MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma

Japanese Journal of Cancer Research

Volumn 88, Issue 4, 1997, Pages 340-343

  Maesawa, Chihaya ^a   Tamura, Gen ^a   Nishizuka, Satoshi ^a   Iwaya, Takeshi ^a   Ogasawara, Satoshi ^a   Ishida, Kaoru ^a   Sakata, Ken ^a   Sato, Nobuhiro ^a   Ikeda, Kenichiro ^a   Kimura, Yusuke ^a   Saito, Kazuyoshi ^a   Satodate, Ryoichi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Esophageal carcinoma; Mutation; Smad2; Smad4; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CHROMOSOME 18Q; CLINICAL ARTICLE; ESOPHAGUS CARCINOMA; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0031006336     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00386.x     Document Type: Article

References (23)

1. Filmus, J. and Kerbel, R. S. Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-β during tumor progression. Curr. Opin. Oncol., 5, 123-129 (1993).
2. Roberts, A. B. and Sporn, M. B. Physiological actions and clinical applications of transforming growth factor-β (TGFβ). Growth Factors, 8, 1-9 (1993).
3. Raftery, L. A., Twombly, V., Wharton, K. and Gelbart, W. M. Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics, 139, 241-245 (1995).
4. Sekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H. and Gelbart, W. M. Genetic characterization and cloning of Mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics, 139, 1347-1358 (1995).
5. Savage, C., Das, P., Finelli, A., Townsend, S., Sun, C., Baird, S. and Padgett, R. The C. elegans sam-2, sam-3 and sam-4 genes define a novel conserved family of TGFβ pathway components. Proc. Natl. Acad. Sci. USA, 93, 790-794 (1995).
6. Graff, J. M., Bansal, A. and Melton, D. A. Xenopus Mad proteins transduce distinct subsets of signaling for the TGFβ superfamily. Cell, 85, 479-487 (1996).
7. Hahn, S. A., Schutte, M., Hoque, A. T. M. S., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fisher, A., Yeo, C. J., Hruban, R. H. and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science, 271, 350-353 (1996).
8. Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M. B., Attisano, L. and Wrana, J. L. MADR1, a MAD-related protein that functions in BMP signaling pathways. Cell, 85, 489-500 (1996).
9. Liu, F., Hata, A., Baker, J. C., Doody, J., Carcamo, J., Harland, R. M. and Massague, J. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature, 381, 620-623 (1996).
10. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W. and Vogelstein, B. MAD-related genes in the human. Nat. Genet., 13, 347-349 (1996).
11. Eppert, K., Schrer, S.W., Ozcelik, H., Pirone, R., Hoodles, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I. L., Thosen, G. H., Warana, J. L. and Attisano, L. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD related protein that is functionally mutated in colorectal carcinoma. Cell 86, 543-552 (1996).
12. Derynck, R., Gelbart, W. M., Harland, R. M., Heldin, C.-H., Kern, S. E., Massague, J., Melton, D. A., Mlodzik, M., Padgett, R. W., Roberts, A. B., Smith, J., Thomsen, G. H., Vogelstein, B. and Wang, X.-F. Nomenclature: vertebrate mediators of TGFβ family signals. Cell, 87, 173 (1996).
13. Schutte, M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., Sidransky, D., Casero, Jr. R. A., Meltzer, P. S., Hahn, S. A. and Kern, S. E. DPC4 gene in various tumor types. Cancer Res., 56, 2527-2530 (1996).
14. Kim, S. K., Fan, Y., Papadimitrakopoulou, V., Clayman, G., Hittelman, W. N., Hong, W. K., Lotan, R. and Mao, L. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res., 56, 2519-2521 (1996).
15. Ogasawara, S., Tamura, G., Maesawa, C., Suzuki, Y., Ishida, K., Sato, N., Uesugi, N., Saito, K. and Satodate, R. Common deleted region on the long arm of chromosome 5 in esophageal carcinoma. Gastroenterology, 110, 52-57 (1996).
16. Maesawa, C., Tamura, G., Ogasawara, S., Suzuki, Y., Sakata, K., Sugimura, J., Nishizuka, S., Sato, N., Ishida, K., Saito, K. and Satodate, R. Loss of heterozygosity at the DCC gene locus is not crucial for the acquisition of metastatic potential in oesophageal squamous cell carcinoma. Eur. J. Cancer, 32A, 896-898 (1996).
17. Maesawa, C., Tamura, G., Nishizuka, S., Ogasawara, S., Ishida, K., Terashima, M., Sakata, K., Sato, N., Saito, K. and Satodate, R. Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma. Cancer Res., 56, 3875-3878 (1996).
18. Hayashi, K. PCR-SSCP: a simple and sensitive method for detection of mutations. Gene PCR Methods Appl., 1, 34-38 (1991).
19. Barrett, M. T., Schutte, M., Kern, S. E. and Reid, B. J. Allelic loss and mutational analysis of DPC4 gene in esophageal adenocarcinoma. Cancer Res., 56, 4351-4353 (1996).
20. Uchida, K., Nagatake, M., Osada, H., Yatabe, Y., Kondo, M., Mitsudomi, T., Masuda, A., Takahashi, To. and Takahashi, Ta. Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Res., 56, 5583-5585 (1996).
21. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M. and Willson, J. K. W. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science, 268, 1336-1338 (1995).
22. Garrigue-Antar, L. G., Souza, R. F., Vellucci, V. F., Meltzer, S. J. and Reiss, M. Loss of transforming growth factor-β type II receptor gene expression in primary human esophageal cancer. Lab. Invest., 75, 263-272 (1996).
23. Tamura, G., Ogasawara, S., Nishizuka, S., Sakata, K., Maesawa, C., Suzuki, Y., Terashima, M., Saito, K. and Satodate, R. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach. Cancer Res., 56, 612-615 (1996).