Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

Molecular Cell

Volumn 38, Issue 4, 2010, Pages 487-499

  Choo, Andrew Y ^a   Kim, Sang Gyun ^a   Vander Heiden, Matthew G ^a,b,c   Mahoney, Sarah J ^a   Vu, Hieu ^a   Yoon, Sang Oh ^a   Cantley, Lewis C ^a,c   Blenis, John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

HUMDISEASE; PROTEINS; SIGNALING

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; HAMARTIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN P53; TUBERIN;

AMINO ACID METABOLISM; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CATABOLISM; CELL DEATH; CELL GROWTH; CELL METABOLISM; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY CONSUMPTION; ENZYME ACTIVATION; NONHUMAN; NULL CELL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; GLUCOSE; PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 77952562382     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.05.007     Document Type: Article

References (34)

1. Balaban R.S., Mandel L.J., Soltoff S.P., and Storey J.M. Coupling of active ion transport and aerobic respiratory rate in isolated renal tubules. Proc. Natl. Acad. Sci. USA 77 (1980) 447-451
2. Bissler J.J., McCormack F.X., Young L.R., Elwing J.M., Chuck G., Leonard J.M., Schmithorst V.J., Laor T., Brody A.S., Bean J., et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N. Engl. J. Med. 358 (2008) 140-151
3. Buller C.L., Loberg R.D., Fan M.H., Zhu Q., Park J.L., Vesely E., Inoki K., Guan K.L., and Brosius III F.C. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am. J. Physiol. Cell Physiol. 295 (2008) C836-C843
4. Buttgereit F., and Brand M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312 (1995) 163-167
5. Buzzai M., Bauer D.E., Jones R.G., Deberardinis R.J., Hatzivassiliou G., Elstrom R.L., and Thompson C.B. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24 (2005) 4165-4173
6. Choo A.Y., Yoon S.O., Kim S.G., Roux P.P., and Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc. Natl. Acad. Sci. USA 105 (2008) 17414-17419
7. DeBerardinis R.J., Lum J.J., Hatzivassiliou G., and Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7 (2008) 11-20
8. Denko N.C. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat. Rev. Cancer 8 (2008) 705-713
9. Ghosh S., Tergaonkar V., Rothlin C.V., Correa R.G., Bottero V., Bist P., Verma I.M., and Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 10 (2006) 215-226
10. Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., and Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 (2008) 214-226
11. Inoki K., Zhu T., and Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003) 577-590
12. Khan N., and Mukhtar H. Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett. 269 (2008) 269-280
13. Korn E.D., Carlier M.F., and Pantaloni D. Actin polymerization and ATP hydrolysis. Science 238 (1987) 638-644
14. Kwiatkowski D.J., and Manning B.D. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum. Mol. Genet. 14 Spec No. 2 (2005) R251-R258
15. Lee C.H., Inoki K., Karbowniczek M., Petroulakis E., Sonenberg N., Henske E.P., and Guan K.L. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 26 (2007) 4812-4823
16. Levine B., and Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 115 (2005) 2679-2688
17. Li C., Allen A., Kwagh J., Doliba N.M., Qin W., Najafi H., Collins H.W., Matschinsky F.M., Stanley C.A., and Smith T.J. Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase. J. Biol. Chem. 281 (2006) 10214-10221
18. Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., and Thompson C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 (2005) 237-248
19. Lum J.J., Bui T., Gruber M., Gordan J.D., DeBerardinis R.J., Covello K.L., Simon M.C., and Thompson C.B. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 (2007) 1037-1049
20. Ma X.M., and Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10 (2009) 307-318
21. Moreadith R.W., and Lehninger A.L. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J. Biol. Chem. 259 (1984) 6215-6221
22. Moriwaki H., Miwa Y., Tajika M., Kato M., Fukushima H., and Shiraki M. Branched-chain amino acids as a protein- and energy-source in liver cirrhosis. Biochem. Biophys. Res. Commun. 313 (2004) 405-409
23. Ozcan U., Ozcan L., Yilmaz E., Düvel K., Sahin M., Manning B.D., and Hotamisligil G.S. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol. Cell 29 (2008) 541-551
24. Plas D.R., Talapatra S., Edinger A.L., Rathmell J.C., and Thompson C.B. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276 (2001) 12041-12048
25. Sancak Y., and Sabatini D.M. Rag proteins regulate amino-acid-induced mTORC1 signalling. Biochem. Soc. Trans. 37 (2009) 289-290
26. Shaw R.J. Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18 (2006) 598-608
27. Shaw R.J., and Cantley L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441 (2006) 424-430
28. Souba W.W. Glutamine and cancer. Ann. Surg. 218 (1993) 715-728
29. L prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3 (1999) 159-167
30. Vander Heiden M.G., Plas D.R., Rathmell J.C., Fox C.J., Harris M.H., and Thompson C.B. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21 (2001) 5899-5912
31. Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B., and Thompson C.B. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc. Natl. Acad. Sci. USA 105 (2008) 18782-18787
32. Yang C., Sudderth J., Dang T., Bachoo R.M., Bachoo R.G., McDonald J.G., and DeBerardinis R.J. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 (2009) 7986-7993
33. Yuneva M., Zamboni N., Oefner P., Sachidanandam R., and Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J. Cell Biol. 178 (2007) 93-105
34. Zini R., Berdeaux A., and Morin D. The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation. Free Radic. Res. 41 (2007) 1159-1166