Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

Nature Cell Biology

Volumn 13, Issue 3, 2011, Pages 263-272

  Zheng, Min ^a   Wang, Yan Hai ^a   Wu, Xiao Nan ^a   Wu, Su Qin ^a   Lu, Bao Ju ^b   Dong, Meng Qiu ^b   Zhang, Hongbing ^c   Sun, Peiqing ^d   Lin, Sheng Cai ^a   Guan, Kun Liang ^e   Han, Jiahuai ^a  

^a XIAMEN UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 11; P38 REGULATED ACTIVATED KINASE; PROTEIN SERINE THREONINE KINASE; RAPTOR PROTEIN; RHEB PROTEIN; SERINE; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SIZE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL PROLIFERATION; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOELECTRIC FOCUSING; MICE; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RNA INTERFERENCE;

MAMMALIA; RAPTORES;

EID: 79952281400     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb2168     Document Type: Article

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