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Volumn 2, Issue 11, 2011, Pages 864-878

Conserved RB functions in development and tumor suppression

Author keywords

cell cycle; chromatin modification; Drosophila Rbf; E2F; RB

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

EID: 84856140976     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-011-1117-z     Document Type: Review
Times cited : (43)

References (151)
  • 1
    • 11244276992 scopus 로고    scopus 로고
    • The E2F family: specific functions and overlapping interests
    • Attwooll, C., Lazzerini Denchi, E., and Helin, K. (2004). The E2F family: specific functions and overlapping interests. Embo J 23, 4709-4716.
    • (2004) Embo J , vol.23 , pp. 4709-4716
    • Attwooll, C.1    Lazzerini Denchi, E.2    Helin, K.3
  • 5
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    • Bergmann, A., Agapite, J., McCall, K., and Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 7
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • Bier, E. (2005). Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 6, 9-23.
    • (2005) Nat Rev Genet , vol.6 , pp. 9-23
    • Bier, E.1
  • 8
    • 33947246502 scopus 로고    scopus 로고
    • Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
    • Binné, U. K., Classon, M. K., Dick, F. A., Wei, W., Rape, M., Kaelin, W. G. Jr, Näär, A. M., and Dyson, N. J. (2007). Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol 9, 225-232.
    • (2007) Nat Cell Biol , vol.9 , pp. 225-232
    • Binné, U.K.1    Classon, M.K.2    Dick, F.A.3    Wei, W.4    Rape, M.5    Kaelin Jr., W.G.6    Näär, A.M.7    Dyson, N.J.8
  • 12
    • 77952387813 scopus 로고    scopus 로고
    • Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding
    • Burke, J. R., Deshong, A. J., Pelton, J. G., and Rubin, S. M. (2010). Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J Biol Chem 285, 16286-16293.
    • (2010) J Biol Chem , vol.285 , pp. 16286-16293
    • Burke, J.R.1    Deshong, A.J.2    Pelton, J.G.3    Rubin, S.M.4
  • 13
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • Burkhart, D. L., and Sage, J. (2008). Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8, 671-682.
    • (2008) Nat Rev Cancer , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 14
    • 34047097318 scopus 로고    scopus 로고
    • A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila
    • Buttitta, L. A., Katzaroff, A. J., Perez, C. L., de la Cruz, A., and Edgar, B. A. (2007). A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell 12, 631-643.
    • (2007) Dev Cell , vol.12 , pp. 631-643
    • Buttitta, L.A.1    Katzaroff, A.J.2    Perez, C.L.3    de la Cruz, A.4    Edgar, B.A.5
  • 17
    • 72449178334 scopus 로고    scopus 로고
    • Division and apoptosis of E2f-deficient retinal progenitors
    • Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G., and Bremner, R. (2009a). Division and apoptosis of E2f-deficient retinal progenitors. Nature 462, 925-929.
    • (2009) Nature , vol.462 , pp. 925-929
    • Chen, D.1    Pacal, M.2    Wenzel, P.3    Knoepfler, P.S.4    Leone, G.5    Bremner, R.6
  • 18
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: an exit from cell cycle control
    • Chen, H. Z., Tsai, S. Y., and Leone, G. (2009b). Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 9, 785-797.
    • (2009) Nat Rev Cancer , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 20
    • 79952610870 scopus 로고    scopus 로고
    • Making sense of cancer genomic data
    • Chin, L., Hahn, W. C., Getz, G., and Meyerson, M. (2011). Making sense of cancer genomic data. Genes Dev 25, 534-555.
    • (2011) Genes Dev , vol.25 , pp. 534-555
    • Chin, L.1    Hahn, W.C.2    Getz, G.3    Meyerson, M.4
  • 25
    • 10044277901 scopus 로고    scopus 로고
    • Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130
    • Dannenberg, J. H., Schuijff, L., Dekker, M., van der Valk, M., and te Riele, H. (2004). Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 18, 2952-2962.
    • (2004) Genes Dev , vol.18 , pp. 2952-2962
    • Dannenberg, J.H.1    Schuijff, L.2    Dekker, M.3    van der Valk, M.4    te Riele, H.5
  • 26
    • 0030473888 scopus 로고    scopus 로고
    • A cyclindependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
    • de Nooij, J. C., Letendre, M. A., and Hariharan, I. K. (1996). A cyclindependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87, 1237-1247.
    • (1996) Cell , vol.87 , pp. 1237-1247
    • de Nooij, J.C.1    Letendre, M.A.2    Hariharan, I.K.3
  • 28
    • 79955686099 scopus 로고    scopus 로고
    • Sweet DREAMs for Hippo
    • Dick, F. A., and Mymryk, J. S. (2011). Sweet DREAMs for Hippo. Genes Dev 25, 889-894.
    • (2011) Genes Dev , vol.25 , pp. 889-894
    • Dick, F.A.1    Mymryk, J.S.2
  • 29
    • 0141706827 scopus 로고    scopus 로고
    • Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway
    • Dimova, D. K., Stevaux, O., Frolov, M. V., and Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev 17, 2308-2320.
    • (2003) Genes Dev , vol.17 , pp. 2308-2320
    • Dimova, D.K.1    Stevaux, O.2    Frolov, M.V.3    Dyson, N.J.4
  • 30
    • 0033558346 scopus 로고    scopus 로고
    • The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis
    • Du, W., and Dyson, N. (1999). The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J 18, 916-925.
    • (1999) EMBO J , vol.18 , pp. 916-925
    • Du, W.1    Dyson, N.2
  • 31
    • 33748067733 scopus 로고    scopus 로고
    • Retinoblastoma family genes
    • Du, W., and Pogoriler, J. (2006). Retinoblastoma family genes. Oncogene 25, 5190-5200.
    • (2006) Oncogene , vol.25 , pp. 5190-5200
    • Du, W.1    Pogoriler, J.2
  • 32
    • 0027936686 scopus 로고
    • Differential regulation of E2F transactivation by cyclin/cdk2 complexes
    • Dynlacht, B. D., Flores, O., Lees, J. A., and Harlow, E. (1994). Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev 8, 1772-1786.
    • (1994) Genes Dev , vol.8 , pp. 1772-1786
    • Dynlacht, B.D.1    Flores, O.2    Lees, J.A.3    Harlow, E.4
  • 34
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., and Livingston, D. M. (1993). Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497.
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.5    Livingston, D.M.6
  • 35
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg, A. P., and Tycko, B. (2004). The history of cancer epigenetics. Nat Rev Cancer 4, 143-153.
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 38
    • 16244392774 scopus 로고    scopus 로고
    • Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye
    • Firth, L. C., and Baker, N. E. (2005). Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8, 541-551.
    • (2005) Dev Cell , vol.8 , pp. 541-551
    • Firth, L.C.1    Baker, N.E.2
  • 39
    • 28844473012 scopus 로고    scopus 로고
    • Mitogen requirement for cell cycle progression in the absence of pocket protein activity
    • Foijer, F., Wolthuis, R. M., Doodeman, V., Medema, R. H., and te Riele, H. (2005). Mitogen requirement for cell cycle progression in the absence of pocket protein activity. Cancer Cell 8, 455-466.
    • (2005) Cancer Cell , vol.8 , pp. 455-466
    • Foijer, F.1    Wolthuis, R.M.2    Doodeman, V.3    Medema, R.H.4    te Riele, H.5
  • 40
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., and Dryja, T. P. (1986). A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323, 643-646.
    • (1986) Nature , vol.323 , pp. 643-646
    • Friend, S.H.1    Bernards, R.2    Rogelj, S.3    Weinberg, R.A.4    Rapaport, J.M.5    Albert, D.M.6    Dryja, T.P.7
  • 42
    • 0037010122 scopus 로고    scopus 로고
    • E2F1 pathways to apoptosis
    • Ginsberg, D. (2002). E2F1 pathways to apoptosis. FEBS Lett 529, 122-125.
    • (2002) FEBS Lett , vol.529 , pp. 122-125
    • Ginsberg, D.1
  • 44
    • 0242380343 scopus 로고    scopus 로고
    • How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein
    • Goodrich, D. W. (2003). How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein. J Cell Physiol 197, 169-180.
    • (2003) J Cell Physiol , vol.197 , pp. 169-180
    • Goodrich, D.W.1
  • 45
    • 84856171382 scopus 로고    scopus 로고
    • Targeting Rb inactivation in cancers by synthetic lethality
    • Gordon, G. M., and Du, W. (2011). Targeting Rb inactivation in cancers by synthetic lethality. Am J Cancer Res 1, 773-786.
    • (2011) Am J Cancer Res , vol.1 , pp. 773-786
    • Gordon, G.M.1    Du, W.2
  • 46
    • 37349070024 scopus 로고    scopus 로고
    • An E2F1-dependent gene expression program that determines the balance between proliferation and cell death
    • Hallstrom, T. C., Mori, S., and Nevins, J. R. (2008). An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13, 11-22.
    • (2008) Cancer Cell , vol.13 , pp. 11-22
    • Hallstrom, T.C.1    Mori, S.2    Nevins, J.R.3
  • 47
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 49
    • 35648942123 scopus 로고    scopus 로고
    • Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture
    • Hassler, M., Singh, S., Yue, W. W., Luczynski, M., Lakbir, R., Sanchez-Sanchez, F., Bader, T., Pearl, L. H., and Mittnacht, S. (2007). Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol Cell 28, 371-385.
    • (2007) Mol Cell , vol.28 , pp. 371-385
    • Hassler, M.1    Singh, S.2    Yue, W.W.3    Luczynski, M.4    Lakbir, R.5    Sanchez-Sanchez, F.6    Bader, T.7    Pearl, L.H.8    Mittnacht, S.9
  • 51
    • 0027212380 scopus 로고
    • Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression
    • Hiebert, S. W. (1993). Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression. Mol Cell Biol 13, 3384-3391.
    • (1993) Mol Cell Biol , vol.13 , pp. 3384-3391
    • Hiebert, S.W.1
  • 52
    • 0026802989 scopus 로고
    • Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    • Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A. (1992). Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993-1006.
    • (1992) Cell , vol.70 , pp. 993-1006
    • Hinds, P.W.1    Mittnacht, S.2    Dulic, V.3    Arnold, A.4    Reed, S.I.5    Weinberg, R.A.6
  • 53
    • 77956340499 scopus 로고    scopus 로고
    • An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein
    • Hirschi, A., Cecchini, M., Steinhardt, R. C., Schamber, M. R., Dick, F. A., and Rubin, S. M. (2010). An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat Struct Mol Biol 17, 1051-1057.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1051-1057
    • Hirschi, A.1    Cecchini, M.2    Steinhardt, R.C.3    Schamber, M.R.4    Dick, F.A.5    Rubin, S.M.6
  • 54
    • 77957353301 scopus 로고    scopus 로고
    • Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival
    • Hsieh, T. C., Nicolay, B. N., Frolov, M. V., and Moon, N. S. (2010). Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet 6, e1001071.
    • (2010) PLoS Genet , vol.6
    • Hsieh, T.C.1    Nicolay, B.N.2    Frolov, M.V.3    Moon, N.S.4
  • 55
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    • Hu, N., Gutsmann, A., Herbert, D. C., Bradley, A., Lee, W. H., and Lee, E. Y. (1994). Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9, 1021-1027.
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1    Gutsmann, A.2    Herbert, D.C.3    Bradley, A.4    Lee, W.H.5    Lee, E.Y.6
  • 58
    • 0034949169 scopus 로고    scopus 로고
    • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis
    • Ishida, S., Huang, E., Zuzan, H., Spang, R., Leone, G., West, M., and Nevins, J. R. (2001). Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol 21, 4684-4699.
    • (2001) Mol Cell Biol , vol.21 , pp. 4684-4699
    • Ishida, S.1    Huang, E.2    Zuzan, H.3    Spang, R.4    Leone, G.5    West, M.6    Nevins, J.R.7
  • 60
    • 75749105049 scopus 로고    scopus 로고
    • mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • Julien, L. A., Carriere, A., Moreau, J., and Roux, P. P. (2010). mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol Cell Biol 30, 908-921.
    • (2010) Mol Cell Biol , vol.30 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 61
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin, W. G. Jr. (2005). The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 5, 689-698.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 64
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
    • Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J. (1993). Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7, 331-342.
    • (1993) Genes Dev , vol.7 , pp. 331-342
    • Kato, J.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 65
    • 1542499463 scopus 로고    scopus 로고
    • For whom the bell tolls: susceptibility to common adult cancers in retinoblastoma survivors
    • Kaye, F. J., and Harbour, J. W. (2004). For whom the bell tolls: susceptibility to common adult cancers in retinoblastoma survivors. J Natl Cancer Inst 96, 342-343.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 342-343
    • Kaye, F.J.1    Harbour, J.W.2
  • 67
    • 76749104377 scopus 로고    scopus 로고
    • Targeting the RB-pathway in cancer therapy
    • Knudsen, E. S., and Wang, J. Y. (2010). Targeting the RB-pathway in cancer therapy. Clin Cancer Res 16, 1094-1099.
    • (2010) Clin Cancer Res , vol.16 , pp. 1094-1099
    • Knudsen, E.S.1    Wang, J.Y.2
  • 68
    • 0015043748 scopus 로고
    • Mutation and cancer: statistical study of retinoblastoma
    • Knudson, A. G. Jr. (1971). Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68, 820-823.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 69
    • 5444237176 scopus 로고    scopus 로고
    • Native E2F/RBF complexes contain Mybinteracting proteins and repress transcription of developmentally controlled E2F target genes
    • Korenjak, M., Taylor-Harding, B., Binné, U. K., Satterlee, J. S., Stevaux, O., Aasland, R., White-Cooper, H., Dyson, N., and Brehm, A. (2004). Native E2F/RBF complexes contain Mybinteracting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119, 181-193.
    • (2004) Cell , vol.119 , pp. 181-193
    • Korenjak, M.1    Taylor-Harding, B.2    Binné, U.K.3    Satterlee, J.S.4    Stevaux, O.5    Aasland, R.6    White-Cooper, H.7    Dyson, N.8    Brehm, A.9
  • 70
    • 0021740412 scopus 로고
    • Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus
    • Lalande, M., Dryja, T. P., Schreck, R. R., Shipley, J., Flint, A., and Latt, S. A. (1984). Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus. Cancer Genet Cytogenet 13, 283-295.
    • (1984) Cancer Genet Cytogenet , vol.13 , pp. 283-295
    • Lalande, M.1    Dryja, T.P.2    Schreck, R.R.3    Shipley, J.4    Flint, A.5    Latt, S.A.6
  • 71
    • 0030468329 scopus 로고    scopus 로고
    • Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development
    • Lane, M. E., Sauer, K., Wallace, K., Jan, Y. N., Lehner, C. F., and Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87, 1225-1235.
    • (1996) Cell , vol.87 , pp. 1225-1235
    • Lane, M.E.1    Sauer, K.2    Wallace, K.3    Jan, Y.N.4    Lehner, C.F.5    Vaessin, H.6
  • 73
    • 0023106062 scopus 로고
    • Human retinoblastoma susceptibility gene: cloning, identification, and sequence
    • Lee, W. H., Bookstein, R., Hong, F., Young, L. J., Shew, J. Y., and Lee, E. Y. (1987). Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235, 1394-1399.
    • (1987) Science , vol.235 , pp. 1394-1399
    • Lee, W.H.1    Bookstein, R.2    Hong, F.3    Young, L.J.4    Shew, J.Y.5    Lee, E.Y.6
  • 74
    • 10044255182 scopus 로고    scopus 로고
    • Identification of a Drosophila Myb-E2F2/ RBF transcriptional repressor complex
    • Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., and Botchan, M. R. (2004). Identification of a Drosophila Myb-E2F2/ RBF transcriptional repressor complex. Genes Dev 18, 2929-2940.
    • (2004) Genes Dev , vol.18 , pp. 2929-2940
    • Lewis, P.W.1    Beall, E.L.2    Fleischer, T.C.3    Georlette, D.4    Link, A.J.5    Botchan, M.R.6
  • 75
    • 77952101348 scopus 로고    scopus 로고
    • Specific killing of Rb mutant cancer cells by inactivating TSC2
    • Li, B., Gordon, G. M., Du, C. H., Xu, J., and Du, W. (2010). Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell 17, 469-480.
    • (2010) Cancer Cell , vol.17 , pp. 469-480
    • Li, B.1    Gordon, G.M.2    Du, C.H.3    Xu, J.4    Du, W.5
  • 78
    • 79955432610 scopus 로고    scopus 로고
    • DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
    • Litovchick, L., Florens, L. A., Swanson, S. K., Washburn, M. P., and DeCaprio, J. A. (2011). DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev 25, 801-813.
    • (2011) Genes Dev , vol.25 , pp. 801-813
    • Litovchick, L.1    Florens, L.A.2    Swanson, S.K.3    Washburn, M.P.4    Decaprio, J.A.5
  • 80
    • 42149095961 scopus 로고    scopus 로고
    • RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
    • Longworth, M. S., Herr, A., Ji, J. Y., and Dyson, N. J. (2008). RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev 22, 1011-1024.
    • (2008) Genes Dev , vol.22 , pp. 1011-1024
    • Longworth, M.S.1    Herr, A.2    Ji, J.Y.3    Dyson, N.J.4
  • 82
  • 85
    • 77954522274 scopus 로고    scopus 로고
    • Loss of pRB causes centromere dysfunction and chromosomal instability
    • Manning, A. L., Longworth, M. S., and Dyson, N. J. (2010). Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev 24, 1364-1376.
    • (2010) Genes Dev , vol.24 , pp. 1364-1376
    • Manning, A.L.1    Longworth, M.S.2    Dyson, N.J.3
  • 86
    • 74549187640 scopus 로고    scopus 로고
    • The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells
    • Milet, C., Rincheval-Arnold, A., Mignotte, B., and Guénal, I. (2010). The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells. Cell Cycle 9, 97-103.
    • (2010) Cell Cycle , vol.9 , pp. 97-103
    • Milet, C.1    Rincheval-Arnold, A.2    Mignotte, B.3    Guénal, I.4
  • 88
    • 33749592371 scopus 로고    scopus 로고
    • A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis
    • Moon, N. S., Di Stefano, L., and Dyson, N. (2006). A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol 26, 7601-7615.
    • (2006) Mol Cell Biol , vol.26 , pp. 7601-7615
    • Moon, N.S.1    di Stefano, L.2    Dyson, N.3
  • 92
    • 0031831681 scopus 로고    scopus 로고
    • The retinoblastoma gene family: cousins with overlapping interests
    • Mulligan, G., and Jacks, T. (1998). The retinoblastoma gene family: cousins with overlapping interests. Trends Genet 14, 223-229.
    • (1998) Trends Genet , vol.14 , pp. 223-229
    • Mulligan, G.1    Jacks, T.2
  • 93
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita, M., Nũnez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., and Lowe, S. W. (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nũnez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6    Spector, D.L.7    Hannon, G.J.8    Lowe, S.W.9
  • 94
    • 79951692812 scopus 로고    scopus 로고
    • Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit
    • Nicolay, B. N., Bayarmagnai, B., Islam, A. B., Lopez-Bigas, N., and Frolov, M. V. (2011). Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev 25, 323-335.
    • (2011) Genes Dev , vol.25 , pp. 323-335
    • Nicolay, B.N.1    Bayarmagnai, B.2    Islam, A.B.3    Lopez-Bigas, N.4    Frolov, M.V.5
  • 95
    • 77952334121 scopus 로고    scopus 로고
    • Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina
    • Nicolay, B. N., Bayarmagnai, B., Moon, N. S., Benevolenskaya, E. V., and Frolov, M. V. (2010). Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet 6, e1000918.
    • (2010) PLoS Genet , vol.6
    • Nicolay, B.N.1    Bayarmagnai, B.2    Moon, N.S.3    Benevolenskaya, E.V.4    Frolov, M.V.5
  • 96
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira, V., Park, Y., Chen, C. C., Xu, P. Z., Chen, M. L., Tonic, I., Unterman, T., and Hay, N. (2008). Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14, 458-470.
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6    Unterman, T.7    Hay, N.8
  • 97
    • 40649104735 scopus 로고    scopus 로고
    • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis
    • Ozcan, U., Ozcan, L., Yilmaz, E., Düvel, K., Sahin, M., Manning, B. D., and Hotamisligil, G. S. (2008). Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29, 541-551.
    • (2008) Mol Cell , vol.29 , pp. 541-551
    • Ozcan, U.1    Ozcan, L.2    Yilmaz, E.3    Düvel, K.4    Sahin, M.5    Manning, B.D.6    Hotamisligil, G.S.7
  • 98
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan, D. (2010). The hippo signaling pathway in development and cancer. Dev Cell 19, 491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 100
    • 32244439530 scopus 로고    scopus 로고
    • Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation
    • Pickering, M. T., and Kowalik, T. F. (2006). Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. Oncogene 25, 746-755.
    • (2006) Oncogene , vol.25 , pp. 746-755
    • Pickering, M.T.1    Kowalik, T.F.2
  • 101
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak, K., Lee, M. H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., and Massagué, J. (1994). Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massagué, J.7
  • 102
    • 0026648086 scopus 로고
    • Identification of a growth suppression domain within the retinoblastoma gene product
    • Qin, X. Q., Chittenden, T., Livingston, D. M., and Kaelin, W. G. Jr. (1992). Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev 6, 953-964.
    • (1992) Genes Dev , vol.6 , pp. 953-964
    • Qin, X.Q.1    Chittenden, T.2    Livingston, D.M.3    Kaelin Jr., W.G.4
  • 103
    • 57749121604 scopus 로고    scopus 로고
    • Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1
    • Racek, T., Buhlmann, S., Rüst, F., Knoll, S., Alla, V., and Pützer, B. M. (2008). Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1. J Biol Chem 283, 34305-34314.
    • (2008) J Biol Chem , vol.283 , pp. 34305-34314
    • Racek, T.1    Buhlmann, S.2    Rüst, F.3    Knoll, S.4    Alla, V.5    Pützer, B.M.6
  • 104
    • 0037080483 scopus 로고    scopus 로고
    • E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
    • Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., and Dynlacht, B. D. (2002). E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 16, 245-256.
    • (2002) Genes Dev , vol.16 , pp. 245-256
    • Ren, B.1    Cam, H.2    Takahashi, Y.3    Volkert, T.4    Terragni, J.5    Young, R.A.6    Dynlacht, B.D.7
  • 105
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., and Wolffe, A. P. (2000). DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25, 338-342.
    • (2000) Nat Genet , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 106
    • 0036311177 scopus 로고    scopus 로고
    • E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis
    • Rogoff, H. A., Pickering, M. T., Debatis, M. E., Jones, S., and Kowalik, T. F. (2002). E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Mol Cell Biol 22, 5308-5318.
    • (2002) Mol Cell Biol , vol.22 , pp. 5308-5318
    • Rogoff, H.A.1    Pickering, M.T.2    Debatis, M.E.3    Jones, S.4    Kowalik, T.F.5
  • 107
    • 28944437358 scopus 로고    scopus 로고
    • Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release
    • Rubin, S. M., Gall, A. L., Zheng, N., and Pavletich, N. P. (2005). Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123, 1093-1106.
    • (2005) Cell , vol.123 , pp. 1093-1106
    • Rubin, S.M.1    Gall, A.L.2    Zheng, N.3    Pavletich, N.P.4
  • 108
    • 36448949026 scopus 로고    scopus 로고
    • Multivalent engagement of chromatin modifications by linked binding modules
    • Ruthenburg, A. J., Li, H., Patel, D. J., and Allis, C. D. (2007). Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol 8, 983-994.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 983-994
    • Ruthenburg, A.J.1    Li, H.2    Patel, D.J.3    Allis, C.D.4
  • 109
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • Sage, J., Miller, A. L., Pérez-Mancera, P. A., Wysocki, J. M., and Jacks, T. (2003). Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424, 223-228.
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Pérez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 110
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 111
    • 79958733630 scopus 로고    scopus 로고
    • Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition
    • Schvartzman, J. M., Duijf, P. H., Sotillo, R., Coker, C., and Benezra, R. (2011). Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell 19, 701-714.
    • (2011) Cancer Cell , vol.19 , pp. 701-714
    • Schvartzman, J.M.1    Duijf, P.H.2    Sotillo, R.3    Coker, C.4    Benezra, R.5
  • 112
    • 80054711625 scopus 로고    scopus 로고
    • Targeting Rb mutant cancers by inactivating TSC2
    • Searle, J. S., Li, B., and Du, W. (2010). Targeting Rb mutant cancers by inactivating TSC2. Oncotarget 1, 228-232.
    • (2010) Oncotarget , vol.1 , pp. 228-232
    • Searle, J.S.1    Li, B.2    Du, W.3
  • 113
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., Hannon, G. J., and Beach, D. (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366, 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 114
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah, O. J., Wang, Z., and Hunter, T. (2004). Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 14, 1650-1656.
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 116
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr, C. J., and McCormick, F. (2002). The RB and p53 pathways in cancer. Cancer Cell 2, 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 118
    • 70349787144 scopus 로고    scopus 로고
    • Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity
    • Steele, L., Sukhanova, M. J., Xu, J., Gordon, G. M., Huang, Y., Yu, L., and Du, W. (2009). Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol 335, 228-236.
    • (2009) Dev Biol , vol.335 , pp. 228-236
    • Steele, L.1    Sukhanova, M.J.2    Xu, J.3    Gordon, G.M.4    Huang, Y.5    Yu, L.6    Du, W.7
  • 121
    • 0032169516 scopus 로고    scopus 로고
    • The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
    • Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K., Hara, E., Vousden, K. H., et al. (1998). The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 17, 5001-5014.
    • (1998) EMBO J , vol.17 , pp. 5001-5014
    • Stott, F.J.1    Bates, S.2    James, M.C.3    McConnell, B.B.4    Starborg, M.5    Brookes, S.6    Palmero, I.7    Ryan, K.8    Hara, E.9    Vousden, K.H.10
  • 122
    • 82455174908 scopus 로고    scopus 로고
    • RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye
    • Sep 2, 2011. [Epub ahead of print]
    • Sukhanova, M. J., Steele, L. J., Zhang, T., Gordon, G. M., and Du, W. RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Dev Biol. Sep 2, 2011. [Epub ahead of print].
    • Dev Biol.
    • Sukhanova, M.J.1    Steele, L.J.2    Zhang, T.3    Gordon, G.M.4    Du, W.5
  • 123
    • 0034175616 scopus 로고    scopus 로고
    • Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression
    • Takahashi, Y., Rayman, J. B., and Dynlacht, B. D. (2000). Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 14, 804-816.
    • (2000) Genes Dev , vol.14 , pp. 804-816
    • Takahashi, Y.1    Rayman, J.B.2    Dynlacht, B.D.3
  • 124
    • 75749111377 scopus 로고    scopus 로고
    • A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence
    • Talluri, S., Isaac, C. E., Ahmad, M., Henley, S. A., Francis, S. M., Martens, A. L., Bremner, R., and Dick, F. A. (2010). A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence. Mol Cell Biol 30, 948-960.
    • (2010) Mol Cell Biol , vol.30 , pp. 948-960
    • Talluri, S.1    Isaac, C.E.2    Ahmad, M.3    Henley, S.A.4    Francis, S.M.5    Martens, A.L.6    Bremner, R.7    Dick, F.A.8
  • 125
    • 0036279279 scopus 로고    scopus 로고
    • E2F1 and c-Myc potentiate apoptosis through inhibition of NFkappaB activity that facilitates MnSOD-mediated ROS elimination
    • Tanaka, H., Matsumura, I., Ezoe, S., Satoh, Y., Sakamaki, T., Albanese, C., Machii, T., Pestell, R. G., and Kanakura, Y. (2002). E2F1 and c-Myc potentiate apoptosis through inhibition of NFkappaB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell 9, 1017-1029.
    • (2002) Mol Cell , vol.9 , pp. 1017-1029
    • Tanaka, H.1    Matsumura, I.2    Ezoe, S.3    Satoh, Y.4    Sakamaki, T.5    Albanese, C.6    Machii, T.7    Pestell, R.G.8    Kanakura, Y.9
  • 126
    • 58649089776 scopus 로고    scopus 로고
    • Regulation of apoptosis of rbf mutant cells during Drosophila development
    • Tanaka-Matakatsu, M., Xu, J., Cheng, L., and Du, W. (2009). Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol 326, 347-356.
    • (2009) Dev Biol , vol.326 , pp. 347-356
    • Tanaka-Matakatsu, M.1    Xu, J.2    Cheng, L.3    Du, W.4
  • 127
    • 2942620920 scopus 로고    scopus 로고
    • E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1
    • Taubert, S., Gorrini, C., Frank, S. R., Parisi, T., Fuchs, M., Chan, H. M., Livingston, D. M., and Amati, B. (2004). E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol 24, 4546-4556.
    • (2004) Mol Cell Biol , vol.24 , pp. 4546-4556
    • Taubert, S.1    Gorrini, C.2    Frank, S.R.3    Parisi, T.4    Fuchs, M.5    Chan, H.M.6    Livingston, D.M.7    Amati, B.8
  • 129
    • 0034840594 scopus 로고    scopus 로고
    • The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
    • Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J. S., Wang, W. F., Forrester, W. C., and Hinds, P. W. (2001). The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell 8, 303-316.
    • (2001) Mol Cell , vol.8 , pp. 303-316
    • Thomas, D.M.1    Carty, S.A.2    Piscopo, D.M.3    Lee, J.S.4    Wang, W.F.5    Forrester, W.C.6    Hinds, P.W.7
  • 130
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima, H., and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 132
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., and Jacks, T. (1998). Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 2, 293-304.
    • (1998) Mol Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 134
    • 50149108858 scopus 로고    scopus 로고
    • Conserved functions of the pRB and E2F families
    • van den Heuvel, S., and Dyson, N. J. (2008). Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 9, 713-724.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 713-724
    • van den Heuvel, S.1    Dyson, N.J.2
  • 137
    • 0347992012 scopus 로고    scopus 로고
    • The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye
    • Voas, M. G., and Rebay, I. (2003). The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye. Genetics 165, 1993-2006.
    • (2003) Genetics , vol.165 , pp. 1993-2006
    • Voas, M.G.1    Rebay, I.2
  • 138
    • 73349139851 scopus 로고    scopus 로고
    • Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1 +/- mice
    • Wang, H., Bauzon, F., Ji, P., Xu, X., Sun, D., Locker, J., Sellers, R. S., Nakayama, K., Nakayama, K. I., Cobrinik, D., et al. (2010). Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1 +/- mice. Nat Genet 42, 83-88.
    • (2010) Nat Genet , vol.42 , pp. 83-88
    • Wang, H.1    Bauzon, F.2    Ji, P.3    Xu, X.4    Sun, D.5    Locker, J.6    Sellers, R.S.7    Nakayama, K.8    Nakayama, K.I.9    Cobrinik, D.10
  • 139
    • 1642399624 scopus 로고    scopus 로고
    • Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
    • Wei, W., Ayad, N. G., Wan, Y., Zhang, G. J., Kirschner, M. W., and Kaelin, W. G. Jr. (2004). Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194-198.
    • (2004) Nature , vol.428 , pp. 194-198
    • Wei, W.1    Ayad, N.G.2    Wan, Y.3    Zhang, G.J.4    Kirschner, M.W.5    Kaelin Jr., W.G.6
  • 140
    • 4644257541 scopus 로고    scopus 로고
    • Rb family proteins differentially regulate distinct cell lineages during epithelial development
    • Wikenheiser-Brokamp, K. A. (2004). Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 131, 4299-4310.
    • (2004) Development , vol.131 , pp. 4299-4310
    • Wikenheiser-Brokamp, K.A.1
  • 141
    • 33646577125 scopus 로고    scopus 로고
    • Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    • Wikenheiser-Brokamp, K. A. (2006a). Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell Mol Life Sci 63, 767-780.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 767-780
    • Wikenheiser-Brokamp, K.A.1
  • 142
    • 33750900241 scopus 로고    scopus 로고
    • Retinoblastoma regulatory pathway in lung cancer
    • Wikenheiser-Brokamp, K. A. (2006b). Retinoblastoma regulatory pathway in lung cancer. Curr Mol Med 6, 783-793.
    • (2006) Curr Mol Med , vol.6 , pp. 783-793
    • Wikenheiser-Brokamp, K.A.1
  • 145
    • 33645925293 scopus 로고    scopus 로고
    • Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1
    • Xie, W., Jiang, P., Miao, L., Zhao, Y., Zhimin, Z., Qing, L., Zhu, W. G., and Wu, M. (2006). Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1. Nucleic Acids Res 34, 2046-2055.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2046-2055
    • Xie, W.1    Jiang, P.2    Miao, L.3    Zhao, Y.4    Zhimin, Z.5    Qing, L.6    Zhu, W.G.7    Wu, M.8
  • 146
    • 0031897273 scopus 로고    scopus 로고
    • Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice
    • Yamasaki, L., Bronson, R., Williams, B. O., Dyson, N. J., Harlow, E., and Jacks, T. (1998). Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-) mice. Nat Genet 18, 360-364.
    • (1998) Nat Genet , vol.18 , pp. 360-364
    • Yamasaki, L.1    Bronson, R.2    Williams, B.O.3    Dyson, N.J.4    Harlow, E.5    Jacks, T.6
  • 148
    • 1642483704 scopus 로고    scopus 로고
    • Ras protects Rb family null fibroblasts from cell death: a role for AP-1
    • Young, A. P., and Longmore, G. D. (2004). Ras protects Rb family null fibroblasts from cell death: a role for AP-1. J Biol Chem 279, 10931-10938.
    • (2004) J Biol Chem , vol.279 , pp. 10931-10938
    • Young, A.P.1    Longmore, G.D.2
  • 149
    • 0034737290 scopus 로고    scopus 로고
    • Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
    • Zhang, H. S., Gavin, M., Dahiya, A., Postigo, A. A., Ma, D., Luo, R. X., Harbour, J. W., and Dean, D. C. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101, 79-89.
    • (2000) Cell , vol.101 , pp. 79-89
    • Zhang, H.S.1    Gavin, M.2    Dahiya, A.3    Postigo, A.A.4    Ma, D.5    Luo, R.X.6    Harbour, J.W.7    Dean, D.C.8
  • 150
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W. G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 151
    • 0028983384 scopus 로고
    • p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
    • Zhu, L., Harlow, E., and Dynlacht, B. D. (1995). p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev 9, 1740-1752.
    • (1995) Genes Dev , vol.9 , pp. 1740-1752
    • Zhu, L.1    Harlow, E.2    Dynlacht, B.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.