BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction

Journal of Experimental Medicine

Volumn 194, Issue 12, 2001, Pages 1823-1834

  Dzionek, Andrzej ^a   Sohma, Yoshiaki ^b   Nagafune, Jun ^b   Cella, Marina ^c   Colonna, Marco ^c   Facchetti, Fabio ^d   Günther, Gritt ^a   Johnston, Ian ^a   Lanzavecchia, Antonio ^e   Nagasaka, Tomoko ^b   Okada, Tsutomu ^b   Vermi, William ^d   Winkels, Gregor ^a   Yamamoto, Terumi ^b   Zysk, Monika ^a   Yamaguchi, Yasunori ^b   Schmitz, Jürgen ^a  

^a MILTENYI BIOTEC GMBH   (Germany)

^b KIRIN BREWERY CO LTD   (Japan)

^c BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^d UNIVERSITY OF BRESCIA   (Italy)

^e INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Interferon inducers; Interferon type I; Magnetic cell sorting; Monoclonal antibodies; Systemic lupus erythematosus

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; LECTIN; PROTEIN BDCA 2; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INTERFERON PRODUCTION; INTERNALIZATION; MOLECULAR CLONING; NORMAL HUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; CLONING, MOLECULAR; DENDRITIC CELLS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; LECTINS; LECTINS, C-TYPE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; RECEPTORS, IMMUNOLOGIC; RECEPTORS, MITOGEN;

EID: 0035905321     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.12.1823     Document Type: Article

References (72)

1. Plasmacytoid T-cell clusters in non-specific lymphadenitis
2. Plasmacytoid T cells: Immunohistochemical evidence for their monocyte/macrophage origin
3. A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses
4. + cell subsets in human peripheral blood
5. Human mononuclear cells which produce interferon-alpha during NK(HSV-FS) assays are HLA-DR positive cells distinct from cytolytic natural killer effectors
6. Sequential enrichment and immunocytochemical visualization of human interferon-alpha-producing cells
7. Human natural interferon-alpha producing cells
8. The nature of the principal type 1 interferon-producing cells in human blood
9. The cell surface phenotype of human natural interferon-alpha producing cells as determined by flow cytometry
10. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
11. Reciprocal control of T helper cell and dendritic cell differentiation
12. + stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2
13. + hematopoietic stem cells
14. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded rna, respectively, stimulate CD11c(-) type 2 dendritic cell precursors and CD11c(+) dendritic cells to produce type I IFN
15. Differential regulation of human blood dendritic cell subsets by ifns
16. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells
17. + peripheral blood dendritic cells are differentially regulated by cytokines
18. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
19. BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
20. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
21. Natural interferon alpha/beta-producing cells link innate and adaptive immunity
22. + dendritic cells
23. Plasmacytoid T cells: A cell population normally present in the reactive lymph node. An immunohistochemical and electronmicroscopic study
24. Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin
25. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
26. - peripheral blood cells with dendritic precursor characteristics
27. Human peripheral blood contains two lineages of dendritic cells
28. - population
29. Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus
30. Human thymus contains 2 distinct dendritic cell populations
31. Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells
32. Plasmacytoid monocytes (so-called plasmacytoid T cells) in granulomatous lymphadenitis
33. Immunohistology and aetiology of histiocytic necrotizing lymphadenitis. Report of three instructive cases
34. Presence of cutaneous interferon-alpha producing cells in patients with systemic lupus erythematosus
35. Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
36. Plasmacytoid monocytes in Jessner's lymphocytic infiltration of the skin
37. Cutaneous Kikuchi's disease
38. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy
39. Two subsets of dendritic cells are present in human cerebrospinal fluid
40. Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases
41. Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms
42. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif
43. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments
44. Role of cAMP in regulating cytotoxic T lymphocyte adhesion and motility
45. Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
46. The C-type lectin superfamily in the immune system
47. Splicing of messenger RNA precursors
48. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
49. Different induction patterns of mRNA for IFN-alpha and -beta in human mononuclear leukocytes after in vitro stimulation with herpes simplex virus-infected fibroblasts and Sendai virus
50. Viral induction of low frequency interferon-alpha producing cells
51. Stimulation of natural interferon-alpha/beta-producing cells by Staphylococcus aureus
52. Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells
53. Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus
54. Immunobiology of dendritic cells
55. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
56. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
57. Fc epsilon RII/CD23 on epidermal Langerhans' cells
58. Langerin, a novel c-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
59. Dendritic cell lineage, plasticity and cross-regulation
60. Human TLIR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
61. Interferon and natural killer cells in systemic lupus erythematosus
62. Serum levels of interferons in patients with systemic lupus erythematosus
63. Serum interferon levels in patients with systemic lupus erythematosus
64. Antibodies against double-stranded DNA and development of polymyositis during treatment with interferon
65. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors
66. Possible induction of systemic lupus erythematosus by interferon-alpha treatment in a patient with a malignant carcinoid tumour
67. Appearance of anti-DNA antibodies in patients treated with interferon-alpha
68. Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha-producing cells
69. Role of tyrosine kinases, protein kinase C, and protein kinase A in the regulation of interferon-alpha production induced by herpes simplex virus type 1
70. Phorbol ester-mediated inhibition of IFN-alpha/beta gene transcription in blood mononuclear leukocytes
71. DAP12: A key accessory protein for relaying signals by natural killer cell receptors
72. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function