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Volumn 129, Issue 9, 2009, Pages 2175-2183

Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 22; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; TUMOR NECROSIS FACTOR ALPHA;

EID: 70349753261     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.65     Document Type: Article
Times cited : (420)

References (39)
  • 1
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007a) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8:942-949
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 4
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG (1999) The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 113:752-759
    • (1999) J Invest Dermatol , vol.113 , pp. 752-759
    • Austin, L.M.1    Ozawa, M.2    Kikuchi, T.3    Walters, I.B.4    Krueger, J.G.5
  • 5
    • 70349750355 scopus 로고    scopus 로고
    • New concepts in the pathogenesis and treatment of psoriasis: Key roles for IL-23, IL-17A and TGF-b1
    • Blauvelt A (2007) New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-b1. Expert Rev Dermatol 2:1-10
    • (2007) Expert Rev Dermatol , vol.2 , pp. 1-10
    • Blauvelt, A.1
  • 6
    • 34547774225 scopus 로고    scopus 로고
    • Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
    • Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L et al. (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 122:201-206
    • (2007) Hum Genet , vol.122 , pp. 201-206
    • Capon, F.1    Di Meglio, P.2    Szaub, J.3    Prescott, N.J.4    Dunster, C.5    Baumber, L.6
  • 7
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80:273-290
    • (2007) Am J Hum Genet , vol.80 , pp. 273-290
    • Cargill, M.1    Schrodi, S.J.2    Chang, M.3    Garcia, V.E.4    Brandon, R.5    Callis, K.P.6
  • 8
    • 33751546237 scopus 로고    scopus 로고
    • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogen-esis
    • Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S et al. (2006) IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogen-esis. J Exp Med 203:2577-2587
    • (2006) J Exp Med , vol.203 , pp. 2577-2587
    • Chan, J.R.1    Blumenschein, W.2    Murphy, E.3    Diveu, C.4    Wiekowski, M.5    Abbondanzo, S.6
  • 9
    • 33750074486 scopus 로고    scopus 로고
    • Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: Implications for dermatitis
    • Farley SM, Dotson AD, Purdy DE, Sundholm AJ, Schneider P, Magun BE et al. (2006) Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis. J Invest Dermatol 126:2438-2451
    • (2006) J Invest Dermatol , vol.126 , pp. 2438-2451
    • Farley, S.M.1    Dotson, A.D.2    Purdy, D.E.3    Sundholm, A.J.4    Schneider, P.5    Magun, B.E.6
  • 10
    • 38149030231 scopus 로고    scopus 로고
    • Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis: Recruitment of the epidermal growth factor receptor and activation of MAP kinases
    • Farley SM, Purdy DE, Ryabinina OP, Schneider P, Magun BE, Iordanov MS (2008) Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis: recruitment of the epidermal growth factor receptor and activation of MAP kinases. J Biol Chem 283:919-928
    • (2008) J Biol Chem , vol.283 , pp. 919-928
    • Farley, S.M.1    Purdy, D.E.2    Ryabinina, O.P.3    Schneider, P.4    Magun, B.E.5    Iordanov, M.S.6
  • 12
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N et al. (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204:2803-2812
    • (2007) J Exp Med , vol.204 , pp. 2803-2812
    • Hirota, K.1    Yoshitomi, H.2    Hashimoto, M.3    Maeda, S.4    Teradaira, S.5    Sugimoto, N.6
  • 13
    • 0034660183 scopus 로고    scopus 로고
    • Up-regulation of macrophage inflammatory protein-3 alpha/ CCL20 and CC chemokine receptor 6 in psoriasis
    • Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E et al. (2000) Up-regulation of macrophage inflammatory protein-3 alpha/ CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164:6621-6632
    • (2000) J Immunol , vol.164 , pp. 6621-6632
    • Homey, B.1    Dieu-Nosjean, M.C.2    Wiesenborn, A.3    Massacrier, C.4    Pin, J.J.5    Oldham, E.6
  • 14
    • 0036315395 scopus 로고    scopus 로고
    • The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor
    • Iordanov MS, Choi RJ, Ryabinina OP, Dinh TH, Bright RK, Magun BE (2002) The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol Cell Biol 22:5380-5394
    • (2002) Mol Cell Biol , vol.22 , pp. 5380-5394
    • Iordanov, M.S.1    Choi, R.J.2    Ryabinina, O.P.3    Dinh, T.H.4    Bright, R.K.5    Magun, B.E.6
  • 15
    • 22144446792 scopus 로고    scopus 로고
    • Cell death-induced activation of epidermal growth factor receptor in keratinocytes: Implications for restricting epidermal damage in dermatitis
    • Iordanov MS, Sundholm AJ, Simpson EL, Hanifin JM, Ryabinina OP, Choi RJ et al. (2005) Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis. J Invest Dermatol 125:134-142
    • (2005) J Invest Dermatol , vol.125 , pp. 134-142
    • Iordanov, M.S.1    Sundholm, A.J.2    Simpson, E.L.3    Hanifin, J.M.4    Ryabinina, O.P.5    Choi, R.J.6
  • 16
    • 4344688669 scopus 로고    scopus 로고
    • IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways
    • Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C et al. (2004) IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol 173:3482-3491
    • (2004) J Immunol , vol.173 , pp. 3482-3491
    • Kao, C.Y.1    Chen, Y.2    Thai, P.3    Wachi, S.4    Huang, F.5    Kim, C.6
  • 17
    • 27744597320 scopus 로고    scopus 로고
    • Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway
    • Kao CY, Huang F, Chen Y, Thai P, Wachi S, Kim C et al. (2005) Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J Immunol 175:6676-6685
    • (2005) J Immunol , vol.175 , pp. 6676-6685
    • Kao, C.Y.1    Huang, F.2    Chen, Y.3    Thai, P.4    Wachi, S.5    Kim, C.6
  • 18
    • 39649108216 scopus 로고    scopus 로고
    • Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: Results of a randomized, placebo-controlled, phase 2 trial
    • Kimball AB, Gordon KB, Langley RG, Menter A, Chartash EK, Valdes JM (2008) Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial. Arch Dermatol 144:200-207
    • (2008) Arch Dermatol , vol.144 , pp. 200-207
    • Kimball, A.B.1    Gordon, K.B.2    Langley, R.G.3    Menter, A.4    Chartash, E.K.5    Valdes, J.M.6
  • 20
    • 58149316658 scopus 로고    scopus 로고
    • Induction of IL-17+ T cell trafficking and development by IFN-gamma: Mechanism and pathological relevance in psoriasis
    • Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L et al. (2008) Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733-4741
    • (2008) J Immunol , vol.181 , pp. 4733-4741
    • Kryczek, I.1    Bruce, A.T.2    Gudjonsson, J.E.3    Johnston, A.4    Aphale, A.5    Vatan, L.6
  • 21
    • 32244441218 scopus 로고    scopus 로고
    • Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ Tcell crosspriming in vivo
    • Le Borgne M, Etchart N, Goubier A, Lira SA, Sirard JC, van Rooijen N et al. (2006) Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ Tcell crosspriming in vivo. Immunity 24:191-201
    • (2006) Immunity , vol.24 , pp. 191-201
    • Le Borgne, M.1    Etchart, N.2    Goubier, A.3    Lira, S.A.4    Sirard, J.C.5    Van Rooijen, N.6
  • 22
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL, Pittman D, Wang F, Chamian F et al. (2004) Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199:125-130
    • (2004) J Exp Med , vol.199 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3    Pittman, D.4    Wang, F.5    Chamian, F.6
  • 23
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • DOI 10.1016/S0140-6736(08)60725-4, PII S0140673608607254
    • Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371:1665-1674 (Pubitemid 351671883)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6    Li, S.7    Dooley, L.T.8    Gordon, K.B.9
  • 24
    • 2342485676 scopus 로고    scopus 로고
    • Psoriasis vulgaris: Cutaneous lymphoid tissue supports T-cell activation and "type 1" inflammatory gene expression
    • Lew W, Bowcock AM, Krueger JG (2004) Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression. Trends Immunol 25:295-305
    • (2004) Trends Immunol , vol.25 , pp. 295-305
    • Lew, W.1    Bowcock, A.M.2    Krueger, J.G.3
  • 25
    • 40449111457 scopus 로고    scopus 로고
    • Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells
    • Lim HW, Lee J, Hillsamer P, Kim CH (2008) Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol 180:122-129
    • (2008) J Immunol , vol.180 , pp. 122-129
    • Lim, H.W.1    Lee, J.2    Hillsamer, P.3    Kim, C.H.4
  • 27
    • 38849187386 scopus 로고    scopus 로고
    • IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
    • Ma HL, Liang S, Li J, Napierata L, Brown T, Benoit S et al. (2008) IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 118:597-607
    • (2008) J Clin Invest , vol.118 , pp. 597-607
    • Ma, H.L.1    Liang, S.2    Li, J.3    Napierata, L.4    Brown, T.5    Benoit, S.6
  • 29
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • DOI 10.1016/S0140-6736(08)60726-6, PII S0140673608607266
    • Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371:1675-1684 (Pubitemid 351671884)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6    Guzzo, C.7    Hsu, M.-C.8    Wang, Y.9    Li, S.10    Dooley, L.T.11    Reich, K.12
  • 30
    • 39149087671 scopus 로고    scopus 로고
    • Essential role of CCR6 in directing activated T cells to the skin during contact hypersensitivity
    • Paradis TJ, Cole SH, Nelson RT, Gladue RP (2007) Essential role of CCR6 in directing activated T cells to the skin during contact hypersensitivity. J Invest Dermatol 128:628-633
    • (2007) J Invest Dermatol , vol.128 , pp. 628-633
    • Paradis, T.J.1    Cole, S.H.2    Nelson, R.T.3    Gladue, R.P.4
  • 31
    • 31144441631 scopus 로고    scopus 로고
    • In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: Enhanced expression in psoriatic skin
    • Piskin G, Sylva-Steenland RM, Bos JD, Teunissen MB (2006) In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 176:1908-1915
    • (2006) J Immunol , vol.176 , pp. 1908-1915
    • Piskin, G.1    Sylva-Steenland, R.M.2    Bos, J.D.3    Teunissen, M.B.4
  • 32
    • 33845492156 scopus 로고    scopus 로고
    • Modelling the human epidermis in vitro: Tools for basic and applied research
    • Poumay Y, Coquette A (2007) Modelling the human epidermis in vitro: tools for basic and applied research. Arch Dermatol Res 298: 361-369
    • (2007) Arch Dermatol Res , vol.298 , pp. 361-369
    • Poumay, Y.1    Coquette, A.2
  • 33
    • 8644225587 scopus 로고    scopus 로고
    • A simple reconstructed human epidermis: Preparation of the culture model and utilization in in vitro studies
    • Poumay Y, Dupont F, Marcoux S, Leclercq-Smekens M, Herin M, Coquette A (2004) A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies. Arch Dermatol Res 296:203-211
    • (2004) Arch Dermatol Res , vol.296 , pp. 203-211
    • Poumay, Y.1    Dupont, F.2    Marcoux, S.3    Leclercq-Smekens, M.4    Herin, M.5    Coquette, A.6
  • 34
    • 40449141770 scopus 로고    scopus 로고
    • Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
    • Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM (2008) Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol 180:214-221
    • (2008) J Immunol , vol.180 , pp. 214-221
    • Singh, S.P.1    Zhang, H.H.2    Foley, J.F.3    Hedrick, M.N.4    Farber, J.M.5
  • 35
    • 22044439846 scopus 로고    scopus 로고
    • CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses
    • Varona R, Cadenas V, Gomez L, Martinez AC, Marquez G (2005) CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses. Blood 106:18-26
    • (2005) Blood , vol.106 , pp. 18-26
    • Varona, R.1    Cadenas, V.2    Gomez, L.3    Martinez, A.C.4    Marquez, G.5
  • 37
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
    • Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K et al. (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309-1323
    • (2006) Eur J Immunol , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3    Docke, W.D.4    Kunz, S.5    Asadullah, K.6
  • 39
    • 0037453146 scopus 로고    scopus 로고
    • Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array
    • Zhou X, Krueger JG, Kao MC, Lee E, Du F, Menter A et al. (2003) Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 13:69-78
    • (2003) Physiol Genomics , vol.13 , pp. 69-78
    • Zhou, X.1    Krueger, J.G.2    Kao, M.C.3    Lee, E.4    Du, F.5    Menter, A.6


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