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Volumn 191, Issue 4, 2010, Pages 809-825

G1 arrest and differentiation can occur independently of Rb family function

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; PROTEIN P130; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

EID: 78349240083     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.201003048     Document Type: Article
Times cited : (31)

References (96)
  • 1
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • doi:10.1101/gad.1588507
    • Adler, A.S., S. Sinha, T.L. Kawahara, J.Y. Zhang, E. Segal, and H.Y. Chang. 2007. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 21:3244-3257. doi:10.1101/gad.1588507
    • (2007) Genes Dev. , vol.21 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 2
    • 33748356239 scopus 로고    scopus 로고
    • Mouse models of cell cycle regulators: New paradigms
    • doi:10.1007/400-023
    • Aleem, E., and P. Kaldis. 2006. Mouse models of cell cycle regulators: new paradigms. Results Probl. Cell Differ. 42:271-328. doi:10.1007/400-023
    • (2006) Results Probl. Cell Differ. , vol.42 , pp. 271-328
    • Aleem, E.1    Kaldis, P.2
  • 3
    • 23144451917 scopus 로고    scopus 로고
    • Cdc2-cyclin e complexes regulate the G1/S phase transition
    • doi:10.1038/ncb1284
    • Aleem, E., H. Kiyokawa, and P. Kaldis. 2005. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol. 7:831-836. doi:10.1038/ncb1284
    • (2005) Nat. Cell Biol. , vol.7 , pp. 831-836
    • Aleem, E.1    Kiyokawa, H.2    Kaldis, P.3
  • 5
    • 19944431321 scopus 로고    scopus 로고
    • A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner
    • doi:10.1074/jbc.M412509200
    • Attwooll, C., S. Oddi, P. Cartwright, E. Prosperini, K. Agger, P. Steensgaard, C. Wagener, C. Sardet, M.C. Moroni, and K. Helin. 2005. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J. Biol. Chem. 280:1199-1208. doi:10.1074/jbc.M412509200
    • (2005) J. Biol. Chem. , vol.280 , pp. 1199-1208
    • Attwooll, C.1    Oddi, S.2    Cartwright, P.3    Prosperini, E.4    Agger, K.5    Steensgaard, P.6    Wagener, C.7    Sardet, C.8    Moroni, M.C.9    Helin, K.10
  • 6
    • 0028907753 scopus 로고
    • Embryonic stem cells express neuronal properties in vitro
    • doi:10.1006/dbio.1995.1085
    • Bain, G., D. Kitchens, M. Yao, J.E. Huettner, and D.I. Gottlieb. 1995. Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 168:342-357. doi:10.1006/dbio.1995.1085
    • (1995) Dev. Biol. , vol.168 , pp. 342-357
    • Bain, G.1    Kitchens, D.2    Yao, M.3    Huettner, J.E.4    Gottlieb, D.I.5
  • 7
    • 70349269164 scopus 로고    scopus 로고
    • Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects
    • doi:10.1073/pnas.0902408106
    • Berman, S.D., J.C. West, P.S. Danielian, A.M. Caron, J.R. Stone, and J.A. Lees. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc. Natl. Acad. Sci. USA. 106:14932-14936. doi:10.1073/pnas.0902408106
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14932-14936
    • Berman, S.D.1    West, J.C.2    Danielian, P.S.3    Caron, A.M.4    Stone, J.R.5    Lees, J.A.6
  • 8
    • 33646528191 scopus 로고    scopus 로고
    • Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation
    • doi:10.1016/j.devcel.2006.03.004
    • Berthet, C., K.D. Klarmann, M.B. Hilton, H.C. Suh, J.R. Keller, H. Kiyokawa, and P. Kaldis. 2006. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev. Cell. 10:563-573. doi:10.1016/j.devcel.2006.03.004
    • (2006) Dev. Cell. , vol.10 , pp. 563-573
    • Berthet, C.1    Klarmann, K.D.2    Hilton, M.B.3    Suh, H.C.4    Keller, J.R.5    Kiyokawa, H.6    Kaldis, P.7
  • 9
    • 50149120366 scopus 로고    scopus 로고
    • Cellular mechanisms of tumour suppression by the retinoblastoma gene
    • doi:10.1038/nrc2399
    • Burkhart, D.L., and J. Sage. 2008. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer. 8:671-682. doi:10.1038/nrc2399
    • (2008) Nat. Rev. Cancer. , vol.8 , pp. 671-682
    • Burkhart, D.L.1    Sage, J.2
  • 11
    • 36749004944 scopus 로고    scopus 로고
    • Mechanisms controlling cell cycle exit upon terminal differentiation
    • doi:10.1016/j.ceb.2007.10.004
    • Buttitta, L.A., and B.A. Edgar. 2007. Mechanisms controlling cell cycle exit upon terminal differentiation. Curr. Opin. Cell Biol. 19:697-704. doi:10.1016/j.ceb.2007.10.004
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 697-704
    • Buttitta, L.A.1    Edgar, B.A.2
  • 12
    • 34047097318 scopus 로고    scopus 로고
    • A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila
    • doi:10.1016/j.devcel.2007.02.020
    • Buttitta, L.A., A.J. Katzaroff, C.L. Perez, A. de la Cruz, and B.A. Edgar. 2007. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell. 12:631-643. doi:10.1016/j.devcel. 2007.02.020
    • (2007) Dev. Cell. , vol.12 , pp. 631-643
    • Buttitta, L.A.1    Katzaroff, A.J.2    Perez, C.L.3    De La Cruz, A.4    Edgar, B.A.5
  • 13
    • 0033559609 scopus 로고    scopus 로고
    • Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity
    • doi:10.1006/dbio.1998.9162
    • Callaghan, D.A., L. Dong, S.M. Callaghan, Y.X. Hou, L. Dagnino, and R.S. Slack. 1999. Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev. Biol. 207:257-270. doi:10.1006/dbio.1998.9162
    • (1999) Dev. Biol. , vol.207 , pp. 257-270
    • Callaghan, D.A.1    Dong, L.2    Callaghan, S.M.3    Hou, Y.X.4    Dagnino, L.5    Slack, R.S.6
  • 14
    • 8644281106 scopus 로고    scopus 로고
    • A common set of gene regulatory networks links metabolism and growth inhibition
    • doi:10.1016/j.molcel.2004.09.037
    • Cam, H., E. Balciunaite, A. Blais, A. Spektor, R.C. Scarpulla, R. Young, Y. Kluger, and B.D. Dynlacht. 2004. A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell. 16:399-411. doi:10.1016/j.molcel.2004.09.037
    • (2004) Mol. Cell. , vol.16 , pp. 399-411
    • Cam, H.1    Balciunaite, E.2    Blais, A.3    Spektor, A.4    Scarpulla, R.C.5    Young, R.6    Kluger, Y.7    Dynlacht, B.D.8
  • 15
    • 27144556188 scopus 로고    scopus 로고
    • Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis
    • doi:10.1038/sj.onc.1208823
    • Casanovas, O., J.H. Hager, M.G. Chun, and D. Hanahan. 2005. Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. Oncogene. 24:6597-6604. doi:10.1038/sj.onc.1208823
    • (2005) Oncogene , vol.24 , pp. 6597-6604
    • Casanovas, O.1    Hager, J.H.2    Chun, M.G.3    Hanahan, D.4
  • 16
    • 34547108871 scopus 로고    scopus 로고
    • Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a
    • doi:10.1371/journal.pbio.0050179
    • Chen, D., R. Opavsky, M. Pacal, N. Tanimoto, P. Wenzel, M.W. Seeliger, G. Leone, and R. Bremner. 2007. Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol. 5:e179. doi:10.1371/journal.pbio.0050179
    • (2007) PLoS Biol. , vol.5
    • Chen, D.1    Opavsky, R.2    Pacal, M.3    Tanimoto, N.4    Wenzel, P.5    Seeliger, M.W.6    Leone, G.7    Bremner, R.8
  • 17
    • 70350518233 scopus 로고    scopus 로고
    • Emerging roles of E2Fs in cancer: An exit from cell cycle control
    • doi:10.1038/nrc2696
    • Chen, H.Z., S.Y. Tsai, and G. Leone. 2009. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat. Rev. Cancer. 9:785-797. doi:10.1038/nrc2696
    • (2009) Nat. Rev. Cancer. , vol.9 , pp. 785-797
    • Chen, H.Z.1    Tsai, S.Y.2    Leone, G.3
  • 18
    • 77950486542 scopus 로고    scopus 로고
    • Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence
    • doi:10.1016/j.ccr.2010.01.023
    • Chicas, A., X. Wang, C. Zhang, M. McCurrach, Z. Zhao, O. Mert, R.A. Dickins, M. Narita, M. Zhang, and S.W. Lowe. 2010. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell. 17:376-387. doi:10.1016/j.ccr.2010.01.023
    • (2010) Cancer Cell. , vol.17 , pp. 376-387
    • Chicas, A.1    Wang, X.2    Zhang, C.3    McCurrach, M.4    Zhao, Z.5    Mert, O.6    Dickins, R.A.7    Narita, M.8    Zhang, M.9    Lowe, S.W.10
  • 20
    • 18344381110 scopus 로고    scopus 로고
    • Cell cycle in mouse development
    • doi:10.1038/sj.onc.1208608
    • Ciemerych, M.A., and P. Sicinski. 2005. Cell cycle in mouse development. Oncogene. 24:2877-2898. doi:10.1038/sj.onc.1208608
    • (2005) Oncogene , vol.24 , pp. 2877-2898
    • Ciemerych, M.A.1    Sicinski, P.2
  • 22
    • 0036884829 scopus 로고    scopus 로고
    • The retinoblastoma tumour suppressor in development and cancer
    • doi:10.1038/nrc950
    • Classon, M., and E. Harlow. 2002. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer. 2:910-917. doi:10.1038/nrc950
    • (2002) Nat. Rev. Cancer. , vol.2 , pp. 910-917
    • Classon, M.1    Harlow, E.2
  • 23
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • doi:10.1038/sj.onc.1208619
    • Cobrinik, D. 2005. Pocket proteins and cell cycle control. Oncogene. 24:2796-2809. doi:10.1038/sj.onc.1208619
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 25
    • 72449130114 scopus 로고    scopus 로고
    • Keeping an eye on retinoblastoma control of human embryonic stem cells
    • doi:10.1002/jcb.22342
    • Conklin, J.F., and J. Sage. 2009. Keeping an eye on retinoblastoma control of human embryonic stem cells. J. Cell. Biochem. 108:1023-1030. doi:10.1002/jcb.22342
    • (2009) J. Cell. Biochem. , vol.108 , pp. 1023-1030
    • Conklin, J.F.1    Sage, J.2
  • 26
    • 43449130065 scopus 로고    scopus 로고
    • E2f6 and Bmi1 cooperate in axial skeletal development
    • doi:10.1002/dvdy.21516
    • Courel, M., L. Friesenhahn, and J.A. Lees. 2008. E2f6 and Bmi1 cooperate in axial skeletal development. Dev. Dyn. 237:1232-1242. doi:10.1002/dvdy.21516
    • (2008) Dev. Dyn. , vol.237 , pp. 1232-1242
    • Courel, M.1    Friesenhahn, L.2    Lees, J.A.3
  • 27
    • 33748375327 scopus 로고    scopus 로고
    • The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis
    • doi:10.1007/400-002
    • Dannenberg, J.H., and H.P. te Riele. 2006. The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis. Results Probl. Cell Differ. 42:183-225. doi:10.1007/400-002
    • (2006) Results Probl. Cell Differ. , vol.42 , pp. 183-225
    • Dannenberg, J.H.1    Te Riele, H.P.2
  • 28
    • 0033635597 scopus 로고    scopus 로고
    • Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
    • doi:10.1101/gad.847700
    • Dannenberg, J.H., A. van Rossum, L. Schuijff, and H. te Riele. 2000. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14:3051-3064. doi:10.1101/gad.847700
    • (2000) Genes Dev. , vol.14 , pp. 3051-3064
    • Dannenberg, J.H.1    Van Rossum, A.2    Schuijff, L.3    Te Riele, H.4
  • 30
    • 33750923736 scopus 로고    scopus 로고
    • The retinoblastoma protein in osteoblast differentiation and osteosarcoma
    • Deshpande, A., and P.W. Hinds. 2006. The retinoblastoma protein in osteoblast differentiation and osteosarcoma. Curr. Mol. Med. 6:809-817.
    • (2006) Curr. Mol. Med. , vol.6 , pp. 809-817
    • Deshpande, A.1    Hinds, P.W.2
  • 31
    • 0032441150 scopus 로고    scopus 로고
    • Cluster analysis and display of genome-wide expression patterns
    • doi:10.1073/pnas.95.25.14863
    • Eisen, M.B., P.T. Spellman, P.O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA. 95:14863-14868. doi:10.1073/pnas.95.25.14863
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14863-14868
    • Eisen, M.B.1    Spellman, P.T.2    Brown, P.O.3    Botstein, D.4
  • 32
    • 0030900851 scopus 로고    scopus 로고
    • Susceptibility to cell death induced by mutant SV40 T-antigen correlates with Purkinje neuron functional development
    • doi:10.1006/mcne.1997.0601
    • Feddersen, R.M., W.S. Yunis, M.A. O'Donnell, T.J. Ebner, L. Shen, C. Iadecola, H.T. Orr, and H.B. Clark. 1997. Susceptibility to cell death induced by mutant SV40 T-antigen correlates with Purkinje neuron functional development. Mol. Cell. Neurosci. 9:42-62. doi:10.1006/mcne.1997.0601
    • (1997) Mol. Cell. Neurosci. , vol.9 , pp. 42-62
    • Feddersen, R.M.1    Yunis, W.S.2    O'Donnell, M.A.3    Ebner, T.J.4    Shen, L.5    Iadecola, C.6    Orr, H.T.7    Clark, H.B.8
  • 36
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes, J., H. Lemke, H. Baisch, H.H. Wacker, U. Schwab, and H. Stein. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1710-1715.
    • (1984) J. Immunol. , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3    Wacker, H.H.4    Schwab, U.5    Stein, H.6
  • 37
    • 1942439150 scopus 로고    scopus 로고
    • Combinatorial gene control involving E2F and e Box family members
    • doi:10.1038/sj.emboj.7600134
    • Giangrande, P.H., W. Zhu, R.E. Rempel, N. Laakso, and J.R. Nevins. 2004. Combinatorial gene control involving E2F and E Box family members. EMBO J. 23:1336-1347. doi:10.1038/sj.emboj.7600134
    • (2004) EMBO J. , vol.23 , pp. 1336-1347
    • Giangrande, P.H.1    Zhu, W.2    Rempel, R.E.3    Laakso, N.4    Nevins, J.R.5
  • 38
    • 25144491542 scopus 로고    scopus 로고
    • Role of Rb family in the epigenetic definition of chromatin
    • Gonzalo, S., and M.A. Blasco. 2005. Role of Rb family in the epigenetic definition of chromatin. Cell Cycle. 4:752-755.
    • (2005) Cell Cycle , vol.4 , pp. 752-755
    • Gonzalo, S.1    Blasco, M.A.2
  • 39
    • 18344381018 scopus 로고    scopus 로고
    • Cyclin e in normal and neoplastic cell cycles
    • doi:10.1038/sj.onc.1208613
    • Hwang, H.C., and B.E. Clurman. 2005. Cyclin E in normal and neoplastic cell cycles. Oncogene. 24:2776-2786. doi:10.1038/sj.onc.1208613
    • (2005) Oncogene , vol.24 , pp. 2776-2786
    • Hwang, H.C.1    Clurman, B.E.2
  • 40
    • 75749093007 scopus 로고    scopus 로고
    • Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets
    • doi:10.1523/JNEUROSCI.4318-09.2010
    • Ideguchi, M., T.D. Palmer, L.D. Recht, and J.M. Weimann. 2010. Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J. Neurosci. 30:894-904. doi:10.1523/JNEUROSCI.4318-09.2010
    • (2010) J. Neurosci. , vol.30 , pp. 894-904
    • Ideguchi, M.1    Palmer, T.D.2    Recht, L.D.3    Weimann, J.M.4
  • 42
    • 0030922363 scopus 로고    scopus 로고
    • The retinoblastoma gene family is differentially expressed during embryogenesis
    • doi:10.1038/sj.onc.1201014
    • Jiang, Z., E. Zacksenhaus, B.L. Gallie, and R.A. Phillips. 1997. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene. 14:1789-1797. doi:10.1038/sj.onc.1201014
    • (1997) Oncogene , vol.14 , pp. 1789-1797
    • Jiang, Z.1    Zacksenhaus, E.2    Gallie, B.L.3    Phillips, R.A.4
  • 44
    • 33748065310 scopus 로고    scopus 로고
    • RB, the conductor that orchestrates life, death and differentiation
    • doi:10.1038/sj.onc.1209612
    • Khidr, L., and P.L. Chen. 2006. RB, the conductor that orchestrates life, death and differentiation. Oncogene. 25:5210-5219. doi:10.1038/sj.onc.1209612
    • (2006) Oncogene , vol.25 , pp. 5210-5219
    • Khidr, L.1    Chen, P.L.2
  • 45
    • 57649228521 scopus 로고    scopus 로고
    • Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells
    • doi:10.1371/journal.pone.0003932
    • Kidder, B.L., J. Yang, and S. Palmer. 2008. Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLoS One. 3:e3932. doi:10.1371/journal.pone.0003932
    • (2008) PLoS One , vol.3
    • Kidder, B.L.1    Yang, J.2    Palmer, S.3
  • 46
    • 0028277921 scopus 로고
    • Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice
    • doi:10.1073/pnas.91.15.6914
    • Kim, S.H., K.A. Roth, C.M. Coopersmith, J.M. Pipas, and J.I. Gordon. 1994. Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice. Proc. Natl. Acad. Sci. USA. 91:6914-6918. doi:10.1073/pnas.91.15.6914
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6914-6918
    • Kim, S.H.1    Roth, K.A.2    Coopersmith, C.M.3    Pipas, J.M.4    Gordon, J.I.5
  • 47
    • 50149084928 scopus 로고    scopus 로고
    • Tailoring to RB: Tumour suppressor status and therapeutic response
    • doi:10.1038/nrc2401
    • Knudsen, E.S., and K.E. Knudsen. 2008. Tailoring to RB: tumour suppressor status and therapeutic response. Nat. Rev. Cancer. 8:714-724. doi:10.1038/nrc2401
    • (2008) Nat. Rev. Cancer. , vol.8 , pp. 714-724
    • Knudsen, E.S.1    Knudsen, K.E.2
  • 49
    • 61749085629 scopus 로고    scopus 로고
    • Atypical E2Fs: New players in the E2F transcription factor family
    • doi:10.1016/j.tcb.2009.01.002
    • Lammens, T., J. Li, G. Leone, and L. De Veylder. 2009. Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol. 19:111-118. doi:10.1016/j.tcb.2009.01.002
    • (2009) Trends Cell Biol. , vol.19 , pp. 111-118
    • Lammens, T.1    Li, J.2    Leone, G.3    De Veylder, L.4
  • 50
    • 0033118927 scopus 로고    scopus 로고
    • Timing of cyclin e gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex
    • doi:10.1093/emboj/18.7.1878
    • Le Cam, L., J. Polanowska, E. Fabbrizio, M. Olivier, A. Philips, E. Ng Eaton, M. Classon, Y. Geng, and C. Sardet. 1999. Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex. EMBO J. 18:1878-1890. doi:10.1093/emboj/18.7.1878
    • (1999) EMBO J. , vol.18 , pp. 1878-1890
    • Le Cam, L.1    Polanowska, J.2    Fabbrizio, E.3    Olivier, M.4    Philips, A.5    Ng Eaton, E.6    Classon, M.7    Geng, Y.8    Sardet, C.9
  • 51
    • 33749657631 scopus 로고    scopus 로고
    • Targeting cyclins and cyclin-dependent kinases in cancer: Lessons from mice, hopes for therapeutic applications in human
    • Lee, Y.M., and P. Sicinski. 2006. Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human. Cell Cycle. 5:2110-2114.
    • (2006) Cell Cycle , vol.5 , pp. 2110-2114
    • Lee, Y.M.1    Sicinski, P.2
  • 52
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • doi:10.1038/359288a0
    • Lee, E.Y., C.Y. Chang, N. Hu, Y.C. Wang, C.C. Lai, K. Herrup, W.H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature. 359:288-294. doi:10.1038/359288a0
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6    Lee, W.H.7    Bradley, A.8
  • 54
    • 77952101348 scopus 로고    scopus 로고
    • Specific killing of Rb mutant cancer cells by inactivating TSC2
    • doi:10.1016/j.ccr.2010.03.019
    • Li, B., G.M. Gordon, C.H. Du, J. Xu, and W. Du. 2010. Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 17:469-480. doi:10.1016/j.ccr.2010.03.019
    • (2010) Cancer Cell. , vol.17 , pp. 469-480
    • Li, B.1    Gordon, G.M.2    Du, C.H.3    Xu, J.4    Du, W.5
  • 55
    • 17744413236 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: Model validation, design issues and standard error application
    • RESEARCH0032. doi:10.1186/gb-2001-2-8-research0032
    • Li, C., and W. Hung Wong. 2001. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2:RESEARCH0032. doi:10.1186/gb-2001-2-8-research0032
    • (2001) Genome Biol. , vol.2
    • Li, C.1    Wong, W.H.2
  • 56
    • 37749005850 scopus 로고    scopus 로고
    • Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development
    • doi:10.1016/j.devcel.2007.10.017
    • Li, J., C. Ran, E. Li, F. Gordon, G. Comstock, H. Siddiqui, W. Cleghorn, H.Z. Chen, K. Kornacker, C.G. Liu, et al. 2008. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev. Cell. 14:62-75. doi:10.1016/j.devcel.2007.10.017
    • (2008) Dev. Cell. , vol.14 , pp. 62-75
    • Li, J.1    Ran, C.2    Li, E.3    Gordon, F.4    Comstock, G.5    Siddiqui, H.6    Cleghorn, W.7    Chen, H.Z.8    Kornacker, K.9    Liu, C.G.10
  • 57
    • 3342996653 scopus 로고    scopus 로고
    • Retinoblastoma: Revisiting the model prototype of inherited cancer
    • doi:10.1002/ajmg.c.30024
    • Lohmann, D.R., and B.L. Gallie. 2004. Retinoblastoma: revisiting the model prototype of inherited cancer. Am. J. Med. Genet. C. Semin. Med. Genet. 129C:23-28. doi:10.1002/ajmg.c.30024
    • (2004) Am. J. Med. Genet. C. Semin. Med. Genet. , vol.129 , pp. 23-28
    • Lohmann, D.R.1    Gallie, B.L.2
  • 58
    • 0028304809 scopus 로고
    • Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element
    • Lu, B., J.A. Rothnagel, M.A. Longley, S.Y. Tsai, and D.R. Roop. 1994. Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J. Biol. Chem. 269:7443-7449.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7443-7449
    • Lu, B.1    Rothnagel, J.A.2    Longley, M.A.3    Tsai, S.Y.4    Roop, D.R.5
  • 59
    • 0037305849 scopus 로고    scopus 로고
    • Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system
    • doi:10.1128/MCB.23.3.1044-1053.2003
    • MacPherson, D., J. Sage, D. Crowley, A. Trumpp, R.T. Bronson, and T. Jacks. 2003. Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol. Cell. Biol. 23:1044-1053. doi:10.1128/MCB.23.3.1044-1053.2003
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1044-1053
    • MacPherson, D.1    Sage, J.2    Crowley, D.3    Trumpp, A.4    Bronson, R.T.5    Jacks, T.6
  • 60
    • 0029036901 scopus 로고
    • MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
    • doi:10.1038/375421a0
    • Madine, M.A., C.Y. Khoo, A.D. Mills, and R.A. Laskey. 1995. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature. 375:421-424. doi:10.1038/375421a0
    • (1995) Nature , vol.375 , pp. 421-424
    • Madine, M.A.1    Khoo, C.Y.2    Mills, A.D.3    Laskey, R.A.4
  • 61
    • 36749056285 scopus 로고    scopus 로고
    • Cyclins and related kinases in cancer cells
    • Malumbres, M. 2007. Cyclins and related kinases in cancer cells. J. BUON. 12:S45-S52.
    • (2007) J. BUON. , vol.12
    • Malumbres, M.1
  • 62
    • 4444247138 scopus 로고    scopus 로고
    • Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    • doi:10.1016/j.cell.2004.08.002
    • Malumbres, M., R. Sotillo, D. Santamaría, J. Galán, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid. 2004. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 118:493-504. doi:10.1016/j.cell.2004.08.002
    • (2004) Cell. , vol.118 , pp. 493-504
    • Malumbres, M.1    Sotillo, R.2    Santamaría, D.3    Galán, J.4    Cerezo, A.5    Ortega, S.6    Dubus, P.7    Barbacid, M.8
  • 63
    • 0032772127 scopus 로고    scopus 로고
    • Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1
    • McCaffrey, J., L. Yamasaki, N.J. Dyson, E. Harlow, and A.E. Griep. 1999. Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol. Cell. Biol. 19:6458-6468.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6458-6468
    • McCaffrey, J.1    Yamasaki, L.2    Dyson, N.J.3    Harlow, E.4    Griep, A.E.5
  • 65
    • 33750625694 scopus 로고    scopus 로고
    • In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates
    • doi:10.1016/j.mcn.2006.07.012
    • McLear, J.A., G. Garcia-Fresco, M.A. Bhat, and T.A. Van Dyke. 2006. In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates. Mol. Cell. Neurosci. 33:260-273. doi:10.1016/j.mcn.2006.07.012
    • (2006) Mol. Cell. Neurosci. , vol.33 , pp. 260-273
    • McLear, J.A.1    Garcia-Fresco, G.2    Bhat, M.A.3    Van Dyke, T.A.4
  • 66
    • 35148845584 scopus 로고    scopus 로고
    • Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells
    • doi:10.1038/nbt1335
    • Meissner, A., M. Wernig, and R. Jaenisch. 2007. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat. Biotechnol. 25:1177-1181. doi:10.1038/nbt1335
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1177-1181
    • Meissner, A.1    Wernig, M.2    Jaenisch, R.3
  • 67
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • doi:10.1038/nrc2231
    • Meyer, N., and L.Z. Penn. 2008. Reflecting on 25 years with MYC. Nat. Rev. Cancer. 8:976-990. doi:10.1038/nrc2231
    • (2008) Nat. Rev. Cancer. , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 68
    • 0033529030 scopus 로고    scopus 로고
    • PRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
    • doi:10.1016/S0960-9822(99)80210-3
    • Novitch, B.G., D.B. Spicer, P.S. Kim, W.L. Cheung, and A.B. Lassar. 1999. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr. Biol. 9:449-459. doi:10.1016/S0960-9822(99)80210-3
    • (1999) Curr. Biol. , vol.9 , pp. 449-459
    • Novitch, B.G.1    Spicer, D.B.2    Kim, P.S.3    Cheung, W.L.4    Lassar, A.B.5
  • 69
    • 0037052539 scopus 로고    scopus 로고
    • A complex with chromatin modifiers that occupies E2F- And Myc-responsive genes in G0 cells
    • doi:10.1126/science.1069861
    • Ogawa, H., K. Ishiguro, S. Gaubatz, D.M. Livingston, and Y. Nakatani. 2002. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 296:1132-1136. doi:10.1126/science.1069861
    • (2002) Science , vol.296 , pp. 1132-1136
    • Ogawa, H.1    Ishiguro, K.2    Gaubatz, S.3    Livingston, D.M.4    Nakatani, Y.5
  • 71
    • 0141737069 scopus 로고    scopus 로고
    • Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    • doi:10.1093/emboj/cdg482
    • Parisi, T., A.R. Beck, N. Rougier, T. McNeil, L. Lucian, Z. Werb, and B. Amati. 2003. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22:4794-4803. doi:10.1093/emboj/cdg482
    • (2003) EMBO J. , vol.22 , pp. 4794-4803
    • Parisi, T.1    Beck, A.R.2    Rougier, N.3    McNeil, T.4    Lucian, L.5    Werb, Z.6    Amati, B.7
  • 72
    • 0035156849 scopus 로고    scopus 로고
    • Escape from premature senescence is not sufficient for oncogenic transformation by Ras
    • doi:10.1038/35055110
    • Peeper, D.S., J.H. Dannenberg, S. Douma, H. te Riele, and R. Bernards. 2001. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat. Cell Biol. 3:198-203. doi:10.1038/35055110
    • (2001) Nat. Cell Biol. , vol.3 , pp. 198-203
    • Peeper, D.S.1    Dannenberg, J.H.2    Douma, S.3    Te Riele, H.4    Bernards, R.5
  • 74
    • 0033637086 scopus 로고    scopus 로고
    • Targeted disruption of the three Rbrelated genes leads to loss of G(1) control and immortalization
    • doi:10.1101/gad.843200
    • Sage, J., G.J. Mulligan, L.D. Attardi, A. Miller, S. Chen, B. Williams, E. Theodorou, and T. Jacks. 2000. Targeted disruption of the three Rbrelated genes leads to loss of G(1) control and immortalization. Genes Dev. 14:3037-3050. doi:10.1101/gad.843200
    • (2000) Genes Dev. , vol.14 , pp. 3037-3050
    • Sage, J.1    Mulligan, G.J.2    Attardi, L.D.3    Miller, A.4    Chen, S.5    Williams, B.6    Theodorou, E.7    Jacks, T.8
  • 75
    • 0038342441 scopus 로고    scopus 로고
    • Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
    • doi:10.1038/nature01764
    • Sage, J., A.L. Miller, P.A. Pérez-Mancera, J.M. Wysocki, and T. Jacks. 2003. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223-228. doi:10.1038/nature01764
    • (2003) Nature , vol.424 , pp. 223-228
    • Sage, J.1    Miller, A.L.2    Pérez-Mancera, P.A.3    Wysocki, J.M.4    Jacks, T.5
  • 77
    • 77952794331 scopus 로고    scopus 로고
    • Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma
    • doi:10.1158/0008-5472. CAN-09-4228
    • Schaffer, B.E., K.S. Park, G. Yiu, J.F. Conklin, C. Lin, D.L. Burkhart, A.N. Karnezis, E.A. Sweet-Cordero, and J. Sage. 2010. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res. 70:3877-3883. doi:10.1158/0008-5472. CAN-09-4228
    • (2010) Cancer Res. , vol.70 , pp. 3877-3883
    • Schaffer, B.E.1    Park, K.S.2    Yiu, G.3    Conklin, J.F.4    Lin, C.5    Burkhart, D.L.6    Karnezis, A.N.7    Sweet-Cordero, E.A.8    Sage, J.9
  • 78
    • 33645064540 scopus 로고    scopus 로고
    • Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha
    • doi:10.1016/j.cmet.2005.10.002
    • Scimè, A., G. Grenier, M.S. Huh, M.A. Gillespie, L. Bevilacqua, M.E. Harper, and M.A. Rudnicki. 2005. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab. 2:283-295. doi:10.1016/j.cmet.2005.10.002
    • (2005) Cell Metab. , vol.2 , pp. 283-295
    • Scimè, A.1    Grenier, G.2    Huh, M.S.3    Gillespie, M.A.4    Bevilacqua, L.5    Harper, M.E.6    Rudnicki, M.A.7
  • 79
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • doi:10.1074/jbc.R100063200
    • Sears, R.C., and J.R. Nevins. 2002. Signaling networks that link cell proliferation and cell fate. J. Biol. Chem. 277:11617-11620. doi:10.1074/jbc.R100063200
    • (2002) J. Biol. Chem. , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 80
    • 6944244084 scopus 로고    scopus 로고
    • A module map showing conditional activity of expression modules in cancer
    • doi:10.1038/ng1434
    • Segal, E., N. Friedman, D. Koller, and A. Regev. 2004. A module map showing conditional activity of expression modules in cancer. Nat. Genet. 36:1090-1098. doi:10.1038/ng1434
    • (2004) Nat. Genet. , vol.36 , pp. 1090-1098
    • Segal, E.1    Friedman, N.2    Koller, D.3    Regev, A.4
  • 81
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • doi:10.1016/S0092-8674(03)01075-4
    • Sherr, C.J. 2004. Principles of tumor suppression. Cell. 116:235-246. doi:10.1016/S0092-8674(03)01075-4
    • (2004) Cell. , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 82
    • 0036023975 scopus 로고    scopus 로고
    • Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6
    • doi:10.1093/embo-reports/kvf141
    • Storre, J., H.P. Elsässer, M. Fuchs, D. Ullmann, D.M. Livingston, and S. Gaubatz. 2002. Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Rep. 3:695-700. doi:10.1093/embo- reports/kvf141
    • (2002) EMBO Rep. , vol.3 , pp. 695-700
    • Storre, J.1    Elsässer, H.P.2    Fuchs, M.3    Ullmann, D.4    Livingston, D.M.5    Gaubatz, S.6
  • 83
    • 0034114458 scopus 로고    scopus 로고
    • Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
    • doi:10.1002/(SICI)1526-968X(200002)26:2〈113:: AID-GENE3〉3.0. CO;2-2
    • Tallquist, M.D., and P. Soriano. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis. 26:113-115. doi:10.1002/(SICI)1526-968X(200002)26:2〈113: : AID-GENE3〉3.0.CO;2-2
    • (2000) Genesis , vol.26 , pp. 113-115
    • Tallquist, M.D.1    Soriano, P.2
  • 85
    • 0034840594 scopus 로고    scopus 로고
    • The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
    • doi:10.1016/S1097-2765(01)00327-6
    • Thomas, D.M., S.A. Carty, D.M. Piscopo, J.S. Lee, W.F. Wang, W.C. Forrester, and P.W. Hinds. 2001. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol. Cell. 8:303-316. doi:10.1016/S1097-2765(01)00327-6
    • (2001) Mol. Cell. , vol.8 , pp. 303-316
    • Thomas, D.M.1    Carty, S.A.2    Piscopo, D.M.3    Lee, J.S.4    Wang, W.F.5    Forrester, W.C.6    Hinds, P.W.7
  • 86
    • 0036371956 scopus 로고    scopus 로고
    • Sibling rivalry in the E2F family
    • doi:10.1038/nrm714
    • Trimarchi, J.M., and J.A. Lees. 2002. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell Biol. 3:11-20. doi:10.1038/nrm714
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 11-20
    • Trimarchi, J.M.1    Lees, J.A.2
  • 87
    • 0035852632 scopus 로고    scopus 로고
    • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
    • doi:10.1073/pnas.041597698
    • Trimarchi, J.M., B. Fairchild, J. Wen, and J.A. Lees. 2001. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. USA. 98:1519-1524. doi:10.1073/pnas.041597698
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1519-1524
    • Trimarchi, J.M.1    Fairchild, B.2    Wen, J.3    Lees, J.A.4
  • 88
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • doi:10.1073/pnas.091062498
    • Tusher, V.G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA. 98:5116-5121. doi:10.1073/pnas.091062498
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 89
    • 0030307556 scopus 로고    scopus 로고
    • Hematopoietic differentiation of embryonic stem cells: An in vitro model to study gene regulation during megakaryocytopoiesis
    • doi:10.1002/stem.5530140725
    • Uzan, G., M.H. Prandini, J.P. Rosa, and R. Berthier. 1996. Hematopoietic differentiation of embryonic stem cells: an in vitro model to study gene regulation during megakaryocytopoiesis. Stem Cells. 14(Suppl 1):194-199. doi:10.1002/stem.5530140725
    • (1996) Stem Cells , vol.14 , Issue.SUPPL. 1 , pp. 194-199
    • Uzan, G.1    Prandini, M.H.2    Rosa, J.P.3    Berthier, R.4
  • 90
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • doi:10.1126/science.8266103
    • van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 262:2050-2054. doi:10.1126/science.8266103
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 92
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • doi:10.1016/0092-8674(95)90385-2
    • Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell. 81:323-330. doi:10.1016/0092-8674(95)90385-2
    • (1995) Cell. , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 94
    • 33646577125 scopus 로고    scopus 로고
    • Retinoblastoma family proteins: Insights gained through genetic manipulation of mice
    • doi:10.1007/s00018-005-5487-3
    • Wikenheiser-Brokamp, K.A. 2006. Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell. Mol. Life Sci. 63:767-780. doi:10.1007/s00018-005-5487-3
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 767-780
    • Wikenheiser-Brokamp, K.A.1
  • 96
    • 35949000033 scopus 로고    scopus 로고
    • A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members
    • doi:10.1101/gr.6783507
    • Xu, X., M. Bieda, V.X. Jin, A. Rabinovich, M.J. Oberley, R. Green, and P.J. Farnham. 2007. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res. 17:1550-1561. doi:10.1101/gr.6783507
    • (2007) Genome Res. , vol.17 , pp. 1550-1561
    • Xu, X.1    Bieda, M.2    Jin, V.X.3    Rabinovich, A.4    Oberley, M.J.5    Green, R.6    Farnham, P.J.7


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