Cutting edge: NKT cells constitutively express IL-23 receptor and RORγt and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion

Journal of Immunology

Volumn 180, Issue 8, 2008, Pages 5167-5171

  Rachitskaya, Aleksandra V ^a,b   Hansen, Anna M ^a   Horai, Reiko ^a   Li, Zhuqing ^a   Villasmil, Rafael ^a   Luger, R Dro ^a   Nussenblatt, Robert B ^a   Caspi, Rachel R ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD3 ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RORGAMMA T; UNCLASSIFIED DRUG; INTERLEUKIN 23 RECEPTOR, MOUSE; INTERLEUKIN RECEPTOR; INTERLEUKIN-23 RECEPTOR, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; ORPHAN NUCLEAR RECEPTOR ROR GAMMA; ORPHAN NUCLEAR RECEPTOR ROR-GAMMA; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; INNATE IMMUNITY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; ANIMAL; C57BL MOUSE; HUMAN; IMMUNOLOGY; METABOLISM;

ANIMALS; CELLS, CULTURED; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; T-LYMPHOCYTE SUBSETS;

EID: 42649110747     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.8.5167     Document Type: Article

References (13)

1. H17 lineage. Nature 441: 231-234.
2. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
3. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240.
4. Lubberts, E., M. I. Koenders, B. Oppers-Walgreen, L. van den Bersselaar, C. J. Coenen-de Roo, L. A. Joosten, and W. B. van den Berg. 2004. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 50: 650-659.
5. Godfrey, D. I., H. R. MacDonald, M. Kronenberg, M. J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4: 231-237.
6. Bendelac, A., P. B. Savage, and L. Teyton. 2007. The biology of NKT cells. Annu. Rev. Immunol. 25: 297-336.
7. Cui, J., T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, and M. Taniguchi. 1997. Requirement for Vα14 NKT cells in IL-12- mediated rejection of tumors. Science 278: 1623-1626.
8. Smiley, S. T., M. H. Kaplan, and M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275: 977-979.
9. Langowski, J. L., X. Zhang, L. Wu, J. D. Mattson, T. Chen, K. Smith, B. Basham, T. McClanahan, R. A. Kastelein, and M. Oft. 2006. IL-23 promotes tumour incidence and growth. Nature 442: 461-465.
10. H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974.
11. Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168: 5699-5708.
12. neg iNKT cell population involved in airway neutrophilia. J. Exp. Med. 204: 995-1001.
13. H17 cells. Nature 448: 484-487.