Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

Genes and Development

Volumn 18, Issue 23, 2004, Pages 2929-2940

  Lewis, Peter W ^a   Beall, Eileen L ^a   Fleischer, Tracey C ^b   Georlette, Daphne ^a   Link, Andrew J ^b   Botchan, Michael R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drosophila; E2F; Myb; RB; SynMuv; Transcription

Indexed keywords

BRAIN TUMOR PROTEIN; HISTONE DEACETYLASE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR E2F6; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DROSOPHILA; EMBRYO; EMBRYO CELL; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; IMMUNOAFFINITY CHROMATOGRAPHY; NONHUMAN; ONCOGENE MYB; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN PURIFICATION; STRUCTURAL HOMOLOGY; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION;

ANIMALS; CHROMATOGRAPHY, GEL; DROSOPHILA; DROSOPHILA PROTEINS; E2F2 TRANSCRIPTION FACTOR; IMMUNOPRECIPITATION; PROTO-ONCOGENE PROTEINS C-MYB; REPRESSOR PROTEINS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 10044255182     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1255204     Document Type: Article

References (59)

1. Aggarwal, B.D. and Calvi, B.R. 2004. Chromatin regulates origin activity in Drosophila follicle cells. Nature 430: 372-376.
2. Bannister, A.J., Zegerman, P., Partridge, J.F., Miska, E.A., Thomas, J.O., Allshire, R.C., and Kouzarides, T. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410: 120-124.
3. Beall, E.L., Manak, J.R., Zhou, M. Bell, S., Lipsick, J.S., and Botchan, M.R. 2002. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420: 833-837.
4. Beall, E.L., Bell, M., Georlette, D., and Botchan, M.R. 2004. Dm-myb mutant lethality in Drosophila is dependent upon mip130: Positive and negative regulation of DNA replication. Genes & Dev. 18: 1667-1680.
5. Beitel, G.J., Lambie, E.J., and Horvitz, H.R. 2000. The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Gene 254: 253-263.
6. Boccuni, P., MacGrogan, D., Scandura, J.M., and Nimer, S.D. 2003. The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). J. Biol. Chem. 278: 15412-15420.
7. Bornemann, D., Miller, E., and Simon, J. 1998. Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor protein. Genetics 150: 675-686.
8. Bosco, G., Du, W., and Orr-Weaver, T.L. 2001. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat. Cell Biol. 3: 289-295.
9. Boxem, M. and van den Heuvel, S. 2002. C. elegans class B synthetic multivulva genes act in G1 regulation. Curr. Biol. 12: 906-911.
10. Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J., and Kouzarides, T. 1998. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597-601.
11. Cam, H. and Dynlacht, B.D. 2003. Emerging roles for E2F: Beyond the G1/S transition and DNA replication. Cancer Cell 3: 311-316.
12. Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R.S., and Zhang, Y. 2002. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298: 1039-1043.
13. Cayirlioglu, P., Bonnette, P.C., Dickson, M.R., and Duronio, R.J. 2001. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Development 128: 5085-5098.
14. Cayirlioglu, P., Ward, W.O., Silver Key, S.C., and Duronio, R.J. 2003. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Mol. Cell Biol. 23: 2123-2134.
15. Ceol, C.J. and Horvitz, H.R. 2001. dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Mol. Cell 7: 461-473.
16. _. 2004. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev. Cell 6: 563-576.
17. Chan, H.M., Smith, L., and La Thangue, N.B. 2001. Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Oncogene 20: 6152-6163.
18. Dimova, D.K., Stevaux, O., Frolov, M.V., and Dyson, N.J. 2003. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes & Dev. 17: 2308-2320.
19. Du, W., Vidal, M., Xie, J.E., and Dyson, N. 1996. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes & Dev. 10: 1206-1218.
20. Ferguson, E.L. and Horvitz, H.R. 1989. The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics 123: 109-121.
21. Frolov, M.V., Stevaux, O., Moon, N.S., Dimova, D., Kwon, E.J., Morris, E.J., and Dyson, N.J. 2003. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes & Dev. 17: 723-728.
22. Gateff, E., Loffler, T., and Wismar, J. 1993. A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster. Developmental studies and molecular localization of the gene. Mech. Dev. 41: 15-31.
23. Harbour, J.W., Luo, R.X., Dei Santi, A., Postigo, A.A., and Dean, D.C. 1999. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98: 859-869.
24. Horvitz, H.R. and Sulston, J.E. 1980. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics 96: 435-454.
25. Hou, D.X., Akimaru, H., and Ishii, S. 1997. Trans-activation by the Drosophila myb gene product requires a Drosophila homologue of CBP. FEBS Lett. 413: 60-64.
26. Hsieh, J., Liu, J., Kostas, S.A., Chang, C., Sternberg, P.W., and Fire, A. 1999. The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans. Genes & Dev. 13: 2958-2970.
27. Joaquin, M., Bessa, M., Saville, M.K., and Watson, R.J. 2002. B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107. Oncogene 21: 7923-7932.
28. Kamakaka, R.T., Tyree, C.M., and Kadonaga, J.T. 1991. Accurate and efficient RNA polymerase II transcription with a soluble nuclear fraction derived from Drosophila embryos. Proc. Natl. Acad. Sci. 88: 1024-1028.
29. Kamakaka, R.T., Bulger, M., and Kadonaga, J.T. 1993. Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly. Genes & Dev. 7: 1779-1795.
30. Katzen, A.L., Kornberg, T.B., and Bishop, J.M. 1985. Isolation of the proto-oncogene c-myb from D. melanogaster. Cell 41: 449-456.
31. Katzen, A.L., Jackson, J., Harmon, B.P., Fung, S.M., Ramsay, G., and Bishop, J.M. 1998. Drosophila myb is required for the G2/M transition and maintenance of diploidy. Genes & Dev. 12: 831-843.
32. Knudsen, E.S. and Wang, J.Y. 1997. Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol. Cell. Biol. 17: 5771-5783.
33. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410: 116-120.
34. Lee, C., Chang, J.H., Lee, H.S., and Cho, Y. 2002. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes & Dev. 16: 3199-3212.
35. Levine, S.S., A. Weiss, A., Erdjument-Bromage, H., Shao, Z., Tempst, P., and Kingston, R.E. 2002. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol. Cell. Biol. 22: 6070-6078.
36. Link, A.J., Eng, J., Schieltz, D.M., Carmack, E., Mize, G.J., Morris, D.R., Garvik, B.M., and Yates III, J.R. 1999. Direct analysis of protein complexes using mass spectrometry. Nat. Biotechnol. 17: 676-682.
37. Logan, N., Delavaine, L., Graham, A., Reilly, C., Wilson, J., Brummelkamp, T.R., Hijmans, E.M., Bernards, R., and La Thangue, N.B. 2004. E2F-7: A distinctive E2F family member with an unusual organization of DNA-binding domains. Oncogene 23: 5138-5150.
38. Lu, X. and Horvitz, H.R. 1998. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95: 981-991.
39. Manak, J.R., Mitiku, N., and Lipsick, J.S. 2002. Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. Proc. Natl. Acad. Sci. 99: 7438-7443.
40. Mizuguchi, G., Tsukiyama, T., Wisniewski, J., and Wu, C. 1997. Role of nucleosome remodeling factor NURF in transcriptional activation of chromatin. Mol. Cell 1: 141-150.
41. Moberg, K., Starz, M.A., and Lees, J.A. 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol. 16: 1436-1449.
42. Mottus, R., Sobel, R.E., and Grigliatti, T.A. 2000. Mutational analysis of a histone deacetylase in Drosophila melanogaster: Missense mutations suppress gene silencing associated with position effect variegation. Genetics 154: 657-668.
43. Nakayama, J., Rice, J.C., Strahl, B.D., Allis, C.D., and Grewal, S.I. 2001. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110-113.
44. Nevins, J.R., Leone, G., DeGregori, J., and Jakoi, L. 1997. Role of the Rb/E2F pathway in cell growth control. J. Cell. Physiol. 173: 233-236.
45. Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D.M., and Nakatani, Y. 2002. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296: 1132-1136.
46. Okada, M., Akimaru, H., Hou, D.X., Takahashi, T., and Ishii, S. 2002. Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21: 675-684.
47. Orr-Weaver, T.L., Johnston, C.G., and Spradling, A.C. 1989. The role of ACE3 in Drosophila chorion gene amplification. EMBO J. 8: 4153-4162.
48. Owen, A.B., Stuart, J., Mach, K., Villeneuve, A.M., and Kim, S. 2003. A gene recommender algorithm to identify coexpressed genes in C. elegans. Genome Res. 13: 1828-1837.
49. Page, B.D., Guedes, S., Waring, D., and Priess, J.R. 2001. The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling. Mol. Cell 7: 451-460.
50. Royzman, I., Austin, R.J., Bosco, G., Bell, S.P., and Orr-Weaver, T.L. 1999. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes & Dev. 13: 827-840.
51. Sanders, S.L., Jennings, J., Canutescu, A., Link, A.J., and Weil, P.A. 2002. Proteomics of the eukaryotic transcription machinery: Identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol. Cell Biol. 22: 4723-4738.
52. Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J.R., Wu, C.T., Bender, W., and Kingston, R.E. 1999. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98: 37-46.
53. Sprangers, R., Groves, M.R., Sinning, I., and Sattler, M. 2003. High-resolution X-ray and NMR structures of the SMN Tudor domain: Conformational variation in the binding site for symmetrically dimethylated arginine residues. J. Mol. Biol. 327: 507-520.
54. Taunton, J., Hassig, C.A., and Schreiber, S.L. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272: 408-411.
55. Thomas, J.H., Ceol, C.J., Schwartz, H.T., and Horvitz, H.R. 2003. New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics 164: 135-151.
56. Tsuboi, D., Qadota, H., Kasuya, K., Amano, M., and Kaibuchi, K. 2002. Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem. Biophys. Res. Commun. 292: 697-701.
57. Wang, W.K., Tereshko, V., Boccuni, P., MacGrogan, D., Nimer, S.D., and Patel, D.J. 2003. Malignant brain tumor repeats: A three-leaved propeller architecture with ligand/peptide binding pockets. Structure (Camb) 11: 775-789.
58. Weintraub, S.J., Prater, C.A., and Dean, D.C. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261.
59. Wysocka, J., Myers, M.P., Laherty, C.D., Eisenman, R.N., and Herr, W. 2003. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes & Dev. 17: 896-911.