Interactions of formulation excipients with proteins in solution and in the dried state

Advanced Drug Delivery Reviews

Volumn 63, Issue 13, 2011, Pages 1053-1073

  Ohtake, Satoshi ^a   Kita, Yoshiko ^b   Arakawa, Tsutomu ^c  

^a Aridis Pharmaceuticals   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ALLIANCE PROTEIN LABORATORIES   (United States)

Author keywords

Amorphous glass; Attraction pressure; Dry; Excipients; Excluded volume; Preferential interaction; Protein formulation; Solution; Stability

Indexed keywords

AMORPHOUS GLASS; ATTRACTION PRESSURE; DRY; EXCIPIENTS; EXCLUDED VOLUME; PREFERENTIAL INTERACTION; PROTEIN FORMULATION;

ADSORPTION; AGGLOMERATION; AMINO ACIDS; PHYSICAL PROPERTIES; SUGARS; SURFACE ACTIVE AGENTS;

PROTEINS;

6 PHOSPHOFRUCTOKINASE; BLOOD CLOTTING FACTOR 13; CARBOHYDRATE; DEXTRAN; EXCIPIENT; HEMOGLOBIN; KERATINOCYTE GROWTH FACTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MN12; POLYMER; POLYOL; RECOMBINANT BLOOD CLOTTING FACTOR 13; SARCOSINE; SOLVENT; UNCLASSIFIED DRUG;

CONCENTRATION (PARAMETERS); CRYSTALLIZATION; DRIED STATE; DRUG STORAGE; EQUILIBRIUM CONSTANT; FREEZE DRYING; HYDROGEN BOND; HYDROPHOBICITY; MELTING POINT; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PASTEURIZATION; PHYSICAL PHASE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN UNFOLDING; REVIEW; SHELF LIFE; SOLUTION AND SOLUBILITY; STOMATITIS; SURFACE CHARGE; TEMPERATURE STRESS; THERMOSTABILITY; VITRIFICATION;

ARGININE; DRUG STABILITY; EXCIPIENTS; HUMANS; POLYMERS; POWDERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; SOLUTIONS; SURFACE-ACTIVE AGENTS;

EID: 80054758768     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.06.011     Document Type: Review

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