Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma

World Journal of Gastroenterology

Volumn 9, Issue 12, 2003, Pages 2764-2767

  Hua, Zhan ^a   Zhang, Yuan Chun ^b   Hu, Xiao Ming ^b   Jia, Zhen Geng ^b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; SMAD4 PROTEIN; TRANSACTIVATOR PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CHROMOSOME 18; CHROMOSOME MAP; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MALE; MORTALITY; MUTATION; ONCOLOGICAL PARAMETERS; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PANCREAS CYST; PANCREAS TUMOR; PATHOLOGY; PROGNOSIS; PROTEIN EXPRESSION; REFERENCE VALUE; STATISTICAL SIGNIFICANCE; SURVIVAL; TUMOR SUPPRESSOR GENE;

EID: 0348227997     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i12.2764     Document Type: Article

References (26)

1. Bramhall SR, Allum WH, Jones AG, Allwood A, Cummins C, Neoptolemos JP. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study. Br J Surg 1995; 85: 111-115
2. Yeo CJ, Cameron JL. Prognostic factors in ductal pancreatic cancer. Langenbecks Arch Surg 1998; 383: 129-133
3. Hruban RH, van Mansfeld AD, Offerhaus GJ, van Weering DH, Allison DC, Goodman SN, Kensler TW, Bose KK, Cameron JL, Bos JL. K-eras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993; 143: 545-554
4. Robinson RA. K-ras mutations and the diagnosis of pancreatic carcinoma. Am J Clin Pathol 1996; 105: 257-259
5. Safran H, Steinhoff M, Mangray S, Rathore R, King TC, Chai L, Berzein K, Moore T, Iannitti D, Reiss P, Pasquariello T, Akerman P, Quirk D, Mass R, Goldstein L, Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol 2001; 24: 496-499
6. Hu YX, Watanabe H, Ohtsubo K, Yamaguchi Y, Ha A, Okai T, Sawabu N. Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res 1997; 3: 1473-1477
7. Li Y, Bhuiyan M, Vaitkevicius VK, Sarkar FH. Molecular analysis of the p53 gene in pancreatic adenocarcinoma. Diagn Mol Pathol 1998; 7: 4-9
8. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271: 350-353
9. Dai JL, Turnacioglu KK, Schutte M, Sugar AY, Kern SE. Dpc4 transcriptional activation and dysfunction in cancer cells. Cancer Res 1998; 58: 4592-4597
10. Maesawa C, Tamura G, Nishizuka S, Iwaya T, Ogasawara S, Ishida K, Sakata K, Sato N, Ikeda K, Kimura Y, Saito K, Satodate R. MAD-related gene on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma. Jpn J Cancer Res 1997; 88: 340-343
11. Lei J, Zou TT, Zhi YQ, Zhou X, Smolinski KN, Yin J, Souza RF, Appel R, Wang S, Cymes K, Chan O, Abraham JM, Harpaz N, Meltzer SJ. Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms. Oncogene 1996; 13: 2459-2462
12. Nishizuka S, Tamura G, Maesawa C, Sakata K, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R. Analysis of the DPC4 gene in gastric carcinoma. Jpn J Cancer Res 1997; 88: 335-339
13. Kim SS, Fan Y, Papadimitrakopoulou V, Clayman G, Hittelman WN, Hong WK, Lotan R, Mao L. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. Cancer Res 1996; 56: 2519-2521
14. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA Jr, Meltzer PS, Hahn SA, Kern SE. DPC4 gene in various tumor types. Cancer Res 1996; 56: 2527-2530
15. Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S. Somatic alteractions of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 1996; 111: 1369-1372
16. Hahn SA, Bartsch D, Schroersi A, Galehdari H, Becker M, Ramaswamy A, Schwarte-Waldhoff I, Maschek H, Schmiegel W. Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. Cancer Res 1998; 58: 1124-1126
17. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE, Hruban RH. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation. Am J Pathol 2000; 156: 37-43
18. Tascilar M, Skinner HG, Rosty C, Sohn T, Wilentz RE, Offerhaus GJ, Adsay V, Abrams RA, Cameron JL, Kern SE, Yeo CJ, Hruban RH, Goggins M. The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res 2001; 7: 415-4121
19. Klöppel G. Pancreatic non-endocrine tumors. In: Klöppel G, Heitz PU ed. Pancreatic Pathology. Edinburg: Churchill Livingstone 1984: 79-113
20. Hermanek P, Sobin LH. UICC TNM Classification of Malignant Tumors. 4th ed. 2nd Revision. Berlin: Springer-Verlag 1992: 71-73
21. Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 1996; 383: 168-172
22. Chiao PJ, Hunt KK, Grau AM, Abramian A, Fleming J, Zhang W, Breslin T, Abbruzzese JL, Evans DB. Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. Ann N Y Acad Sci 1999; 880: 31-37
23. Shi Y, Hata A, Lo RS, Massague J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 1997; 388: 87-93
24. De Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ. Characterization of functional domains within Smad4/DPC4. J Biol Chem 1997; 272: 13690-13696
25. Moore PS, Orlandini S, Zamboni G, Capelli P, Rigaud G, Falconi M, Bassi C, Lemoine NR, Scarpa A. Pancreatic tumours: Molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. Br J Cancer 2001; 84: 253-262
26. Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, Kern SE, Hruban RH. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 2000; 60: 2002-2006