Reactivity of resident immunocytes in normal and prepsoriatic skin using an ex vivo skin-explant model system

Archives of Pathology and Laboratory Medicine

Volumn 127, Issue 3, 2003, Pages 289-296

  Curry, Jonathan L ^a   Qin, Jian Zhong ^a   Robinson, June ^a   Nickoloff, Brian J ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; GAMMA INTERFERON; HEAT SHOCK PROTEIN; INTERLEUKIN 2; KERATINOCYTE GROWTH FACTOR; LIPOPOLYSACCHARIDE;

ADULT; AGED; ARTICLE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NORMAL HUMAN; ORGAN CULTURE; PSORIASIS; SKIN; T LYMPHOCYTE; TISSUE REACTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; CULTURE MEDIA; CYTOKINES; ENTEROTOXINS; GROWTH SUBSTANCES; HUMANS; IMMUNITY, CELLULAR; IMMUNOPHENOTYPING; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; MIDDLE AGED; ORGAN CULTURE TECHNIQUES; PSORIASIS; SKIN; SUPERANTIGENS;

EID: 0037347622     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Medzhitov R. An ancient system of host defense. Curr Opin Immunol. 1998;10:12-15.
2. Chuong CM, Nickoloff BJ, Elias PM. What is the true function of skin? Exp Dermatol. 2002;11:159-187.
3. Henderson CA, Highet AS. Acute psoriasis associated with Lancefield Group C and Group G cutaneous streptococcal infections. Br J Dermatol. 1988;118:559-561.
4. Leung DY, Harbeck R, Bina P, et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis: evidence for a new group of allergens. J Clin Invest. 1993;92:1374-1380.
5. Travers JB, Hamid QA, Norris DA, et al. Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis. J Clin Invest. 1999;104:1181-1189.
6. Nickoloff BJ. The cytokine network in psoriasis. Arch Dermatol. 1991;127:871-884.
7. Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol. 1999;113:752-759.
8. Bowcock AM, Shannon W, Du F, et al. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet. 2001;10:1793-1805.
9. Nickoloff BJ. Skin innate immune system in psoriasis: friend or foe? J Clin Invest. 1999;104:1161-1164.
10. Curry JL, Qin J-Z, Bonish B, et al. Innate immune-related receptors in normal and psoriatic skin. Arch Pathol Lab Med. 2003;127:178-186.
11. Nickoloff BJ, Wrone-Smith T. Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis. Am J Pathol. 1999;155:145-158.
12. Schechner JS, Edelson RL, McNiff JM, Heald PW, Pober JS. Integrins alpha4beta7 and alphaEbeta7 are expressed on epidermotropic T cells in cutaneous T cell lymphoma and spongiotic dermatitis. Lab Invest. 1999;79:601-607.
13. Nickoloff BJ, Wrone-Smith T, Bonish B, Porcelli SA. Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161. Arch Dermatol. 1999;135:546-552.
14. Nickoloff BJ, Bonish B, Huang BB, Porcelli SA. Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. J Dermatol Sci. 2000;24:212-225.
15. Uyemura K, Yamamura M, Fivenson DF, Modlin RL, Nickoloff BJ. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol. 1993;101:701-705.
16. Schlaak JF, Buslau M, Jochum W, et al. T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol. 1993;101:145-149.
17. Spetz AL, Strominger J, Groh-Spies V. T cell subsets in normal human epidermis. Am J Pathol. 1996;149:665-674.
18. Shiohara T, Moriya N. Epidermal T cells: their functional role and disease relevance for dermatologists. J Invest Dermatol. 1997;109:271-275.
19. Girardi M, Lewis J, Glusac E, et al. Resident skin-specific gamma delta T cells provide local, nonredundant regulation of cutaneous inflammation. J Exp Med. 2002;195:855-867.
20. Vollmer S, Menssen A, Trommler P, Schendel D, Prinz JC. T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells. Eur J Immunol. 1994;24:2377-2382.
21. Ferenczi K, Burack L, Pope M, Krueger JG, Austin LM. CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J Autoimmun. 2000;14:63-78.
22. Nickoloff BJ. The immunologic and genetic basis of psoriasis. Arch Dermatol. 1999;135:1104-1110.
23. Baker BS, Griffiths CE, Lambert S, et al. The effects of cyclosporin A on T lymphocyte and dendritic cell sub-populations in psoriasis. Br J Dermatol. 1987;116:503-510.
24. Weinshenker BG, Bass BH, Ebers GC, Rice GP. Remission of psoriatic lesions with muromonab-CD3 (orthoclone OKT3) treatment. J Am Acad Dermatol. 1989;20:1132-1133.
25. Thomson AW, Nalesnik M, Abu-Elmagd K, Starzl TE. Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study. Transplant Proc. 1991;23:3330-3331.
26. Coven TR, Murphy FP, Gilleaudeau P, Cardinale I, Krueger JG. Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris: evidence that epidermal immunocytes are direct therapeutic targets. Arch Dermatol. 1998;134:1263-1268.
27. Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab Invest. 2001;81:335-347.
28. Homey B, Alenius H, Muller A, et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med. 2002;8:157-165.
29. Schon MP, Krahn T, Schon M, et al. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nat Med. 2002;8:366-372.
30. Lee RE, Gaspari AA, Lotze MT, Chang AE, Rosenberg SA. Interleukin 2 and psoriasis. Arch Dermatol. 1988;124:1811-1815.
31. Nizet V, Ohtake T, Lauth X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 2001;414:454-457.
32. Farber EM, Nickoloff BJ, Recht B, Fraki JE. Stress, symmetry, and psoriasis: possible role of neuropeptides. J Am Acad Dermatol. 1986;14:305-311.
33. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet. 1988;22:631-677.
34. Asea A, Kraeft SK, Kurt-Jones EA, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000;6:435-442.
35. Boyman O, Hefti H, Suter M, Nickoloff BJ, Nestle FO. Conversion of un-involved to involved psoriatic skin transplanted onto AGR mice indicates intrinsic default pathway of psoriasis disease pathogenesis. J Invest Dermatol. 2002;119:302.
36. Binder RJ, Karimeddini D, Srivastava PK. Adjuvanticity of alpha 2-macroglobulin, an independent ligand for the heat shock protein receptor CD91. J Immunol. 2001;166:4968-4672.
37. Marchese C, Chedid M, Dirsch OR, et al. Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J Exp Med. 1995;182:1369-1376.
38. Boismenu R, Havran WL. Modulation of epithelial cell growth by intra-epithelial gamma delta T cells. Science. 1994;266:1253-1255.
39. Nestle FO, Turka LA, Nickoloff BJ. Characterization of dermal dendritic cells in psoriasis: autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest. 1994;94:202-209.