Dual effects of Tween 80 on protein stability

International Journal of Pharmaceutics

Volumn 347, Issue 1-2, 2008, Pages 31-38

  Wang, Wei ^b   Wang, Y John ^c   Wang, D Q ^a  

^a BAYER CORPORATION   (United States)

^b PFIZER INC   (United States)

^c GENENTECH INC   (United States)

Author keywords

Protein; Stability; Surfactant; Tween 80

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2SA; POLYSORBATE 80; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DRUG FORMULATION; FEMALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STABILITY; SHELF LIFE; STORAGE TEMPERATURE;

DRUG STORAGE; GLYCINE; HISTIDINE; HUMANS; HYDROPHOBICITY; INTERLEUKIN-2; MANNITOL; MUTATION; NEPHELOMETRY AND TURBIDIMETRY; OXIDATION-REDUCTION; PHARMACEUTIC AIDS; POLYSORBATES; PROTEIN DENATURATION; PROTEINS; RECOMBINANT PROTEINS; STRESS, MECHANICAL; SUCROSE; TEMPERATURE;

EID: 36549040103     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.06.042     Document Type: Article

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