Rb regulates fate choice and lineage commitment in vivo

Nature

Volumn 466, Issue 7310, 2010, Pages 1110-1114

  Calo, Eliezer ^a   Quintero Estades, Jose A ^a   Danielian, Paul S ^a   Nedelcu, Simona ^a   Berman, Seth D ^a   Lees, Jacqueline A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR E2F;

BONE; GENE EXPRESSION; INHIBITION; MUTATION; PROTEIN; RODENT; TUMOR;

ADIPOCYTE; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; GENE CONTROL; GENE REPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPOMA; MICE; MUTATION; OSTEOBLASTS; PPAR GAMMA; RETINOBLASTOMA PROTEIN; SARCOMA;

EID: 77956182397     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09264     Document Type: Article

References (20)

1. Burkhart, D. L. & Sage, J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nature Rev. Cancer 8, 671-682 (2008).
2. Korenjak, M. & Brehm, A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr. Opin. Genet. Dev. 15, 520-527 (2005).
3. Thomas, D. M. et al. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol. Cell 8, 303-316 (2001).
4. Fajas, L. et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARc and adipocyte differentiation. Dev. Cell 3, 903-910 (2002).
5. Fajas, L. et al. E2Fs regulate adipocyte differentiation. Dev. Cell 3, 39-49 (2002).
6. Clark, J. C. , Dass, C. R. & Choong, P. F. Areviewof clinical and molecular prognostic factors in osteosarcoma. J. Cancer Res. Clin. Oncol. 134, 281-297 (2008).
7. Kansara, M. & Thomas, D. M. Molecular pathogenesis of osteosarcoma. DNA Cell Biol. 26, 1-18 (2007).
8. Sage, J. et al. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424, 223-228 (2003).
9. Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genet. 29, 418-425 (2001).
10. Logan, M. et al. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33, 77-80 (2002).
11. Hansen, J. B. et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc. Natl Acad. Sci. USA 101, 4112-4117 (2004).
12. Scime, A. et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab. 2, 283-295 (2005).
13. Dali-Youcef, N. et al. Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc. Natl Acad. Sci. USA 104, 10703-10708 (2007).
14. Rodda, S. J. & McMahon, A. P. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133, 3231-3244 (2006).
15. Berman, S. D. et al. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc. Natl Acad. Sci. USA 105, 11851-11856 (2008).
16. Lengner, C. J. et al. Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J. Cell Biol. 172, 909-921 (2006).
17. Tallquist, M. D. & Soriano, P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26, 113-115 (2000).
18. Wu, L. et al. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421, 942-947 (2003).
19. Berman, S. D. et al. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol. Cancer Res. 6, 1440-1451 (2008).
20. Barski, A. , Pregizer, S. & Frenkel, B. Identification of transcription factor target genes by ChIP display. Methods Mol. Biol. 455, 177-190 (2008).