Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation

Oncogene

Volumn 25, Issue 5, 2006, Pages 746-754

  Pickering, M T ^a   Kowalik, T F ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

c MYC; Double strand breaks; DSBs; E2F1; Rb inactivation

Indexed keywords

ATM PROTEIN; CASPASE; MYC PROTEIN; ONCOPROTEIN; PROTEIN P16INK4A; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DEREGULATION; DIPLOIDY; DNA STRAND BREAKAGE; EMBRYO; ENZYME INACTIVATION; GENE DISRUPTION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION;

BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DNA DAMAGE; E2F1 TRANSCRIPTION FACTOR; GENES, RETINOBLASTOMA; HUMANS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, SMALL INTERFERING;

EID: 32244439530     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209103     Document Type: Article

References (27)

1. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K et al. (2005). Nature 434: 864-870.
2. Berkovich E, Ginsberg D. (2003). Oncogene 22: 161-167.
3. Biroccio A, Benassi B, Amodei S, Gabellini C, Del Bufalo D, Zupi G. (2001). Mol Pharmacol 60: 174-182.
4. Bosco EE. (2004). Nucleic Acids Res 32: 25-34.
5. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. (1997). Proc Natl Acad Sci USA 94: 7245-7250.
6. Duensing S, Munger K. (2002). Cancer Res 62: 7075-7082.
7. Dyson N. (1998). Genes Dev 12: 2245-2262.
8. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T et al. (2005). Nature 434: 907-913.
9. Johnson DG, Schwarz JK, Cress WD, Nevins JR. (1993). Nature 365: 349-352.
10. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. (1995). J Virol 69: 2491-2500.
11. Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH et al. (2001). Mol Cell 8: 105-113.
12. Lomazzi M, Moroni MC, Jensen MR, Frittoli E, Helin K. (2002). Nat Genet 31: 190-194.
13. Matsumura I, Tanaka H, Kanakura Y. (2003). Cell Cycle 2: 333-338.
14. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. (1994). Nature 371: 72-74.
15. Nevins JR. (2001). Hum Mol Genet 10: 699-703.
16. Olive PL, Wlodek D, Banath JP. (1991). Cancer Res 51: 4671-4676.
17. Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. (2000). Curr Biol 10: 886-895.
18. Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG. (2004). Mol Cancer Res 2: 203-214.
19. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. (1998). J Biol Chem 273: 5858-5868.
20. Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S et al. (2004). Mol Cell Biol 24: 2968-2977.
21. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. (2004). Annu Rev Biochem 73: 39-85.
22. Schwarz JK, Bassing CH, Kovesdi I, Datto MB, Blazing M, George S et al. (1995). Proc Natl Acad Sci USA 92: 483-487.
23. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. (2000). Genes Dev 14: 2501-2514.
24. Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C et al. (2002). Mol Cell 9: 1017-1029.
25. Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M et al (1999). J Biol Chem 274: 31463-31467.
26. Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM et al. (2002). Mol Cell 9: 1031-1044.
27. White AE, Livanos EM, Tlsty TD. (1994). Genes Dev 8: 666-677.