: 135-142.
17. Hocking DC, Sottile J, McKeown-Longo PJ. Activation of distinct alpha5beta1 -mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains. J Cell Biol 1998; 141: 241-253.
18. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against a-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103: 2787-2796.
19. 2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo. J Cell Biol 1995; 130: 887-895.
20. 2-terminal peptide of α-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. J Cell Biol 2002; 157: 657-663.