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This demonstrates the crucial role of mast cells in initiating local inflammatory responses as well as lymph node hypertrophy, including dendritic cell localization, in response to mosquito bites.
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Depinay N., Hacini F., Beghdadi W., Peronet R., and Mecheri S. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176 (2006) 4141-4146. This article demonstrates that mosquito bites in the skin induce local MIP-2 and IL-10 responses in the draining lymph node by way of a mast cell dependent mechanism. Decreased antigen-specific immune responses are observed following mosquito bites, suggesting a mechanism for decreased potential responses to infection with mosquito-borne pathogens.
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