-
1
-
-
0029931509
-
A human Mad protein acting as a BMP-regulated transcriptional activator
-
F. Liu, A. Hata, J.C. Baker, J. Doody, J. Carcamo, R.M. Harland, and J. Massague A human Mad protein acting as a BMP-regulated transcriptional activator Nature 381 1996 620 623
-
(1996)
Nature
, vol.381
, pp. 620-623
-
-
Liu, F.1
Hata, A.2
Baker, J.C.3
Doody, J.4
Carcamo, J.5
Harland, R.M.6
Massague, J.7
-
2
-
-
0029834067
-
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
-
G. Lagna, A. Hata, A. Hemmati-Brivanlou, and J. Massague Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways Nature 383 1996 832 836
-
(1996)
Nature
, vol.383
, pp. 832-836
-
-
Lagna, G.1
Hata, A.2
Hemmati-Brivanlou, A.3
Massague, J.4
-
3
-
-
15844387270
-
Mad-related genes in the human
-
G.J. Riggins Mad-related genes in the human Nat. Genet. 13 1996 347 349
-
(1996)
Nat. Genet.
, vol.13
, pp. 347-349
-
-
Riggins, G.J.1
-
4
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Y. Shi, and J. Massague Mechanisms of TGF-beta signaling from cell membrane to the nucleus Cell 113 2003 685 700
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
6
-
-
2342488852
-
New insights into TGF-beta-Smad signalling
-
P. ten Dijke, and C.S. Hill New insights into TGF-beta-Smad signalling Trends Biochem. Sci. 29 2004 265 273
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 265-273
-
-
Ten Dijke, P.1
Hill, C.S.2
-
7
-
-
23044466047
-
Specificity and versatility in tgf-beta signaling through Smads
-
X.H. Feng, and R. Derynck Specificity and versatility in tgf-beta signaling through Smads Annu. Rev. Cell Dev. Biol. 21 2005 659 693
-
(2005)
Annu. Rev. Cell Dev. Biol.
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
8
-
-
30944444113
-
Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
-
L. Levy, and C.S. Hill Alterations in components of the TGF-beta superfamily signaling pathways in human cancer Cytokine Growth Factor Rev. 17 2006 41 58
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
9
-
-
0034604110
-
Role of transforming growth factor beta in human disease
-
G.C. Blobe, W.P. Schiemann, and H.F. Lodish Role of transforming growth factor beta in human disease N. Engl. J. Med. 342 2000 1350 1358
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 1350-1358
-
-
Blobe, G.C.1
Schiemann, W.P.2
Lodish, H.F.3
-
10
-
-
58149213801
-
Non-Smad pathways in TGF-beta signaling
-
Y.E. Zhang Non-Smad pathways in TGF-beta signaling Cell Res. 19 2009 128 139
-
(2009)
Cell Res.
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
11
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
-
P.M. Siegel, and J. Massague Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer Nat. Rev. Cancer 3 2003 807 821
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massague, J.2
-
12
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
S.A. Hahn DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 Science 271 1996 350 353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
-
14
-
-
67650874081
-
Cancer statistics, 2009
-
A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M.J. Thun Cancer statistics, 2009 CA Cancer J. Clin. 59 2009 225 249
-
(2009)
CA Cancer J. Clin.
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
15
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
E. Rozenblum Tumor-suppressive pathways in pancreatic carcinoma Cancer Res. 57 1997 1731 1734
-
(1997)
Cancer Res.
, vol.57
, pp. 1731-1734
-
-
Rozenblum, E.1
-
16
-
-
0023735997
-
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
-
V.T. Smit, A.J. Boot, A.M. Smits, G.J. Fleuren, C.J. Cornelisse, and J.L. Bos KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas Nucleic Acids Res. 16 1988 7773 7782
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 7773-7782
-
-
Smit, V.T.1
Boot, A.J.2
Smits, A.M.3
Fleuren, G.J.4
Cornelisse, C.J.5
Bos, J.L.6
-
17
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
C. Caldas Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma Nat. Genet. 8 1994 27 32
-
(1994)
Nat. Genet.
, vol.8
, pp. 27-32
-
-
Caldas, C.1
-
18
-
-
0027404269
-
P53 and K-RAS alterations in pancreatic epithelial cell lesions
-
H. Kalthoff P53 and K-RAS alterations in pancreatic epithelial cell lesions Oncogene 8 1993 289 298
-
(1993)
Oncogene
, vol.8
, pp. 289-298
-
-
Kalthoff, H.1
-
19
-
-
0034032009
-
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
-
R.E. Wilentz, C.A. Iacobuzio-Donahue, P. Argani, D.M. McCarthy, J.L. Parsons, C.J. Yeo, S.E. Kern, and R.H. Hruban Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression Cancer Res. 60 2000 2002 2006
-
(2000)
Cancer Res.
, vol.60
, pp. 2002-2006
-
-
Wilentz, R.E.1
Iacobuzio-Donahue, C.A.2
Argani, P.3
McCarthy, D.M.4
Parsons, J.L.5
Yeo, C.J.6
Kern, S.E.7
Hruban, R.H.8
-
20
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
C.A. Iacobuzio-Donahue DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer J. Clin. Oncol. 27 2009 1806 1813
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1806-1813
-
-
Iacobuzio-Donahue, C.A.1
-
21
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
A. Blackford SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer Clin. Cancer Res. 15 2009 4674 4679
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4674-4679
-
-
Blackford, A.1
-
22
-
-
0035671396
-
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
-
M. Tascilar The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma Clin. Cancer Res. 7 2001 4115 4121
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 4115-4121
-
-
Tascilar, M.1
-
23
-
-
79955472083
-
Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer
-
R.A. Smith, J. Tang, C. Tudur-Smith, J.P. Neoptolemos, and P. Ghaneh Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer Br. J. Cancer 104 2011 1440 1451
-
(2011)
Br. J. Cancer
, vol.104
, pp. 1440-1451
-
-
Smith, R.A.1
Tang, J.2
Tudur-Smith, C.3
Neoptolemos, J.P.4
Ghaneh, P.5
-
24
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
G. Gu, J. Dubauskaite, and D.A. Melton Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors Development 129 2002 2447 2457
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
25
-
-
0036730427
-
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
-
Y. Kawaguchi, B. Cooper, M. Gannon, M. Ray, R.J. MacDonald, and C.V. Wright The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors Nat. Genet. 32 2002 128 134
-
(2002)
Nat. Genet.
, vol.32
, pp. 128-134
-
-
Kawaguchi, Y.1
Cooper, B.2
Gannon, M.3
Ray, M.4
MacDonald, R.J.5
Wright, C.V.6
-
26
-
-
33751251034
-
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
-
N. Bardeesy Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer Genes Dev. 20 2006 3130 3146
-
(2006)
Genes Dev.
, vol.20
, pp. 3130-3146
-
-
Bardeesy, N.1
-
27
-
-
33847387472
-
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
-
K. Izeradjene Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas Cancer Cell 11 2007 229 243
-
(2007)
Cancer Cell
, vol.11
, pp. 229-243
-
-
Izeradjene, K.1
-
28
-
-
34548550427
-
Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia
-
K. Kojima, S.M. Vickers, N.V. Adsay, N.C. Jhala, H.G. Kim, T.R. Schoeb, W.E. Grizzle, and C.A. Klug Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia Cancer Res. 67 2007 8121 8130
-
(2007)
Cancer Res.
, vol.67
, pp. 8121-8130
-
-
Kojima, K.1
Vickers, S.M.2
Adsay, N.V.3
Jhala, N.C.4
Kim, H.G.5
Schoeb, T.R.6
Grizzle, W.E.7
Klug, C.A.8
-
29
-
-
76349101165
-
Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
-
X. Xu, B. Ehdaie, N. Ohara, T. Yoshino, and C.X. Deng Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice Oncogene 29 2010 674 686
-
(2010)
Oncogene
, vol.29
, pp. 674-686
-
-
Xu, X.1
Ehdaie, B.2
Ohara, N.3
Yoshino, T.4
Deng, C.X.5
-
30
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
N. Agrawal Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 Science 333 2011 1154 1157
-
(2011)
Science
, vol.333
, pp. 1154-1157
-
-
Agrawal, N.1
-
31
-
-
0000799313
-
DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma
-
S.K. Kim, Y. Fan, V. Papadimitrakopoulou, G. Clayman, W.N. Hittelman, W.K. Hong, R. Lotan, and L. Mao DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma Cancer Res. 56 1996 2519 2521
-
(1996)
Cancer Res.
, vol.56
, pp. 2519-2521
-
-
Kim, S.K.1
Fan, Y.2
Papadimitrakopoulou, V.3
Clayman, G.4
Hittelman, W.N.5
Hong, W.K.6
Lotan, R.7
Mao, L.8
-
32
-
-
0031946721
-
Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer
-
V.A. Papadimitrakopoulou, Y. Oh, A. El-Naggar, J. Izzo, G. Clayman, and L. Mao Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer Clin. Cancer Res. 4 1998 539 544
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 539-544
-
-
Papadimitrakopoulou, V.A.1
Oh, Y.2
El-Naggar, A.3
Izzo, J.4
Clayman, G.5
Mao, L.6
-
33
-
-
0034235567
-
Identification of new minimally lost regions on 18q in head and neck squamous cell carcinoma
-
S. Takebayashi, T. Ogawa, K.Y. Jung, A. Muallem, H. Mineta, S.G. Fisher, R. Grenman, and T.E. Carey Identification of new minimally lost regions on 18q in head and neck squamous cell carcinoma Cancer Res. 60 2000 3397 3403
-
(2000)
Cancer Res.
, vol.60
, pp. 3397-3403
-
-
Takebayashi, S.1
Ogawa, T.2
Jung, K.Y.3
Muallem, A.4
Mineta, H.5
Fisher, S.G.6
Grenman, R.7
Carey, T.E.8
-
34
-
-
70449338760
-
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
-
S. Bornstein Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation J. Clin. Invest. 119 2009 3408 3419
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3408-3419
-
-
Bornstein, S.1
-
35
-
-
0031006336
-
MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma
-
C. Maesawa MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma Jpn. J. Cancer Res. 88 1997 340 343
-
(1997)
Jpn. J. Cancer Res.
, vol.88
, pp. 340-343
-
-
Maesawa, C.1
-
36
-
-
0034293056
-
Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma
-
H. Osawa, Y. Shitara, H. Shoji, A. Mogi, H. Kuwano, K. Hagiwara, and S. Takenoshita Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma Int. J. Oncol. 17 2000 723 728
-
(2000)
Int. J. Oncol.
, vol.17
, pp. 723-728
-
-
Osawa, H.1
Shitara, Y.2
Shoji, H.3
Mogi, A.4
Kuwano, H.5
Hagiwara, K.6
Takenoshita, S.7
-
37
-
-
3242668449
-
-
(3rd ed.). Mendelsohn, J. (Ed.)
-
Kern, S.E. (2008) Molecular Basis of Cancer (3rd ed.). Mendelsohn, J. (Ed.), pp. 41-69.
-
(2008)
Molecular Basis of Cancer
, pp. 41-69
-
-
Kern, S.E.1
-
38
-
-
0842327354
-
Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: A tissue microarray analysis
-
W. Xie, S. Bharathy, D. Kim, B.G. Haffty, D.L. Rimm, and M. Reiss Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis Oncol. Res. 14 2003 61 73
-
(2003)
Oncol. Res.
, vol.14
, pp. 61-73
-
-
Xie, W.1
Bharathy, S.2
Kim, D.3
Haffty, B.G.4
Rimm, D.L.5
Reiss, M.6
-
39
-
-
63949087863
-
Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma
-
X. Wang Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma Mol. Biol. Rep. 36 2009 861 869
-
(2009)
Mol. Biol. Rep.
, vol.36
, pp. 861-869
-
-
Wang, X.1
-
40
-
-
0036281395
-
Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus
-
S. Natsugoe Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus Clin. Cancer Res. 8 2002 1838 1842
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1838-1842
-
-
Natsugoe, S.1
-
41
-
-
0037103055
-
Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma
-
M. Fukuchi, N. Masuda, T. Miyazaki, M. Nakajima, H. Osawa, H. Kato, and H. Kuwano Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma Cancer 95 2002 737 743
-
(2002)
Cancer
, vol.95
, pp. 737-743
-
-
Fukuchi, M.1
Masuda, N.2
Miyazaki, T.3
Nakajima, M.4
Osawa, H.5
Kato, H.6
Kuwano, H.7
-
42
-
-
33746919897
-
Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse
-
Y. Teng, A.N. Sun, X.C. Pan, G. Yang, L.L. Yang, M.R. Wang, and X. Yang Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse Cancer Res. 66 2006 6972 6981
-
(2006)
Cancer Res.
, vol.66
, pp. 6972-6981
-
-
Teng, Y.1
Sun, A.N.2
Pan, X.C.3
Yang, G.4
Yang, L.L.5
Wang, M.R.6
Yang, X.7
-
43
-
-
77952600845
-
Susceptibility pathways in Fanconi's anemia and breast cancer
-
A.D. D'Andrea Susceptibility pathways in Fanconi's anemia and breast cancer N. Engl. J. Med. 362 2010 1909 1919
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1909-1919
-
-
D'Andrea, A.D.1
-
44
-
-
0037228326
-
High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia
-
D.I. Kutler High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia Arch. Otolaryngol. Head Neck Surg. 129 2003 106 112
-
(2003)
Arch. Otolaryngol. Head Neck Surg.
, vol.129
, pp. 106-112
-
-
Kutler, D.I.1
-
45
-
-
0042519602
-
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice
-
S. Houghtaling, C. Timmers, M. Noll, M.J. Finegold, S.N. Jones, M.S. Meyn, and M. Grompe Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice Genes Dev. 17 2003 2021 2035
-
(2003)
Genes Dev.
, vol.17
, pp. 2021-2035
-
-
Houghtaling, S.1
Timmers, C.2
Noll, M.3
Finegold, M.J.4
Jones, S.N.5
Meyn, M.S.6
Grompe, M.7
-
46
-
-
33745578957
-
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
-
B.G. Kim Smad4 signalling in T cells is required for suppression of gastrointestinal cancer Nature 441 2006 1015 1019
-
(2006)
Nature
, vol.441
, pp. 1015-1019
-
-
Kim, B.G.1
-
47
-
-
40949083607
-
Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype
-
S. Bharathy, W. Xie, J.M. Yingling, and M. Reiss Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype Cancer Res. 68 2008 1656 1666
-
(2008)
Cancer Res.
, vol.68
, pp. 1656-1666
-
-
Bharathy, S.1
Xie, W.2
Yingling, J.M.3
Reiss, M.4
-
48
-
-
0033104503
-
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
-
X. Yang, J.J. Letterio, R.J. Lechleider, L. Chen, R. Hayman, H. Gu, A.B. Roberts, and C. Deng Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta EMBO J. 18 1999 1280 1291
-
(1999)
EMBO J.
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
Chen, L.4
Hayman, R.5
Gu, H.6
Roberts, A.B.7
Deng, C.8
-
49
-
-
48749122568
-
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
-
K.E. Hoot Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression J. Clin. Invest. 118 2008 2722 2732
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2722-2732
-
-
Hoot, K.E.1
-
50
-
-
34250711876
-
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma
-
B.A. Frederick, B.A. Helfrich, C.D. Coldren, D. Zheng, D. Chan, P.A. Bunn Jr., and D. Raben Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma Mol. Cancer Ther. 6 2007 1683 1691
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1683-1691
-
-
Frederick, B.A.1
Helfrich, B.A.2
Coldren, C.D.3
Zheng, D.4
Chan, D.5
Bunn, Jr.P.A.6
Raben, D.7
-
51
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
H.E. Bryant Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
-
52
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
H. Farmer Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
-
53
-
-
0033858528
-
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
-
D.C. Chung The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis Gastroenterology 119 2000 854 865
-
(2000)
Gastroenterology
, vol.119
, pp. 854-865
-
-
Chung, D.C.1
-
54
-
-
72449176846
-
Molecular origins of cancer: Molecular basis of colorectal cancer
-
S.D. Markowitz, and M.M. Bertagnolli Molecular origins of cancer: molecular basis of colorectal cancer N. Engl. J. Med. 361 2009 2449 2460
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2449-2460
-
-
Markowitz, S.D.1
Bertagnolli, M.M.2
-
55
-
-
0025899162
-
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
-
I. Nishisho Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science 253 1991 665 669
-
(1991)
Science
, vol.253
, pp. 665-669
-
-
Nishisho, I.1
-
56
-
-
0026630266
-
APC mutations occur early during colorectal tumorigenesis
-
S.M. Powell, N. Zilz, Y. Beazer-Barclay, T.M. Bryan, S.R. Hamilton, S.N. Thibodeau, B. Vogelstein, and K.W. Kinzler APC mutations occur early during colorectal tumorigenesis Nature 359 1992 235 237
-
(1992)
Nature
, vol.359
, pp. 235-237
-
-
Powell, S.M.1
Zilz, N.2
Beazer-Barclay, Y.3
Bryan, T.M.4
Hamilton, S.R.5
Thibodeau, S.N.6
Vogelstein, B.7
Kinzler, K.W.8
-
57
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
J.L. Bos, E.R. Fearon, S.R. Hamilton, M. Verlaan-de Vries, J.H. van Boom, A.J. van der Eb, and B. Vogelstein Prevalence of ras gene mutations in human colorectal cancers Nature 327 1987 293 297
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
Verlaan-De Vries, M.4
Van Boom, J.H.5
Van Der Eb, A.J.6
Vogelstein, B.7
-
58
-
-
0025040233
-
Suppression of human colorectal carcinoma cell growth by wild-type p53
-
S.J. Baker, S. Markowitz, E.R. Fearon, J.K. Willson, and B. Vogelstein Suppression of human colorectal carcinoma cell growth by wild-type p53 Science 249 1990 912 915
-
(1990)
Science
, vol.249
, pp. 912-915
-
-
Baker, S.J.1
Markowitz, S.2
Fearon, E.R.3
Willson, J.K.4
Vogelstein, B.5
-
59
-
-
15844390729
-
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
-
S. Thiagalingam Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers Nat. Genet. 13 1996 343 346
-
(1996)
Nat. Genet.
, vol.13
, pp. 343-346
-
-
Thiagalingam, S.1
-
60
-
-
0033587156
-
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
-
M. Miyaki Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis Oncogene 18 1999 3098 3103
-
(1999)
Oncogene
, vol.18
, pp. 3098-3103
-
-
Miyaki, M.1
-
61
-
-
0033814963
-
Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease
-
A. Maitra, K. Molberg, J. Albores-Saavedra, and G. Lindberg Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease Am. J. Pathol. 157 2000 1105 1111
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1105-1111
-
-
Maitra, A.1
Molberg, K.2
Albores-Saavedra, J.3
Lindberg, G.4
-
62
-
-
20144378766
-
Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis
-
Y. Tang Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis Cancer Res. 65 2005 4228 4237
-
(2005)
Cancer Res.
, vol.65
, pp. 4228-4237
-
-
Tang, Y.1
-
63
-
-
84862763184
-
High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis
-
M. Isaksson-Mettavainio, R. Palmqvist, A.M. Dahlin, B. Van Guelpen, J. Rutegard, A. Oberg, and M.L. Henriksson High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis Int. J. Cancer 2011
-
(2011)
Int. J. Cancer
-
-
Isaksson-Mettavainio, M.1
Palmqvist, R.2
Dahlin, A.M.3
Van Guelpen, B.4
Rutegard, J.5
Oberg, A.6
Henriksson, M.L.7
-
64
-
-
84655163944
-
Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome
-
C. Le Goff Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome Nat. Genet. 44 2011 85 88
-
(2011)
Nat. Genet.
, vol.44
, pp. 85-88
-
-
Le Goff, C.1
-
65
-
-
0032584068
-
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
-
X. Yang, C. Li, X. Xu, and C. Deng The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice Proc. Natl. Acad. Sci. USA 95 1998 3667 3672
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3667-3672
-
-
Yang, X.1
Li, C.2
Xu, X.3
Deng, C.4
-
66
-
-
0032489508
-
Intestinal tumorigenesis in compound mutant mice of both DPC4 (SMAD4) and APC genes
-
K. Takaku, M. Oshima, H. Miyoshi, M. Matsui, M.F. Seldin, and M.M. Taketo Intestinal tumorigenesis in compound mutant mice of both DPC4 (SMAD4) and APC genes Cell 92 1998 645 656
-
(1998)
Cell
, vol.92
, pp. 645-656
-
-
Takaku, K.1
Oshima, M.2
Miyoshi, H.3
Matsui, M.4
Seldin, M.F.5
Taketo, M.M.6
-
67
-
-
0033572255
-
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
-
K. Takaku, H. Miyoshi, A. Matsunaga, M. Oshima, N. Sasaki, and M.M. Taketo Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice Cancer Res. 59 1999 6113 6117
-
(1999)
Cancer Res.
, vol.59
, pp. 6113-6117
-
-
Takaku, K.1
Miyoshi, H.2
Matsunaga, A.3
Oshima, M.4
Sasaki, N.5
Taketo, M.M.6
-
68
-
-
0034611611
-
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
-
X. Xu Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice Oncogene 19 2000 1868 1874
-
(2000)
Oncogene
, vol.19
, pp. 1868-1874
-
-
Xu, X.1
-
70
-
-
80053430421
-
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
-
J.N. Hahn, V.G. Falck, and F.R. Jirik Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice J. Clin. Invest. 121 2011 4030 4042
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4030-4042
-
-
Hahn, J.N.1
Falck, V.G.2
Jirik, F.R.3
-
71
-
-
34047138860
-
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion
-
T. Kitamura SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion Nat. Genet. 39 2007 467 475
-
(2007)
Nat. Genet.
, vol.39
, pp. 467-475
-
-
Kitamura, T.1
-
72
-
-
33745856213
-
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
-
X. Xu Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice J. Clin. Invest. 116 2006 1843 1852
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1843-1852
-
-
Xu, X.1
-
73
-
-
0036742764
-
Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma
-
Y.K. Kang, W.H. Kim, and J.J. Jang Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma Hum. Pathol. 33 2002 877 883
-
(2002)
Hum. Pathol.
, vol.33
, pp. 877-883
-
-
Kang, Y.K.1
Kim, W.H.2
Jang, J.J.3
-
74
-
-
79951512852
-
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
-
Z. Ding SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression Nature 470 2011 269 273
-
(2011)
Nature
, vol.470
, pp. 269-273
-
-
Ding, Z.1
-
75
-
-
25444473619
-
Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors
-
L. Yang Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors Cancer Res. 65 2005 8671 8678
-
(2005)
Cancer Res.
, vol.65
, pp. 8671-8678
-
-
Yang, L.1
-
76
-
-
30544444184
-
Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
-
W. Qiao, A.G. Li, P. Owens, X. Xu, X.J. Wang, and C.X. Deng Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin Oncogene 25 2006 207 217
-
(2006)
Oncogene
, vol.25
, pp. 207-217
-
-
Qiao, W.1
Li, A.G.2
Owens, P.3
Xu, X.4
Wang, X.J.5
Deng, C.X.6
-
77
-
-
0030800924
-
Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas
-
D. MacGrogan, M. Pegram, D. Slamon, and R. Bookstein Comparative mutational analysis of DPC4 (Smad4) in prostatic and colorectal carcinomas Oncogene 15 1997 1111 1114
-
(1997)
Oncogene
, vol.15
, pp. 1111-1114
-
-
MacGrogan, D.1
Pegram, M.2
Slamon, D.3
Bookstein, R.4
-
78
-
-
42949087886
-
Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer
-
A.A. Aitchison, A. Veerakumarasivam, M. Vias, R. Kumar, F.C. Hamdy, D.E. Neal, and I.G. Mills Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer Prostate 68 2008 661 674
-
(2008)
Prostate
, vol.68
, pp. 661-674
-
-
Aitchison, A.A.1
Veerakumarasivam, A.2
Vias, M.3
Kumar, R.4
Hamdy, F.C.5
Neal, D.E.6
Mills, I.G.7
-
79
-
-
73949160612
-
Epidermal Smad4 deletion results in aberrant wound healing
-
P. Owens, E. Engelking, G. Han, S.M. Haeger, and X.J. Wang Epidermal Smad4 deletion results in aberrant wound healing Am. J. Pathol. 176 2010 122 133
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 122-133
-
-
Owens, P.1
Engelking, E.2
Han, G.3
Haeger, S.M.4
Wang, X.J.5
-
80
-
-
10744224096
-
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice
-
W. Li Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice Development 130 2003 6143 6153
-
(2003)
Development
, vol.130
, pp. 6143-6153
-
-
Li, W.1
-
81
-
-
16044369574
-
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
-
K. Eppert MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma Cell 86 1996 543 552
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
-
82
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
T. Sjoblom The consensus coding sequences of human breast and colorectal cancers Science 314 2006 268 274
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
-
83
-
-
0642306985
-
Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis
-
W. Xie, D.L. Rimm, Y. Lin, W.J. Shih, and M. Reiss Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis Cancer J. 9 2003 302 312
-
(2003)
Cancer J.
, vol.9
, pp. 302-312
-
-
Xie, W.1
Rimm, D.L.2
Lin, Y.3
Shih, W.J.4
Reiss, M.5
-
84
-
-
0032549806
-
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
-
W.R. Waldrip, E.K. Bikoff, P.A. Hoodless, J.L. Wrana, and E.J. Robertson Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo Cell 92 1998 797 808
-
(1998)
Cell
, vol.92
, pp. 797-808
-
-
Waldrip, W.R.1
Bikoff, E.K.2
Hoodless, P.A.3
Wrana, J.L.4
Robertson, E.J.5
-
85
-
-
0032482751
-
Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
-
M. Weinstein, X. Yang, C. Li, X. Xu, J. Gotay, and C.X. Deng Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2 Proc. Natl. Acad. Sci. USA 95 1998 9378 9383
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9378-9383
-
-
Weinstein, M.1
Yang, X.2
Li, C.3
Xu, X.4
Gotay, J.5
Deng, C.X.6
-
86
-
-
0033607183
-
Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis
-
J. Heyer, D. Escalante-Alcalde, M. Lia, E. Boettinger, W. Edelmann, C.L. Stewart, and R. Kucherlapati Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis Proc. Natl. Acad. Sci. USA 96 1999 12595 12600
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12595-12600
-
-
Heyer, J.1
Escalante-Alcalde, D.2
Lia, M.3
Boettinger, E.4
Edelmann, W.5
Stewart, C.L.6
Kucherlapati, R.7
-
87
-
-
0032565859
-
Smad2 role in mesoderm formation, left-right patterning and craniofacial development
-
M. Nomura, and E. Li Smad2 role in mesoderm formation, left-right patterning and craniofacial development Nature 393 1998 786 790
-
(1998)
Nature
, vol.393
, pp. 786-790
-
-
Nomura, M.1
Li, E.2
-
88
-
-
0037108882
-
Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice
-
T. Hamamoto, H. Beppu, H. Okada, M. Kawabata, T. Kitamura, K. Miyazono, and M. Kato Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice Cancer Res. 62 2002 5955 5961
-
(2002)
Cancer Res.
, vol.62
, pp. 5955-5961
-
-
Hamamoto, T.1
Beppu, H.2
Okada, H.3
Kawabata, M.4
Kitamura, T.5
Miyazono, K.6
Kato, M.7
-
89
-
-
0034901345
-
Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2
-
C.A. Muro-Cacho, K. Rosario-Ortiz, S. Livingston, and T. Munoz-Antonia Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2 Clin. Cancer Res. 7 2001 1618 1626
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1618-1626
-
-
Muro-Cacho, C.A.1
Rosario-Ortiz, K.2
Livingston, S.3
Munoz-Antonia, T.4
-
90
-
-
33845683318
-
Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4
-
W. Qiu, F. Schonleben, X. Li, and G.H. Su Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4 Cancer Lett. 245 2007 163 170
-
(2007)
Cancer Lett.
, vol.245
, pp. 163-170
-
-
Qiu, W.1
Schonleben, F.2
Li, X.3
Su, G.H.4
-
91
-
-
77957855880
-
HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
-
K.E. Hoot, M. Oka, G. Han, E. Bottinger, Q. Zhang, and X.J. Wang HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion J. Clin. Invest. 120 2010 3606 3616
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3606-3616
-
-
Hoot, K.E.1
Oka, M.2
Han, G.3
Bottinger, E.4
Zhang, Q.5
Wang, X.J.6
-
92
-
-
2542450984
-
The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice
-
S.H. Tannehill-Gregg, D.F. Kusewitt, T.J. Rosol, and M. Weinstein The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice Vet. Pathol. 41 2004 278 282
-
(2004)
Vet. Pathol.
, vol.41
, pp. 278-282
-
-
Tannehill-Gregg, S.H.1
Kusewitt, D.F.2
Rosol, T.J.3
Weinstein, M.4
-
93
-
-
0029731630
-
Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers
-
K. Uchida, M. Nagatake, H. Osada, Y. Yatabe, M. Kondo, T. Mitsudomi, A. Masuda, and T. Takahashi Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers Cancer Res. 56 1996 5583 5585
-
(1996)
Cancer Res.
, vol.56
, pp. 5583-5585
-
-
Uchida, K.1
Nagatake, M.2
Osada, H.3
Yatabe, Y.4
Kondo, M.5
Mitsudomi, T.6
Masuda, A.7
Takahashi, T.8
-
94
-
-
0042066370
-
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer
-
T.T. Maliekal, M.L. Antony, A. Nair, R. Paulmurugan, and D. Karunagaran Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer Oncogene 22 2003 4889 4897
-
(2003)
Oncogene
, vol.22
, pp. 4889-4897
-
-
Maliekal, T.T.1
Antony, M.L.2
Nair, A.3
Paulmurugan, R.4
Karunagaran, D.5
-
95
-
-
0033606964
-
Smad2 and Smad4 gene mutations in hepatocellular carcinoma
-
M.C. Yakicier, M.B. Irmak, A. Romano, M. Kew, and M. Ozturk Smad2 and Smad4 gene mutations in hepatocellular carcinoma Oncogene 18 1999 4879 4883
-
(1999)
Oncogene
, vol.18
, pp. 4879-4883
-
-
Yakicier, M.C.1
Irmak, M.B.2
Romano, A.3
Kew, M.4
Ozturk, M.5
-
96
-
-
77956546075
-
SMAD2 is essential for TGF beta-mediated Th17 cell generation
-
N. Malhotra, E. Robertson, and J. Kang SMAD2 is essential for TGF beta-mediated Th17 cell generation J. Biol. Chem. 285 2010 29044 29048
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 29044-29048
-
-
Malhotra, N.1
Robertson, E.2
Kang, J.3
-
97
-
-
77956552342
-
Smad2 positively regulates the generation of Th17 cells
-
G.J. Martinez Smad2 positively regulates the generation of Th17 cells J. Biol. Chem. 285 2010 29039 29043
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 29039-29043
-
-
Martinez, G.J.1
-
98
-
-
32044468317
-
B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate
-
J. Klein B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate J. Immunol. 176 2006 2389 2396
-
(2006)
J. Immunol.
, vol.176
, pp. 2389-2396
-
-
Klein, J.1
-
99
-
-
79956327468
-
Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice
-
L. Wang Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice J. Biol. Chem. 286 2011 18766 18774
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 18766-18774
-
-
Wang, L.1
-
100
-
-
77956548300
-
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
-
X.M. Meng Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis J. Am. Soc. Nephrol. 21 2010 1477 1487
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 1477-1487
-
-
Meng, X.M.1
-
101
-
-
77953668555
-
Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
-
S. Rajanahally, J.E. Agno, R.L. Nalam, M.B. Weinstein, K.L. Loveland, M.M. Matzuk, and Q. Li Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice Reprod. Biol. Endocrinol. 8 2010 69
-
(2010)
Reprod. Biol. Endocrinol.
, vol.8
, pp. 69
-
-
Rajanahally, S.1
Agno, J.E.2
Nalam, R.L.3
Weinstein, M.B.4
Loveland, K.L.5
Matzuk, M.M.6
Li, Q.7
-
102
-
-
30644479959
-
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
-
W. Ju, A. Ogawa, J. Heyer, D. Nierhof, L. Yu, R. Kucherlapati, D.A. Shafritz, and E.P. Bottinger Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation Mol. Cell. Biol. 26 2006 654 667
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 654-667
-
-
Ju, W.1
Ogawa, A.2
Heyer, J.3
Nierhof, D.4
Yu, L.5
Kucherlapati, R.6
Shafritz, D.A.7
Bottinger, E.P.8
-
103
-
-
79251602475
-
Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
-
I.M. van de Laar Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis Nat. Genet. 43 2011 121 126
-
(2011)
Nat. Genet.
, vol.43
, pp. 121-126
-
-
Van De Laar, I.M.1
-
105
-
-
0033050721
-
Expression of Smad proteins in human colorectal cancer
-
O. Korchynskyi, M. Landstrom, R. Stoika, K. Funa, C.H. Heldin, P. ten Dijke, and S. Souchelnytskyi Expression of Smad proteins in human colorectal cancer Int. J. Cancer 82 1999 197 202
-
(1999)
Int. J. Cancer
, vol.82
, pp. 197-202
-
-
Korchynskyi, O.1
Landstrom, M.2
Stoika, R.3
Funa, K.4
Heldin, C.H.5
Ten Dijke, P.6
Souchelnytskyi, S.7
-
106
-
-
79951626443
-
Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis
-
S. Kawamata, K. Matsuzaki, M. Murata, T. Seki, K. Matsuoka, Y. Iwao, T. Hibi, and K. Okazaki Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis Inflamm. Bowel Dis. 17 2011 683 695
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 683-695
-
-
Kawamata, S.1
Matsuzaki, K.2
Murata, M.3
Seki, T.4
Matsuoka, K.5
Iwao, Y.6
Hibi, T.7
Okazaki, K.8
-
107
-
-
0032544448
-
Smad3 mutant mice develop metastatic colorectal cancer
-
Y. Zhu, J.A. Richardson, L.F. Parada, and J.M. Graff Smad3 mutant mice develop metastatic colorectal cancer Cell 94 1998 703 714
-
(1998)
Cell
, vol.94
, pp. 703-714
-
-
Zhu, Y.1
Richardson, J.A.2
Parada, L.F.3
Graff, J.M.4
-
108
-
-
0032934979
-
Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
-
M.B. Datto, J.P. Frederick, L. Pan, A.J. Borton, Y. Zhuang, and X.F. Wang Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction Mol. Cell. Biol. 19 1999 2495 2504
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2495-2504
-
-
Datto, M.B.1
Frederick, J.P.2
Pan, L.3
Borton, A.J.4
Zhuang, Y.5
Wang, X.F.6
-
109
-
-
31544465904
-
Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice
-
L. Maggio-Price, P. Treuting, W. Zeng, M. Tsang, H. Bielefeldt-Ohmann, and B.M. Iritani Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice Cancer Res. 66 2006 828 838
-
(2006)
Cancer Res.
, vol.66
, pp. 828-838
-
-
Maggio-Price, L.1
Treuting, P.2
Zeng, W.3
Tsang, M.4
Bielefeldt-Ohmann, H.5
Iritani, B.M.6
-
110
-
-
33749008552
-
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice
-
N.M. Sodir Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice Cancer Res. 66 2006 8430 8438
-
(2006)
Cancer Res.
, vol.66
, pp. 8430-8438
-
-
Sodir, N.M.1
-
111
-
-
33745661630
-
Lack of activated Smad2 in transforming growth factor-beta signaling is an unfavorable prognostic factor in patients with esophageal squamous cell carcinoma
-
M. Fukuchi Lack of activated Smad2 in transforming growth factor-beta signaling is an unfavorable prognostic factor in patients with esophageal squamous cell carcinoma J. Surg. Oncol. 94 2006 51 56
-
(2006)
J. Surg. Oncol.
, vol.94
, pp. 51-56
-
-
Fukuchi, M.1
-
112
-
-
0037742433
-
Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
-
K. Vijayachandra, J. Lee, and A.B. Glick Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model Cancer Res. 63 2003 3447 3452
-
(2003)
Cancer Res.
, vol.63
, pp. 3447-3452
-
-
Vijayachandra, K.1
Lee, J.2
Glick, A.B.3
-
113
-
-
7444272649
-
Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis
-
A.G. Li, S.L. Lu, M.X. Zhang, C. Deng, and X.J. Wang Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis Cancer Res. 64 2004 7836 7845
-
(2004)
Cancer Res.
, vol.64
, pp. 7836-7845
-
-
Li, A.G.1
Lu, S.L.2
Zhang, M.X.3
Deng, C.4
Wang, X.J.5
-
114
-
-
65649153346
-
Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3
-
D.S. Bae, N. Blazanin, M. Licata, J. Lee, and A.B. Glick Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3 Mol. Carcinog. 48 2009 441 453
-
(2009)
Mol. Carcinog.
, vol.48
, pp. 441-453
-
-
Bae, D.S.1
Blazanin, N.2
Licata, M.3
Lee, J.4
Glick, A.B.5
-
115
-
-
0033195998
-
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
-
G.S. Ashcroft Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response Nat. Cell Biol. 1 1999 260 266
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 260-266
-
-
Ashcroft, G.S.1
-
116
-
-
70349310420
-
Acceleration of palatal wound healing in Smad3-deficient mice
-
K. Jinno, T. Takahashi, K. Tsuchida, E. Tanaka, and K. Moriyama Acceleration of palatal wound healing in Smad3-deficient mice J. Dent. Res. 88 2009 757 761
-
(2009)
J. Dent. Res.
, vol.88
, pp. 757-761
-
-
Jinno, K.1
Takahashi, T.2
Tsuchida, K.3
Tanaka, E.4
Moriyama, K.5
-
117
-
-
52649124170
-
Smad3 knockout mice exhibit impaired intestinal mucosal healing
-
C.R. Owen, L. Yuan, and M.D. Basson Smad3 knockout mice exhibit impaired intestinal mucosal healing Lab. Invest. 88 2008 1101 1109
-
(2008)
Lab. Invest.
, vol.88
, pp. 1101-1109
-
-
Owen, C.R.1
Yuan, L.2
Basson, M.D.3
-
118
-
-
80051488277
-
Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)
-
E. Tram, I. Ibrahim-Zada, L. Briollais, J.A. Knight, I.L. Andrulis, and H. Ozcelik Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR) Breast Cancer Res. 13 2011 R77
-
(2011)
Breast Cancer Res.
, vol.13
, pp. 77
-
-
Tram, E.1
Ibrahim-Zada, I.2
Briollais, L.3
Knight, J.A.4
Andrulis, I.L.5
Ozcelik, H.6
-
119
-
-
79960456699
-
Expression and clinical significance of the transforming growth factor-beta signalling pathway in endometrial cancer
-
P. Mhawech-Fauceglia, J. Kesterson, D. Wang, S. Akers, N.C. Dupont, K. Clark, S. Lele, and S. Liu Expression and clinical significance of the transforming growth factor-beta signalling pathway in endometrial cancer Histopathology 59 2011 63 72
-
(2011)
Histopathology
, vol.59
, pp. 63-72
-
-
Mhawech-Fauceglia, P.1
Kesterson, J.2
Wang, D.3
Akers, S.4
Dupont, N.C.5
Clark, K.6
Lele, S.7
Liu, S.8
-
120
-
-
1442332673
-
Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
-
S.U. Han, H.T. Kim, D.H. Seong, Y.S. Kim, Y.S. Park, Y.J. Bang, H.K. Yang, and S.J. Kim Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer Oncogene 23 2004 1333 1341
-
(2004)
Oncogene
, vol.23
, pp. 1333-1341
-
-
Han, S.U.1
Kim, H.T.2
Seong, D.H.3
Kim, Y.S.4
Park, Y.S.5
Bang, Y.J.6
Yang, H.K.7
Kim, S.J.8
-
121
-
-
0036348541
-
Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors
-
T.M. Shattuck, J. Costa, M. Bernstein, R.T. Jensen, D.C. Chung, and A. Arnold Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors J. Clin. Endocrinol. Metab. 87 2002 3911 3914
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 3911-3914
-
-
Shattuck, T.M.1
Costa, J.2
Bernstein, M.3
Jensen, R.T.4
Chung, D.C.5
Arnold, A.6
-
122
-
-
3442886238
-
Loss of Smad3 in acute T-cell lymphoblastic leukemia
-
L.A. Wolfraim Loss of Smad3 in acute T-cell lymphoblastic leukemia N. Engl. J. Med. 351 2004 552 559
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 552-559
-
-
Wolfraim, L.A.1
-
123
-
-
33744801153
-
Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
-
Y.A. Yang, G.M. Zhang, L. Feigenbaum, and Y.E. Zhang Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2 Cancer Cell 9 2006 445 457
-
(2006)
Cancer Cell
, vol.9
, pp. 445-457
-
-
Yang, Y.A.1
Zhang, G.M.2
Feigenbaum, L.3
Zhang, Y.E.4
-
124
-
-
34548386862
-
SMAD3 regulates gonadal tumorigenesis
-
Q. Li, J.M. Graff, A.E. O'Connor, K.L. Loveland, and M.M. Matzuk SMAD3 regulates gonadal tumorigenesis Mol. Endocrinol. 21 2007 2472 2486
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 2472-2486
-
-
Li, Q.1
Graff, J.M.2
O'Connor, A.E.3
Loveland, K.L.4
Matzuk, M.M.5
-
125
-
-
0036304111
-
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
-
M. Oft, R.J. Akhurst, and A. Balmain Metastasis is driven by sequential elevation of H-ras and Smad2 levels Nat. Cell Biol. 4 2002 487 494
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 487-494
-
-
Oft, M.1
Akhurst, R.J.2
Balmain, A.3
-
126
-
-
33745778678
-
Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomas
-
D. Zhong Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomas Cancer Biol. Ther. 5 2006 601 607
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 601-607
-
-
Zhong, D.1
-
127
-
-
0029933642
-
Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers
-
M. Nagatake, Y. Takagi, H. Osada, K. Uchida, T. Mitsudomi, S. Saji, K. Shimokata, and T. Takahashi Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers Cancer Res. 56 1996 2718 2720
-
(1996)
Cancer Res.
, vol.56
, pp. 2718-2720
-
-
Nagatake, M.1
Takagi, Y.2
Osada, H.3
Uchida, K.4
Mitsudomi, T.5
Saji, S.6
Shimokata, K.7
Takahashi, T.8
-
128
-
-
18244404839
-
Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma
-
A. Baez, A. Cantor, S. Fonseca, M. Marcos-Martinez, L.A. Mathews, C.A. Muro-Cacho, and T. Munoz-Antonia Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma Clin. Cancer Res. 11 2005 3191 3197
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 3191-3197
-
-
Baez, A.1
Cantor, A.2
Fonseca, S.3
Marcos-Martinez, M.4
Mathews, L.A.5
Muro-Cacho, C.A.6
Munoz-Antonia, T.7
-
129
-
-
0033871565
-
Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma
-
E. Heinmoller, W. Dietmaier, H. Zirngibl, P. Heinmoller, W. Scaringe, K.W. Jauch, F. Hofstadter, and J. Ruschoff Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma Am. J. Pathol. 157 2000 83 92
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 83-92
-
-
Heinmoller, E.1
Dietmaier, W.2
Zirngibl, H.3
Heinmoller, P.4
Scaringe, W.5
Jauch, K.W.6
Hofstadter, F.7
Ruschoff, J.8
-
130
-
-
0033869735
-
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma
-
T. Yatsuoka Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma Am. J. Gastroenterol. 95 2000 2080 2085
-
(2000)
Am. J. Gastroenterol.
, vol.95
, pp. 2080-2085
-
-
Yatsuoka, T.1
-
131
-
-
0032889954
-
Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer
-
T. Jonson, L. Gorunova, S. Dawiskiba, A. Andren-Sandberg, G. Stenman, P. ten Dijke, B. Johansson, and M. Hoglund Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer Genes Chromosomes Cancer 24 1999 62 71
-
(1999)
Genes Chromosomes Cancer
, vol.24
, pp. 62-71
-
-
Jonson, T.1
Gorunova, L.2
Dawiskiba, S.3
Andren-Sandberg, A.4
Stenman, G.5
Ten Dijke, P.6
Johansson, B.7
Hoglund, M.8
-
132
-
-
2442533068
-
The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome
-
T. Toga, Y. Nio, K. Hashimoto, T. Higami, and R. Maruyama The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome Anticancer Res. 24 2004 1173 1178
-
(2004)
Anticancer Res.
, vol.24
, pp. 1173-1178
-
-
Toga, T.1
Nio, Y.2
Hashimoto, K.3
Higami, T.4
Maruyama, R.5
-
133
-
-
0035004797
-
Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
-
J. Luttges, H. Galehdari, V. Brocker, I. Schwarte-Waldhoff, D. Henne-Bruns, G. Kloppel, W. Schmiegel, and S.A. Hahn Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis Am. J. Pathol. 158 2001 1677 1683
-
(2001)
Am. J. Pathol.
, vol.158
, pp. 1677-1683
-
-
Luttges, J.1
Galehdari, H.2
Brocker, V.3
Schwarte-Waldhoff, I.4
Henne-Bruns, D.5
Kloppel, G.6
Schmiegel, W.7
Hahn, S.A.8
-
134
-
-
0035893388
-
Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia
-
A.V. Biankin Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia Cancer Res. 61 2001 8830 8837
-
(2001)
Cancer Res.
, vol.61
, pp. 8830-8837
-
-
Biankin, A.V.1
-
135
-
-
0036894028
-
DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma
-
A.V. Biankin DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma J. Clin. Oncol. 20 2002 4531 4542
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4531-4542
-
-
Biankin, A.V.1
-
136
-
-
0348227997
-
Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
-
Z. Hua, Y.C. Zhang, X.M. Hu, and Z.G. Jia Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma World J. Gastroenterol. 9 2003 2764 2767
-
(2003)
World J. Gastroenterol.
, vol.9
, pp. 2764-2767
-
-
Hua, Z.1
Zhang, Y.C.2
Hu, X.M.3
Jia, Z.G.4
-
137
-
-
24044507297
-
Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer
-
A.A. Khorana, Y.C. Hu, C.K. Ryan, R.A. Komorowski, G. Hostetter, and S.A. Ahrendt Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer J. Gastrointest. Surg. 9 2005 903 911
-
(2005)
J. Gastrointest. Surg.
, vol.9
, pp. 903-911
-
-
Khorana, A.A.1
Hu, Y.C.2
Ryan, C.K.3
Komorowski, R.A.4
Hostetter, G.5
Ahrendt, S.A.6
|