-
1
-
-
0036561908
-
Modelling the molecular circuitry of cancer
-
Hahn, W. C. & Weinberg, R. A. Modelling the molecular circuitry of cancer. Nature Rev. Cancer 2, 331-341 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
2
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein, B. & Kinzler, K. W. Cancer genes and the pathways they control. Nature Med. 10, 789-799 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
0001510491
-
The RB and p53 pathways in cancer
-
Sherr, C. J. & McCormick, F. The RB and p53 pathways in cancer. Cancer Cell 2, 103-112 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 103-112
-
-
Sherr, C.J.1
McCormick, F.2
-
4
-
-
0037313618
-
Coordinated regulation of life and death by RB
-
Chau, B. N. & Wang, J. Y. Coordinated regulation of life and death by RB. Nature Rev. Cancer 3, 130-138 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 130-138
-
-
Chau, B.N.1
Wang, J.Y.2
-
5
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307-310 (2000).
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
6
-
-
0038075338
-
Decision making by p53: Life, death and cancer
-
Oren, M. Decision making by p53: life, death and cancer. Cell Death Differ. 10, 431-442 (2003).
-
(2003)
Cell Death Differ.
, vol.10
, pp. 431-442
-
-
Oren, M.1
-
7
-
-
0032931517
-
The p53 pathway
-
Prives, C. & Hall, P. A. The p53 pathway. J. Pathol. 187, 112-126 (1999).
-
(1999)
J. Pathol.
, vol.187
, pp. 112-126
-
-
Prives, C.1
Hall, P.A.2
-
8
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda, R., Tanaka, H. & Yasuda, H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420, 25-27 (1997).
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
9
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat, M. H., Jones, S. N. & Vousden, K. H. Regulation of p53 stability by Mdm2. Nature 387, 299-303 (1997).
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
10
-
-
0032145989
-
The MDM2 gene amplification database
-
Momand, J., Jung, D., Wilczynski, S. & Niland, J. The MDM2 gene amplification database. Nucleic Acids Res. 26, 3453-3459 (1998).
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 3453-3459
-
-
Momand, J.1
Jung, D.2
Wilczynski, S.3
Niland, J.4
-
11
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang, Y. et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7, 547-559 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
-
12
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
13
-
-
0030598937
-
Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma
-
Kato, M. V. et al. Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Cancer Lett. 106, 75-82 (1996).
-
(1996)
Cancer Lett.
, vol.106
, pp. 75-82
-
-
Kato, M.V.1
-
14
-
-
0031044873
-
p53 regulates apoptosis in human retinoblastoma
-
Nork, T. M., Poulsen, G. L., Millecchia, L. L., Jantz, R. G. & Nickells, R. W. p53 regulates apoptosis in human retinoblastoma. Arch. Ophthalmol. 115, 213-219 (1997).
-
(1997)
Arch. Ophthalmol.
, vol.115
, pp. 213-219
-
-
Nork, T.M.1
Poulsen, G.L.2
Millecchia, L.L.3
Jantz, R.G.4
Nickells, R.W.5
-
15
-
-
2942574955
-
Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
-
Chen, D. et al. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5, 539-551 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 539-551
-
-
Chen, D.1
-
16
-
-
13444249786
-
The search for the retinoblastoma cell of origin
-
Dyer, M. A. & Bremner, R. The search for the retinoblastoma cell of origin. Nature Rev. Cancer 5, 91-101 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 91-101
-
-
Dyer, M.A.1
Bremner, R.2
-
17
-
-
2942547243
-
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics
-
Aslanian, A., Iaquinta, P. J., Verona, R. & Lees, J. A. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 18, 1413-1422 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1413-1422
-
-
Aslanian, A.1
Iaquinta, P.J.2
Verona, R.3
Lees, J.A.4
-
18
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: Progress and puzzles
-
Lowe, S. W. & Sherr, C. J. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13, 77-83 (2003).
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
19
-
-
9744274770
-
The first knockout mouse model of retinoblastoma
-
Zhang, J., Schweers, B. & Dyer, M. A. The first knockout mouse model of retinoblastoma. Cell Cycle 3, 952-959 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 952-959
-
-
Zhang, J.1
Schweers, B.2
Dyer, M.A.3
-
20
-
-
33745304849
-
Compensation by tumor suppressor genes during retinal development in mice and humans
-
Donovan, S., Schweers, B., Martins, R., Johnson, D. & Dyer, M. A. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol. 4, 14 (2006).
-
(2006)
BMC Biol.
, vol.4
, pp. 14
-
-
Donovan, S.1
Schweers, B.2
Martins, R.3
Johnson, D.4
Dyer, M.A.5
-
21
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts, A. et al. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J. 15, 5349-5357 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
-
22
-
-
2942738959
-
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
-
Danovi, D. et al. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol. Cell. Biol. 24, 5835-5843 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5835-5843
-
-
Danovi, D.1
-
23
-
-
0012655497
-
MDM2 does not influence p53-mediated sensitivity to DNA-damaging drugs
-
McKenzie, P. P., McPake, C. R., Ashford, A. A., Vanin, E. F. & Harris, L. C. MDM2 does not influence p53-mediated sensitivity to DNA-damaging drugs. Mol. Cancer Ther. 1, 1097-1104 (2002).
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 1097-1104
-
-
McKenzie, P.P.1
McPake, C.R.2
Ashford, A.A.3
Vanin, E.F.4
Harris, L.C.5
-
24
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman, C. E. et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679 (1998).
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
-
25
-
-
0035189448
-
ATM-akey determinant of multiple cellular responses to irradiation
-
Kastan, M. B., Lim, D. S., Kim, S. T. & Yang, D. ATM-akey determinant of multiple cellular responses to irradiation. Acta Oncol. 40, 686-688 (2001).
-
(2001)
Acta Oncol.
, vol.40
, pp. 686-688
-
-
Kastan, M.B.1
Lim, D.S.2
Kim, S.T.3
Yang, D.4
-
26
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304-6311 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
27
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
28
-
-
0025040233
-
Suppression of human colorectal carcinoma cell growth by wild-type p53
-
Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K. & Vogelstein, B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912-915 (1990).
-
(1990)
Science
, vol.249
, pp. 912-915
-
-
Baker, S.J.1
Markowitz, S.2
Fearon, E.R.3
Willson, J.K.4
Vogelstein, B.5
-
29
-
-
2642631746
-
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
-
Robanus-Maandag, E. et al. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12, 1599-1609 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 1599-1609
-
-
Robanus-Maandag, E.1
-
30
-
-
2942512013
-
Cell type-specific effects of Rb deletion in the murine retina
-
MacPherson, D. et al. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 18, 1681-1694 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1681-1694
-
-
MacPherson, D.1
-
31
-
-
84945498687
-
-
Ch. 66 (eds Singh, A. D., Damato, B., Murphree, A. L. & Perry, J. D.) (Elsevier, London, in the press)
-
Dyer, M. A. & Harbour, J. W. in Clinical Ocular Oncology Ch. 66 (eds Singh, A. D., Damato, B., Murphree, A. L. & Perry, J. D.) (Elsevier, London, in the press).
-
Clinical Ocular Oncology
-
-
Dyer, M.A.1
Harbour, J.W.2
-
32
-
-
27644469013
-
Use of preclinical models to improve treatment of retinoblastoma
-
Dyer, M. A., Rodriguez-Galindo, C. & Wilson, M. W. Use of preclinical models to improve treatment of retinoblastoma. PLoS Med. 2, e332 (2005).
-
(2005)
PLoS Med.
, vol.2
-
-
Dyer, M.A.1
Rodriguez-Galindo, C.2
Wilson, M.W.3
-
33
-
-
0035815295
-
Pax6 is required for the multipotent state of retinal progenitor cells
-
Marquardt, T. et al. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105, 43-55 (2001).
-
(2001)
Cell
, vol.105
, pp. 43-55
-
-
Marquardt, T.1
-
34
-
-
33744460279
-
Proteomimetic libraries: Design, synthesis, and evaluation of p53-MDM2 interaction inhibitors
-
Lu, F. et al. Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. J. Comb. Chem. 8, 315-325 (2006).
-
(2006)
J. Comb. Chem.
, vol.8
, pp. 315-325
-
-
Lu, F.1
-
35
-
-
0036168984
-
The RING domain of Mdm2 can inhibit cell proliferation
-
Dang, J. et al. The RING domain of Mdm2 can inhibit cell proliferation. Cancer Res. 62, 1222-1230 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1222-1230
-
-
Dang, J.1
-
36
-
-
27144450572
-
Topotecan combination chemotherapy in two new rodent models of retinoblastoma
-
Laurie, N. A. et al. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin. Cancer Res. 11, 7569-7578 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 7569-7578
-
-
Laurie, N.A.1
|