-
1
-
-
69949084209
-
The TOR pathway comes of age
-
Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. and Kennedy, B. K., The TOR pathway comes of age. Biochim. Biophys. Acta 2009. 1790: 1067-1074.
-
(2009)
Biochim. Biophys. Acta
, vol.1790
, pp. 1067-1074
-
-
Stanfel, M.N.1
Shamieh, L.S.2
Kaeberlein, M.3
Kennedy, B.K.4
-
2
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D. A. and Sabatini, D. M., Defining the role of mTOR in cancer. Cancer Cell 2007. 12: 9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
3
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P. et al., Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 2004. 14: 1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
-
4
-
-
79954618943
-
Negative regulation of mTOR activation by diacylglycerol kinases
-
Gorentla, B. K., Wan, C. K. and Zhong, X. P., Negative regulation of mTOR activation by diacylglycerol kinases. Blood 2011. 117: 4022-4031.
-
(2011)
Blood
, vol.117
, pp. 4022-4031
-
-
Gorentla, B.K.1
Wan, C.K.2
Zhong, X.P.3
-
5
-
-
73349119966
-
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells
-
Salmond, R. J., Emery, J., Okkenhaug, K. and Zamoyska, R., MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J. Immunol. 2009. 183: 7388-7397.
-
(2009)
J. Immunol.
, vol.183
, pp. 7388-7397
-
-
Salmond, R.J.1
Emery, J.2
Okkenhaug, K.3
Zamoyska, R.4
-
6
-
-
79952696874
-
Receptor signaling in immune cell development and function
-
Zhong, X. P., Shin, J., Gorentla, B. K., O'Brien, T., Srivatsan, S., Xu, L., Chen, Y. et al., Receptor signaling in immune cell development and function. Immunol. Res. 2011. 49: 109-123.
-
(2011)
Immunol. Res.
, vol.49
, pp. 109-123
-
-
Zhong, X.P.1
Shin, J.2
Gorentla, B.K.3
O'Brien, T.4
Srivatsan, S.5
Xu, L.6
Chen, Y.7
-
7
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A. et al., T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 2008. 105: 7797-7802.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
-
8
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng, Y., Collins, S. L., Lutz, M. A., Allen, A. N., Kole, T. P., Zarek, P. E. and Powell, J. D., A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J. Immunol. 2007. 178: 2163-2170.
-
(2007)
J. Immunol.
, vol.178
, pp. 2163-2170
-
-
Zheng, Y.1
Collins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
Powell, J.D.7
-
9
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G. M., Kole, T. P., Zheng, Y., Zarek, P. E., Matthews, K. L., Xiao, B., Worley, P. F. et al., The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009. 30: 832-844.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
-
10
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M. A. and Boothby, M., Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010. 32: 743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
11
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P. et al., mTOR regulates memory CD8 T-cell differentiation. Nature 2009. 460: 108-112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
-
12
-
-
74649085700
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010. 32: 67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
13
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K. et al., Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat. Immunol. 2008. 9: 513-521.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
Okkenhaug, K.7
-
14
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K. L., TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell. Biol. 2002. 4: 648-657.
-
(2002)
Nat. Cell. Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
15
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C. and Blenis, J., Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 2003. 13: 1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
16
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C. and Blenis, J., Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc. Natl. Acad. Sci. USA 2002. 99: 13571-13576.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
17
-
-
0035902509
-
A germ-line TSC1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by TSC2 mutation in mice
-
Kobayashi, T., Minowa, O., Sugitani, Y., Takai, S., Mitani, H., Kobayashi, E., Noda, T. et al., A germ-line TSC1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by TSC2 mutation in mice. Proc. Natl. Acad. Sci. USA 2001. 98: 8762-8767.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8762-8767
-
-
Kobayashi, T.1
Minowa, O.2
Sugitani, Y.3
Takai, S.4
Mitani, H.5
Kobayashi, E.6
Noda, T.7
-
18
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K. L. and Zheng, P., TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 2008. 205: 2397-2408.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Zheng, P.6
-
19
-
-
65349159281
-
Immunoregulatory functions of mTOR inhibition
-
Thomson, A. W., Turnquist, H. R. and Raimondi, G., Immunoregulatory functions of mTOR inhibition. Nat. Rev. Immunol. 2009. 9: 324-337.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 324-337
-
-
Thomson, A.W.1
Turnquist, H.R.2
Raimondi, G.3
-
20
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao, X. and Pan, D., TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 2001. 15: 1383-1392.
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
21
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D. C., Richardson, C. J., Tee, A. R., Cheatham, L., Tsou, C. and Blenis, J., mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 2004. 24: 200-216.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
22
-
-
69449095860
-
Caspases and kinases in a death grip
-
Kurokawa, M. and Kornbluth, S., Caspases and kinases in a death grip. Cell 2009. 138: 838-854.
-
(2009)
Cell
, vol.138
, pp. 838-854
-
-
Kurokawa, M.1
Kornbluth, S.2
-
23
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
Kim, I., Rodriguez-Enriquez, S. and Lemasters, J. J., Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 2007. 462: 245-253.
-
(2007)
Arch. Biochem. Biophys.
, vol.462
, pp. 245-253
-
-
Kim, I.1
Rodriguez-Enriquez, S.2
Lemasters, J.J.3
-
24
-
-
64249123646
-
Autophagy is essential for mitochondrial clearance in mature T lymphocytes
-
Pua, H. H., Guo, J., Komatsu, M. and He, Y. W., Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J. Immunol. 2009. 182: 4046-4055.
-
(2009)
J. Immunol.
, vol.182
, pp. 4046-4055
-
-
Pua, H.H.1
Guo, J.2
Komatsu, M.3
He, Y.W.4
-
25
-
-
53549113031
-
The role of TOR in autophagy regulation from yeast to plants and mammals
-
Diaz-Troya, S., Perez-Perez, M. E., Florencio, F. J. and Crespo, J. L., The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy 2008. 4: 851-865.
-
(2008)
Autophagy
, vol.4
, pp. 851-865
-
-
Diaz-Troya, S.1
Perez-Perez, M.E.2
Florencio, F.J.3
Crespo, J.L.4
-
26
-
-
0037005262
-
Autophagosome formation in mammalian cells
-
Mizushima, N., Ohsumi, Y. and Yoshimori, T., Autophagosome formation in mammalian cells. Cell Struct. Funct. 2002. 27: 421-429.
-
(2002)
Cell Struct. Funct.
, vol.27
, pp. 421-429
-
-
Mizushima, N.1
Ohsumi, Y.2
Yoshimori, T.3
-
27
-
-
0033151622
-
Reactive oxygen species regulate activation-induced T cell apoptosis
-
Hildeman, D. A., Mitchell, T., Teague, T. K., Henson, P., Day, B. J., Kappler, J. and Marrack, P. C., Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 1999. 10: 735-744.
-
(1999)
Immunity
, vol.10
, pp. 735-744
-
-
Hildeman, D.A.1
Mitchell, T.2
Teague, T.K.3
Henson, P.4
Day, B.J.5
Kappler, J.6
Marrack, P.C.7
-
28
-
-
0642303647
-
Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage
-
Jacquel, A., Herrant, M., Legros, L., Belhacene, N., Luciano, F., Pages, G., Hofman, P. et al., Imatinib induces mitochondria-dependent apoptosis of the Bcr-Abl-positive K562 cell line and its differentiation toward the erythroid lineage. FASEB J. 2003. 17: 2160-2162.
-
(2003)
FASEB J.
, vol.17
, pp. 2160-2162
-
-
Jacquel, A.1
Herrant, M.2
Legros, L.3
Belhacene, N.4
Luciano, F.5
Pages, G.6
Hofman, P.7
-
29
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M. and Sabatini, D. M., Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005. 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
30
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J. et al., Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999. 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
-
31
-
-
28844434558
-
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R. C. and Mueckler, M., mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 2005. 280: 40406-40416.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
32
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y. and Mills, G. B., Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 2005. 4: 988-1004.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
33
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang, J., Dibble, C. C., Matsuzaki, M. and Manning, B. D., The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 2008. 28: 4104-4115.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
34
-
-
75749105049
-
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
Julien, L. A., Carriere, A., Moreau, J. and Roux, P. P., mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol. Cell. Biol. 2010. 30: 908-921.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
Roux, P.P.4
-
35
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J. et al., The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell. Biol. 2004. 166: 213-223.
-
(2004)
J. Cell. Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
-
36
-
-
67651148536
-
S6K1 deficiency protects against apoptosis in hepatocytes
-
Gonzalez-Rodriguez, A., Alba, J., Zimmerman, V., Kozma, S. C. and Valverde, A. M., S6K1 deficiency protects against apoptosis in hepatocytes. Hepatology 2009. 50: 216-229.
-
(2009)
Hepatology
, vol.50
, pp. 216-229
-
-
Gonzalez-Rodriguez, A.1
Alba, J.2
Zimmerman, V.3
Kozma, S.C.4
Valverde, A.M.5
-
37
-
-
34948823880
-
S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling
-
Djouder, N., Metzler, S. C., Schmidt, A., Wirbelauer, C., Gstaiger, M., Aebersold, R., Hess, D. et al., S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell 2007. 28: 28-40.
-
(2007)
Mol. Cell
, vol.28
, pp. 28-40
-
-
Djouder, N.1
Metzler, S.C.2
Schmidt, A.3
Wirbelauer, C.4
Gstaiger, M.5
Aebersold, R.6
Hess, D.7
-
38
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski, D. J., Zhang, H., Bandura, J. L., Heiberger, K. M., Glogauer, M., el-Hashemite, N. and Onda, H., A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 2002. 11: 525-534.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
el-Hashemite, N.6
Onda, H.7
-
39
-
-
18244365863
-
Critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee, P. P., Fitzpatrick, D. R., Beard, C., Jessup, H. K., Lehar, S., Makar, K. W., Perez-Melgosa, M. et al., Critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 2001. 15: 763-774.
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
Perez-Melgosa, M.7
-
40
-
-
0042383362
-
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency
-
Zhong, X. P., Hainey, E. A., Olenchock, B. A., Jordan, M. S., Maltzman, J. S., Nichols, K. E., Shen, H. and Koretzky, G. A., Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat. Immunol. 2003. 4: 882-890.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 882-890
-
-
Zhong, X.P.1
Hainey, E.A.2
Olenchock, B.A.3
Jordan, M.S.4
Maltzman, J.S.5
Nichols, K.E.6
Shen, H.7
Koretzky, G.A.8
|