Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site

Journal of Biological Chemistry

Volumn 285, Issue 3, 2010, Pages 2165-2173

  Hoopes, James T ^a   Liu, Xuying ^a   Xu, Xiaomeng ^b   Demeler, Borries ^c   Folta Stogniew, Ewa ^a   Li, Chris ^b   Ha, Ya ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CITY COLLEGE OF NEW YORK   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BINDING POCKETS; BIOCHEMICAL DATA; BIOLOGICAL FUNCTIONS; BRAIN TISSUE; CAENORHABDITIS ELEGANS; HEPARIN-BINDING PROTEINS; HEPARIN-BINDING SITE; HISTIDINE RESIDUES; NEUTRAL PH; SITE DIRECTED MUTAGENESIS; STRUCTURAL CHARACTERIZATION; SUCROSE OCTASULFATE; SURFACE GROOVES; X-RAY STRUCTURE;

APL (PROGRAMMING LANGUAGE); BINDING ENERGY; BINDING SITES; GLYCOPROTEINS; PHOSPHATASES; POLYSACCHARIDES; PROTEINS; PUMPING PLANTS; SUGAR (SUCROSE);

CRYSTAL STRUCTURE;

AMYLOID PRECURSOR PROTEIN; DISACCHARIDE; HEPARIN; HISTIDINE; PROTEIN APL 1; SUCROSE OCTASULFATE; SULFATE; UNCLASSIFIED DRUG; APL 1 PROTEIN, C ELEGANS; APL-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; DRUG DERIVATIVE; MEMBRANE PROTEIN; SUCROSE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; LIGHT SCATTERING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; ULTRACENTRIFUGATION; WESTERN BLOTTING; X RAY DIFFRACTION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SOLUTION AND SOLUBILITY; X RAY CRYSTALLOGRAPHY;

CAENORHABDITIS ELEGANS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CRYSTALLOGRAPHY, X-RAY; HEPARIN; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; SUCROSE;

EID: 76249098107     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.018432     Document Type: Article

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