Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

British Journal of Dermatology

Volumn 159, Issue 5, 2008, Pages 1092-1102

  Nograles, K E ^a   Zaba, L C ^a   Guttman Yassky, E ^a   Fuentes Duculan, J ^a   Suarez Farinas M ^a   Cardinale, I ^a   Khatcherian, A ^a   Gonzalez, J ^a   Pierson, K C ^a   White, T R ^a   Pensabene, C ^a   Coats, I ^a   Novitskaya, I ^a   Lowes, M A ^a   Krueger, J G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Interleukin 17; Interleukin 22; Keratinocytes; Th1; Th17

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 22;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PSORIASIS; T LYMPHOCYTE;

CHRONIC DISEASE; CYTOKINES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKINS; KERATINOCYTES; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TISSUE ARRAY ANALYSIS;

EID: 54249130813     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08769.x     Document Type: Article

References (51)

1. Ellis CN, Gorsulowsky DC, Hamilton TA et al. Cyclosporine improves psoriasis in a double-blind study. JAMA 1986 256 : 3110 16.
2. Jegasothy BV, Ackerman CD, Todo S et al. Tacrolimus (FK 506) - a new therapeutic agent for severe recalcitrant psoriasis. Arch Dermatol 1992 128 : 781 5.
3. Nicolas JF, Chamchick N, Thivolet J et al. CD4 antibody treatment of severe psoriasis. Lancet 1991 338 : 321.
4. Gottlieb AB, Lebwohl M, Shirin S et al. Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: results of a pilot, multicenter, multiple-dose, placebo-controlled study. J Am Acad Dermatol 2000 43 : 595 604.
5. Barker JN, Karabin GD, Stoof TJ et al. Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction. J Dermatol Sci 1991 2 : 106 11.
6. Szabo SK, Hammerberg C, Yoshida Y et al. Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions: localization to both CD4+ and CD8+ subsets. J Invest Dermatol 1998 111 : 1072 8.
7. Uyemura K, Yamamura M, Fivenson DF et al. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 1993 101 : 701 5.
8. Harrington LE, Hatton RD, Mangan PR et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005 6 : 1123 32.
9. Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 2006 18 : 349 56.
10. Chen Y, Langrish CL, McKenzie B et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 2006 116 : 1317 26.
11. Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441 : 235 8.
12. Chen Z, Tato CM, Muul L et al. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 2007 56 : 2936 46.
13. Aggarwal S, Ghilardi N, Xie MH et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003 278 : 1910 14.
14. Annunziato F, Cosmi L, Santarlasci V et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007 204 : 1849 61.
15. Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006 203 : 2271 9.
16. Zheng Y, Danilenko DM, Valdez P et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007 445 : 648 51.
17. Lee E, Trepicchio WL, Oestreicher JL et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004 199 : 125 30.
18. Lowes MA, Kikuchi T, Fuentes-Duculan J et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008 128 : 1207 11.
19. Zaba LC, Cardinale I, Gilleaudeau P et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 2007 204 : 3183 94.
20. Boniface K, Guignouard E, Pedretti N et al. A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol 2007 150 : 407 15.
21. Li J, Chen X, Liu Z et al. Expression of Th17 cytokines in skin lesions of patients with psoriasis. J Huazhong Univ Sci Technolog Med Sci 2007 27 : 330 2.
22. Boniface K, Bernard FX, Garcia M et al. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol 2005 174 : 3695 702.
23. Sa SM, Valdez PA, Wu J et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol 2007 178 : 2229 40.
24. Ma HL, Liang S, Li J et al. IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 2008 118 : 597 607.
25. Wilson NJ, Boniface K, Chan JR et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007 8 : 950 7.
26. Linden A, Hoshino H, Laan M. Airway neutrophils and interleukin-17. Eur Respir J 2000 15 : 973 7.
27. McAllister F, Henry A, Kreindler JL et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 2005 175 : 404 12.
28. Laan M, Cui ZH, Hoshino H et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 1999 162 : 2347 52.
29. Colobran R, Pujol-Borrell R, Armengol MP et al. The chemokine network. I. How the genomic organization of chemokines contains clues for deciphering their functional complexity. Clin Exp Immunol 2007 148 : 208 17.
30. Weathington NM, Blalock JE. The biology of CXC chemokines and their receptors. In : Chemokines, Chemokine Receptors and Disease (Current Topics in Membranes Vol. 55) (Schwiebert LM, ed New York : Academic Press, 2005 49 71.
31. Fossiez F, Djossou O, Chomarat P et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996 183 : 2593 603.
32. Albanesi C, Cavani A, Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J Immunol 1999 162 : 494 502.
33. Chamian F, Lowes MA, Lin SL et al. Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris. Proc Natl Acad Sci USA 2005 102 : 2075 80.
34. Zhou X, Krueger JG, Kao MC et al. Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 2003 13 : 69 78.
35. Suarez-Farinas M, Pellegrino M, Wittkowski KM et al. Harshlight: a 'corrective make-up' program for microarray chips. BMC Bioinformatics 2005 6 : 294.
36. Baechler EC, Batliwalla FM, Karypis G et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003 100 : 2610 15.
37. Rottman JB, Smith TL, Ganley KG et al. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab Invest 2001 81 : 335 47.
38. Dieu MC, Vanbervliet B, Vicari A et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998 188 : 373 86.
39. Liao F, Rabin RL, Smith CS et al. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol 1999 162 : 186 94.
40. Homey B, Dieu-Nosjean MC, Wiesenborn A et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000 164 : 6621 32.
41. Schroder JM, Gregory H, Young J et al. Neutrophil-activating proteins in psoriasis. J Invest Dermatol 1992 98 : 241 7.
42. van Damme J, van Beeumen J, Opdenakker G et al. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J Exp Med 1988 167 : 1364 76.
43. Meyer-Hoffert U, Wingertszahn J, Wiedow O. Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation. J Invest Dermatol 2004 123 : 338 45.
44. Glinski W, Barszcz D, Janczura E et al. Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity. Br J Dermatol 1984 111 : 147 54.
45. Ludolph-Hauser D, Schubert C, Wiedow O. Structural changes of human epidermis induced by human leukocyte-derived proteases. Exp Dermatol 1999 8 : 46 52.
46. Rogalski C, Meyer-Hoffert U, Proksch E et al. Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo. J Invest Dermatol 2002 118 : 49 54.
47. Barker JN, Jones ML, Mitra RS et al. Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. Am J Pathol 1991 139 : 869 76.
48. Terui T, Ozawa M, Tagami H. Role of neutrophils in induction of acute inflammation in T-cell-mediated immune dermatosis, psoriasis: a neutrophil-associated inflammation-boosting loop. Exp Dermatol 2000 9 : 1 10.
49. Singh SP, Zhang HH, Foley JF et al. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol 2008 180 : 214 21.
50. Wolk K, Witte E, Wallace E et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006 36 : 1309 23.
51. Teraki Y, Miyake A, Takebayashi R et al. Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris. Clin Exp Dermatol 2004 29 : 658 63.