Drying-induced variations in physico-chemical properties of amorphous pharmaceuticals and their impact on stability II: Stability of a vaccine

Pharmaceutical Research

Volumn 24, Issue 4, 2007, Pages 715-727

  Abdul Fattah, Ahmad M ^a,c   Truong Le, Vu ^b   Yee, Luisa ^b   Pan, Emilie ^b   Ao, Yi ^b   Kalonia, Devendra S ^a   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b MEDIMMUNE   (United States)

^c AMGEN INC   (United States)

Author keywords

Drying vaccines; Electron spectroscopy for chemical analysis (ESCA); Glass transition temperature (Tg); Parainfluenza virus; Specific surface area; Surface coverage; Total surface accumulation; Vaccine stability

Indexed keywords

LIVE VACCINE; PARAINFLUENZA VACCINE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; DRY POWDER; ELECTRON MICROSCOPY; FOAM; FREEZE DRYING; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; SPRAY DRYING; VIRUS INFECTIVITY;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CERCOPITHECUS AETHIOPS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; CYTOPATHOGENIC EFFECT, VIRAL; DESICCATION; DRUG STABILITY; DRUG STORAGE; ELECTRONS; EXCIPIENTS; FREEZE DRYING; INFLUENZA VACCINES; KINETICS; PARAINFLUENZA VIRUS 3, HUMAN; POLOXAMER; POWDERS; SPECTRUM ANALYSIS; SUCROSE; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE; VACCINES, ATTENUATED; VERO CELLS; WATER;

EID: 33947203155     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9191-2     Document Type: Article

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