메뉴 건너뛰기




Volumn 9, Issue 1, 2010, Pages 97-103

The Drosophila retinoblastoma protein induces apoptosis in proliferating but not in post-mitotic cells

Author keywords

Apoptosis; Cell cycle; Cell type specific; Drosophila; RBF; Retinoblastoma protein

Indexed keywords

CASPASE; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

EID: 74549187640     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.1.10251     Document Type: Article
Times cited : (12)

References (50)
  • 1
    • 50149108858 scopus 로고    scopus 로고
    • Conserved functions of the pRB and E2F families
    • van den Heuvel S, Dyson NJ. Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 2008; 9:713-24.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 713-724
    • van den Heuvel, S.1    Dyson, N.J.2
  • 2
    • 0029894254 scopus 로고    scopus 로고
    • Du W, Vidal M, Xie JE, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev 1996; 10:1206-18.
    • Du W, Vidal M, Xie JE, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev 1996; 10:1206-18.
  • 4
    • 0036333186 scopus 로고    scopus 로고
    • The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth
    • Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development 2002; 129:1345-56.
    • (2002) Development , vol.129 , pp. 1345-1356
    • Xin, S.1    Weng, L.2    Xu, J.3    Du, W.4
  • 5
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992; 359:288-94.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6
  • 7
    • 0037975570 scopus 로고    scopus 로고
    • Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
    • de Bruin A, Wu L, Saavedra HI, Wilson P, Yang Y, Rosol TJ, et al. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci USA 2003; 100:6546-51.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6546-6551
    • de Bruin, A.1    Wu, L.2    Saavedra, H.I.3    Wilson, P.4    Yang, Y.5    Rosol, T.J.6
  • 9
    • 3042813439 scopus 로고    scopus 로고
    • Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
    • Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A, et al. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 2004; 131:2737-48.
    • (2004) Development , vol.131 , pp. 2737-2748
    • Ruiz, S.1    Santos, M.2    Segrelles, C.3    Leis, H.4    Jorcano, J.L.5    Berns, A.6
  • 10
    • 35748930599 scopus 로고    scopus 로고
    • Wang Y, Ray SK, Hinds PW, Leiter AB. The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression. Dev Biol 2007; 311:478-86.
    • Wang Y, Ray SK, Hinds PW, Leiter AB. The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression. Dev Biol 2007; 311:478-86.
  • 11
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2Fresponsive genes, and apoptosis
    • Almasan A, Yin Y, Kelly RE, Lee EY, Bradley A, Li W, et al. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2Fresponsive genes, and apoptosis. Proc Natl Acad Sci USA 1995; 92:5436-40.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.4    Bradley, A.5    Li, W.6
  • 13
    • 4544378400 scopus 로고    scopus 로고
    • Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
    • Huh MS, Parker MH, Scime A, Parks R, Rudnicki MA. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol 2004; 166:865-76.
    • (2004) J Cell Biol , vol.166 , pp. 865-876
    • Huh, M.S.1    Parker, M.H.2    Scime, A.3    Parks, R.4    Rudnicki, M.A.5
  • 14
    • 0033558346 scopus 로고    scopus 로고
    • The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis
    • Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J 1999; 18:916-25.
    • (1999) EMBO J , vol.18 , pp. 916-925
    • Du, W.1    Dyson, N.2
  • 15
    • 1642315228 scopus 로고    scopus 로고
    • Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin
    • Duman-Scheel M, Johnston LA, Du W. Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci USA 2004; 101:3857-62.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3857-3862
    • Duman-Scheel, M.1    Johnston, L.A.2    Du, W.3
  • 16
    • 26444452667 scopus 로고    scopus 로고
    • Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development
    • Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, et al. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell 2005; 9:463-75.
    • (2005) Dev Cell , vol.9 , pp. 463-475
    • Moon, N.S.1    Frolov, M.V.2    Kwon, E.J.3    Di Stefano, L.4    Dimova, D.K.5    Morris, E.J.6
  • 17
    • 33749592371 scopus 로고    scopus 로고
    • A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis
    • Moon NS, Di Stefano L, Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol 2006; 26:7601-15.
    • (2006) Mol Cell Biol , vol.26 , pp. 7601-7615
    • Moon, N.S.1    Di Stefano, L.2    Dyson, N.3
  • 18
    • 16244392774 scopus 로고    scopus 로고
    • Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye
    • Firth LC, Baker NE. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 2005; 8:541-51.
    • (2005) Dev Cell , vol.8 , pp. 541-551
    • Firth, L.C.1    Baker, N.E.2
  • 19
    • 0032146778 scopus 로고    scopus 로고
    • Radiation-induced apoptosis mediated by retinoblastoma protein
    • Bowen C, Spiegel S, Gelmann EP. Radiation-induced apoptosis mediated by retinoblastoma protein. Cancer Res 1998; 58:3275-81.
    • (1998) Cancer Res , vol.58 , pp. 3275-3281
    • Bowen, C.1    Spiegel, S.2    Gelmann, E.P.3
  • 20
    • 50349083305 scopus 로고    scopus 로고
    • Retinoblastoma RB94 enhances radiation treatment of head and neck squamous cell carcinoma
    • Araki K, Ahmad SM, Li G, Bray DA Jr, Saito K, Wang D, et al. Retinoblastoma RB94 enhances radiation treatment of head and neck squamous cell carcinoma. Clin Cancer Res 2008; 14:3514-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 3514-3519
    • Araki, K.1    Ahmad, S.M.2    Li, G.3    Bray Jr, D.A.4    Saito, K.5    Wang, D.6
  • 22
    • 0033575960 scopus 로고    scopus 로고
    • The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: Inhibition of cell cycle progression and induction of cell death
    • Knudsen KE, Weber E, Arden KC, Cavenee WK, Feramisco JR, Knudsen ES. The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene 1999; 18:5239-45.
    • (1999) Oncogene , vol.18 , pp. 5239-5245
    • Knudsen, K.E.1    Weber, E.2    Arden, K.C.3    Cavenee, W.K.4    Feramisco, J.R.5    Knudsen, E.S.6
  • 23
    • 0035035730 scopus 로고    scopus 로고
    • RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells
    • Zhao X, Day ML. RB activation and repression of C-MYC transcription precede apoptosis of human prostate epithelial cells. Urology 2001; 57:860-5.
    • (2001) Urology , vol.57 , pp. 860-865
    • Zhao, X.1    Day, M.L.2
  • 24
    • 18844446687 scopus 로고    scopus 로고
    • Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb
    • Lemaire C, Godefroy N, Costina-Parvu I, Rincheval V, Renaud F, Trotot P, et al. Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb. Oncogene 2005; 24:3297-308.
    • (2005) Oncogene , vol.24 , pp. 3297-3308
    • Lemaire, C.1    Godefroy, N.2    Costina-Parvu, I.3    Rincheval, V.4    Renaud, F.5    Trotot, P.6
  • 27
    • 0043026892 scopus 로고    scopus 로고
    • Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development
    • Weng L, Zhu C, Xu J, Du W. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J 2003; 22:3865-75.
    • (2003) EMBO J , vol.22 , pp. 3865-3875
    • Weng, L.1    Zhu, C.2    Xu, J.3    Du, W.4
  • 28
    • 0032568795 scopus 로고    scopus 로고
    • Coordination of growth and cell division in the Drosophila wing
    • Neufeld TP, de la Cruz AF, Johnston LA, Edgar BA. Coordination of growth and cell division in the Drosophila wing. Cell 1998; 93:1183-93.
    • (1998) Cell , vol.93 , pp. 1183-1193
    • Neufeld, T.P.1    de la Cruz, A.F.2    Johnston, L.A.3    Edgar, B.A.4
  • 29
    • 0028141705 scopus 로고
    • Expression of baculovirus P35 prevents cell death in Drosophila
    • Hay BA, Wolff T, Rubin GM. Expression of baculovirus P35 prevents cell death in Drosophila. Development 1994; 120:2121-9.
    • (1994) Development , vol.120 , pp. 2121-2129
    • Hay, B.A.1    Wolff, T.2    Rubin, G.M.3
  • 30
    • 0033824366 scopus 로고    scopus 로고
    • Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila
    • Gaumer S, Guenal I, Brun S, Theodore L, Mignotte B. Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila. Cell Death Differ 2000; 7:804-14.
    • (2000) Cell Death Differ , vol.7 , pp. 804-814
    • Gaumer, S.1    Guenal, I.2    Brun, S.3    Theodore, L.4    Mignotte, B.5
  • 31
    • 0034704098 scopus 로고    scopus 로고
    • An essential role for the caspase dronc in developmentally programmed cell death in Drosophila
    • Quinn LM, Dorstyn L, Mills K, Colussi PA, Chen P, Coombe M, et al. An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J Biol Chem 2000; 275:40416-24.
    • (2000) J Biol Chem , vol.275 , pp. 40416-40424
    • Quinn, L.M.1    Dorstyn, L.2    Mills, K.3    Colussi, P.A.4    Chen, P.5    Coombe, M.6
  • 32
    • 0034651987 scopus 로고    scopus 로고
    • The Drosophila caspase DRONC is regulated by DIAP1
    • Meier P, Silke J, Leevers SJ, Evan GI. The Drosophila caspase DRONC is regulated by DIAP1. EMBO J 2000; 19:598-611.
    • (2000) EMBO J , vol.19 , pp. 598-611
    • Meier, P.1    Silke, J.2    Leevers, S.J.3    Evan, G.I.4
  • 33
    • 19444366944 scopus 로고    scopus 로고
    • The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
    • Xu D, Li Y, Arcaro M, Lackey M, Bergmann A. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 2005; 132:2125-34.
    • (2005) Development , vol.132 , pp. 2125-2134
    • Xu, D.1    Li, Y.2    Arcaro, M.3    Lackey, M.4    Bergmann, A.5
  • 34
    • 0029747143 scopus 로고    scopus 로고
    • Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs
    • Asano M, Nevins JR, Wharton RP. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev 1996; 10:1422-32.
    • (1996) Genes Dev , vol.10 , pp. 1422-1432
    • Asano, M.1    Nevins, J.R.2    Wharton, R.P.3
  • 35
    • 0029954340 scopus 로고    scopus 로고
    • Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye
    • Du W, Xie JE, Dyson N. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J 1996; 15:3684-92.
    • (1996) EMBO J , vol.15 , pp. 3684-3692
    • Du, W.1    Xie, J.E.2    Dyson, N.3
  • 37
    • 0016613341 scopus 로고
    • Minutes: Mutants of drosophila autonomously affecting cell division rate
    • Morata G, Ripoll P. Minutes: mutants of drosophila autonomously affecting cell division rate. Dev Biol 1975; 42:211-21.
    • (1975) Dev Biol , vol.42 , pp. 211-221
    • Morata, G.1    Ripoll, P.2
  • 38
    • 38549147654 scopus 로고    scopus 로고
    • Is cell competition relevant to cancer?
    • Moreno E. Is cell competition relevant to cancer? Nat Rev Cancer 2008; 8:141-7.
    • (2008) Nat Rev Cancer , vol.8 , pp. 141-147
    • Moreno, E.1
  • 39
    • 33745026748 scopus 로고    scopus 로고
    • p53 and Retinoblastoma protein (pRb): A complex network of interactions
    • Godefroy N, Lemaire C, Mignotte B, Vayssiere JL. p53 and Retinoblastoma protein (pRb): a complex network of interactions. Apoptosis 2006; 11:659-61.
    • (2006) Apoptosis , vol.11 , pp. 659-661
    • Godefroy, N.1    Lemaire, C.2    Mignotte, B.3    Vayssiere, J.L.4
  • 40
    • 0034193520 scopus 로고    scopus 로고
    • The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
    • Brachmann CB, Jassim OW, Wachsmuth BD, Cagan RL. The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol 2000; 10:547-50.
    • (2000) Curr Biol , vol.10 , pp. 547-550
    • Brachmann, C.B.1    Jassim, O.W.2    Wachsmuth, B.D.3    Cagan, R.L.4
  • 41
    • 0034695914 scopus 로고    scopus 로고
    • Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery
    • Colussi PA, Quinn LM, Huang DC, Coombe M, Read SH, Richardson H, et al. Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery. J Cell Biol 2000; 148:703-14.
    • (2000) J Cell Biol , vol.148 , pp. 703-714
    • Colussi, P.A.1    Quinn, L.M.2    Huang, D.C.3    Coombe, M.4    Read, S.H.5    Richardson, H.6
  • 43
    • 0034284864 scopus 로고    scopus 로고
    • Evolutionarily conserved Bok proteins in the Bcl-2 family
    • Zhang H, Holzgreve W, De Geyter C. Evolutionarily conserved Bok proteins in the Bcl-2 family. FEBS Lett 2000; 480:311-3.
    • (2000) FEBS Lett , vol.480 , pp. 311-313
    • Zhang, H.1    Holzgreve, W.2    De Geyter, C.3
  • 44
    • 0034282917 scopus 로고    scopus 로고
    • Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms
    • Zhang H, Huang Q, Ke N, Matsuyama S, Hammock B, Godzik A, et al. Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. J Biol Chem 2000; 275:27303-6.
    • (2000) J Biol Chem , vol.275 , pp. 27303-27306
    • Zhang, H.1    Huang, Q.2    Ke, N.3    Matsuyama, S.4    Hammock, B.5    Godzik, A.6
  • 45
    • 0036841678 scopus 로고    scopus 로고
    • The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2
    • Decary S, Decesse JT, Ogryzko V, Reed JC, Naguibneva I, Harel-Bellan A, et al. The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol Cell Biol 2002; 22:7877-88.
    • (2002) Mol Cell Biol , vol.22 , pp. 7877-7888
    • Decary, S.1    Decesse, J.T.2    Ogryzko, V.3    Reed, J.C.4    Naguibneva, I.5    Harel-Bellan, A.6
  • 46
    • 0028999429 scopus 로고
    • p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
    • Haupt Y, Rowan S, Oren M. p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene 1995; 10:1563-71.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 47
    • 0035796491 scopus 로고    scopus 로고
    • Cell-autonomous and noncell-autonomous functions of the Rb tumor suppressor in developing central nervous system
    • Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and noncell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J 2001; 20:3402-13.
    • (2001) EMBO J , vol.20 , pp. 3402-3413
    • Lipinski, M.M.1    Macleod, K.F.2    Williams, B.O.3    Mullaney, T.L.4    Crowley, D.5    Jacks, T.6
  • 48
    • 0030003157 scopus 로고    scopus 로고
    • Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells
    • Brook A, Xie JE, Du W, Dyson N. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J 1996; 15:3676-83.
    • (1996) EMBO J , vol.15 , pp. 3676-3683
    • Brook, A.1    Xie, J.E.2    Du, W.3    Dyson, N.4
  • 49
    • 20244385424 scopus 로고    scopus 로고
    • Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    • Ollmann M, Young LM, Di Como CJ, Karim F, Belvin M, Robertson S, et al. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 2000; 101:91-101.
    • (2000) Cell , vol.101 , pp. 91-101
    • Ollmann, M.1    Young, L.M.2    Di Como, C.J.3    Karim, F.4    Belvin, M.5    Robertson, S.6
  • 50
    • 0037136675 scopus 로고    scopus 로고
    • Reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila
    • Brun S, Rincheval V, Gaumer S, Mignotte B, Guenal I. Reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila. Oncogene 2002; 21:6458-70.
    • (2002) Oncogene , vol.21 , pp. 6458-6470
    • Brun, S.1    Rincheval, V.2    Gaumer, S.3    Mignotte, B.4    Guenal, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.