Expression of smad proteins in human colorectal cancer

International Journal of Cancer

Volumn 82, Issue 2, 1999, Pages 197-202

  Korchynskyi, Olexander ^a,b   Landström, Maréne ^a   Stoika, Rostyslav ^b   Funa, Keiko ^c   Heldin, Carl Henrik ^a   Ten Dijke, Peter ^a   Souchelnytskyi, Serhiy ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b INSTITUTE OF HYDROBIOLOGY   (Ukraine)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; CARCINOEMBRYONIC ANTIGEN; CARCINOMA; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, APC; GENES, DCC; HUMANS; IN SITU NICK-END LABELING; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033050721     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990719)82:2<197::AID-IJC8>3.0.CO;2-V     Document Type: Article

References (22)

1. ATFI, A., BUISINE, M., MAZARS, A. and GESPACH, C., Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J. biol. Chem., 272, 24731-24734 (1997).
2. AVERY, A., PARASKEVA, C., HALL, P., FLANDERS, K.C., SPORN, M. and MOORGHEN, M., TGF-β expression in the human colon: differential immunostaining along crypt epithelium. Brit. J. Cancer, 68, 137-139 (1993).
3. COTRAN, R.S., ROBBINS, S.L. and KUMAR, V., The gastrointestinal tract. In: Robbins ' pathologic basis of disease (5th ed.), pp. 784-785, W.B. Saunders, Philadelphia (1994).
4. DERYNCK, R. and FENG, X.-H., TGF-β receptor signaling. Biochim. Biophys. Acta, 1333, F105-F150 (1997).
5. FEARON, E.R., CHO, K.R., NIGRO, J.M., KERN, S.E., SIMONS, J.W., RUPPERT, J.M., HAMILTON, S.R., PREISINGER, A.C., THOMAS, G., KINZLER, K.W. and VOGELSTEIN, B., Identification of a chromosome 18q gene that is altered in colorectal cancers. Science, 247, 49-56 (1990).
6. FILIPE, M.I., Transitional mucosa. Histopathohgy, 8, 707-708 (1984).
7. HELDIN, C.-H., MIYAZONO, K. and TEN DIJKE, P., TGF-β signaling from cell membrane to nucleus via Smad proteins. Nature (Loud.), 390, 465-471 (1997).
8. HOGAN, B., BEDDINGTON, R., COSTANTINI, F. and LACY, E., Manipulating the mouse embryo (2nd ed.), pp. 330-335, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1994).
9. KINZLER, K.W. and VOGELSTEIN, B., Lessons from hereditary colorectal cancer. Cell, 87, 159-170 (1996).
10. LAHM, H. and ODARTCHENKO, N., Role of transforming growth factor β in colorectal cancer. Growth Factors, 9, 1-9 (1993).
11. MANNING, A.M., WILLIAMS, A.C., GAME, S.M. and PARASKEVA, C., Differential sensitivity of human colonic adenoma and carcinoma cells to TGF-β: conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-β. Oncogene, 6, 1471-1476 (1991).
12. MASSAGUÉ, J., TGF-β signal transduction. Ann. Rev. Biochem., 67, 753-791 (1998).
13. MORIN, P.J., VOGELSTEIN, B. and KINZLER, K.W., Apoptosis and APC in colorectal tumorigenesis. Proc. natl. Acad. Sci. (Wash.), 93, 7950-7954 (1996).
14. NAKAO, A., IMAMURA, T., SOUCHELNYTSKYI, S., HEUCHEL, R., KAWABATA, M., ISHISAKI, A., OEDA, E., TAMAKI, K., HANAI, J.-I., HELDIN, C.-H., MIYAZONO, K. and TEN DIJKE, P., TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J., 16, 5353-5362 (1997).
15. RIGGINS, G.J., THIAGALINGAM, S., ROZENBLUM, E., WEISTEIN, C.L., KERN, S.E., HAMILTON, S.R., WILLSON, J.K.V., MARKOVITZ, S.D., KINZLER, K.W. and VOGELSTEIN, B., Mad-related genes in the human. Nature (Genet.), 13, 347-349 (1996).
16. ROBERTS, A.B. and SPORN, M.B., The transforming growth factor-β's, In: M.B. Sporn and A.B. Roberts (eds.), Handbook of experimental pharmacology. Peptide growth factors and their receptors, vol. 95, pp. 419-472, Springer, New York (1990).
17. SMITH, K.J., JOHNSON, K.A., BRYAN, T.M., HILL, D.E., MARKOVITZ, S., WILLSON, J.K., PARASKEVA, C., PETERSEN, G.M., HAMILTON, S.R., VOGELSTEIN, B. and KINZLER, K.W., The APC gene product in normal and tumor cells. Proc. natl. Acad. Sci. (Wash.), 90, 2846-2850 (1993).
18. SMYRK, T. and LYNCH, H.T., Colorectal cancer: molecular and cellular abnormalities. In: J.R. Bertino (ed.), Encyclopedia of cancer, vol. 1, pp. 451-463, Academic Press, San Diego (1997).
19. TAKAKU, K., OSHIMA, M., MIYOSHI, H., MATSUI, M., SELDIN, M.F. and TAKETO, M.M., Intestinal tumorigenesis in compound mutant mice of both Dpc-4 (Smad4) and APC genes. Cell, 92, 645-656 (1998).
20. TAMAKI, K., SOUCHELNYTSKYI, S., ITOH, S., NAKAO, A., SAMPATH, K., HELDIN, C.-H. and TEN DIJKE, P., Intracellular signaling of osteogenic protein-1 through Smad5 activation. J. Cell Physiol., 177, 355-363 (1998).
21. UNION INTERNATIONALE CONTRE LE CANCER (UICC), TNM classification of malignant tumors (4th ed.), Springer, Berlin (1987).
22. YANAGISAWA, K., OSADA, H., MASUDA, A., KONDO, M., SAITO, T., YATABE, Y., TAKAGI, K., TAKAHASHI, T. and TAKAHASHI, T., Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells. Oncogene, 17, 1743-1747 (1998).