Induction of terminal differentiation in melanoma cells on downregulation of β-amyloid precursor protein

Journal of Investigative Dermatology

Volumn 130, Issue 5, 2010, Pages 1400-1410

  Botelho, Michelle G ^a   Wang, Xiaolei ^b   Arndt Jovin, Donna J ^a   Becker, Dorothea ^b   Jovin, Thomas M ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTINEOPLASTIC AGENT; CELL SURFACE RECEPTOR; DOXORUBICIN; PACLITAXEL; TEMOZOLOMIDE;

ADVANCED CANCER; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SUSCEPTIBILITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MELANOCYTE; MELANOMA; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TARGETING; REGULATOR GENE; RNA INTERFERENCE; TUMOR CELL;

AMYLOID BETA-PROTEIN PRECURSOR; ANTIBIOTICS, ANTINEOPLASTIC; BIOPSY; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE, TUMOR; CRYOPRESERVATION; DISEASE PROGRESSION; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; MELANOCYTES; MELANOMA; P-GLYCOPROTEIN; PIGMENTATION; QUANTUM DOTS; RNA INTERFERENCE; SKIN NEOPLASMS; UP-REGULATION;

EID: 77951093230     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.296     Document Type: Article

References (46)

1. Alivisatos AP, Gu WW, Larabell C (2005) Quantum dots as cellular probes. Annu Rev Biomed Eng 7:55-76 (Pubitemid 41170185)
2. Ando H, Kondoh H, Ichihashi M, Hearing VJ (2007) Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase. J Invest Dermatol 127:751-761 (Pubitemid 46437203)
3. Annaert W, De Strooper B (2002) A cell biological perspective on Alzheimers disease. Annu Rev Cell Dev Biol 18:25-51 (Pubitemid 35387344)
4. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770-776 (Pubitemid 29291335)
5. Becker D, Lee PL, Rodeck U, Herlyn M (1992) Inhibition of the fibroblast growth-factor receptor 1 (FGFR-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation. Oncogene 7:2303-2313
6. Becker D, Meier CB, Herlyn M (1989) Proliferation of human-malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor. EMBO J 8:3685-3691 (Pubitemid 20016047)
7. Belyaev ND, Nalivaeva NN, Makova NZ, Turner AJ (2009) Neprilysin gene expression requires binding of the amyloid precursor protein intracel-lular domain to its promoter: implications for Alzheimer disease. EMBO Rep 10:94-100
8. Bradbury J (2005) RNA interference: new drugs on the horizon. Drug Discov Today 10:1266-1267 (Pubitemid 41416696)
9. Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B et al. (1993) A novel zinc(II)-binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimers disease. J Biol Chem 268:16109-16112 (Pubitemid 23229904)
10. Culicchia F, Cui JG, Li YY, Lukiw WJ (2008) Upregulation of beta-amyloid precursor protein expression in glioblastoma multiforme. Neuroreport 19:981-985
11. Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN et al. (2005) Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. FASEB J 19:1451-1458 (Pubitemid 41279003)
12. Gralle M, Botelho MM, de Oliveira CL, Torriani I, Ferreira ST (2002) Solution studies and structural model of the extracellular domain of the human amyloid precursor protein. Biophys J 83:3513-3524 (Pubitemid 36041968)
13. Gralle M, Ferreira ST (2007) Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts. Prog Neurobiol 82:11-32 (Pubitemid 46719589)
14. Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A (2003) Increased expression and processing of the alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res 63:7032-7037 (Pubitemid 37413434)
15. Hoffmann J, Pietrzik CU, Kummer MP, Twiesselmann C, Bauer C, Herzog V (1999) Binding and selective detection of the secretory N-terminal domain of the Alzheimer amyloid precursor protein on cell surfaces. J Histochem Cytochem 47:373-382
16. Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V (2000) A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. Eur J Cell Biol 79:905-914
17. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH et al. (1987) The precursor of Alzheimers disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736
18. Kim HS, Kim EM, Lee JP, Park CH, Kim S, Seo JH et al. (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3 beta expression. FASEB J 17:1951-1953
19. Kim SY, Kim MY, Mo JS, Park HS (2007) Notchl1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction. Biochim Biophys Acta 1773:736-746
20. Kirfel G, Borm B, Rigort A, Herzog V (2002) The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes. Eur J Cell Biol 81:664-676
21. Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H (1988) Novel precursor of Alzheimers-disease amyloid protein shows protease inhibitory activity. Nature 331:530-532
22. Ko SY, Lin SC, Chang KW, Wong YK, Liu CJ, Chi CW et al. (2004) Increased expression of amyloid precursor protein in oral squamous cell carcinoma. Int J Cancer 111:727-732
23. Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D et al. (2007) Structural studies of the Alzheimers amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol 367:148-161
24. Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O et al. (2008) Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol 198:291-299
25. Kummer C, Wehner S, Quast T, Werner S, Herzog V (2002) Expression and potential function of beta-amyloid precursor proteins during cutaneous wound repair. Exp Cell Res 280:222-232
26. Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M et al. (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimers amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96:3922-3927
27. Li HL, Roch JM, Sundsmo M, Otero D, Sisodia S, Thomas R et al. (1997) Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimers disease. J Neurobiol 32:469-480
28. Lleo A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T et al. (2003) Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem 278:47370-47375
29. Meng JY, Kataoka H, Itoh H, Koono M (2001) Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo. Int J Cancer 92:31-39
30. Narindrasorasak S, Lowery D, Gonzalezdewhitt P, Poorman RA, Greenberg B, Kisilevsky R (1991) High-affinity interactions between the Alzheimers beta-amyloid precursor proteins and the basement-membrane form of heparan-sulfate proteoglycan. J Biol Chem 266:12878-12883
31. Ninomiya H, Roch JM, Sundsmo MP, Otero DA, Saitoh T (1993) Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth. J Cell Biol 121:879-886
32. Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE et al. (2005) Amyloid precursor protein interacts with notch receptors. J Neurosci Res 82:32-42
33. Ponte P, Gonzalezdewhitt P, Schilling J, Miller J, Hsu D, Greenberg B et al. (1988) A new A4-amyloid messenger-RNA contains a domain homologous to serine proteinase-inhibitors. Nature 331:525-527
34. Quast T, Wehner S, Kirfel G, Jaeger K, De Luca M, Herzog V (2003) sAPP as a regulator of dendrite motility and melanin release in epidermal melanocytes and melanoma cells. FASEB J 17:1739-1741
35. Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D et al. (1999) Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6:327-331
36. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M et al. (2008) Identification of cells initiating human melanomas. Nature 451:345-349
37. Siemes C, Quast T, Kummer C, Wehner S, Kirfel G, Muller U et al. (2006) Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro. Exp Cell Res 312:1939-1949
38. Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K et al. (1994) A heparin-binding domain in the amyloid protein-precursor of Alzhei-mers-disease is involved in the regulation of neurite outgrowth. J Neurosci 14:2117-2127
39. Smith AP, Hoek K, Becker D (2005) Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas. Cancer Biol Ther 4:1018-1029
40. Tanzi RE, McClatchey AI, Lamperti ED, Villakomaroff L, Gusella JF, Neve RL (1988) Protease inhibitor domain encoded by an amyloid protein-precursor messenger-RNA associated with Alzheimers-disease. Nature 331:528-530
41. Telese F, Bruni P, Donizetti A, Gianni D, DAmbrosio C, Scaloni A et al. (2005) Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. EMBO Rep 6:77-82
42. von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM et al. (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci 117:4435-4448
43. Wang YP, Rao U, Mascari R, Richards TJ, Panson AJ, Edington HD et al. (1996) Molecular analysis of melanoma precursor lesions. Cell Growth Differ 7:1733-1740
44. Wehner S, Siemes C, Kirfel G, Herzog V (2004) Cytoprotective function of sAPP alpha in human keratinocytes. Eur J Cell Biol 83:701-708
45. Zhang YW, Wangt RS, Liu Q, Zhang H, Liao FF, Xu HX (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci USA 104:10613-10618
46. Zhuang LQ, Lee CS, Scolyer RA, McCarthy SW, Zhang XD, Thompson JF et al. (2007) Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol 20:416-426