Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state

Immunity

Volumn 21, Issue 3, 2004, Pages 391-400

  Mayerova, Dita ^a   Parke, Evan A ^a   Bursch, Laura S ^a   Odumade, Oludare A ^a   Hogquist, Kristin A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVITY; CHRONIC DISEASE; CONTROLLED STUDY; LANGERHANS CELL; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN DISEASE; STEADY STATE; T LYMPHOCYTE ACTIVATION; TISSUE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DISEASE MODELS, ANIMAL; HUMANS; IMMUNE TOLERANCE; KERATIN-14; KERATINS; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; OVALBUMIN; PROMOTER REGIONS (GENETICS); SKIN DISEASES;

EID: 4444383117     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2004.07.019     Document Type: Article

References (59)

1. Adler A.J., Marsh D.W., Yochum G.S., Guzzo J.L., Nigam A., Nelson W.G., Pardoll D.M. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187:1998;1555-1564
2. Allan R.S., Smith C.M., Belz G.T., Van Lint A.L., Wakim L.M., Heath W.R., Carbone F.R. Epidermal viral immunity induced by CD8{alpha}+ dendritic cells but tot by Langerhans cells. Science. 301:2003;1925-1928
3. Azukizawa H., Kosaka H., Sano S., Heath W.R., Takahashi I., Gao X.H., Sumikawa Y., Okabe M., Yoshikawa K., Itami S. Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes. Eur. J. Immunol. 33:2003;1879-1888
4. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252
5. Belz G.T., Behrens G.M., Smith C.M., Miller J.F., Jones C., Lejon K., Fathman C.G., Mueller S.N., Shortman K., Carmone F.R., Heath W.R. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 196:2002;1099
6. Bergstresser P.R., Fletcher C.R., Streilein J.W. Surface densities of Langerhans cells in relation to rodent epidermal sites with special immunologic properties. J. Invest. Dermatol. 74:1980;77-80
7. Blank C., Fuchs H., Rappersberger K., Rollinghoff M., Moll H. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major. J. Infect. Dis. 167:1993;418-425
8. Bonifaz L., Bonnyay D., Mahnke K., Rivera M., Nussenzweig M.C., Steinman R.M. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 196:2002;1627-1638
9. Borkowski T.A., Van Dyke B.J., Schwarzenberger K., McFarland V.W., Farr A.G., Udey M.C. Expression of E-cadherin by murine dendritic cells. E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells Eur. J. Immunol. 24:1994;2767-2774
10. Borkowski T.A., Letterio J.J., Mackall C.L., Saitoh A., Wang X.J., Roop D.R., Gress R.E., Udey M.C. A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice. J. Clin. Invest. 100:1997;575-581
11. Curtsinger J.M., Lins D.C., Mescher M.F. Signal 3 determines tolerance versus full activation of naive CD8 T cells. dissociating proliferation and development of effector function J. Exp. Med. 197:2003;1141-1151
12. Ehst B.D., Ingulli E., Jenkins M.K. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3:2003;1355-1362
13. Goldrath A.W., Bevan M.J. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity. 11:1999;183-190
14. Harkness J.E., Wagner J.E. The Biology and Medicine of Rabbits and Rodents. 3rd edn:1989;Lea & Febiger, Philadelphia
15. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M., Ravetch J.V., Steinman R.M., Nussenzweig M.C. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:2001;769-779
16. Heath W.R., Carbone F.R. Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19:2001;47-64
17. Hemmi H., Yoshino M., Yamazaki H., Naito M., Iyoda T., Omatsu Y., Shimoyama S., Letterio J.J., Nakabayashi T., Tagaya H., et al. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int. Immunol. 13:2001;695-704
18. Henri S., Vremec D., Kamath A., Waithman J., Williams S., Benoist C., Burnham K., Saeland S., Handman E., Shortman K. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167:2001;741-748
19. Hernandez J., Aung S., Redmond W.L., Sherman L.A. Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med. 194:2001;707-717
20. Hernandez J., Aung S., Marquardt K., Sherman L.A. Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens. J. Exp. Med. 196:2002;323-333
21. Hogquist K.A., Jameson S.C., Heath W.R., Howard J.L., Bevan M.J., Carbone F.R. T cell receptor antagonist peptides induce positive selection. Cell. 76:1994;17-27
22. Huang F.P., Platt N., Wykes M., Major J.R., Powell T.J., Jenkins C.D., MacPherson G.G. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191:2000;435-444
23. Itano A.A., McSorley S.J., Reinhardt R.L., Ehst B.D., Ingulli E., Rudensky A.Y., Jenkins M.K. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 19:2003;47-57
24. Kamath A.T., Henri S., Battye F., Tough D.F., Shortman K. Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Blood. 100:2002;1734-1741
25. Katz S.I., Tamaki K., Sachs D.H. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature. 282:1979;324-326
26. Kearney E.R., Pape K.A., Loh D.Y., Jenkins M.K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:1994;327-339
27. Kupper T.S., Fuhlbrigge R.C. Immune surveillance in the skin. mechanisms and clinical consequences Nat. Rev. Immunol. 4:2004;211-222
28. Kurts C. Cross-presentation. inducing CD8 T cell immunity and tolerance J. Mol. Med. 78:2000;326-332
29. Kurts C., Heath W.R., Carbone F.R., Allison J., Miller J.F., Kosaka H. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184:1996;923-930
30. Kurts C., Kosaka H., Carbone F.R., Miller J.F., Heath W.R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J. Exp. Med. 186:1997;239-245
31. Lo D., Freedman J., Hesse S., Palmiter R.D., Brinster R.L., Sherman L.A. Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur. J. Immunol. 22:1992;1013-1022
32. Lucas A., MacPherson G. Langerhans cells. immigrants or residents? Nat. Immunol. 3:2002;1125-1126
33. Mayerova D., Hogquist K.A. Central tolerance to self-antigen expressed by cortical epithelial cells. J. Immunol. 172:2004;851-856
34. McGargill M.A., Derbinski J.M., Hogquist K.A. Receptor editing in developing T cells. Nat. Immunol. 1:2000;336-341
35. McGargill M.A., Mayerova D., Stefanski H.E., Koehn B., Parke E.A., Jameson S.C., Panoskaltsis-Mortari A., Hogquist K.A. A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J. Immunol. 169:2002;2141-2147
36. Mellman I., Steinman R.M. Dendritic cells. specialized and regulated antigen processing machines Cell. 106:2001;255-258
37. Merad M., Manz M.G., Karsunky H., Wagers A., Peters W., Charo I., Weissman I.L., Cyster J.G., Engleman E.G. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3:2002;1135-1141
38. Morgan D.J., Kurts C., Kreuwel H.T., Holst K.L., Heath W.R., Sherman L.A. Ontogeny of T cell tolerance to peripherally expressed antigens. Proc. Natl. Acad. Sci. USA. 96:1999;3854-3858
39. Mueller S.N., Jones C.M., Smith C.M., Heath W.R., Carbone F.R. Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. J. Exp. Med. 195:2002;651-656
40. Nikolic-Zugic J., Bevan M.J. Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection. Proc. Natl. Acad. Sci. USA. 85:1988;8633-8637
41. Prlic M., Blazar B.R., Khoruts A., Zell T., Jameson S.C. Homeostatic expansion occurs independently of costimulatory signals. J. Immunol. 167:2001;5664-5668
42. Probst H.C., Lagnel J., Kollias G., van den Broek M. Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity. 18:2003;713-720
43. Randolph G.J. Is maturation required for Langerhans cell migration? J. Exp. Med. 196:2002;413-416
44. Romani N., Holzmann S., Tripp C.H., Koch F., Stoitzner P. Langerhans cells - dendritic cells of the epidermis. APMIS. 111:2003;725-740
45. Ruedl C., Koebel P., Bachmann M., Hess M., Karjalainen K. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J. Immunol. 165:2000;4910-4916
46. Saeki H., Moore A.M., Brown M.J., Hwang S.T. Cutting edge. secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes J. Immunol. 162:1999;2472-2475
47. Sato N., Ahuja S.K., Quinones M., Kostecki V., Reddick R.L., Melby P.C., Kuziel W.A., Ahuja S.S. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation. J. Exp. Med. 192:2000;205-218
48. Sauter B., Albert M.L., Francisco L., Larsson M., Somersan S., Bhardwaj N. Consequences of cell death. exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells J. Exp. Med. 191:2000;423-434
49. Schwarz A., Maeda A., Wild M.K., Kernebeck K., Gross N., Aragane Y., Beissert S., Vestweber D., Schwarz T. Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J. Immunol. 172:2004;1036-1043
50. Starr T.K., Jameson S.C., Hogquist K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21:2003;139-176
51. Stefanski H.E., Mayerova D., Jameson S.C., Hogquist K.A. A low affinity TCR ligand restores positive selection of CD8+ T cells in vivo. J. Immunol. 166:2001;6602-6607
52. Steinman R.M., Nussenzweig M.C. Avoiding horror autotoxicus. the importance of dendritic cells in peripheral T cell tolerance Proc. Natl. Acad. Sci. USA. 99:2002;351-358
53. Stockinger B. T lymphocyte tolerance. from thymic deletion to peripheral control mechanisms Adv. Immunol. 71:1999;229-265
54. Stoitzner P., Holzmann S., McLellan A.D., Ivarsson L., Stossel H., Kapp M., Kammerer U., Douillard P., Kampgen E., Koch F., et al. Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. J. Invest. Dermatol. 120:2003;266-274
55. Valladeau J., Clair-Moninot V., Dezutter-Dambuyant C., Pin J.J., Kissenpfennig A., Mattei M.G., Ait-Yahia S., Bates E.E., Malissen B., Koch F., et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168:2002;782-792
56. Vremec D., Zorbas M., Scollay R., Saunders D.J., Ardavin C.F., Wu L., Shortman K. The surface phenotype of dendritic cells purified from mouse thymus and spleen. investigation of the CD8 expression by a subpopulation of dendritic cells J. Exp. Med. 176:1992;47-58
57. Walker L.S., Abbas A.K. The enemy within. keeping self-reactive T cells at bay in the periphery Nat. Rev. Immunol. 2:2002;11-19
58. Wilson N.S., El-Sukkari D., Belz G.T., Smith C.M., Steptoe R.J., Heath W.R., Shortman K., Villadangos J.A. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood. 102:2003;2187-2194
59. Yoshino M., Yamazaki H., Nakano H., Kakiuchi T., Ryoke K., Kunisada T., Hayashi S. Distinct antigen trafficking from skin in the steady and active states. Int. Immunol. 15:2003;773-779