Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence

Molecular Cell

Volumn 26, Issue 4, 2007, Pages 539-551

  Litovchick, Larisa ^a   Sadasivam, Subhashini ^a   Florens, Laurence ^b   Zhu, Xiaopeng ^c   Swanson, Selene K ^b   Velmurugan, Soundarapandian ^d   Chen, Runsheng ^c   Washburn, Michael P ^b   Liu, X Shirley ^a,e   DeCaprio, James A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

CELLCYCLE; DNA

Indexed keywords

CALSENILIN; PROTEIN P130; TRANSCRIPTION FACTOR E2F4;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN CELL; HUMAN GENOME; PROTEIN INTERACTION; PROTEOMICS;

ANIMALS; CAENORHABDITIS ELEGANS; CELL AGING; CELL CYCLE; CONSERVED SEQUENCE; CRK-ASSOCIATED SUBSTRATE PROTEIN; DROSOPHILA MELANOGASTER; E2F4 TRANSCRIPTION FACTOR; EVOLUTION, MOLECULAR; GENE DELETION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KV CHANNEL-INTERACTING PROTEINS; MUTATION; NEOPLASMS; PROTEIN SUBUNITS; PROTEOME; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; SUPPRESSION, GENETIC;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 34249109173     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.04.015     Document Type: Article

References (39)

1. Balciunaite E., Spektor A., Lents N.H., Cam H., Te Riele H., Scime A., Rudnicki M.A., Young R., and Dynlacht B.D. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol. Cell. Biol. 25 (2005) 8166-8178
2. Beall E.L., Manak J.R., Zhou S., Bell M., Lipsick J.S., and Botchan M.R. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420 (2002) 833-837
3. Beall E.L., Bell M., Georlette D., and Botchan M.R. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev. 18 (2004) 1667-1680
4. Boxem M., and van den Heuvel S. C. elegans class B synthetic multivulva genes act in G(1) regulation. Curr. Biol. 12 (2002) 906-911
5. Cam H., Balciunaite E., Blais A., Spektor A., Scarpulla R.C., Young R., Kluger Y., and Dynlacht B.D. A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16 (2004) 399-411
6. Carroll J.S., Meyer C.A., Song J., Li W., Geistlinger T.R., Eeckhoute J., Brodsky A.S., Keeton E.K., Fertuck K.C., Hall G.F., et al. Genome-wide analysis of estrogen receptor binding sites. Nat. Genet. 38 (2006) 1289-1297
7. Ceol C.J., Stegmeier F., Harrison M.M., and Horvitz H.R. Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development. Genetics 173 (2006) 709-726
8. Classon M., and Dyson N. p107 and p130: versatile proteins with interesting pockets. Exp. Cell Res. 264 (2001) 135-147
9. Classon M., and Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2 (2002) 910-917
10. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 24 (2005) 2796-2809
11. Dai M., Wang P., Boyd A.D., Kostov G., Athey B., Jones E.G., Bunney W.E., Myers R.M., Speed T.P., Akil H., et al. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 33 (2005) e175
12. Dennis Jr. G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., and Lempicki R.A. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4 (2003) P3
13. Dimova D.K., and Dyson N.J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24 (2005) 2810-2826
14. Dimova D.K., Stevaux O., Frolov M.V., and Dyson N.J. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17 (2003) 2308-2320
15. Elkon R., Linhart C., Sharan R., Shamir R., and Shiloh Y. Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells. Genome Res. 13 (2003) 773-780
16. Fay D.S., and Han M. The synthetic multivulval genes of C. elegans: functional redundancy, Ras-antagonism, and cell fate determination. Genesis 26 (2000) 279-284
17. Florens L., and Washburn M.P. Proteomic analysis by multidimensional protein identification technology. Methods Mol. Biol. 328 (2006) 159-175
18. Florens L., Carozza M.J., Swanson S.K., Fournier M., Coleman M.K., Workman J.L., and Washburn M.P. Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors. Methods 40 (2006) 303-311
19. Frolov M.V., and Dyson N.J. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J. Cell Sci. 117 (2004) 2173-2181
20. Gagrica S., Hauser S., Kolfschoten I., Osterloh L., Agami R., and Gaubatz S. Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J. 23 (2004) 4627-4638
21. Harrison M.M., Ceol C.J., Lu X., and Horvitz H.R. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc. Natl. Acad. Sci. USA 103 (2006) 16782-16787
22. Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., and Speed T.P. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4 (2003) 249-264
23. Ji X., Li W., Song J., Wei L., and Liu X.S. CEAS: cis-regulatory element annotation system. Nucleic Acids Res. 34 (2006) W551-W554
24. Johnson W.E., Li W., Meyer C.A., Gottardo R., Carroll J.S., Brown M., and Liu X.S. Model-based analysis of tiling-arrays for ChIP-chip. Proc. Natl. Acad. Sci. USA 103 (2006) 12457-12462
25. Korenjak M., Taylor-Harding B., Binne U.K., Satterlee J.S., Stevaux O., Aasland R., White-Cooper H., Dyson N., and Brehm A. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119 (2004) 181-193
26. Lewis P.W., Beall E.L., Fleischer T.C., Georlette D., Link A.J., and Botchan M.R. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18 (2004) 2929-2940
27. Litovchick L., Chestukhin A., and DeCaprio J.A. Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Mol. Cell. Biol. 24 (2004) 8970-8980
28. Osterloh L., Von Eyss B., Schmit F., Rein L., Hubner D., Samans B., Hauser S., and Gaubatz S. The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis. EMBO J. 26 (2007) 144-157
29. Papp B., and Muller J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 20 (2006) 2041-2054
30. Payton M., and Coats S. Cyclin E2, the cycle continues. Int. J. Biochem. Cell Biol. 34 (2002) 315-320
31. Pilkinton M., Sandoval R., Song J., Ness S.A., and Colamonici O.R. Mip/LIN-9 regulates the expression of B-MYB, and the induction of cyclin a, cyclin B and CDK1. J. Biol. Chem. 282 (2006) 168-175
32. Poulin G., Dong Y., Fraser A.G., Hopper N.A., and Ahringer J. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. EMBO J. 24 (2005) 2613-2623
33. Rayman J.B., Takahashi Y., Indjeian V.B., Dannenberg J.H., Catchpole S., Watson R.J., te Riele H., and Dynlacht B.D. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 16 (2002) 933-947
34. Ren B., Cam H., Takahashi Y., Volkert T., Terragni J., Young R.A., and Dynlacht B.D. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev. 16 (2002) 245-256
35. Smith E.J., Leone G., DeGregori J., Jakoi L., and Nevins J.R. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol. Cell. Biol. 16 (1996) 6965-6976
36. Solari F., and Ahringer J. NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans. Curr. Biol. 10 (2000) 223-226
37. Taylor-Harding B., Binne U.K., Korenjak M., Brehm A., and Dyson N.J. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol. Cell. Biol. 24 (2004) 9124-9136
38. Wikenheiser-Brokamp K.A. Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell. Mol. Life Sci. 63 (2006) 767-780
39. Wolffe A.P., Urnov F.D., and Guschin D. Co-repressor complexes and remodelling chromatin for repression. Biochem. Soc. Trans. 28 (2000) 379-386