Innate immunity in the pathogenesis of psoriasis

Archives of Dermatological Research

Volumn 303, Issue 10, 2011, Pages 691-705

  Sweeney, Cheryl M ^a   Tobin, Ann Marie ^a   Kirby, Brian ^a  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Inflammation; Innate immunity; Psoriasis; T cells

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; GAMMA DELTA T LYMPHOCYTE; GENETIC PREDISPOSITION; HUMAN; INFLAMMATION; INNATE IMMUNITY; KERATINOCYTE; LANGERHANS CELL; MACROPHAGE; MAST CELL; MYELOID DENDRITIC CELL; NATURAL KILLER T CELL; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ANIMALS; CYTOKINES; HUMANS; IMMUNITY, INNATE; PSORIASIS; SIGNAL TRANSDUCTION; SKIN; TH1 CELLS; TH17 CELLS;

EID: 84860389384     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-011-1169-1     Document Type: Review

References (190)

1. B Agerberth J Charo J Werr B Olsson F Idali L Lindbom R Kiessling H Jornvall H Wigzell GH Gudmundsson 2000 The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations Blood 96 3086 3093 11049988 1:CAS:528:DC%2BD3cXnslGnt74%3D
2. S Akira S Uematsu O Takeuchi 2006 Pathogen recognition and innate immunity Cell 124 783 801 16497588 1:CAS:528:DC%2BD28Xit1Kltb8%3D 10.1016/j.cell.2006.02.015 (Pubitemid 43261452)
3. E Aliahmadi R Gramlich A Grutzkau M Hitzler M Kruger R Baumgrass M Schreiner B Wittig R Wanner M Peiser 2009 TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23 Eur J Immunol 39 1221 1230 19350551 1:CAS:528:DC%2BD1MXltlegtL0%3D 10.1002/eji.200838742
4. LM Austin M Ozawa T Kikuchi IB Walters JG Krueger 1999 The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients J Invest Dermatol 113 752 759 10571730 1:CAS:528:DyaK1MXns1egtLY%3D 10.1046/j.1523-1747.1999.00749.x
5. BS Baker JM Ovigne AV Powles S Corcoran L Fry 2003 Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis Br J Dermatol 148 670 679 12752123 1:CAS:528: DC%2BD3sXkslemurY%3D 10.1046/j.1365-2133.2003.05287.x (Pubitemid 36629744)
6. F Bazzoni MA Cassatella F Rossi M Ceska B Dewald M Baggiolini 1991 Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8 J Exp Med 173 771 774 1997655 1:CAS:528:DyaK3MXhsVWhtL8%3D 10.1084/jem.173.3.771
7. E Begon L Michel B Flageul I Beaudoin F Jean-Louis H Bachelez L Dubertret P Musette 2007 Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin Eur J Dermatol 17 497 506 17951129 1:CAS:528: DC%2BD1cXht12mtbY%3D (Pubitemid 350207160)
8. SC Bischoff S Kramer 2007 Human mast cells, bacteria, and intestinal immunity Immunol Rev 217 329 337 17498069 1:CAS:528:DC%2BD2sXnt1Gmu7g%3D 10.1111/j.1600-065X.2007.00523.x (Pubitemid 46718156)
9. AP Black MR Ardern-Jones V Kasprowicz P Bowness L Jones AS Bailey GS Ogg 2007 Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells Eur J Immunol 37 1485 1493 17506032 1:CAS:528:DC%2BD2sXntVSgsrY%3D 10.1002/eji.200636915 (Pubitemid 46939485)
10. B Bonetti C Stegagno B Cannella N Rizzuto G Moretto CS Raine 1999 Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology Am J Pathol 155 1433 1438 10550297 1:CAS:528:DyaK1MXnvVKisrY%3D 10.1016/S0002-9440(10)65456-9
11. C Bonifati M Carducci P Cordiali Fei E Trento G Sacerdoti M Fazio F Ameglio 1994 Correlated increases of tumour necrosis factor-alpha, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients-relationships with disease severity Clin Exp Dermatol 19 383 387 7955493 1:STN:280:DyaK2M%2FktlGisw%3D%3D 10.1111/j.1365-2230.1994.tb02687.x (Pubitemid 24308596)
12. B Bonish D Jullien Y Dutronc BB Huang R Modlin FM Spada SA Porcelli BJ Nickoloff 2000 Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells J Immunol 165 4076 4085 11034419 1:CAS:528:DC%2BD3cXntVyitrY%3D (Pubitemid 32057319)
13. K Bottomly 1988 A functional dichotomy in CD4+ T lymphocytes Immunol Today 9 268 274 2908229 1:STN:280:DyaL1MzltFCktA%3D%3D 10.1016/0167-5699(88) 91308-4
14. O Boyman C Conrad G Tonel M Gilliet FO Nestle 2007 The pathogenic role of tissue-resident immune cells in psoriasis Trends Immunol 28 51 57 17197238 10.1016/j.it.2006.12.005 (Pubitemid 46176734)
15. O Boyman HP Hefti C Conrad BJ Nickoloff M Suter FO Nestle 2004 Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha J Exp Med 199 731 736 14981113 1:CAS:528:DC%2BD2cXitFyjtL8%3D 10.1084/jem.20031482 (Pubitemid 38316440)
16. KD Brown E Claudio U Siebenlist 2008 The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis Arthritis Res Ther 10 212 18771589 10.1186/ar2457 1:CAS:528:DC%2BD1cXht1Glt7fE
17. RA Calderone PC Braun 1991 Adherence and receptor relationships of Candida albicans Microbiol Rev 55 1 20 2030668 1:CAS:528:DyaK3MXktVCkt7k%3D (Pubitemid 21895143)
18. AL Cameron B Kirby W Fei CE Griffiths 2002 Natural killer and natural killer-T cells in psoriasis Arch Dermatol Res 294 363 369 12420105 1:CAS:528:DC%2BD38XosVCnurg%3D (Pubitemid 35341029)
19. L Candia J Marquez C Hernandez AH Zea LR Espinoza 2007 Toll-like receptor-2 expression is upregulated in antigen-presenting cells from patients with psoriatic arthritis: a pathogenic role for innate immunity? J Rheumatol 34 374 379 17183618 1:CAS:528:DC%2BD2sXjtFCntrw%3D
20. W Cao DB Rosen T Ito L Bover M Bao G Watanabe Z Yao L Zhang LL Lanier YJ Liu 2006 Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production J Exp Med 203 1399 1405 16735691 1:CAS:528:DC%2BD28XmtVansb8%3D 10.1084/jem.20052454 (Pubitemid 43877601)
21. A Cerwenka LL Lanier 2001 Natural killer cells, viruses and cancer Nat Rev Immunol 1 41 49 11905813 1:CAS:528:DC%2BD38XlvF2qtLk%3D 10.1038/35095564 (Pubitemid 33741974)
22. I Chatzidakis C Mamalaki 2010 T cells as sources and targets of TNF: implications for immunity and autoimmunity Curr Dir Autoimmun 11 105 118 20173390 1:CAS:528:DC%2BC3cXnvFWmsLw%3D 10.1159/000289200
23. O Chowaniec S Jablonska EH Beutner M Proniewska M Jarzabek-Chorzelska G Rzesa 1981 Earliest clinical and histological changes in psoriasis Dermatologica 163 42 51 7274515 1:STN:280:DyaL38%2FgsVykug%3D%3D 10.1159/000250139 (Pubitemid 11094542)
24. Y Chung SH Chang GJ Martinez XO Yang R Nurieva HS Kang L Ma SS Watowich AM Jetten Q Tian C Dong 2009 Critical regulation of early Th17 cell differentiation by interleukin-1 signaling Immunity 30 576 587 19362022 1:CAS:528:DC%2BD1MXls1Sqsr0%3D 10.1016/j.immuni.2009.02.007
25. C Conrad O Boyman G Tonel A Tun-Kyi U Laggner A de Fougerolles V Kotelianski H Gardner FO Nestle 2007 Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis Nat Med 13 836 842 17603494 1:CAS:528:DC%2BD2sXnsFWmtrc%3D 10.1038/nm1605 (Pubitemid 47038192)
26. DJ Cua J Sherlock Y Chen CA Murphy B Joyce B Seymour L Lucian W To S Kwan T Churakova S Zurawski M Wiekowski SA Lira D Gorman RA Kastelein JD Sedgwick 2003 Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 744 748 12610626 1:CAS:528:DC%2BD3sXhsV2rsbs%3D 10.1038/nature01355 (Pubitemid 36227625)
27. M Cumberbatch M Singh RJ Dearman HS Young I Kimber CE Griffiths 2006 Impaired Langerhans cell migration in psoriasis J Exp Med 203 953 960 16567387 1:CAS:528:DC%2BD28Xjsl2is7k%3D 10.1084/jem.20052367
28. JL Curry JZ Qin B Bonish R Carrick P Bacon J Panella J Robinson BJ Nickoloff 2003 Innate immune-related receptors in normal and psoriatic skin Arch Pathol Lab Med 127 178 186 12562231 1:CAS:528:DC%2BD3sXmsVCjs7g%3D (Pubitemid 36231763)
29. JL Curry JZ Qin J Robinson BJ Nickoloff 2003 Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model system Arch Pathol Lab Med 127 289 296 12653571 (Pubitemid 36378691)
30. W Dawicki JS Marshall 2007 New and emerging roles for mast cells in host defence Curr Opin Immunol 19 31 38 17126541 1:CAS:528:DC%2BD2sXmtVeltA%3D%3D 10.1016/j.coi.2006.11.006 (Pubitemid 46073696)
31. R Debets JP Hegmans RJ Troost R Benner EP Prens 1995 Enhanced production of biologically active interleukin-1 alpha and interleukin-1 beta by psoriatic epidermal cells ex vivo: evidence of increased cytosolic interleukin-1 beta levels and facilitated interleukin-1 release Eur J Immunol 25 1624 1630 7614991 1:CAS:528:DyaK2MXms1Klsro%3D 10.1002/eji.1830250623
32. R Derynck 1990 Transforming growth factor-alpha Mol Reprod Dev 27 3 9 2271184 1:CAS:528:DyaK3MXktVSqsr4%3D 10.1002/mrd.1080270104
33. M Detmar LF Brown KP Claffey KT Yeo O Kocher RW Jackman B Berse HF Dvorak 1994 Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis J Exp Med 180 1141 1146 8064230 1:CAS:528:DyaK2cXlsFCksbw%3D 10.1084/jem.180.3.1141 (Pubitemid 24256627)
34. M Detmar CE Orfanos 1990 Tumor necrosis factor-alpha inhibits cell proliferation and induces class II antigens and cell adhesion molecules in cultured normal human keratinocytes in vitro Arch Dermatol Res 282 238 245 2115318 1:CAS:528:DyaK3cXltlSgur0%3D 10.1007/BF00371643 (Pubitemid 20205646)
35. N Dietrich M Rohde R Geffers A Kroger H Hauser S Weiss NO Gekara 2010 Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria Proc Natl Acad Sci USA 107 19 8748 8753 20421474 1:CAS:528:DC%2BC3cXmsFWmtbc%3D 10.1073/pnas.0912551107
36. N Djemadji-Oudjiel S Goerdt V Kodelja M Schmuth CE Orfanos 1996 Immunohistochemical identification of type II alternatively activated dendritic macrophages (RM 3/1 + 3, MS-1±, 25F9-) in psoriatic dermis Arch Dermatol Res 288 757 764 8950456 1:CAS:528:DyaK28XnsFemu7o%3D 10.1007/BF02505293 (Pubitemid 26388134)
37. H Duan T Koga F Kohda H Hara K Urabe M Furue 2001 Interleukin-8-positive neutrophils in psoriasis J Dermatol Sci 26 119 124 11378328 1:CAS:528: DC%2BD3MXjvV2kur8%3D 10.1016/S0923-1811(00)00167-5 (Pubitemid 32510719)
38. DB Dubravec DR Spriggs JA Mannick ML Rodrick 1990 Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha Proc Natl Acad Sci USA 87 6758 6761 1697688 1:CAS:528:DyaK3cXlvV2nt74%3D 10.1073/pnas.87.17.6758
39. A Dzionek Y Sohma J Nagafune M Cella M Colonna F Facchetti G Gunther I Johnston A Lanzavecchia T Nagasaka T Okada W Vermi G Winkels T Yamamoto M Zysk Y Yamaguchi J Schmitz 2001 BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction J Exp Med 194 1823 1834 11748283 1:CAS:528:DC%2BD38Xpt1am 10.1084/jem.194.12.1823 (Pubitemid 34028661)
40. P Ettehadi MW Greaves D Wallach D Aderka RD Camp 1994 Elevated tumour necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions Clin Exp Immunol 96 146 151 8149659 1:CAS:528:DyaK2cXktVOit7w%3D 10.1111/j.1365-2249.1994.tb06244.x (Pubitemid 24213812)
41. L Feldmeyer M Keller G Niklaus D Hohl S Werner HD Beer 2007 The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes Curr Biol 17 1140 1145 17600714 1:CAS:528:DC%2BD2sXntFars70%3D 10.1016/j.cub.2007.05.074 (Pubitemid 46990888)
42. CG Figdor Y van Kooyk GJ Adema 2002 C-type lectin receptors on dendritic cells and Langerhans cells Nat Rev Immunol 2 77 84 11910898 1:CAS:528: DC%2BD38XitFSnu78%3D 10.1038/nri723 (Pubitemid 37323231)
43. JM Fletcher SJ Lalor CM Sweeney N Tubridy KH Mills 2010 T cells in multiple sclerosis and experimental autoimmune encephalomyelitis Clin Exp Immunol 162 1 11 20682002 1:CAS:528:DC%2BC3cXhtlSnsLbK 10.1111/j.1365-2249.2010. 04143.x
44. H Fujita KE Nograles T Kikuchi J Gonzalez JA Carucci JG Krueger 2009 Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production Proc Natl Acad Sci USA 106 21795 21800 19996179 1:CAS:528:DC%2BC3cXltlKgsg%3D%3D 10.1073/pnas.0911472106
45. SJ Galli J Kalesnikoff MA Grimbaldeston AM Piliponsky CM Williams M Tsai 2005 Mast cells as "tunable" effector and immunoregulatory cells: recent advances Annu Rev Immunol 23 749 786 15771585 1:CAS:528: DC%2BD2MXktFOju70%3D 10.1146/annurev.immunol.21.120601.141025 (Pubitemid 40563184)
46. D Ganguly G Chamilos R Lande J Gregorio S Meller V Facchinetti B Homey FJ Barrat T Zal M Gilliet 2009 Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 J Exp Med 206 1983 1994 19703986 1:CAS:528:DC%2BD1MXhtVyitLbM 10.1084/jem.20090480
47. F Geissmann MC Dieu-Nosjean C Dezutter J Valladeau S Kayal M Leborgne N Brousse S Saeland J Davoust 2002 Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin J Exp Med 196 417 430 12186835 1:CAS:528:DC%2BD38XmsV2htLo%3D 10.1084/jem.20020018
48. K Ghoreschi P Thomas S Breit M Dugas R Mailhammer W van Eden R van der Zee T Biedermann J Prinz M Mack U Mrowietz E Christophers D Schlondorff G Plewig CA Sander M Rocken 2003 Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease Nat Med 9 40 46 12461524 1:CAS:528:DC%2BD3sXivF2k 10.1038/nm804 (Pubitemid 36098258)
49. M Gilliet C Conrad M Geiges A Cozzio W Thurlimann G Burg FO Nestle R Dummer 2004 Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors Arch Dermatol 140 1490 1495 15611427 1:CAS:528:DC%2BD2MXjslSjtw%3D%3D 10.1001/archderm.140.12.1490 (Pubitemid 39627441)
50. R Gillitzer K Wolff D Tong C Muller T Yoshimura AA Hartmann G Stingl R Berger 1993 MCP-1 mRNA expression in basal keratinocytes of psoriatic lesions J Invest Dermatol 101 127 131 8345212 1:CAS:528:DyaK3sXmt1ehur8%3D 10.1111/1523-1747.ep12363613 (Pubitemid 23218685)
51. EJ Gosselin K Wardwell WF Rigby PM Guyre 1993 Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3 J Immunol 151 1482 1490 8335942 1:CAS:528:DyaK3sXmtVWgurs%3D (Pubitemid 23219286)
52. AB Gottlieb F Chamian S Masud I Cardinale MV Abello MA Lowes F Chen M Magliocco JG Krueger 2005 TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques J Immunol 175 2721 2729 16081850 1:CAS:528:DC%2BD2MXntVSqsbg%3D (Pubitemid 41113889)
53. SL Gottlieb P Gilleaudeau R Johnson L Estes TG Woodworth AB Gottlieb JG Krueger 1995 Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis Nat Med 1 442 447 7585092 1:CAS:528:DyaK2MXls1SgtLw%3D 10.1038/nm0595-442
54. CE Griffiths JN Barker 2007 Pathogenesis and clinical features of psoriasis Lancet 370 263 271 17658397 1:CAS:528:DC%2BD2sXnvF2gs7w%3D 10.1016/S0140-6736(07)61128-3 (Pubitemid 47069537)
55. RM Grossman J Krueger D Yourish A Granelli-Piperno DP Murphy LT May TS Kupper PB Sehgal AB Gottlieb 1989 Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes Proc Natl Acad Sci USA 86 6367 6371 2474833 1:CAS:528:DyaL1MXlslahsLc%3D 10.1073/pnas.86.16.6367 (Pubitemid 19210653)
56. J Grousson M Concha D Schmitt J Peguet-Navarro 1998 Effects of CD40 ligation on human keratinocyte accessory function Arch Dermatol Res 290 325 330 9705164 1:CAS:528:DyaK1cXmtFKrt7k%3D 10.1007/s004030050312 (Pubitemid 28369389)
57. K Hancock IM Leigh 1989 Cultured keratinocytes and keratinocyte grafts BMJ 299 1179 1180 2513046 1:STN:280:DyaK3c%2FovFKrsQ%3D%3D 10.1136/bmj.299.6709. 1179
58. EG Harper C Guo H Rizzo JV Lillis SE Kurtz I Skorcheva D Purdy E Fitch M Iordanov A Blauvelt 2009 Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis J Invest Dermatol 129 2175 2183 19295614 1:CAS:528:DC%2BD1MXhtF2qsLrI 10.1038/jid.2009.65
59. H Hemmi M Yoshino H Yamazaki M Naito T Iyoda Y Omatsu S Shimoyama JJ Letterio T Nakabayashi H Tagaya T Yamane M Ogawa S Nishikawa K Ryoke K Inaba S Hayashi T Kunisada 2001 Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells Int Immunol 13 695 704 11312257 1:CAS:528:DC%2BD3MXjsVyjt74%3D 10.1093/intimm/13.5. 695 (Pubitemid 32427872)
60. S Hida K Ogasawara K Sato M Abe H Takayanagi T Yokochi T Sato S Hirose T Shirai S Taki T Taniguchi 2000 CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13 643 655 11114377 1:CAS:528:DC%2BD3cXovV2ht7o%3D 10.1016/S1074-7613(00)00064-9
61. B Homey MC Dieu-Nosjean A Wiesenborn C Massacrier JJ Pin E Oldham D Catron ME Buchanan A Muller R de Waal Malefyt G Deng R Orozco T Ruzicka P Lehmann S Lebecque C Caux A Zlotnik 2000 Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis J Immunol 164 6621 6632 10843722 1:CAS:528:DC%2BD3cXktFWlurY%3D (Pubitemid 30408849)
62. K Hong A Chu BR Ludviksson EL Berg RO Ehrhardt 1999 IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder J Immunol 162 7480 7491 10358203 1:CAS:528:DyaK1MXktFertr8%3D (Pubitemid 29277728)
63. CS Hsieh SE Macatonia CS Tripp SF Wolf A O'Garra KM Murphy 1993 Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages Science 260 547 549 8097338 1:CAS:528:DyaK3sXitlajsLg%3D 10.1126/science.8097338 (Pubitemid 23161621)
64. BZ Igyarto MC Jenison JC Dudda A Roers W Muller PA Koni DJ Campbell MJ Shlomchik DH Kaplan 2009 Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10 J Immunol 183 5085 5093 19801524 1:CAS:528:DC%2BD1MXht1WhsbzO 10.4049/jimmunol. 0901884
65. Kagami S, Rizzo HL, Lee JJ, Koguchi Y, Blauvelt (2010) A Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol 130:1373-1383
66. BN Kalali G Kollisch J Mages T Muller S Bauer H Wagner J Ring R Lang M Mempel M Ollert 2008 Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling J Immunol 181 2694 2704 18684960 1:CAS:528: DC%2BD1cXptlOjs78%3D
67. N Kanda S Shibata Y Tada K Nashiro K Tamaki S Watanabe 2009 Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes Eur J Immunol 39 996 1006 19350575 1:CAS:528:DC%2BD1MXltlamurk%3D 10.1002/eji. 200838852
68. DH Kaplan MC Jenison S Saeland WD Shlomchik MJ Shlomchik 2005 Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity Immunity 23 611 620 16356859 1:CAS:528:DC%2BD28XjvFCruw%3D%3D 10.1016/j.immuni.2005.10.008 (Pubitemid 41779483)
69. ML Kapsenberg 2003 Dendritic-cell control of pathogen-driven T-cell polarization Nat Rev Immunol 3 984 993 14647480 1:CAS:528:DC%2BD3sXpvFCgs74%3D 10.1038/nri1246 (Pubitemid 37521540)
70. T Karashima H Hachisuka Y Sasai 1996 FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0/G1 phases of the cell cycle J Dermatol Sci 12 246 254 8884530 1:CAS:528:DyaK28XmsFWlsbg%3D 10.1016/0923-1811(95)00480-7 (Pubitemid 26290411)
71. M Keller A Ruegg S Werner HD Beer 2008 Active caspase-1 is a regulator of unconventional protein secretion Cell 132 818 831 18329368 1:CAS:528: DC%2BD1cXjs1ait74%3D 10.1016/j.cell.2007.12.040 (Pubitemid 351312798)
72. D Kess T Peters J Zamek C Wickenhauser S Tawadros K Loser G Varga S Grabbe R Nischt C Sunderkotter W Muller T Krieg K Scharffetter-Kochanek 2003 CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis J Immunol 171 5697 5706 14634077 1:CAS:528:DC%2BD3sXptFOlu74%3D (Pubitemid 37467184)
73. L Klareskog U Tjernlund U Forsum PA Peterson 1977 Epidermal Langerhans cells express Ia antigens Nature 268 248 250 329142 1:CAS:528:DyaE2sXlvVantr8%3D 10.1038/268248a0 (Pubitemid 8139186)
74. CE Kleyn L Schneider R Saraceno C Mantovani HL Richards DG Fortune M Cumberbatch RJ Dearman G Terenghi I Kimber CE Griffiths 2008 The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides J Invest Dermatol 128 1273 1279 17989731 1:CAS:528:DC%2BD1cXksFyhsrc%3D 10.1038/sj.jid.5701144 (Pubitemid 351543193)
75. JK Kolls A Linden 2004 Interleukin-17 family members and inflammation Immunity 21 467 476 15485625 1:CAS:528:DC%2BD2cXpvVygt7k%3D 10.1016/j.immuni. 2004.08.018 (Pubitemid 39370503)
76. NV Konstantinova DM Duong E Remenyik P Hazarika A Chuang M Duvic 1996 Interleukin-8 is induced in skin equivalents and is highest in those derived from psoriatic fibroblasts J Invest Dermatol 107 615 621 8823370 1:CAS:528:DyaK28XmsVagtb4%3D 10.1111/1523-1747.ep12584215 (Pubitemid 26338589)
77. T Kopp JD Kieffer A Rot S Strommer G Stingl TS Kupper 2001 Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40 J Invest Dermatol 117 618 626 11564168 1:CAS:528: DC%2BD3MXntFWhsLg%3D 10.1046/j.1523-1747.2001.01441.x (Pubitemid 32955589)
78. M Kristensen CQ Chu DJ Eedy M Feldmann FM Brennan SM Breathnach 1993 Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor Clin Exp Immunol 94 354 362 8222328 1:CAS:528:DyaK2cXivFSquw%3D%3D 10.1111/j.1365-2249.1993.tb03457.x (Pubitemid 23337840)
79. I Kryczek AT Bruce JE Gudjonsson A Johnston A Aphale L Vatan W Szeliga Y Wang Y Liu TH Welling JT Elder W Zou 2008 Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis J Immunol 181 4733 4741 18802076 1:CAS:528:DC%2BD1cXhtFarurrP
80. R Lande J Gregorio V Facchinetti B Chatterjee YH Wang B Homey W Cao B Su FO Nestle T Zal I Mellman JM Schroder YJ Liu M Gilliet 2007 Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide Nature 449 564 569 17873860 1:CAS:528:DC%2BD2sXhtFagtL7K 10.1038/nature06116 (Pubitemid 47525141)
81. CL Langrish Y Chen WM Blumenschein J Mattson B Basham JD Sedgwick T McClanahan RA Kastelein DJ Cua 2005 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233 240 15657292 1:CAS:528:DC%2BD2MXot12mtA%3D%3D 10.1084/jem.20041257 (Pubitemid 40189432)
82. E Lee WL Trepicchio JL Oestreicher D Pittman F Wang F Chamian M Dhodapkar JG Krueger 2004 Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris J Exp Med 199 125 130 14707118 1:CAS:528:DC%2BD2cXjvFWktw%3D%3D 10.1084/jem.20030451 (Pubitemid 38076484)
83. EG Lee DL Boone S Chai SL Libby M Chien JP Lodolce A Ma 2000 Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice Science 289 2350 2354 11009421 1:CAS:528:DC%2BD3cXmvF2qtbY%3D 10.1126/science.289.5488.2350
84. S LeibundGut-Landmann O Gross MJ Robinson F Osorio EC Slack SV Tsoni E Schweighoffer V Tybulewicz GD Brown J Ruland CRE Sousa 2007 Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 Nat Immunol 8 630 638 17450144 1:CAS:528: DC%2BD2sXlsVSrs78%3D 10.1038/ni1460 (Pubitemid 46785127)
85. CL Leonardi AB Kimball KA Papp N Yeilding C Guzzo Y Wang S Li LT Dooley KB Gordon 2008 Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) Lancet 371 1665 1674 18486739 1:CAS:528:DC%2BD1cXlvFymt7o%3D 10.1016/S0140-6736(08)60725-4 (Pubitemid 351671883)
86. W Lew AM Bowcock JG Krueger 2004 Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression Trends Immunol 25 295 305 15145319 1:CAS:528:DC%2BD2cXktVKqs7k%3D 10.1016/j.it.2004.03.006 (Pubitemid 38610353)
87. SC Liang XY Tan DP Luxenberg R Karim K Dunussi-Joannopoulos M Collins LA Fouser 2006 Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 2271 2279 16982811 1:CAS:528:DC%2BD28XhtVGls7fF 10.1084/jem.20061308 (Pubitemid 44498362)
88. YH Liao SH Jee BC Sheu YL Huang MP Tseng SM Hsu TF Tsai 2006 Increased expression of the natural killer cell inhibitory receptor CD94/NKG2A and CD158b on circulating and lesional T cells in patients with chronic plaque psoriasis Br J Dermatol 155 318 324 16882169 1:STN:280:DC%2BD28vlvVKqtg%3D%3D 10.1111/j.1365-2133.2006.07301.x (Pubitemid 44050564)
89. Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, Villanueva EC, Shah P, Kaplan MJ, Bruce AT (2011) Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol
90. YJ Liu 2005 IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors Annu Rev Immunol 23 275 306 15771572 1:CAS:528:DC%2BD2MXktFOjur4%3D 10.1146/annurev.immunol.23.021704.115633 (Pubitemid 40563171)
91. PC Lord LM Wilmoth SB Mizel CE McCall 1991 Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes J Clin Invest 87 1312 1321 2010544 1:CAS:528:DyaK3MXitVGhur0%3D 10.1172/JCI115134
92. MA Lowes F Chamian MV Abello J Fuentes-Duculan SL Lin R Nussbaum I Novitskaya H Carbonaro I Cardinale T Kikuchi P Gilleaudeau M Sullivan-Whalen KM Wittkowski K Papp M Garovoy W Dummer RM Steinman JG Krueger 2005 Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) Proc Natl Acad Sci USA 102 19057 19062 16380428 1:CAS:528:DC%2BD28XivV2hsQ%3D%3D 10.1073/pnas.0509736102 (Pubitemid 43049565)
93. MA Lowes T Kikuchi J Fuentes-Duculan I Cardinale LC Zaba AS Haider EP Bowman JG Krueger 2008 Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells J Invest Dermatol 128 1207 1211 18200064 1:CAS:528:DC%2BD1cXksFyhsbs%3D 10.1038/sj.jid.5701213 (Pubitemid 351543220)
94. H Lu YH Kuang J Su J Chang LS Wu T Kanekura D Li ML Chen X Chen 2011 CD147 is highly expressed on peripheral blood neutrophils from patients with psoriasis and induces neutrophil chemotaxis J Dermatol 37 1053 1056 10.1111/j.1346-8138.2010.00935.x 1:CAS:528:DC%2BC3MXotlOisg%3D%3D
95. SS Makarov 2001 NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction Arthritis Res 3 200 206 11438035 1:CAS:528:DC%2BD3MXmt1Cmtbk%3D 10.1186/ar300 (Pubitemid 32621955)
96. DJ Marble KB Gordon BJ Nickoloff 2007 Targeting TNFalpha rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation J Dermatol Sci 48 87 101 17689932 1:CAS:528:DC%2BD2sXhtVCntL7M 10.1016/j.jdermsci.2007.06.006 (Pubitemid 47381571)
97. D Mayerova EA Parke LS Bursch OA Odumade KA Hogquist 2004 Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state Immunity 21 391 400 15357950 1:CAS:528:DC%2BD2cXotFaktLw%3D 10.1016/j.immuni. 2004.07.019 (Pubitemid 39208340)
98. R Medzhitov CA Janeway Jr 1997 Innate immunity: impact on the adaptive immune response Curr Opin Immunol 9 4 9 9039775 1:CAS:528:DyaK2sXhsl2hurs%3D 10.1016/S0952-7915(97)80152-5 (Pubitemid 27095892)
99. R Medzhitov CA Janeway Jr 1997 Innate immunity: the virtues of a nonclonal system of recognition Cell 91 295 298 9363937 1:CAS:528: DyaK2sXnt1Clsrw%3D 10.1016/S0092-8674(00)80412-2 (Pubitemid 27467959)
100. JB Mee MJ Cork FS di Giovine GW Duff RW Groves 2006 Interleukin-1: a key inflammatory mediator in psoriasis? Cytokine 33 72 78 16460958 1:CAS:528:DC%2BD28XisF2htb4%3D 10.1016/j.cyto.2005.12.001
101. A Mehling K Loser G Varga D Metze TA Luger T Schwarz S Grabbe S Beissert 2001 Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity J Exp Med 194 615 628 11535630 1:CAS:528:DC%2BD3MXms1KhsL0%3D 10.1084/jem.194.5.615 (Pubitemid 32844772)
102. KH Mills 2004 Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol 4 841 855 15516964 1:CAS:528:DC%2BD2cXptFegtLc%3D 10.1038/nri1485 (Pubitemid 39490760)
103. TR Mosmann H Cherwinski MW Bond MA Giedlin RL Coffman 1986 Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J Immunol 136 2348 2357 2419430 1:CAS:528:DyaL28XhvVClsbk%3D (Pubitemid 16136806)
104. TR Mosmann RL Coffman 1987 Two types of mouse helper T-cell clone: implications for immune regulation Immunol Today 8 223 227 10.1016/0167-5699(87) 90171-X (Pubitemid 17147143)
105. RP Nair KC Duffin C Helms J Ding PE Stuart D Goldgar JE Gudjonsson Y Li T Tejasvi BJ Feng A Ruether S Schreiber M Weichenthal D Gladman P Rahman SJ Schrodi S Prahalad SL Guthery J Fischer W Liao PY Kwok A Menter GM Lathrop CA Wise AB Begovich JJ Voorhees JT Elder GG Krueger AM Bowcock GR Abecasis 2009 Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways Nat Genet 41 199 204 19169254 1:CAS:528:DC%2BD1MXhtVWmtb8%3D 10.1038/ng.311
106. FO Nestle C Conrad A Tun-Kyi B Homey M Gombert O Boyman G Burg YJ Liu M Gilliet 2005 Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production J Exp Med 202 135 143 15998792 1:CAS:528: DC%2BD2MXmtVaqsbc%3D 10.1084/jem.20050500 (Pubitemid 41002916)
107. E Neuman JW Huleatt H Vargas EE Rupp RM Jack 1992 Regulation of MHC class I synthesis and expression by human neutrophils J Immunol 148 3520 3527 1534098 1:CAS:528:DyaK38XksVKhsrk%3D
108. KE Nograles LC Zaba E Guttman-Yassky J Fuentes-Duculan M Suarez-Farinas I Cardinale A Khatcherian J Gonzalez KC Pierson TR White C Pensabene I Coats I Novitskaya MA Lowes JG Krueger 2008 Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways Br J Dermatol 159 1092 1102 18684158 1:CAS:528:DC%2BD1cXhsV2ksLfP
109. S Onuma 1994 Immunohistochemical studies of infiltrating cells in early and chronic lesions of psoriasis J Dermatol 21 223 232 7914525 1:STN:280:DyaK2czjsVCntQ%3D%3D (Pubitemid 24187009)
110. JJ Oppenheim D Yang 2005 Alarmins: chemotactic activators of immune responses Curr Opin Immunol 17 359 365 15955682 1:CAS:528:DC%2BD2MXlvVWls78%3D 10.1016/j.coi.2005.06.002 (Pubitemid 40848537)
111. B Oppmann R Lesley B Blom JC Timans Y Xu B Hunte F Vega N Yu J Wang K Singh F Zonin E Vaisberg T Churakova M Liu D Gorman J Wagner S Zurawski Y Liu JS Abrams KW Moore D Rennick R Waal-Malefyt C Hannum JF Bazan RA Kastelein 2000 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715 725 11114383 1:CAS:528:DC%2BD3cXovV2ht7c%3D 10.1016/S1074-7613(00)00070-4
112. C Ortega AS Fernandez JM Carrillo P Romero IJ Molina JC Moreno M Santamaria 2009 IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines J Leukoc Biol 86 435 443 19487306 1:CAS:528:DC%2BD1MXps1elsrc%3D 10.1189/JLB.0109046
113. M Ozawa T Terui H Tagami 2005 Localization of IL-8 and complement components in lesional skin of psoriasis vulgaris and pustulosis palmaris et plantaris Dermatology 211 249 255 16205070 1:CAS:528:DC%2BD2MXhtVKls7rN 10.1159/000087019 (Pubitemid 41415865)
114. SO Ozdamar D Seckin B Kandemir AY Turanli 1996 Mast cells in psoriasis Dermatology 192 190 8829514 1:STN:280:DyaK283mtVKisA%3D%3D 10.1159/000246359
115. H Park Z Li XO Yang SH Chang R Nurieva YH Wang Y Wang L Hood Z Zhu Q Tian C Dong 2005 A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 6 1133 1141 16200068 1:CAS:528: DC%2BD2MXhtFamsb%2FO 10.1038/ni1261 (Pubitemid 41541791)
116. M Pasparakis G Courtois M Hafner M Schmidt-Supprian A Nenci A Toksoy M Krampert M Goebeler R Gillitzer A Israel T Krieg K Rajewsky I Haase 2002 TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 Nature 417 861 866 12075355 1:CAS:528:DC%2BD38Xks1Wmu7o%3D 10.1038/nature00820 (Pubitemid 34670334)
117. ST Passos JS Silver AC O'Hara D Sehy JS Stumhofer CA Hunter 2010 IL-6 promotes NK cell production of IL-17 during toxoplasmosis J Immunol 184 4 1776 1783 20083665 1:CAS:528:DC%2BC3cXhsVGltbo%3D 10.4049/jimmunol.0901843
118. C Paustian R Caspell T Johnson PA Cohen S Shu S Xu BJ Czerniecki GK Koski 2011 Effect of multiple activation stimuli on the generation of Th1-polarizing dendritic cells Hum Immunol 72 24 31 20951755 1:CAS:528:DC%2BC3cXhsFyks7jL 10.1016/j.humimm.2010.10.004
119. G Piskin RM Sylva-Steenland JD Bos MB Teunissen 2006 In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin J Immunol 176 1908 1915 16424222 1:CAS:528:DC%2BD28XlsFyktA%3D%3D (Pubitemid 43134336)
120. S Porcelli MB Brenner JL Greenstein SP Balk C Terhorst PA Bleicher 1989 Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes Nature 341 447 450 2477705 1:CAS:528:DyaL1MXmtlShtL0%3D
121. J Prinz O Braun-Falco M Meurer P Daddona C Reiter P Rieber G Riethmuller 1991 Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis Lancet 338 320 321 1677143 1:STN:280:DyaK3MzgsVagsw%3D%3D 10.1016/0140-6736(91)90464-Z
122. B Pulendran 2004 Immune activation: death, danger and dendritic cells Curr Biol 14 30 32 10.1016/j.cub.2003.12.020 1:CAS:528:DC%2BD2cXjsFensQ%3D%3D (Pubitemid 38069967)
123. AV Rachitskaya AM Hansen R Horai Z Li R Villasmil D Luger RB Nussenblatt RR Caspi 2008 Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion J Immunol 180 5167 5171 18390697 1:CAS:528: DC%2BD1cXkt1ars7o%3D
124. A Ragaz AB Ackerman 1979 Evolution, maturation, and regression of lesions of psoriasis. New observations and correlation of clinical and histologic findings Am J Dermatopathol 1 199 214 543520 1:STN:280:DyaL3c7ntlWhsQ%3D%3D 10.1097/00000372-197900130-00002 (Pubitemid 11214679)
125. B Rebholz I Haase B Eckelt S Paxian MJ Flaig K Ghoreschi SA Nedospasov R Mailhammer S Debey-Pascher JL Schultze G Weindl I Forster R Huss A Stratis T Ruzicka M Rocken K Pfeffer RM Schmid RA Rupec 2007 Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin Immunity 27 296 307 17692539 1:CAS:528:DC%2BD2sXhtVSgtb3K 10.1016/j.immuni.2007.05.024 (Pubitemid 47284918)
126. J Renne V Schafer T Werfel M Wittmann 2010 Interleukin-1 from epithelial cells fosters T cell-dependent skin inflammation Br J Dermatol 162 1198 1205 20128791 1:CAS:528:DC%2BC3cXos1Ggu7o%3D 10.1111/j.1365-2133.2010.09662.x
127. PC Res G Piskin OJ de Boer CM van der Loos P Teeling JD Bos MB Teunissen 2010 Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis PLoS One 5 14108 10.1371/journal.pone.0014108 1:CAS:528:DC%2BC3cXhsFSkt7%2FM
128. N Romani BE Clausen P Stoitzner 2010 Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin Immunol Rev 234 120 141 20193016 1:CAS:528:DC%2BC3cXjslartrY%3D 10.1111/j.0105-2896.2009.00886.x
129. G Rowden MG Lewis AK Sullivan 1977 Ia antigen expression on human epidermal Langerhans cells Nature 268 247 248 329141 1:CAS:528: DyaE2sXlvVantr4%3D 10.1038/268247a0 (Pubitemid 8139185)
130. R Ruckert K Asadullah M Seifert VM Budagian R Arnold C Trombotto R Paus S Bulfone-Paus 2000 Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J Immunol 165 2240 2250 10925312 1:CAS:528:DC%2BD3cXls1Kmt70%3D (Pubitemid 30643174)
131. S Sano KS Chan S Carbajal J Clifford M Peavey K Kiguchi S Itami BJ Nickoloff J DiGiovanni 2005 Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model Nat Med 11 43 49 15592573 1:CAS:528:DC%2BD2MXovF2k 10.1038/nm1162 (Pubitemid 40215836)
132. N Saunders A Dahler S Jones R Smith A Jetten 1996 Interferon-gamma as a regulator of squamous differentiation J Dermatol Sci 13 98 106 8953408 1:CAS:528:DyaK28XntlWju70%3D 10.1016/S0923-1811(96)00535-X (Pubitemid 26386277)
133. J Schauber RA Dorschner AB Coda AS Buchau PT Liu D Kiken YR Helfrich S Kang HZ Elalieh A Steinmeyer U Zugel DD Bikle RL Modlin RL Gallo 2007 Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism J Clin Invest 117 803 811 17290304 1:CAS:528: DC%2BD2sXis12htb8%3D 10.1172/JCI30142 (Pubitemid 46348539)
134. OG Shaker W Moustafa S Essmat M Abdel-Halim M El-Komy 2006 The role of interleukin-12 in the pathogenesis of psoriasis Clin Biochem 39 119 125 16386240 1:CAS:528:DC%2BD28XhsF2hs7Y%3D 10.1016/j.clinbiochem.2005.11.008 (Pubitemid 43255499)
135. FL Shaw M Cumberbatch CE Kleyn R Begum RJ Dearman I Kimber CE Griffiths 2010 Langerhans cell mobilization distinguishes between early-onset and late-onset psoriasis J Invest Dermatol 130 1940 1942 20237494 1:CAS:528:DC%2BC3cXnsVyisr4%3D 10.1038/jid.2010.57
136. J Shepherd MC Little MJ Nicklin 2004 Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist J Invest Dermatol 122 665 669 15086551 1:CAS:528:DC%2BD2cXjt1Smsro%3D 10.1111/j.0022-202X.2004. 22305.x (Pubitemid 38471334)
137. FP Siegal N Kadowaki M Shodell PA Fitzgerald-Bocarsly K Shah S Ho S Antonenko YJ Liu 1999 The nature of the principal type 1 interferon-producing cells in human blood Science 284 1835 1837 10364556 1:CAS:528:DyaK1MXjvFSqsbg%3D 10.1126/science.284.5421.1835 (Pubitemid 29291433)
138. I Silberberg-Sinakin GJ Thorbecke RL Baer SA Rosenthal V Berezowsky 1976 Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes Cell Immunol 25 137 151 782728 1:STN:280:DyaE283lsFOntA%3D%3D 10.1016/0008-8749(76)90105-2
139. CR Sousa 2006 Essay-dendritic cells in a mature age Nat Rev Immunol 6 476 483 10.1038/nri1845 1:CAS:528:DC%2BD28XkvVyrtro%3D
140. RM Steinman M Pope 2002 Exploiting dendritic cells to improve vaccine efficacy J Clin Invest 109 1519 1526 12070296 1:CAS:528:DC%2BD38Xks12ltLw%3D (Pubitemid 34663511)
141. LA Stephens KH Malpass SM Anderton 2009 Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg Eur J Immunol 39 1108 1117 19350586 1:CAS:528:DC%2BD1MXltlamu7Y%3D 10.1002/eji.200839073
142. P Stoitzner CH Tripp A Eberhart KM Price JY Jung L Bursch F Ronchese N Romani 2006 Langerhans cells cross-present antigen derived from skin Proc Natl Acad Sci USA 103 7783 7788 16672373 1:CAS:528:DC%2BD28XlsVGks7s%3D 10.1073/pnas.0509307103
143. Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Huffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mossner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Stahle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42:985-990
144. A Stratis M Pasparakis RA Rupec D Markur K Hartmann K Scharffetter-Kochanek T Peters N van Rooijen T Krieg I Haase 2006 Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation J Clin Invest 116 2094 2104 16886058 1:CAS:528:DC%2BD28XnvF2mtr0%3D 10.1172/JCI27179 (Pubitemid 44162318)
145. MM Suter K Schulze W Bergman M Welle P Roosje EJ Muller 2009 The keratinocyte in epidermal renewal and defence Vet Dermatol 20 515 523 20178490 10.1111/j.1365-3164.2009.00819.x
146. C Sutton C Brereton B Keogh KH Mills EC Lavelle 2006 A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis J Exp Med 203 1685 1691 16818675 1:CAS:528:DC%2BD28XntVCgs78%3D 10.1084/jem.20060285 (Pubitemid 44036274)
147. CE Sutton SJ Lalor CM Sweeney CF Brereton EC Lavelle KH Mills 2009 Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity Immunity 31 331 341 19682929 1:CAS:528:DC%2BD1MXhtFOgsL%2FP 10.1016/j.immuni.2009.08.001
148. H Takatori Y Kanno WT Watford CM Tato G Weiss II Ivanov DR Littman JJ O'Shea 2009 Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22 J Exp Med 206 35 41 19114665 1:CAS:528:DC%2BD1MXhtVOhtb0%3D 10.1084/jem.20072713
149. PR Taylor GD Brown DM Reid JA Willment L Martinez-Pomares S Gordon SY Wong 2002 The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages J Immunol 169 3876 3882 12244185 1:CAS:528:DC%2BD38XnsFeltLY%3D
150. S Terajima M Higaki Y Igarashi T Nogita M Kawashima 1998 An important role of tumor necrosis factor-alpha in the induction of adhesion molecules in psoriasis Arch Dermatol Res 290 246 252 9681675 1:CAS:528:DyaK1cXkvVagsLo%3D 10.1007/s004030050299 (Pubitemid 28301550)
151. MB Teunissen CW Koomen R de Waal Malefyt EA Wierenga JD Bos 1998 Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes J Invest Dermatol 111 645 649 9764847 1:CAS:528:DyaK1cXmtlyjtrk%3D 10.1046/j.1523-1747.1998.00347.x (Pubitemid 28452327)
152. TC Theoharides B Zhang D Kempuraj M Tagen M Vasiadi A Angelidou KD Alysandratos D Kalogeromitros S Asadi N Stavrianeas E Peterson S Leeman P Conti 2010 IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin Proc Natl Acad Sci USA 107 4448 4453 20160089 1:CAS:528:DC%2BC3cXjtlKitbw%3D 10.1073/pnas.1000803107
153. KM Thomas L Taylor J Navarro 1991 The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R J Biol Chem 266 14839 14841 1714446 1:CAS:528:DyaK3MXlsFKku7c%3D (Pubitemid 21907579)
154. G Tonel C Conrad U Laggner P Di Meglio K Grys TK McClanahan WM Blumenschein JZ Qin H Xin E Oldham R Kastelein BJ Nickoloff FO Nestle 2010 Cutting edge: a critical functional role for IL-23 in psoriasis J Immunol 185 5688 5691 20956338 1:CAS:528:DC%2BC3cXhtlOhsb%2FK 10.4049/jimmunol.1001538
155. MF Tsan B Gao 2004 Endogenous ligands of Toll-like receptors J Leukoc Biol 76 514 519 15178705 1:CAS:528:DC%2BD2cXnsVaksrk%3D 10.1189/jlb.0304127 (Pubitemid 39129081)
156. S Uematsu S Sato M Yamamoto T Hirotani H Kato F Takeshita M Matsuda C Coban KJ Ishii T Kawai O Takeuchi S Akira 2005 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction J Exp Med 201 915 923 15767370 1:CAS:528:DC%2BD2MXislOhu78%3D 10.1084/jem.20042372 (Pubitemid 40524461)
157. J Valladeau C Dezutter-Dambuyant S Saeland 2003 Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells Immunol Res 28 93 107 14610287 1:CAS:528:DC%2BD3sXpslGntLs%3D 10.1385/IR:28:2:93 (Pubitemid 37465160)
158. J Valladeau S Saeland 2005 Cutaneous dendritic cells Semin Immunol 17 273 283 15953735 1:CAS:528:DC%2BD2MXmsVWkt7c%3D 10.1016/j.smim.2005.05.009 (Pubitemid 40984021)
159. HJ van der Vliet BM von Blomberg N Nishi M Reijm AE Voskuyl AA van Bodegraven CH Polman T Rustemeyer P Lips AJ van den Eertwegh G Giaccone RJ Scheper HM Pinedo 2001 Circulating V(alpha24+) Vbeta11 + NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage Clin Immunol 100 144 148 11465942 10.1006/clim.2001.5060 (Pubitemid 32703418)
160. WH Vissers M Berends L Muys PE van Erp EM de Jong PC van de Kerkhof 2004 The effect of the combination of calcipotriol and betamethasone dipropionate versus both monotherapies on epidermal proliferation, keratinization and T-cell subsets in chronic plaque psoriasis Exp Dermatol 13 106 112 15009104 1:CAS:528:DC%2BD2cXitlart7w%3D 10.1111/j.0906-6705.2004.00151.x (Pubitemid 38247869)
161. PE Wakefield WD James CP Samlaska MS Meltzer 1991 Tumor necrosis factor J Am Acad Dermatol 24 675 685 1869638 1:STN:280:DyaK3Mzjt1Wquw%3D%3D 10.1016/0190-9622(91)70102-8
162. Wang D, Eiz-Vesper B, Zeitvogel J, Dressel R, Werfel T, Wittmann M (2011) Human keratinocytes release high levels of inducible heat shock protein 70 that enhances peptide uptake. Exp Dermatol
163. H Wang T Peters D Kess A Sindrilaru T Oreshkova N Van Rooijen A Stratis AC Renkl C Sunderkotter M Wlaschek I Haase K Scharffetter-Kochanek 2006 Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation J Clin Invest 116 2105 2114 16886059 1:CAS:528:DC%2BD28XnvF2mtro%3D 10.1172/JCI27180 (Pubitemid 44162319)
164. H Wang T Syrovets D Kess B Buchele H Hainzl O Lunov JM Weiss K Scharffetter-Kochanek T Simmet 2009 Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis J Immunol 183 4755 4763 19752240 1:CAS:528:DC%2BD1MXhtFGjsL3I 10.4049/jimmunol. 0900521
165. K Weber-Matthiesen W Sterry 1990 Organization of the monocyte/macrophage system of normal human skin J Invest Dermatol 95 83 89 2104511 1:STN:280:DyaK3czgvVeguw%3D%3D 10.1111/1523-1747.ep12874002 (Pubitemid 20219448)
166. A Wetzel T Wetzig UF Haustein M Sticherling U Anderegg JC Simon A Saalbach 2006 Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90) J Invest Dermatol 126 441 452 16374458 1:CAS:528:DC%2BD28XhsFWksrs%3D 10.1038/sj.jid.5700072 (Pubitemid 43323182)
167. JA Willment HH Lin DM Reid PR Taylor DL Williams SY Wong S Gordon GD Brown 2003 Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide J Immunol 171 4569 4573 14568930 1:CAS:528:DC%2BD3sXot1Cns7Y%3D (Pubitemid 37310572)
168. MT Wilson C Johansson D Olivares-Villagomez AK Singh AK Stanic CR Wang S Joyce MJ Wick L Van Kaer 2003 The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion Proc Natl Acad Sci USA 100 10913 10918 12960397 1:CAS:528: DC%2BD3sXnslyntLc%3D 10.1073/pnas.1833166100 (Pubitemid 37140127)
169. MT Wilson L Van Kaer 2003 Natural killer T cells as targets for therapeutic intervention in autoimmune diseases Curr Pharm Des 9 201 220 12570826 1:CAS:528:DC%2BD3sXisValsw%3D%3D 10.2174/1381612033392080 (Pubitemid 36131715)
170. NJ Wilson K Boniface JR Chan BS McKenzie WM Blumenschein JD Mattson B Basham K Smith T Chen F Morel JC Lecron RA Kastelein DJ Cua TK McClanahan EP Bowman R de Waal Malefyt 2007 Development, cytokine profile and function of human interleukin 17-producing helper T cells Nat Immunol 8 950 957 17676044 1:CAS:528:DC%2BD2sXptlSku7o%3D 10.1038/ni1497 (Pubitemid 47300009)
171. K Wolk HS Haugen W Xu E Witte K Waggie M Anderson E Vom Baur K Witte K Warszawska S Philipp C Johnson-Leger HD Volk W Sterry R Sabat 2009 IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not J Mol Med 87 523 536 19330474 1:CAS:528: DC%2BD1MXkvV2jsbs%3D 10.1007/s00109-009-0457-0
172. K Wolk S Kunz E Witte M Friedrich K Asadullah R Sabat 2004 IL-22 increases the innate immunity of tissues Immunity 21 241 254 15308104 1:CAS:528:DC%2BD2cXnsVKlt7k%3D 10.1016/j.immuni.2004.07.007 (Pubitemid 39094053)
173. K Wolk E Witte K Warszawska G Schulze-Tanzil K Witte S Philipp S Kunz WD Docke K Asadullah HD Volk W Sterry R Sabat 2009 The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis Eur J Immunol 39 3570 3581 19830738 1:CAS:528: DC%2BD1MXhsFaku77K 10.1002/eji.200939687
174. GM Woods RC Malley HK Muller 2005 The skin immune system and the challenge of tumour immunosurveillance Eur J Dermatol 15 63 69 15757812 1:CAS:528:DC%2BD2MXjsV2nu7c%3D (Pubitemid 40434626)
175. T Wrone-Smith BJ Nickoloff 1996 Dermal injection of immunocytes induces psoriasis J Clin Invest 98 1878 1887 8878440 1:CAS:528:DyaK28XmtlOrsrc%3D 10.1172/JCI118989 (Pubitemid 26359206)
176. JK Wu G Siller G Strutton 2004 Psoriasis induced by topical imiquimod Australas J Dermatol 45 47 50 14961909 10.1111/j.1440-0960.2004.00030.x (Pubitemid 38315850)
177. Z Yao SL Painter WC Fanslow D Ulrich BM Macduff MK Spriggs RJ Armitage 1995 Human IL-17: a novel cytokine derived from T cells J Immunol 155 5483 5486 7499828 1:CAS:528:DyaK2MXpvVertbk%3D
178. Y Yoshinaga M Higaki S Terajima E Ohkubo T Nogita N Miyasaka M Kawashima 1995 Detection of inflammatory cytokines in psoriatic skin Arch Dermatol Res 287 158 164 7763087 1:STN:280:DyaK2M3otlelsA%3D%3D 10.1007/BF01262325
179. Young MS, Furfaro N (2006) The rheumatology/dermatology collaboration. Dermatol Nurs Suppl:10-22
180. LC Zaba J Fuentes-Duculan NJ Eungdamrong MV Abello I Novitskaya KC Pierson J Gonzalez JG Krueger MA Lowes 2009 Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells J Invest Dermatol 129 79 88 18633443 1:CAS:528:DC%2BD1cXhsVymu7%2FK 10.1038/jid.2008.194
181. LC Zaba J Fuentes-Duculan RM Steinman JG Krueger MA Lowes 2007 Normal human dermis contains distinct populations of CD11c + BDCA-1 + dendritic cells and CD163 + FXIIIA + macrophages J Clin Invest 117 2517 2525 17786242 1:CAS:528:DC%2BD2sXhtVCms7jM 10.1172/JCI32282 (Pubitemid 47494353)
182. R Zenz R Eferl L Kenner L Florin L Hummerich D Mehic H Scheuch P Angel E Tschachler EF Wagner 2005 Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins Nature 437 369 375 16163348 1:CAS:528:DC%2BD2MXpvFOrt7k%3D 10.1038/nature03963 (Pubitemid 41613493)
183. K Zepter A Haffner LF Soohoo D De Luca HP Tang P Fisher J Chavinson CA Elmets 1997 Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli J Immunol 159 6203 6208 9550423 1:CAS:528:DyaK1cXht1SqtQ%3D%3D (Pubitemid 127471561)
184. Y Zhao R Fishelevich JP Petrali L Zheng MA Anatolievna A Deng RL Eckert AA Gaspari 2008 Activation of keratinocyte protein kinase C zeta in psoriasis plaques J Invest Dermatol 128 2190 2197 18385757 1:CAS:528:DC%2BD1cXpslWgu7s%3D 10.1038/jid.2008.81
185. Y Zheng DM Danilenko P Valdez I Kasman J Eastham-Anderson J Wu W Ouyang 2007 Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Nature 445 648 651 17187052 1:CAS:528: DC%2BD2sXhtlOrtLk%3D 10.1038/nature05505 (Pubitemid 46232884)
186. L Zhou II Ivanov R Spolski R Min K Shenderov T Egawa DE Levy WJ Leonard DR Littman 2007 IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 8 967 974 17581537 1:CAS:528:DC%2BD2sXptlSkurw%3D 10.1038/ni1488 (Pubitemid 47300011)
187. Y Dombrowski M Peric S Koglin T Ruzicka J Schauber 2010 Control of cutaneous antimicrobial peptides by vitamin D3 Arch Dermatol Res 302 401 408 20221619 1:CAS:528:DC%2BC3cXotVOrs7s%3D 10.1007/s00403-010-1045-4
188. SK Kim HY Kang YC Kim ES Lee 2010 Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers Arch Dermatol Res 302 295 299 20063005 1:CAS:528:DC%2BC3cXltlyqsbg%3D 10.1007/s00403-009-1025-8
189. U Mrowietz K Kragballe K Reich P Spuls CE Griffiths A Nast J Franke C Antoniou P Arenberger F Balieva M Bylaite O Correia E Dauden P Gisondi L Iversen L Kemeny M Lahfa T Nijsten T Rantanen A Reich T Rosenbach S Segaert C Smith T Talme B Volc-Platzer N Yawalkar 2011 Definition of treatment goals for moderate to severe psoriasis: a European consensus Arch Dermatol Res 303 1 10 20857129 1:STN:280:DC%2BC3M%2Fns1Glsw%3D%3D 10.1007/s00403-010-1080-1
190. OH Munz S Sela BS Baker CE Griffiths AV Powles L Fry 2010 Evidence for the presence of bacteria in the blood of psoriasis patients Arch Dermatol Res 302 495 498 20607546 10.1007/s00403-010-1065-0