Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers

Cancer Research

Volumn 56, Issue 12, 1996, Pages 2718-2720

  Nagatake, Masaaki ^a,b   Takagi, Yukihiro ^a,c   Osada, Hirotaka ^a   Uchida, Kosaku ^a   Mitsudomi, Tetsuya ^a   Saji, Shigetoyo ^c   Shimokata, Kaoru ^b   Takahashi, Toshitada ^a   Takahashi, Takashi ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CHROMOSOME 18Q; CHROMOSOME DELETION; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; MISSENSE MUTATION; MUTATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CHROMOSOMES, HUMAN, PAIR 18; DNA-BINDING PROTEINS; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTEINS; SEQUENCE ANALYSIS, DNA; SMAD4 PROTEIN; TRANS-ACTIVATORS;

EID: 0029933642     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Naylor, S., Johnson, B , Minna, J , and Sakaguchi, A. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature (Lond.), 329: 451-454, 1987
2. Harbour, J. W., Lai, S-L., Whang-Peng, J., Gazdar, A. F., Minna, J. D , and Kaye, F J Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science (Washington DC), 241: 353-357, 1988.
3. Takahashi, T., Nau, M. M., Chiba, I., Birrer, M. J , Rosenberg, R. K , Vinocour, M., Levitt, M , Pass, H., Gazdar, A. F., and Minna, J. D p53, a frequent target for genetic abnormalities in lung cancer Science (Washington DC), 246: 491-494, 1989.
4. Hibi, K., Takahashi, T , Yamakawa, K , Ueda, R., Sekido, Y., Ariyoshi, Y , Suyama, M , Takagi, H., Kakamura, Y , and Takahashi, T Three distinct regions involved in 3p deletion in human lung cancer Oncogene, 7: 445-449, 1992.
5. Kamb, A., Gruis, N A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavugian, S. V , Stockert, E., Day, R S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
6. Washimi, O., Nagatake, M., Osada, H , Ueda, R., Koshikawa, T., Seki, T., Takahashi, T., and Takahashi, T. In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res., 55: 514-517, 1995
7. Shiseki, M., Kohno, T., Nishikawa, R., Sameshima, Y., Mizoguchi, H., and Yokota, J. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. Cancer Res., 54: 5643-5648, 1994.
8. Nagatake, M , Osada, H , Kondo, M , Uchida, K., Nishio, M., Shimokata, K., Takahashi, T., and Takahashi, T. Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers Cancer Res., 56: 1886-1891, 1996.
9. Vogelstein, B., Fearon, E., Kern, S., Hamilton, S., Preisinger, A., Nakamura, Y., and White, R. Allelotype of colorectal carcinomas. Science (Washington DC), 244: 207-211, 1989.
10. Cliby, W., Ritland, S , Hartmann, L., Dodson, M., Halling, K. C., Keeney, G., Podrats, K. C., and Jenkins, R. B. Human epithelial ovarian cancer allelotype. Cancer Res., 53: 2393-2398, 1993.
11. Brewster, S. F , Gingell, J. C., Browne, S., and Brown, K W. Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder Br. J. Cancer, 70: 697-700, 1994.
12. Shibagaki, I , Shimada, Y., Wagata, T., Ikenaga, M , Imamura, M , and Ishigaki, K. Allelotype analysis of esophageal squamous cell carcinoma Cancer Res , 54: 2996-3000, 1994
13. Hahn, S A , Seumour, A. B., Hoque, A. T. M. S., Schutte, M., da Costa, L. T., Redston, M. S., Caldas, C., Weinstein, C. L , Fischer, A., Yeo, C. J., Hruban, R. H , and Kern, S. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res., 55: 4670-4675, 1995.
14. Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton. S. R., Preisinger, A C., Thomas, G., Kinzler, K W , and Vogelstein, B Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (Washington DC), 247: 49-56, 1990.
15. Hahn, S. A., Schutte, M., Hoque, A. T. M. S , Moskaluk, C. A., da Costa, L T , Rozenblum, E , Weinstein, C L., Fischer, A., Yeo, C. J , Hruban, R. H., and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Washington DC), 271: 350-353, 1996.
16. Masui, T., Wakefield, L. M., Lechner, J. F., LaVeck, M. A., Sporn, M B., and Harris, C. C. Type β transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells Proc Natl. Acad. Sci. USA, 83: 2438-2442, 1986.
17. Hibi, K , Yamakawa, K., Ueda, R., Mono, Y , Murata, Y., Tamari, M., Uchida, K., Takahashi, T., Nakamura, Y., and Takahashi, T. Aberrant upregulation of a novel integrin α subunit gene at 3p21 3 in small cell lung cancer. Oncogene, 9: 611-619, 1994
18. Suzuki, H., Takahashi, T., Kuroishi, T., Suyama, M., Anyoshi, Y., Takahashi, T., and Ueda, R. p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. Cancer Res , 52 734-736, 1992.
19. Maquat, L E., Kinniburgh, A. J , Rachmilewitz, E. A., and Ross, J. Unstable β-globin mRNA in mRNA-deficient β° thalassemia. Cell, 27, 543-553, 1981.
20. Daar, I O , and Maquat, L. E. Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol. Cell Biol , 8: 802-813, 1988.