The evolution of Aβ peptide burden in the APP23 transgenic mice: Implications for Aβ deposition in Alzheimer disease

Molecular Medicine

Volumn 7, Issue 9, 2001, Pages 609-618

  Kuo, Yu Min ^a   Beach, Thomas G ^a   Sue, Lucia I ^a   Scott, Sarah ^a   Layne, Kathryn J ^a   Kokjohn, Tyler A ^a   Kalback, Walter M ^a   Luehrs, Dean C ^a   Vishnivetskaya, Tatiana A ^a   Abramowski, Dorothee ^a   Sturchler Pierrat, Christine ^a   Staufenbiel, Matthias ^a   Weller, Roy O ^a   Roher, Alex E ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN CORTEX; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOCYTOCHEMISTRY; LIFESPAN; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TRANSGENIC MOUSE; VASCULAR AMYLOIDOSIS; WESTERN BLOTTING;

EID: 0035718905     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401867     Document Type: Article

References (34)

1. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
2. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
3. Extracellular space structure revealed by diffusion analysis
4. Drainage of cerebral extracellular fluids into cervical lymph: An afferent limb in brain/immune system interactions
5. Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain
6. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
7. Brain parenchymal and microvascular amyloid in Alzheimer's disease
8. The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage
9. Prion protein hereditary amyloidosis: Parenchymal and vascular
10. Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
11. Familial British dementia with amyloid angiopathy: Early clinical, neuropsychological and imaging findings
12. Cerebral amyloid angiopathy: Amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
13. Comparative analysis of Aβ chemical structure and amyloid plaque morphology of APP23 transgenic mice
14. Apolipoprotein E alleles as risk factors in Alzheimer's disease
15. Elevated Aβ and apolipoprotein E in AβPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease
16. Selective extraction of human serum very low density apolipoproteins with organic solvents
17. Organic extraction and preparative isolectric focusing of rat serum apolipoproteins
18. A comparison of some immunological characteristics of very low density lipoproteins of normal and hypercholesterolemic rat sera
19. Perfusion-fixation of the human brain for immunohistochemistry: Comparison with immersion-fixation
20. Increased plasma amyloid Aβ protein 1-42 levels in Down syndrome
21. The immunohistochemical demonstration of subsequences of the precursor of the amyloid A4 protein in senile plaques in Alzheimer's disease
22. Intraneuronal Aβ 42 accumulation in human brain
23. Intracellular APP processing and Aβ production in Alzheimer's disease
24. Cerebral amyloid angiopathy: Accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease
25. Amyloid beta-proteins 1-40 and 1-42(43) in the soluble fraction of extra-and intracranial blood vessels
26. Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum
27. CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance
28. Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain
29. Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability
30. Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat
31. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
32. Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
33. Amyloid beta-protein deposition in the leptomeninges and cerebral cortex
34. Progress toward valid transgenic mouse models for Alzheimer's disease