Plasmacytoid predendritic cells initiate psoriasis through interferon-α production

Journal of Experimental Medicine

Volumn 202, Issue 1, 2005, Pages 135-143

  Nestle, Frank O ^a   Conrad, Curdin ^a   Tun Kyi, Adrian ^a   Homey, Bernhard ^b   Gombert, Michael ^b   Boyman, Onur ^a   Burg, Günter ^a   Liu, Yong Jun ^c   Gilliet, Michel ^a,c  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSORIASIS; SIGNAL TRANSDUCTION; SKIN INFILTRATE; T LYMPHOCYTE; XENOGRAFT;

ANIMALS; DENDRITIC CELLS; HUMANS; IMMUNITY, NATURAL; INTERFERON-ALPHA; INTERFERON-BETA; KINETICS; MICE; MICE, KNOCKOUT; PLASMA CELLS; PSORIASIS; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; STEM CELLS; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS;

EID: 22344438901     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050500     Document Type: Article

References (64)

1. Lebwohl, M. 2003. Psoriasis. Lancet. 361:1197-1204.
2. Lew, W., A.M. Bowcock, and J.G. Krueger. 2004. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and 'Type 1' inflammatory gene expression. Trends Immunol. 25:295-305.
3. Adorini, L., and F. Sinigaglia. 1997. Pathogenesis and immunotherapy of autoimmune diseases. Immunol. Today. 18:209-211.
4. Davidson, A., and B. Diamond. 2001. Autoimmune diseases. N. Engl. J. Med. 345:340-350.
5. Griffiths, C.E., and J.J. Voorhees. 1996. Psoriasis, T cells and autoimmunity. J. R. Soc. Med. 89:315-319.
6. Nickoloff, B.J., and F.O. Nestle. 2004. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J. Clin. Invest. 113:1664-1675.
7. Lowes, M.A., W. Lew, and J.G. Krueger. 2004. Current concepts in the immunopathogenesis of psoriasis. Dermatol. Clin. 22:349-369.
8. Liu, Y.J. 2005. IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23:275-306.
9. Siegal, F.P., N. Kadowaki, M. Shodell, P.A. Fitzgerald-Bocarsly, K. Shah, S. Ho, S. Antonenko, and Y.J. Liu. 1999. The nature of the principal type 1 interferon-producing cells in human blood. Science. 284:1835-1837.
10. Cella, M., D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, and M. Colonna. 1999. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5:919-923.
11. Kadowaki, N., S. Antonenko, J.Y. Lau, and Y.J. Liu. 2000. Natural interferon α/β-producing cells link innate and adaptive immunity. J. Exp. Med. 192:219-226.
12. Fonteneau, J.F., M. Gilliet, M. Larsson, I. Dasilva, C. Munz, Y.J. Liu, and N. Bhardwaj. 2003. Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood. 101:3520-3526.
13. Blanco, P., A.K. Palucka, M. Gill, V. Pascual, and J. Banchereau. 2001. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science. 294:1540-1543.
14. Vanbervliet, B., N. Bendriss-Vermare, C. Massacrier, B. Homey, O. de Bouteiller, F. Briere, G. Trinchieri, and C. Caux. 2003. The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12. J. Exp. Med. 198:823-830.
15. Farkas, L., K. Beiske, F. Lund-Johansen, P. Brandtzaeg, and F.L. Jahnsen. 2001. Plasmacytoid dendritic cells (natural interferon-alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am. J. Pathol. 159:237-243.
16. Jahnsen, F.L., F. Lund-Johansen, J.F. Dunne, L. Farkas, R. Haye, and P. Brandtzaeg. 2000. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J. Immunol. 165:4062-4068.
17. Wollenberg, A., M. Wagner, S. Gunther, A. Towarowski, E. Tuma, M. Moderer, S. Rothenfusser, S. Wetzel, S. Endres, and G. Hartmann. 2002. Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J. Invest. Dermatol. 119:1096-1102.
18. Bangert, C., J. Friedl, G. Stary, G. Stingl, and T. Kopp. 2003. Immunopathologic features of allergic contact dermatitis in humans: participation of plasmacytoid dendritic cells in the pathogenesis of the disease? J. Invest. Dermatol. 121:1409-1418.
19. Gilliet, M., C. Conrad, M. Geiges, A. Cozzio, W. Thurlimann, G. Burg, F.O. Nestle, and R. Dummer. 2004. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch. Dermatol. 140:1490-1495.
20. van der Fits, L., L.I. van der Wel, J.D. Laman, E.P. Prens, and M.C. Verschuren. 2004. In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered. J. Invest. Dermatol. 122:51-60.
21. Schmid, P., P. Itin, D. Cox, G.K. McMaster, and M.A. Horisberger. 1994. The type I interferon system is locally activated in psoriatic lesions. J. Interferon Res. 14:229-234.
22. Fah, J., J. Pavlovic, and G. Burg. 1995. Expression of MxA protein in inflammatory dermatoses. J. Histochem. Cytochem. 43:47-52.
23. Suomela, S., L. Cao, A. Bowcock, and U. Saarialho-Kere. 2004. Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers. J. Invest. Dermatol. 122:717-721.
24. Hida, S., K. Ogasawara, K. Sato, M. Abe, H. Takayanagi, T. Yokochi, T. Sato, S. Hirose, T. Shirai, S. Taki, and T. Taniguchi. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. Immunity. 13:643-655.
25. Funk, J., T. Langeland, E. Schrumpf, and L.E. Hanssen. 1991. Psoriasis induced by interferon-alpha. Br. J. Dermatol. 125:463-465.
26. Pauluzzi, P., F. Kokelj, V. Perkan, G. Pozzato, and M. Moretti. 1993. Psoriasis exacerbation induced by interferon-alpha. Report of two cases. Acta Derm. Venereol. 73:395.
27. Downs, A.M., and M.G. Dunnill. 2000. Exacerbation of psoriasis by interferon-alpha therapy for hepatitis C. Clin. Exp. Dermatol. 25:351-352.
28. Ketikoglou, I., S. Karatapanis, I. Elefsiniotis, G. Kafiri, and A. Moulakakis. 2005. Extensive psoriasis induced by pegylated interferon alpha-2b treatment for chronic hepatitis B. Eur. J. Dermatol. 15:107-109.
29. Dzionek, A., Y. Sohma, J. Nagafune, M. Cella, M. Colonna, F. Facchetti, G. Gunther, I. Johnston, A. Lanzavecchia, T. Nagasaka, et al. 2001. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon α/β induction. J. Exp. Med. 194:1823-1834.
30. Grouard, G., M.C. Rissoan, L. Filgueira, I. Durand, J. Banchereau, and Y.J. Liu. 1997. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185: 1101-1111.
31. Cederblad, B., S. Blomberg, H. Vallin, A. Perers, G.V. Alm, and L. Ronnblom. 1998. Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha-producing cells. J. Autoimmun. 11:465-470.
32. Sato, M., H. Suemori, N. Hata, M. Asagiri, K. Ogasawara, K. Nakao, T. Nakaya, M. Katsuki, S. Noguchi, N. Tanaka, and T. Taniguchi. 2000. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity. 13:539-548.
33. Kawai, T., S. Sato, K.J. Ishii, C. Coban, H. Hemmi, M. Yamamoto, K. Terai, M. Matsuda, J. Inoue, S. Uematsu, et al. 2004. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5:1061-1068.
34. Ronni, T., K. Melen, A. Malygin, and I. Julkunen. 1993. Control of IFN-inducible MxA gene expression in human cells. J. Immunol. 150: 1715-1726.
35. Roers, A., H.K. Hochkeppel, M.A. Horisberger, A. Hovanessian, and O. Haller. 1994. MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J. Infect. Dis. 169: 807-813.
36. Boyman, O., H.P. Hefti, C. Conrad, B.J. Nickoloff, M. Suter, and F.O. Nestle. 2004. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α. J. Exp. Med. 199:731-736.
37. Vissers, W.H., C.H. Arndtz, L. Muys, P.E. Van Erp, E.M. De Jong, and P.C. Van De Kerkhof. 2004. Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late. Br. J. Dermatol. 150:852-859.
38. Colamonici, O.R., and P. Domanski. 1993. Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J. Biol. Chem. 268:10895-10899.
39. Kadowaki, N., S. Ho, S. Antonenko, R.W. Malefyt, R.A. Kastelein, F. Bazan, and Y.J. Liu. 2001. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:863-869.
40. Jarrossay, D., G. Napolitani, M. Colonna, F. Sallusto, and A. Lanzavecchia. 2001. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31:3388-3393.
41. Van Krinks, C.H., M.K. Matyszak, and J.S. Gaston. 2004. Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid. Rheumatology (Oxford). 43:453-460.
42. Kupper, T.S., and R.C. Fuhlbrigge. 2004. Immune surveillance in the skin: mechanisms and clinical consequences. Nat. Rev. Immunol. 4:211-222.
43. Diebold, S.S., T. Kaisho, H. Hemmi, S. Akira, and E.S.C. Reis. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science. 303:1529-1531.
44. Lang, K.S., M. Recher, T. Junt, A.A. Navarini, N.L. Harris, S. Freigang, B. Odermatt, C. Conrad, L.M. Ittner, S. Bauer, et al. 2005. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat. Med. 11:138-145.
45. Banchereau, J., V. Pascual, and A.K. Palucka. 2004. Autoimmunity through cytokine-induced dendritic cell activation. Immunity. 20:539-550.
46. Nestle, F.O., L.A. Turka, and B.J. Nickoloff. 1994. Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J. Clin. Invest. 94:202-209.
47. Le Bon, A., N. Etchart, C. Rossmann, M. Ashton, S. Hou, D. Gewert, P. Borrow, and D.F. Tough. 2003. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 4:1009-1015.
48. Zhang, X., S. Sun, I. Hwang, D.F. Tough, and J. Sprent. 1998. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity. 8:591-599.
49. Hibbert, L., S. Pflanz, R. De Waal Malefyt, and R.A. Kastelein. 2003. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interferon Cytokine Res. 23:513-522.
50. Leonardi, C.L., J.L. Powers, R.T. Matheson, B.S. Goffe, R. Zitnik, A. Wang, and A.B. Gottlieb. 2003. Etanercept as monotherapy in patients with psoriasis. N. Engl. J. Med. 349:2014-2022.
51. Chaudhari, U., P. Romano, L.D. Mulcahy, L.T. Dooley, D.G. Baker, and A.B. Gottlieb. 2001. Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet. 357:1842-1847.
52. Schottelius, A.J., L.L. Moldawer, C.A. Dinarello, K. Asadullah, W. Sterry, and C.K. Edwards III. 2004. Biology of tumor necrosis factor-alpha: implications for psoriasis. Exp. Dermatol. 13:193-222.
53. Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature. 434:1035-1040.
54. Theofilopoulos, A.N., R. Baccala, B. Beutler, and D.H. Kono. 2005. Type I interferons in immunity and autoimmunity. Annu. Rev. Immunol. 23:307-335.
55. Gota, C., and L. Calabrese. 2003. Induction of clinical autoimmune disease by therapeutic interferon-alpha. Autoimmunity. 36:511-518.
56. Guerci, A.P., B. Guerci, C. Levy-Marchal, J. Ongagna, O. Ziegler, H. Candiloros, O. Guerci, and P. Drouin. 1994. Onset of insulin-dependent diabetes mellitus after interferon-alpha therapy for hairy cell leukaemia. Lancet. 343:1167-1168.
57. Passos de Souza, E., P.T. Evangelista Segundo, F.F. Jose, D. Lemaire, and M. Santiago. 2001. Rheumatoid arthritis induced by alpha-interferon therapy. Clin. Rheumatol. 20:297-299.
58. Bengtsson, A.A., G. Sturfelt, L. Truedsson, J. Blomberg, G. Alm, H. Vallin, and L. Ronnblom. 2000. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus. 9:664-671.
59. Bennett, L., A.K. Palucka, E. Arce, V. Cantrell, J. Borvak, J. Banchereau, and V. Pascual. 2003. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J. Exp. Med. 197:711-723.
60. Vallin, H., A. Perers, G.V. Alm, and L. Ronnblom. 1999. Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. J. Immunol. 163:6306-6313.
61. Huang, X., J. Yuang, A. Goddard, A. Foulis, R.F. James, A. Lernmark, R. Pujol-Borrell, A. Rabinovitch, N. Somoza, and T.A. Stewart. 1995. Interferon expression in the pancreases of patients with type I diabetes. Diabetes. 44:658-664.
62. Stewart, T.A., B. Hultgren, X. Huang, S. Pitts-Meek, J. Hully, and N.J. MacLachlan. 1993. Induction of type I diabetes by interferon-alpha in transgenic mice. Science. 260:1942-1946.
63. Lande, R., E. Giacomini, B. Serafini, B. Rosicarelli, G.D. Sebastiani, G. Minisola, U. Tarantino, V. Riccieri, G. Valesini, and E.M. Coccia. 2004. Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis. J. Immunol. 173:2815-2824.
64. Sterry, W., J. Barker, W.H. Boehncke, J.D. Bos, S. Chimenti, E. Christophers, M. De La Brassinne, C. Ferrandiz, C. Griffiths, A. Katsambas, et al. 2004. Biological therapies in the systemic management of psoriasis: International Consensus Conference. Br. J. Dermatol. 151:3-17.