Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30598-30605

  Li, Hongmei ^a,b   Wang, Zilai ^a   Wang, Baiping ^a   Guo, Qinxi ^a   Dolios, Georgia ^d   Tabuchi, Katsuhiko ^b,f   Hammer, Robert E ^b   Südhof, Thomas C ^b,c,e   Wang, Rong ^d   Zheng, Hui ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY   (United States)

^f NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; GENES; GLYCOPROTEINS;

AMYLOID PRECURSOR PROTEINS; C-TERMINAL DOMAINS; CAENORHABDITIS ELEGANS; DEVELOPMENT ACTIVITY; ELEGANS; EXTRACELLULAR; FRAME-SHIFT MUTATION; GENETIC DISSECTION; INTRACELLULAR DOMAIN; MUTANT ALLELES; PROTEOLYTIC PROCESSING; TERMINAL MUTATION;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APL-1 PROTEIN, C ELEGANS; APLP2 PROTEIN, MOUSE; APP PROTEIN, HUMAN; CAENORHABDITIS ELEGANS PROTEIN; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; PROTEASE NEXIN;

AMYLOID NEUROPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE TARGETING; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MOUSE; MUTATIONAL ANALYSIS; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; SEQUENCE ANALYSIS; ALLELE; ALZHEIMER DISEASE; ANIMAL; CAENORHABDITIS ELEGANS; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

CAENORHABDITIS ELEGANS; MUS;

ALLELES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; FRAMESHIFT MUTATION; GENE KNOCK-IN TECHNIQUES; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEUROMUSCULAR JUNCTION; PROTEASE NEXINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE;

EID: 77957254613     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.137729     Document Type: Article

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